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16.01.2020 | Original Article

The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction

verfasst von: Hongzhi Quan, Zhongyan Shan, Ziyi Liu, Sixuan Liu, Liu Yang, Xiaodan Fang, Kun Li, Baisheng Wang, Zhiyuan Deng, Yanjia Hu, Zhigang Yao, Junhui Huang, Jianjun Yu, Kun Xia, Zhangui Tang, Liangjuan Fang

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 3/2020

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Abstract

Background

The role of tumor-infiltrating lymphocytes (TILs) in the immune remodeling of tumor microenvironments (TME) in oral squamous cell carcinoma (OSCC) remains controversial. In this study, we pursued a comprehensive characterization of the repertoire of TILs and then analyzed its clinical significance and potential prognostic value.

Methods

Fresh tumor tissue samples and peripheral blood from 83 OSCC patients were collected to comprehensively characterize the phenotypes and frequencies of TILs by flow cytometry. Archived paraffin-embedded tissues derived from 159 OSCC patients were analyzed by immunohistochemistry to further assess the TIL repertoire. The clinical significance of TILs and their potential prognostic value were further analyzed.

Results

A series of unique features of TILs were observed. IL-17 was highly expressed in betel nut chewers, and CD20 was abundantly expressed in patients who did not drink alcohol; high expression of CD138, PD-L1, and Foxp3 was associated with poor prognosis. The Th17/Treg ratio was an independent prognostic factor for patient survival with greater predictive accuracy for overall survival.

Conclusions

Our results suggest an antigen-driven immune response; however, the immune dysfunction within the microenvironment in OSCC and the Th17/Treg balance may play important roles in the modulation of antitumor immunity.

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Titel: The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction
verfasst von: Hongzhi Quan
Zhongyan Shan
Ziyi Liu
Sixuan Liu
Liu Yang
Xiaodan Fang
Kun Li
Baisheng Wang
Zhiyuan Deng
Yanjia Hu
Zhigang Yao
Junhui Huang
Jianjun Yu
Kun Xia
Zhangui Tang
Liangjuan Fang
Publikationsdatum: 16.01.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 3/2020
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-020-02479-x

Neu im Fachgebiet Onkologie

16.04.2024 | Maligne primäre ZNS-Tumoren | Nachrichten

Springer Medizin

The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction

Abstract

Background

Methods

Results

Conclusions

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Abstract

Background

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Results

Conclusions

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