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Erschienen in: International Orthopaedics 4/2015

01.04.2015 | ORTHOPAEDIC HERITAGE

Bone transplantation and tissue engineering, part IV. Mesenchymal stem cells: history in orthopedic surgery from Cohnheim and Goujon to the Nobel Prize of Yamanaka

verfasst von: Philippe Hernigou

Erschienen in: International Orthopaedics | Ausgabe 4/2015

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Abstract

In 1867 the German pathologist Cohnheim hypothesized that non-hematopoietic, bone marrow-derived cells could migrate through the blood stream to distant sites of injury and participate in tissue regeneration. In 1868, the French physiologist Goujon studied the osteogenic potential of bone marrow on rabbits. Friedenstein demonstrated the existence of a nonhematopoietic stem cell within bone marrow more than a hundred years later. Since this discovery, the research on mesenchymal stem cell (MSC) has explored their therapeutic potential. The prevalent view during the second century was that mature cells were permanently locked into the differentiated state and could not return to a fully immature, pluripotent stem-cell state. Recently, Japanese scientist (first orthopaedist) Shinya Yamanaka proved that introduction of a small set of transcription factors into a differentiated cell was sufficient to revert the cell to a pluripotent state. Yamanaka shared the Nobel Prize in Physiology or Medicine and opened a new door for potential applications of MSCs. This manuscript describes the concept of MSCs from the period when it was relegated to the imagination to the beginning of the twenty-first century and their application in orthopaedic surgery.
Literatur
2.
Zurück zum Zitat Baxter MA, Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I (2004) Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22:675–682CrossRefPubMed Baxter MA, Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I (2004) Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22:675–682CrossRefPubMed
3.
Zurück zum Zitat Becker AJ, McCulloch CA, Till JE (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197:452–454CrossRefPubMed Becker AJ, McCulloch CA, Till JE (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197:452–454CrossRefPubMed
4.
Zurück zum Zitat Beltrami AP, Cesselli D, Bergamin N, Marcon P, Rigo S, Puppato E, D’Aurizio F, Verardo R, Piazza S, Pignatelli A et al (2007) Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow). Blood 110:3438–3446CrossRefPubMed Beltrami AP, Cesselli D, Bergamin N, Marcon P, Rigo S, Puppato E, D’Aurizio F, Verardo R, Piazza S, Pignatelli A et al (2007) Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow). Blood 110:3438–3446CrossRefPubMed
5.
Zurück zum Zitat Bianco P, Robey PG, Saggio I, Riminucci M (2010) "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease. Hum Gene Ther 21:1057–1066CrossRefPubMed Bianco P, Robey PG, Saggio I, Riminucci M (2010) "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease. Hum Gene Ther 21:1057–1066CrossRefPubMed
7.
Zurück zum Zitat Brighton CT, Lorich DG, Kupcha R, Reilly TM, Jones AR, Woodbury RA (1992) The pericyte as a possible osteoblast progenitor cell. Clin Orthop Relat Res 275:287–299PubMed Brighton CT, Lorich DG, Kupcha R, Reilly TM, Jones AR, Woodbury RA (1992) The pericyte as a possible osteoblast progenitor cell. Clin Orthop Relat Res 275:287–299PubMed
8.
Zurück zum Zitat Bruder SP, Fink DJ, Caplan AI (1994) Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283–294CrossRefPubMed Bruder SP, Fink DJ, Caplan AI (1994) Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283–294CrossRefPubMed
10.
11.
Zurück zum Zitat Chailakhian RK, Latsinik NV, Gerasimov YUV et al (2006) Life in research. In memory of AJ Friedenstein. The scientist and the teacher. Cell Transplant Tissue Eng 4(6):9–12, Russian Chailakhian RK, Latsinik NV, Gerasimov YUV et al (2006) Life in research. In memory of AJ Friedenstein. The scientist and the teacher. Cell Transplant Tissue Eng 4(6):9–12, Russian
12.
Zurück zum Zitat Cohnheim J (1880) Cohnheim’s Vorlesungen über allgemeine Pathologie, 2 vol. (1877–80) Lectures on general pathology Cohnheim J (1880) Cohnheim’s Vorlesungen über allgemeine Pathologie, 2 vol. (1877–80) Lectures on general pathology
13.
Zurück zum Zitat Connolly JF (1998) Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis. Clin Orthop Relat Res 355:S257–S266CrossRefPubMed Connolly JF (1998) Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis. Clin Orthop Relat Res 355:S257–S266CrossRefPubMed
14.
Zurück zum Zitat Connolly JF, Shindell R (1986) Percutaneous marrow injection for an ununited tibia. Nebr Med J 71(4):105–107PubMed Connolly JF, Shindell R (1986) Percutaneous marrow injection for an ununited tibia. Nebr Med J 71(4):105–107PubMed
15.
Zurück zum Zitat Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 91:335–344CrossRefPubMed Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 91:335–344CrossRefPubMed
16.
Zurück zum Zitat Dominici M, Marino R, Rasini V, Spano C, Paolucci P, Conte P, Hofmann T, Horwitz E (2008) Donor cell–derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation. Blood 111(8):4386–4391CrossRefPubMedCentralPubMed Dominici M, Marino R, Rasini V, Spano C, Paolucci P, Conte P, Hofmann T, Horwitz E (2008) Donor cell–derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation. Blood 111(8):4386–4391CrossRefPubMedCentralPubMed
19.
Zurück zum Zitat Friedenstein AJ (1980) Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo. Haematol Blood Transfus 25:19–29PubMed Friedenstein AJ (1980) Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo. Haematol Blood Transfus 25:19–29PubMed
20.
Zurück zum Zitat Friedenstein AJ (1990) Osteogenic stem cells in bone marrow. In: Heersche JNM, Kanis JA (eds) Bone and mineral research. Elsevier Science Publishers, The Netherlands, pp 243–272CrossRef Friedenstein AJ (1990) Osteogenic stem cells in bone marrow. In: Heersche JNM, Kanis JA (eds) Bone and mineral research. Elsevier Science Publishers, The Netherlands, pp 243–272CrossRef
21.
Zurück zum Zitat Friedenstein AJ (1995) Marrow stromal fibroblasts. Calcif Tissue Int 56(Suppl 1):S17CrossRef Friedenstein AJ (1995) Marrow stromal fibroblasts. Calcif Tissue Int 56(Suppl 1):S17CrossRef
22.
Zurück zum Zitat Friedenstein AJ, Chailakhjan RK, Latsinik NV, Kletki (1973) otvetstvennie za perenos mikrookrujenia v krovetvorniy I limphoidtoy tkani. (Stromal cell responsible for transfer of microenvironment of hematopoietic and lymphoid tissue). Probl Hematol Blood Transfus 10:14–23 Friedenstein AJ, Chailakhjan RK, Latsinik NV, Kletki (1973) otvetstvennie za perenos mikrookrujenia v krovetvorniy I limphoidtoy tkani. (Stromal cell responsible for transfer of microenvironment of hematopoietic and lymphoid tissue). Probl Hematol Blood Transfus 10:14–23
24.
Zurück zum Zitat Friedenstein AJ, Chailakhjan RK, Vasiliev AV (1970) Clonoobrasovanie v monosloinich kulturach kostnogo mozga (Formation of clone in monolayer of bone marrow cultures). Bull Exp Biol Med 2:94–96 Friedenstein AJ, Chailakhjan RK, Vasiliev AV (1970) Clonoobrasovanie v monosloinich kulturach kostnogo mozga (Formation of clone in monolayer of bone marrow cultures). Bull Exp Biol Med 2:94–96
25.
Zurück zum Zitat Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV (1974) Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17:331–340CrossRefPubMed Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV (1974) Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17:331–340CrossRefPubMed
27.
Zurück zum Zitat Friedenstein AJ, Deriglasova UF, Kulagina NN, Panasuk AF, Ruadkowa SF, Luriá EA, Ruadkow IA (1974) Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol 2:83–92PubMed Friedenstein AJ, Deriglasova UF, Kulagina NN, Panasuk AF, Ruadkowa SF, Luriá EA, Ruadkow IA (1974) Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol 2:83–92PubMed
28.
Zurück zum Zitat Friedenstein AJ, Kurolesova AI (1971) Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 12:99–108CrossRefPubMed Friedenstein AJ, Kurolesova AI (1971) Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 12:99–108CrossRefPubMed
30.
Zurück zum Zitat Friedenstein AJ, Lalykina KS (1973) Indukcija kostnoj tkani i osteogennye kletki-predshestvenniki [Induction of bone tissue and osteogenic cell-precursors]. Moscow: Izd-vo “Medizina Publ.”; 216 p. Russian Friedenstein AJ, Lalykina KS (1973) Indukcija kostnoj tkani i osteogennye kletki-predshestvenniki [Induction of bone tissue and osteogenic cell-precursors]. Moscow: Izd-vo “Medizina Publ.”; 216 p. Russian
31.
Zurück zum Zitat Friedenstein AJ, Lalykina KS (1973) Bone tissue induction and osteogenic presursor cells. Moscow:vIzd-vo “Medizina Publ.” Russian Friedenstein AJ, Lalykina KS (1973) Bone tissue induction and osteogenic presursor cells. Moscow:vIzd-vo “Medizina Publ.” Russian
32.
Zurück zum Zitat Friedenstein AJ, Latzinik NV, Gorskaya YF, Luria EA, Moskvina IL (1992) Bone marrow stromal colony formation requires stimulation by haemopoietic cells. Bone Miner 18:199–213CrossRefPubMed Friedenstein AJ, Latzinik NV, Gorskaya YF, Luria EA, Moskvina IL (1992) Bone marrow stromal colony formation requires stimulation by haemopoietic cells. Bone Miner 18:199–213CrossRefPubMed
33.
Zurück zum Zitat Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP (1968) Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6:230–247CrossRefPubMed Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP (1968) Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6:230–247CrossRefPubMed
34.
Zurück zum Zitat Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV (1966) Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morpholog 16:381–390 Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV (1966) Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morpholog 16:381–390
35.
Zurück zum Zitat Goujon E (1869) Recherches expérimentales sur les propriétés physiologiques de la moelle des os. J Anat Physiol 6:399–412 Goujon E (1869) Recherches expérimentales sur les propriétés physiologiques de la moelle des os. J Anat Physiol 6:399–412
36.
Zurück zum Zitat Gurdon JB (2013) The egg and the nucleus: a battle for supremacy. Development 140:2449–2456CrossRefPubMed Gurdon JB (2013) The egg and the nucleus: a battle for supremacy. Development 140:2449–2456CrossRefPubMed
38.
Zurück zum Zitat Hernigou P (2014) Bone transplantation and tissue engineering, part I. Mythology, miracles and fantasy: from Chimera to the Miracle of the Black Leg of Saints Cosmas and Damian and the cock of John Hunter. Int Orthop 38(12):2631–2638. doi:10.1007/s00264-014- 2511-y CrossRefPubMed Hernigou P (2014) Bone transplantation and tissue engineering, part I. Mythology, miracles and fantasy: from Chimera to the Miracle of the Black Leg of Saints Cosmas and Damian and the cock of John Hunter. Int Orthop 38(12):2631–2638. doi:10.​1007/​s00264-014- 2511-y CrossRefPubMed
39.
Zurück zum Zitat Hernigou P (2014) Bone transplantation and tissue engineering. Part II: bone graft and osteogenesis in the seventeenth, eighteenth and nineteenth centuries (Duhamel, Haller, Ollier and MacEwen). Int Orthop. doi:10.1007/s00264-014-2578-5 Hernigou P (2014) Bone transplantation and tissue engineering. Part II: bone graft and osteogenesis in the seventeenth, eighteenth and nineteenth centuries (Duhamel, Haller, Ollier and MacEwen). Int Orthop. doi:10.​1007/​s00264-014-2578-5
40.
Zurück zum Zitat Hernigou P (2015) Bone transplantation and tissue engineering, part III: allografts, bone grafting and bone banking in the 20th century. Int Orthop 39(3) doi:10.1007/s00264-015-2669-y Hernigou P (2015) Bone transplantation and tissue engineering, part III: allografts, bone grafting and bone banking in the 20th century. Int Orthop 39(3) doi:10.​1007/​s00264-015-2669-y
41.
Zurück zum Zitat Hernigou P, Beaujean F (1993) La moëlle osseuse, une clé dans la compréhension de certaines pathologies : un potentiel thérapeutique l’autogreffe de moëlle. Rev Chir Orthop 79(Suppl 1):136–137 Hernigou P, Beaujean F (1993) La moëlle osseuse, une clé dans la compréhension de certaines pathologies : un potentiel thérapeutique l’autogreffe de moëlle. Rev Chir Orthop 79(Suppl 1):136–137
42.
Zurück zum Zitat Hernigou P, Beaujean F (2002) Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 405:14–23CrossRefPubMed Hernigou P, Beaujean F (2002) Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 405:14–23CrossRefPubMed
43.
Zurück zum Zitat Hernigou P, Bernaudin F (1994) Evolution du tissu osseux après allogreffe de moelle osseuse chez l’adolescent drépanocytaire. Rev Chir Orthop 80:138–143PubMed Hernigou P, Bernaudin F (1994) Evolution du tissu osseux après allogreffe de moelle osseuse chez l’adolescent drépanocytaire. Rev Chir Orthop 80:138–143PubMed
44.
Zurück zum Zitat Hernigou P, Bernaudin F, Reinert P, Kuentz M, Vernant JP (1997) Bone marrow transplantation in sickle cell disease; effect on osteonecrosis. J Bone Joint Surg 79-A:1726–1730 Hernigou P, Bernaudin F, Reinert P, Kuentz M, Vernant JP (1997) Bone marrow transplantation in sickle cell disease; effect on osteonecrosis. J Bone Joint Surg 79-A:1726–1730
45.
Zurück zum Zitat Hernigou P, Homma Y, Flouzat-Lachaniette CH, Poignard A, Chevallier N, Rouard H (2013) Cancer risk is not increased in patients treated for orthopaedic diseases with autologous bone marrow cell concentrate. J Bone Joint Surg Am 95(24):2215–2221CrossRefPubMed Hernigou P, Homma Y, Flouzat-Lachaniette CH, Poignard A, Chevallier N, Rouard H (2013) Cancer risk is not increased in patients treated for orthopaedic diseases with autologous bone marrow cell concentrate. J Bone Joint Surg Am 95(24):2215–2221CrossRefPubMed
46.
Zurück zum Zitat Hernigou PH, Poignard A, Beaujean F, Rouard H (2005) Percutaneous autologous bone-marrow grafting for nonunions: influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 87(7):1430–1437CrossRefPubMed Hernigou PH, Poignard A, Beaujean F, Rouard H (2005) Percutaneous autologous bone-marrow grafting for nonunions: influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 87(7):1430–1437CrossRefPubMed
47.
Zurück zum Zitat Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A (2005) Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy 7:393–395CrossRefPubMed Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A (2005) Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy 7:393–395CrossRefPubMed
48.
Zurück zum Zitat Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, Sussman M, Orchard P, Marx JC, Pyeritz RE, Brenner MK (1999) Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5:309–313CrossRefPubMed Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, Sussman M, Orchard P, Marx JC, Pyeritz RE, Brenner MK (1999) Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5:309–313CrossRefPubMed
49.
Zurück zum Zitat Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, McCarville ME, Orchard PJ, Pyeritz RE, Brenner MK (2001) Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 97:1227–1231CrossRefPubMed Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, McCarville ME, Orchard PJ, Pyeritz RE, Brenner MK (2001) Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 97:1227–1231CrossRefPubMed
50.
Zurück zum Zitat Legault Coutu D (2010) Studies on mesenchymal stem cells: In vivo identity, cellular biochemistry and use in gene therapy and tissue engineering. McGill University, Canada Legault Coutu D (2010) Studies on mesenchymal stem cells: In vivo identity, cellular biochemistry and use in gene therapy and tissue engineering. McGill University, Canada
51.
Zurück zum Zitat Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, Quarto R, Mastrogiacomo M, Cancedda R (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 13(5):947–955CrossRefPubMed Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, Quarto R, Mastrogiacomo M, Cancedda R (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 13(5):947–955CrossRefPubMed
52.
Zurück zum Zitat Muschler GF, Boehm C, Easley K (1997) Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am 79:1699–1709PubMed Muschler GF, Boehm C, Easley K (1997) Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am 79:1699–1709PubMed
53.
Zurück zum Zitat Muschler GF, Nakamoto C, Griffith LG (2004) Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 86-A:1541–1558PubMed Muschler GF, Nakamoto C, Griffith LG (2004) Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 86-A:1541–1558PubMed
55.
Zurück zum Zitat Owen M (1967) Uptake of [3H] uridine into precursor pools and RNA in osteogenic cells. J Cell Sci 2:39–56PubMed Owen M (1967) Uptake of [3H] uridine into precursor pools and RNA in osteogenic cells. J Cell Sci 2:39–56PubMed
56.
Zurück zum Zitat Owen M (1985) Lineage of osteogenic cells and their relationship tothe stromal system. In: Peck WA (ed) Bone and mineral research. Elsevier, Amsterdam, pp 1–25 Owen M (1985) Lineage of osteogenic cells and their relationship tothe stromal system. In: Peck WA (ed) Bone and mineral research. Elsevier, Amsterdam, pp 1–25
58.
Zurück zum Zitat Owen M, Cavé J, Joyner CJ (1987) Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F. J Cell Sci 87:731–738PubMed Owen M, Cavé J, Joyner CJ (1987) Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F. J Cell Sci 87:731–738PubMed
59.
Zurück zum Zitat Owen M, Friedenstein AJ (1988) Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp 136:42–60PubMed Owen M, Friedenstein AJ (1988) Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp 136:42–60PubMed
60.
Zurück zum Zitat Pećina M, Vukičević S (2014) Tissue engineering and regenerative orthopaedics (TERO). Int Orthop 38(9):1757–1760CrossRefPubMed Pećina M, Vukičević S (2014) Tissue engineering and regenerative orthopaedics (TERO). Int Orthop 38(9):1757–1760CrossRefPubMed
61.
Zurück zum Zitat Phinney DG, Kopen G, Isaacson RL, Prockop DJ (1999) Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. J Cell Biochem 72:570–585CrossRefPubMed Phinney DG, Kopen G, Isaacson RL, Prockop DJ (1999) Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. J Cell Biochem 72:570–585CrossRefPubMed
62.
Zurück zum Zitat Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147CrossRefPubMed Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147CrossRefPubMed
63.
Zurück zum Zitat Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–74CrossRefPubMed Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–74CrossRefPubMed
64.
Zurück zum Zitat Prockop DJ (2007) "Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs). Clin Pharmacol Ther 82:241–243CrossRefPubMed Prockop DJ (2007) "Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs). Clin Pharmacol Ther 82:241–243CrossRefPubMed
65.
66.
Zurück zum Zitat Prockop DJ, Kota DJ, Bazhanov N, Reger RL (2010) Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med 14(9):2190–2199CrossRefPubMedCentralPubMed Prockop DJ, Kota DJ, Bazhanov N, Reger RL (2010) Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med 14(9):2190–2199CrossRefPubMedCentralPubMed
67.
Zurück zum Zitat Prockop DJ, Olson SD (2007) Clinical trials with adult stem/progenitor cells for tissue repair: let’s not overlook some essential precautions. Blood 109:3147–3151CrossRefPubMedCentralPubMed Prockop DJ, Olson SD (2007) Clinical trials with adult stem/progenitor cells for tissue repair: let’s not overlook some essential precautions. Blood 109:3147–3151CrossRefPubMedCentralPubMed
68.
Zurück zum Zitat Reddi A (1995) Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Maureen Owen revisited. Clin Orthop Relat Res 313:115–119PubMed Reddi A (1995) Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Maureen Owen revisited. Clin Orthop Relat Res 313:115–119PubMed
69.
Zurück zum Zitat Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP (2007) Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells. Stem Cells Dev 16:105–157CrossRefPubMed Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP (2007) Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells. Stem Cells Dev 16:105–157CrossRefPubMed
70.
Zurück zum Zitat Tavassoli M, Crosby DH (1968) Transplantation of marrow to extramedullary sites. Science 161:54–56CrossRefPubMed Tavassoli M, Crosby DH (1968) Transplantation of marrow to extramedullary sites. Science 161:54–56CrossRefPubMed
71.
Zurück zum Zitat Till JE, McCulloch EA (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213–222CrossRefPubMed Till JE, McCulloch EA (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213–222CrossRefPubMed
72.
Zurück zum Zitat Triffitt JT, Russell RG (2011) From nuclear physics to bone cell biology-Maureen Owen-1927-2011. Bone 49(6):1121–1124CrossRefPubMed Triffitt JT, Russell RG (2011) From nuclear physics to bone cell biology-Maureen Owen-1927-2011. Bone 49(6):1121–1124CrossRefPubMed
73.
Zurück zum Zitat Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385(6619):810–813CrossRefPubMed Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385(6619):810–813CrossRefPubMed
74.
Zurück zum Zitat Wilmut I, Sullivan G, Taylor J (2009) A decade of progress since the birth of Dolly. Reprod Fertil Dev 21(1):95–100CrossRefPubMed Wilmut I, Sullivan G, Taylor J (2009) A decade of progress since the birth of Dolly. Reprod Fertil Dev 21(1):95–100CrossRefPubMed
76.
Zurück zum Zitat Yamanaka S (2009) Elite and stochastic models for induced pluripotent stem cell generation. Nature 460:49–52CrossRefPubMed Yamanaka S (2009) Elite and stochastic models for induced pluripotent stem cell generation. Nature 460:49–52CrossRefPubMed
79.
Zurück zum Zitat Yamanaka S (2012) Induced pluripotent stem cells: past, present, and future. Cell Stem Cell 10(6):678–684CrossRefPubMed Yamanaka S (2012) Induced pluripotent stem cells: past, present, and future. Cell Stem Cell 10(6):678–684CrossRefPubMed
80.
Zurück zum Zitat Yamanaka S (2013) The winding road to pluripotency (nobel lecture). Angew Chem Int Ed Engl 52(52):13900–13909CrossRefPubMed Yamanaka S (2013) The winding road to pluripotency (nobel lecture). Angew Chem Int Ed Engl 52(52):13900–13909CrossRefPubMed
Metadaten
Titel
Bone transplantation and tissue engineering, part IV. Mesenchymal stem cells: history in orthopedic surgery from Cohnheim and Goujon to the Nobel Prize of Yamanaka
verfasst von
Philippe Hernigou
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
International Orthopaedics / Ausgabe 4/2015
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-015-2716-8

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