nach oben

Erschienen in:

03.08.2019 | Focussed Research Review

Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy

verfasst von: Michael Friedrich, Simon Jasinski-Bergner, Maria-Filothei Lazaridou, Karthikeyan Subbarayan, Chiara Massa, Sandy Tretbar, Anja Mueller, Diana Handke, Katharina Biehl, Jürgen Bukur, Marco Donia, Ofer Mandelboim, Barbara Seliger

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 10/2019

Einloggen, um Zugang zu erhalten

Abstract

Immunotherapy aims to activate the immune system to fight cancer in a very specific and targeted manner. Despite the success of different immunotherapeutic strategies, in particular antibodies directed against checkpoints as well as adoptive T-cell therapy, the response of patients is limited in different types of cancers. This attributes to escape of the tumor from immune surveillance and development of acquired resistances during therapy. In this review, the different evasion and resistance mechanisms that limit the efficacy of immunotherapies targeting tumor-associated antigens presented by major histocompatibility complex molecules on the surface of the malignant cells are summarized. Overcoming these escape mechanisms is a great challenge, but might lead to a better clinical outcome of patients and is therefore currently a major focus of research.

Leone P et al (2013) MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells. J Natl Cancer Inst 105(16):1172–1187PubMed

Zanker D, Chen W (2014) Standard and immunoproteasomes show similar peptide degradation specificities. Eur J Immunol 44(12):3500–3503PubMed

Saveanu L et al (2005) Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol 6(7):689–697PubMed

Norbury CC, Eisenlohr LC (2016) Editorial overview: antigen processing. Curr Opin Immunol 40:5–6

Mintern JD, Macri C, Villadangos JA (2015) Modulation of antigen presentation by intracellular trafficking. Curr Opin Immunol 34:16–21PubMed

Han LY et al (2008) HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinoma. Clin Cancer Res 14(11):3372–3379PubMedPubMedCentral

Perea F et al (2017) The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration. Int J Cancer 140(4):888–899PubMed

Garrido F et al (2017) The escape of cancer from T cell-mediated immune surveillance: HLA class I loss and tumor tissue architecture. Vaccines (Basel) 5(1):7

Seliger B (2016) Role of microRNAs on HLA-G expression in human tumors. Hum Immunol 77(9):760–763PubMed

10.

Real LM et al (1999) Expression of HLA G in human tumors is not a frequent event. Int J Cancer 81(4):512–518PubMed

11.

Davies B et al (2001) HLA-G expression by tumors. Am J Reprod Immunol 45(2):103–107PubMed

12.

Polakova K et al (2003) Analysis of HLA-G expression in malignant hematopoietic cells from leukemia patients. Leuk Res 27(7):643–648PubMed

13.

Frumento G et al (2000) Melanomas and melanoma cell lines do not express HLA-G, and the expression cannot be induced by gamma IFN treatment. Tissue Antigens 56(1):30–37PubMed

14.

Pangault C et al (1999) HLA-G protein expression is not induced during malignant transformation. Tissue Antigens 53(4 Pt 1):335–346PubMed

15.

Chang CC, Ferrone S (2003) HLA-G in melanoma: can the current controversies be solved? Semin Cancer Biol 13(5):361–369PubMed

16.

Wang Y et al (2011) Expression of HLA-G in patients with hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 10(2):158–163PubMed

17.

Yie SM et al (2007) Expression of human leucocyte antigen G (HLA-G) is associated with prognosis in non-small cell lung cancer. Lung Cancer 58(2):267–274PubMed

18.

Tronik-Le Roux D et al (2017) Novel landscape of HLA-G isoforms expressed in clear cell renal cell carcinoma patients. Mol Oncol 11(11):1561–1578PubMedPubMedCentral

19.

Lin A, Yan WH (2018) Heterogeneity of HLA-G expression in cancers: facing the challenges. Front Immunol 9:2164PubMedPubMedCentral

20.

Lin A, Yan WH (2015) Human leukocyte antigen-G (HLA-G) expression in cancers: roles in immune evasion, metastasis and target for therapy. Mol Med 21(1):782–791PubMedPubMedCentral

21.

Contini P et al (2003) Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8 + cells and inhibit cytotoxic T cell activity through CD8 ligation. Eur J Immunol 33(1):125–134PubMed

22.

Menier C et al (2002) MICA triggering signal for NK cell tumor lysis is counteracted by HLA-G1-mediated inhibitory signal. Int J Cancer 100(1):63–70PubMed

23.

Fons P et al (2006) Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells. Blood 108(8):2608–2615PubMed

24.

Morandi F et al (2010) A novel mechanism of soluble HLA-G mediated immune modulation: downregulation of T cell chemokine receptor expression and impairment of chemotaxis. PLoS One 5(7):e11763PubMedPubMedCentral

25.

Morandi F et al (2011) Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56bright and CD56dim NK cells. Blood 118(22):5840–5850PubMed

26.

Agaugue S, Carosella ED, Rouas-Freiss N (2011) Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17. Blood 117(26):7021–7031PubMed

27.

Loumagne L et al (2014) In vivo evidence that secretion of HLA-G by immunogenic tumor cells allows their evasion from immunosurveillance. Int J Cancer 135(9):2107–2117PubMed

28.

Seliger B (2014) The link between MHC class I abnormalities of tumors, oncogenes, tumor suppressor genes, and transcription factors. J Immunotoxicol 11(4):308–310PubMed

29.

Cai L et al (2018) Defective HLA class I antigen processing machinery in cancer. Cancer Immunol Immunother 67(6):999–1009PubMedPubMedCentral

30.

Donia M et al (2017) Acquired Immune resistance follows complete tumor regression without loss of target antigens or IFN gamma signaling. Cancer Res 77(17):4562–4566PubMed

31.

Kloor M, Michel S, von Knebel Doeberitz M (2010) Immune evasion of microsatellite unstable colorectal cancers. Int J Cancer 127(5):1001–1010PubMed

32.

Hicklin DJ et al (1998) Beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma. J Clin Invest 101(12):2720–2729PubMedPubMedCentral

33.

Chang CC et al (2005) Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy. J Immunol 174(3):1462–1471PubMed

34.

Geertsen R et al (2002) Loss of single HLA class I allospecificities in melanoma cells due to selective genomic abbreviations. Int J Cancer 99(1):82–87PubMed

35.

del Campo AB et al (2014) Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma. Int J Cancer 134(1):102–113PubMed

36.

McGranahan N et al (2017) Allele-specific HLA loss and immune escape in lung cancer evolution. Cell 171(6):1259–1271PubMedPubMedCentral

37.

Zehir A et al (2017) Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med 23(6):703–713PubMedPubMedCentral

38.

Seliger B (2017) Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors. Cytokine Growth Factor Rev 36:49–56PubMed

39.

Ritter C et al (2017) Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma. Sci Rep 7(1):2290PubMedPubMedCentral

40.

Jongsma MLM, Guarda G, Spaapen RM (2017) The regulatory network behind MHC class I expression. Mol Immunol. https://doi.org/10.1016/j.molimm.2017.12.005 CrossRefPubMed

41.

Drukker M et al (2002) Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci USA 99(15):9864–9869PubMedPubMedCentral

42.

Vlkova V et al (2014) Epigenetic regulations in the IFNgamma signalling pathway: IFNgamma-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes. Oncotarget 5(16):6923–6935PubMedPubMedCentral

43.

Manning J et al (2008) Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. Immunology 123(2):218–227PubMedPubMedCentral

44.

Setiadi AF et al (2008) Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. Cancer Res 68(23):9601–9607PubMed

45.

Dunker K et al (2008) Expression and regulation of non-classical HLA-G in renal cell carcinoma. Tissue Antigens 72(2):137–148PubMed

46.

Ramsuran V et al (2015) Epigenetic regulation of differential HLA-A allelic expression levels. Hum Mol Genet 24(15):4268–4275PubMedPubMedCentral

47.

Gustafsson JR et al (2018) DNMT1 regulates expression of MHC class I in post-mitotic neurons. Mol Brain 11(1):36PubMedPubMedCentral

48.

Khan AN, Gregorie CJ, Tomasi TB (2008) Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. Cancer Immunol Immunother 57(5):647–654PubMed

49.

Komatsu Y, Hayashi H (1998) Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells. J Antibiot (Tokyo) 51(1):89–91

50.

Robbins GR et al (2012) Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem 287(29):24294–24303PubMedPubMedCentral

51.

Moreau P et al (2003) HLA-G gene repression is reversed by demethylation. Proc Natl Acad Sci USA 100(3):1191–1196PubMedPubMedCentral

52.

Holling TM et al (2009) Genetic and epigenetic control of the major histocompatibility complex class Ib gene HLA-G in trophoblast cell lines. Ann N Y Acad Sci 1173:538–544PubMed

53.

van den Elsen PJ (2011) Expression regulation of major histocompatibility complex class I and class II encoding genes. Front Immunol 2:48PubMedPubMedCentral

54.

van den Elsen PJ et al (1998) Regulation of MHC class I and II gene transcription: differences and similarities. Immunogenetics 48(3):208–221PubMed

55.

Howcroft TK et al (2003) Distinct transcriptional pathways regulate basal and activated major histocompatibility complex class I expression. Mol Cell Biol 23(10):3377–3391PubMedPubMedCentral

56.

Gobin SJ et al (1998) The role of enhancer A in the locus-specific transactivation of classical and nonclassical HLA class I genes by nuclear factor kappa B. J Immunol 161(5):2276–2283PubMed

57.

Gobin SJ et al (1999) Transactivation of classical and nonclassical HLA class I genes through the IFN-stimulated response element. J Immunol 163(3):1428–1434PubMed

58.

Gobin SJ et al (2001) The MHC-specific enhanceosome and its role in MHC class I and beta(2)-microglobulin gene transactivation. J Immunol 167(9):5175–5184PubMed

59.

van den Elsen PJ et al (2004) Transcriptional regulation of antigen presentation. Curr Opin Immunol 16(1):67–75PubMed

60.

Gobin SJ et al (1997) Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity 6(5):601–611PubMed

61.

Bukur J et al (2010) Identification of E2F1 as an important transcription factor for the regulation of tapasin expression. J Biol Chem 285(40):30419–30426PubMedPubMedCentral

62.

Zheng P et al (1998) Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature 396(6709):373–376PubMed

63.

Geiser AG et al (1993) Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. Proc Natl Acad Sci USA 90(21):9944–9948PubMedPubMedCentral

64.

Baldeon ME et al (1997) Interferon-gamma independently activates the MHC class I antigen processing pathway and diminishes glucose responsiveness in pancreatic beta-cell lines. Diabetes 46(5):770–778PubMed

65.

Israel A et al (1989) TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors. EMBO J 8(12):3793–3800PubMedPubMedCentral

66.

Komov L et al (2018) Cell surface MHC class I expression is limited by the availability of peptide-receptive “empty” molecules rather than by the supply of peptide ligands. Proteomics 18(12):e1700248PubMed

67.

Parker BS, Rautela J, Hertzog PJ (2016) Antitumour actions of interferons: implications for cancer therapy. Nat Rev Cancer 16(3):131–144PubMed

68.

Schroder K et al (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75(2):163–189PubMed

69.

Ting JP, Baldwin AS (1993) Regulation of MHC gene expression. Curr Opin Immunol 5(1):8–16PubMed

70.

Hertzog PJ, Williams BR (2013) Fine tuning type I interferon responses. Cytokine Growth Factor Rev 24(3):217–225PubMed

71.

Zhou F (2009) Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation. Int Rev Immunol 28(3–4):239–260PubMed

72.

Strehl B et al (2005) Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing. Immunol Rev 207:19–30PubMed

73.

Meissner TB et al (2010) NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci USA 107(31):13794–13799PubMedPubMedCentral

74.

Kulski JK et al (2001) Genomic and phylogenetic analysis of the human CD1 and HLA class I multicopy genes. J Mol Evol 53(6):642–650PubMed

75.

Gobin SJ, van den Elsen PJ (1999) The regulation of HLA class I expression: is HLA-G the odd one out? Semin Cancer Biol 9(1):55–59PubMed

76.

Gobin SJ et al (2002) HLA-G transactivation by cAMP-response element-binding protein (CREB) An alternative transactivation pathway to the conserved major histocompatibility complex (MHC) class I regulatory routes. J Biol Chem 277(42):39525–39531PubMed

77.

Flajollet S et al (2009) RREB-1 is a transcriptional repressor of HLA-G. J Immunol 183(11):6948–6959PubMed

78.

Eichmuller SB et al (2017) Immune modulatory microRNAs involved in tumor attack and tumor immune escape. J Natl Cancer Inst 109(10):1–14

79.

Seliger B (2008) Different regulation of MHC class I antigen processing components in human tumors. J Immunotoxicol 5(4):361–367PubMed

80.

Kulkarni S et al (2011) Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature 472(7344):495–498PubMedPubMedCentral

81.

Tan Z et al (2007) Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet 81(4):829–834PubMedPubMedCentral

82.

Zhu XM et al (2010) Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells. Am J Obstet Gynecol 202(6):592PubMed

83.

Jasinski-Bergner S et al (2016) Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. Oncotarget 7(18):26866–26878PubMedPubMedCentral

84.

Friedrich M et al (2017) The role of the miR-148/-152 family in physiology and disease. Eur J Immunol 47(12):2026–2038PubMed

85.

Manaster I et al (2012) MiRNA-mediated control of HLA-G expression and function. PLoS ONE 7(3):e33395PubMedPubMedCentral

86.

Jasinski-Bergner S et al (2015) Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. Oncoimmunology 4(6):e1008805PubMedPubMedCentral

87.

Wang Y et al (2017) MicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma. Oncotarget 8(17):28125–28134PubMedPubMedCentral

88.

Gao F et al (2013) miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells. Biochem Biophys Res Commun 431(3):610–616PubMed

89.

Bartoszewski R et al (2011) The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. J Biol Chem 286(48):41862–41870PubMedPubMedCentral

90.

Albanese M et al (2016) Epstein–Barr virus microRNAs reduce immune surveillance by virus-specific CD8 + T cells. Proc Natl Acad Sci USA 113(42):E6467–E6475PubMedPubMedCentral

91.

Kim S et al (2011) Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1. Nat Immunol 12(10):984–991PubMedPubMedCentral

92.

Huang L et al (2018) The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression. Clin Cancer Res 24(14):3366–3376PubMed

93.

Cano F et al (2012) The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. EMBO J 31(17):3596–3606PubMedPubMedCentral

94.

Reches A et al (2016) HNRNPR regulates the expression of classical and nonclassical MHC class I proteins. J Immunol 196(12):4967–4976PubMed

95.

Shankaran V et al (2001) IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410(6832):1107–1111PubMed

96.

Kaplan DH et al (1998) Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 95(13):7556–7561PubMedPubMedCentral

97.

Ivashkiv LB, Donlin LT (2014) Regulation of type I interferon responses. Nat Rev Immunol 14(1):36–49PubMedPubMedCentral

98.

Greenlund AC et al (1994) Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J 13(7):1591–1600PubMedPubMedCentral

99.

Decker T et al (1991) Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. EMBO J 10(4):927–932PubMedPubMedCentral

100.

Chatterjee-Kishore M et al (2000) How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J 19(15):4111–4122PubMedPubMedCentral

101.

Rettino A, Clarke NM (2013) Genome-wide identification of IRF1 binding sites reveals extensive occupancy at cell death associated genes. J Carcinog Mutagen (Spec Iss Apoptosis). https://doi.org/10.4172/2157-2518.S6-009 CrossRef

102.

Starr R et al (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387(6636):917–921PubMed

103.

Castro F et al (2018) Interferon-Gamma at the crossroads of tumor immune surveillance or evasion. Front Immunol 9:847PubMedPubMedCentral

104.

Seliger B et al (1997) IFN-gamma-mediated coordinated transcriptional regulation of the human TAP-1 and LMP-2 genes in human renal cell carcinoma. Clin Cancer Res 3(4):573–578PubMed

105.

Seliger B, Ruiz-Cabello F, Garrido F (2008) IFN inducibility of major histocompatibility antigens in tumors. Adv Cancer Res 101:249–276PubMedPubMedCentral

106.

Respa A et al (2011) Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines. Clin Cancer Res 17(9):2668–2678PubMedPubMedCentral

107.

Aqbi HF et al (2018) IFN-gamma orchestrates tumor elimination, tumor dormancy, tumor escape, and progression. J Leukoc Biol. https://doi.org/10.1002/JLB.5MIR0917-351R CrossRefPubMed

108.

Schaefer L et al (2017) Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J 284(1):10–26PubMed

109.

Recktenwald CV et al (2008) Altered detoxification status and increased resistance to oxidative stress by K-ras transformation. Cancer Res 68(24):10086–10093PubMed

110.

Recktenwald CV et al (2012) HER-2/neu-mediated down-regulation of biglycan associated with altered growth properties. J Biol Chem 287(29):24320–24329PubMedPubMedCentral

111.

Subbarayan K et al (2018) Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells. Oncoimmunology 7(4):e1373233PubMedPubMedCentral

112.

Subbarayan K, Seliger B (2018) Tumor-dependent effects of proteoglycans and various glycosaminoglycan synthesizing enzymes and sulfotransferases on patients’ outcome. Curr Cancer Drug Targets 19(3):210–221

113.

Yan L, DeMars LC (2012) Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. Int J Cancer 131(6):1260–1266PubMed

114.

Chen YC et al (2013) Dietary selenium supplementation modifies breast tumor growth and metastasis. Int J Cancer 133(9):2054–2064PubMed

115.

Labunskyy VM, Hatfield DL, Gladyshev VN (2014) Selenoproteins: molecular pathways and physiological roles. Physiol Rev 94(3):739–777PubMedPubMedCentral

116.

Lennicke C et al (2017) Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid. Oncoimmunology 6(6):e1259049PubMed

117.

Kukita K et al (2015) Cancer-associated oxidase ERO1-alpha regulates the expression of MHC class I molecule via oxidative folding. J Immunol 194(10):4988–4996PubMed

118.

Paz-Ares L et al (2018) Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N Engl J Med 379(21):2040–2051PubMed

119.

Koshkin VS, Grivas P (2018) Emerging role of immunotherapy in advanced urothelial carcinoma. Curr Oncol Rep 20(6):48PubMed

120.

Boussiotis VA (2016) Molecular and biochemical aspects of the PD-1 checkpoint pathway. N Engl J Med 375(18):1767–1778PubMedPubMedCentral

121.

Wolchok JD et al (2017) Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med 377(14):1345–1356PubMedPubMedCentral

122.

Sharma P et al (2017) Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell 168(4):707–723PubMedPubMedCentral

123.

Barkal AA et al (2018) Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat Immunol 19(1):76–84PubMed

124.

Haworth KB et al (2015) Going back to class I: MHC and immunotherapies for childhood cancer. Pediatr Blood Cancer 62(4):571–576PubMed

125.

Chowell D et al (2018) Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science 359(6375):582–587PubMed

126.

Goodman AM et al (2017) Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers. Mol Cancer Ther 16(11):2598–2608PubMedPubMedCentral

127.

Le DT et al (2017) Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357(6349):409–413PubMedPubMedCentral

128.

Yeon Yeon S et al (2019) Immune checkpoint blockade resistance-related B2M hotspot mutations in microsatellite-unstable colorectal carcinoma. Pathol Res Pract 215(1):209–214PubMed

129.

Sade-Feldman M et al (2017) Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Nat Commun 8(1):1136PubMedPubMedCentral

130.

Anagnostou V et al (2017) Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer. Cancer Discov 7(3):264–276PubMed

131.

Ayers M et al (2017) IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade. J Clin Invest 127(8):2930–2940PubMedPubMedCentral

132.

Zaretsky JM et al (2016) Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med 375(9):819–829PubMedPubMedCentral

133.

Budczies J et al (2017) Mutation patterns in genes encoding interferon signaling and antigen presentation: a pan-cancer survey with implications for the use of immune checkpoint inhibitors. Genes Chromosomes Cancer 56(8):651–659PubMed

134.

Ye Z et al (2018) Prevalent homozygous deletions of type I interferon and defensin genes in human cancers associate with immunotherapy resistance. Clin Cancer Res 24(14):3299–3308PubMedPubMedCentral

135.

Paulson KG et al (2018) Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Nat Commun 9(1):3868PubMedPubMedCentral

136.

Marijt KA, Doorduijn EM, van Hall T (2018) TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I(low) cancers. Mol Immunol. https://doi.org/10.1016/j.molimm.2018.03.029 CrossRefPubMed

137.

Koyama S et al (2016) Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun 7:10501PubMedPubMedCentral

138.

Chojnacki S et al (2017) Programmatic access to bioinformatics tools from EMBL-EBI update: 2017. Nucleic Acids Res 45(W1):W550–W553PubMedPubMedCentral

139.

Belmont PJ et al (2012) Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response. J Mol Cell Cardiol 52(5):1176–1182PubMedPubMedCentral

140.

Colangelo T et al (2016) Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer. Cell Death Dis 7:e2120PubMedPubMedCentral

141.

Hisaoka M, Matsuyama A, Nakamoto M (2012) Aberrant calreticulin expression is involved in the dedifferentiation of dedifferentiated liposarcoma. Am J Pathol 180(5):2076–2083PubMed

142.

Zhao S et al (2015) MicroRNA-148a inhibits the proliferation and promotes the paclitaxel-induced apoptosis of ovarian cancer cells by targeting PDIA3. Mol Med Rep 12(3):3923–3929PubMed

143.

Mari L et al (2018) microRNA 125a regulates MHC-I expression on esophageal adenocarcinoma cells, associated with suppression of antitumor immune response and poor outcomes of patients. Gastroenterology 155(3):784–798PubMed

144.

Liu Y et al (2009) Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line. Chin Med J (Engl) 122(1):10–14

145.

Kulkarni S et al (2017) Posttranscriptional regulation of HLA-A protein expression by alternative polyadenylation signals involving the RNA-binding protein syncrip. J Immunol 199(11):3892–3899PubMed

146.

Nachmani D et al (2014) MicroRNA editing facilitates immune elimination of HCMV infected cells. PLoS Pathog 10(2):e1003963PubMedPubMedCentral

147.

Kulkarni S et al (2013) Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease. Proc Natl Acad Sci USA 110(51):20705–20710PubMedPubMedCentral

148.

Yin P et al (2015) MiR-451 suppresses cell proliferation and metastasis in A549 lung cancer cells. Mol Biotechnol 57(1):1–11PubMed

149.

Knox B et al (2018) A functional SNP in the 3′-UTR of TAP2 gene interacts with microRNA hsa-miR-1270 to suppress the gene expression. Environ Mol Mutagen 59(2):134–143PubMed

Titel: Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy
verfasst von: Michael Friedrich
Simon Jasinski-Bergner
Maria-Filothei Lazaridou
Karthikeyan Subbarayan
Chiara Massa
Sandy Tretbar
Anja Mueller
Diana Handke
Katharina Biehl
Jürgen Bukur
Marco Donia
Ofer Mandelboim
Barbara Seliger
Publikationsdatum: 03.08.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 10/2019
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-019-02373-1

Neu im Fachgebiet Onkologie

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy

Abstract

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2019

Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment

ANTXR1 (TEM8) overexpression in gastric adenocarcinoma makes the protein a potential target of immunotherapy

Unlocking the therapeutic potential of primary tumor-draining lymph nodes

The BRCA2 mutation status shapes the immune phenotype of prostate cancer

PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor

Induction of tumor-specific CD8+ cytotoxic T lymphocytes from naïve human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie