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World Journal of Surgery
Erschienen in: World Journal of Surgery 3/2004

01.03.2004 | World Progress in Surgery

Aging and Wound Healing

verfasst von: Ankush Gosain, M.D., Luisa A. DiPietro, D.D.S., Ph.D.

Erschienen in: World Journal of Surgery | Ausgabe 3/2004

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Abstract

Impaired wound healing in the elderly presents a major clinical and economic problem. With the aging population growing in both number and percentage, the importance of understanding the mechanisms underlying age-related impairments in healing is increased. Normal skin exhibits characteristic changes with age that have implications for wound healing. Additionally, the process of wound healing is altered in aged individuals. Although historically healing in the aged was considered defective, there is now consensus that healing in the elderly is delayed but the final result is qualitatively similar to that in young subjects.
Literatur
1.
U.S. Census Bureau. Census 2000. U.S. Census Bureau, Washington, DC, 2000
2.
U.S. Census Bureau. Population Projections Program, Population Division, U.S. Census Bureau, Washington, DC, 2000
3.
McMahon, DJ, Schwab, CW, Kauder, D 1996Comorbidity and the elderly trauma patientWorld J. Surg.2011131119CrossRefPubMed
4.
DuNouy, PL 1916The relation between the age of the patient, the area of the wound, and the index of cicatrisationJ. Exp. Med.24461470
5.
Quirinia, A, Viidik, A 1991The influence of age on the healing of normal and ischemic incisional skin woundsMech. Ageing Dev.58221232CrossRefPubMed
6.
Ashcroft, GS, Horan, MA, Ferguson, MW 1997Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing modelJ. Invest. Dermatol.108430437PubMed
7.
Virchow, R 1860Cellular PathologyJohn ChurchillLondon
8.
Harrist, TJ,  et al. 1999The skinRubin, EFarber, JL eds. PathologyLippincott-RavenPhiladelphia12361299
9.
Fisher, GJ,  et al. 1997Pathophysiology of premature skin aging induced by ultraviolet lightN. Engl. J. Med.33714191428CrossRefPubMed
10.
Gilchrest, BA, Garmyn, M, Yaar, M 1994Aging and photoaging affect gene expression in cultured human keratinocytesArch. Dermatol.1308286CrossRefPubMed
11.
Whitton, JT, Everall, JD 1973The thickness of the epidermisBr. J. Dermatol.89467476PubMed
12.
Kurban, RS, Bhawan, J 1990Histologic changes in skin associated with agingJ. Dermatol. Surg. Oncol.16908914PubMed
13.
Gilchrest, BA, Murphy, GF, Soter, NA 1982Effect of chronologic aging and ultraviolet irradiation on Langerhans cells in human epidermisJ. Invest. Dermatol.798588PubMed
14.
Montagna, W, Carlisle, K 1979Structural changes in aging human skinJ. Invest. Dermatol.734753PubMed
15.
Swift, ME,  et al. 2001Age-related alterations in the inflammatory response to dermal injuryJ. Invest. Dermatol.11710271035CrossRefPubMed
16.
Bernstein, EF,  et al. 1996Long-term sun exposure alters the collagen of the papillary dermis. Comparison of sun-protected and photoaged skin by northern analysis, immunohistochemical staining, and confocal laser scanning microscopyJ. Am. Acad. Dermatol.34209218PubMed
17.
Lavker, RM, Zheng, PS, Dong, G 1987Aged skin: a study by light, transmission electron, and scanning electron microscopyJ. Invest. Dermatol.8844S51SPubMed
18.
Tsuchida, Y 1993The effect of aging and arteriosclerosis on human skin blood flowJ. Dermatol. Sci.5175181PubMed
19.
Gniadecka, M, Serup, J, Sondergaard, J 1994Age-related diurnal changes of dermal oedema: evaluation by high-frequency ultrasoundBr. J. Dermatol.131849855PubMed
20.
Montagna, W, Carlisle, K 1990Structural changes in ageing skinBr. J. Dermatol.1226170
21.
Pochi, PE, Strauss, JS, Downing, DT 1979Age-related changes in sebaceous gland activityJ. Invest. Dermatol.73108111PubMed
22.
Montagna, W, Kirchner, S, Carlisle, K 1989Histology of sun-damaged human skinJ. Am. Acad. Dermatol.21907918PubMed
23.
Smith, JG,  et al. 1962Alterations in human dermal connective tissue with age and chronic sun damageJ. Invest. Dermatol.39347350PubMed
24.
DiPietro, LA,  et al. 1998MIP-1alpha as a critical macrophage chemoattractant in murine wound repairJ. Clin. Invest.10116931698PubMed
25.
Ross, R, Benditt, EP 1962Wound healing and collagen formation: fine structure in experimental scurvyJ. Cell Biol.12533551PubMed
26.
Polverini, PJ,  et al. 1977Activated macrophages induce vascular proliferationNature269804806PubMed
27.
Hunt, TK,  et al. 1984Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophagesSurgery964854PubMed
28.
Grigorova-Borsos, AM,  et al. 1988Aging and diabetes increase the aggregating potency of rat skin collagen towards normal plateletsThromb. Haemost.607578
29.
Silverman, EM, Silverman, AG 1977Granulocyte adherence in the elderlyAm. J. Clin. Pathol.674952PubMed
30.
Yonezawa, Y, Kondo, H, Nomaguchi, TA 1989Age-related changes in serotonin content and its release reaction of rat plateletsMech. Ageing Dev.476575CrossRefPubMed
31.
Rivard, A,  et al. 1999Age-dependent impairment of angiogenesisCirculation99111120PubMed
32.
Doria, G, Frasca, D 1994Regulation of cytokine production in aging miceAnn. N. Y. Acad. Sci.741299304PubMed
33.
Ershler, WB, Keller, ET 2000Age-associated increased interleukin-6 gene expression, late-life diseases, and frailtyAnnu. Rev. Med.51245270CrossRefPubMed
34.
Mascarucci, P,  et al. 2001Age-related changes in cytokine production by leukocytes in rhesus monkeysAging (Milano).138594
35.
Ginaldi, L,  et al. 2001Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysisAm. J. Hematol.676372CrossRefPubMed
36.
Bruunsgaard, H,  et al. 2000Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine productionClin. Exp. Immunol.119433440CrossRefPubMed
37.
Plackett, TP,  et al. 2003Aging enhances lymphocyte cytokine defects after injuryFASEB J.17688689PubMed
38.
Cohen, BJ, Danon, D, Roth, GS 1987Wound repair in mice as influenced by age and antimacrophage serumJ. Gerontol.42295301PubMed
39.
Danon, D, Kowatch, MA, Roth, GS 1989Promotion of wound repair in old mice by local injection of macrophagesProc. Natl. Acad. Sci. U. S. A.8620182020PubMed
40.
Swift, ME, Kleinman, HK, DiPietro, LA 1999Impaired wound repair and delayed angiogenesis in aged miceLab. Invest.7914791487PubMed
41.
Reed, MJ, Ferara, NS, Vernon, RB 2001Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donorsMech. Ageing Dev.12212031220CrossRefPubMed
42.
Puolakkainen, PA,  et al. 1995The enhancement in wound healing by transforming growth factor-beta 1 (TGF-beta 1) depends on the topical delivery systemJ. Surg. Res.58321329CrossRefPubMed
43.
Plisko, A, Gilchrest, BA 1983Growth factor responsiveness of cultured human fibroblasts declines with ageJ. Gerontol.38513518PubMed
44.
45.
Bruce, SA, Deamond, SF 1991Longitudinal study of in vivo wound repair and in vitro cellular senescence of dermal fibroblastsExp. Gerontol.261727CrossRefPubMed
46.
Grove, GL, Kligman, AM 1983Age-associated changes in human epidermal cell renewalJ. Gerontol.38137142PubMed
47.
Butcher, EO, Klingsberg, J 1963Age, gonadectomy and wound healing in palatal mucosa of the ratOral Surg16482492
48.
Billingham, RE, Russell, PS 1956Studies on wound healing with special reference to the phenomenon of contraction in experimental wounds in rabbits’ skinAnn. Surg.144961980PubMed
49.
Cuthbertson, AM 1959Contraction of full thickness skin wounds in the ratSurg. Gynecol. Obstet.108421432PubMed
50.
Fatah, MF, Ward, CM 1984The morbidity of split-skin graft donor sites in the elderly: the case for mesh-grafting the donor siteBr. J. Plast. Surg.37184190PubMed
51.
Holt, DR,  et al. 1992Effect of age on wound healing in healthy human beingsSurgery112293297PubMed
52.
Orentreich, N, Salmanowitz, VJ 1969Levels of biological functions with agingTrans. N. Y. Acad. Sci.29921012
53.
54.
Holm-Pedersen, P, Viidik, A 1972Tensile properties and morphology of healing wounds in young and old ratsScand. J. Plast. Reconstr. Surg.62435PubMed
55.
Passaniti, A,  et al. 1992A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factorLab. Invest.67519528PubMed
56.
Pili, R,  et al. 1994Altered angiogenesis underlying age-dependent changes in tumor growthJ. Natl. Cancer Inst.8613031314PubMed
57.
Yamaura, H, Matsuzawa, T 1980Decrease in capillary growth during agingExp. Gerontol.15145150CrossRefPubMed
58.
Arthur, WT,  et al. 1998Growth factors reverse the impaired sprouting of microvessels from aged miceMicrovasc. Res.55260270CrossRefPubMed
59.
Viljanto, J 1969A sponge implantation method for testing connective tissue regeneration in surgical patientsActa Chir. Scand.135297300PubMed
60.
Beck, LS,  et al. 1993One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healingJ. Clin. Invest.9228412849PubMed
61.
Reed, MJ,  et al. 2000A deficit in collagenase activity contributes to impaired migration of aged microvascular endothelial cellsJ. Cell. Biochem.77116126CrossRefPubMed
62.
Salo, T,  et al. 1994Expression of matrix metalloproteinase-2 and -9 during early human wound healingLab. Invest.70176182PubMed
63.
Wysocki, AB, Staiano-Coico, L, Grinnell, F 1993Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9J. Invest. Dermatol.1016468PubMed
64.
Zeng, G, Millis, AJ 1994Expression of 72-kDa gelatinase and TIMP-2 in early and late passage human fibroblastsExp. Cell Res.213148155CrossRefPubMed
65.
Millis, AJ,  et al. 1992Metalloproteinase and TIMP-1 gene expression during replicative senescenceExp. Gerontol.27425428CrossRefPubMed
66.
Ashcroft, GS,  et al. 1997Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humansCell Tissue Res.290581591CrossRefPubMed
67.
Ashcroft, GS,  et al. 1997Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNAJ. Pathol.183169176CrossRefPubMed
68.
Platt, D, Ruhl, W 1972An age-dependent determination of lysosomal enzyme activities, as well as the measurements on the incorporation of 14-C-proline and 14-C-glucosamine in a subcutaneously implanted polyether spongeGerontologia1896112PubMed
69.
Younai, S,  et al. 1994Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblastsAnn. Plast. Surg.33148151PubMed
70.
Shah, M, Foreman, DM, Ferguson, MW 1992Control of scarring in adult wounds by neutralising antibody to transforming growth factor betaLancet339213214CrossRefPubMed
71.
Howes, EL, Harvey, SC 1932The age factor in the velocity of the growth of fibroblasts in the healing woundJ. Exp. Med.55557590
72.
Sussman, MD 1973Aging of connective tissue: physical properties of healing wounds in young and old ratsAm. J. Physiol.22411671171PubMed
73.
Sandbloom, PH, Petersen, P, Muren, A 1953Determination of the tensile strength of the healing wound as a clinical testActa Chir. Scand.105252257PubMed
74.
Halasz, NA 1968Dehiscence of laparotomy woundsAm. J. Surg.116210214PubMed
75.
Mendoza, CB,Jr, Postlethwait, RW, Johnson, WD 1970Veterans Administration cooperative study of surgery for duodenal ulcer. II. Incidence of wound disruption following operationArch. Surg.101396398PubMed
76.
Capewell, S,  et al. 1990Purpura and dermal thinning associated with high dose inhaled corticosteroidsBMJ30015481551PubMed
77.
Pollack, SV 1984Systemic drugs and nutritional aspects of wound healingClin. Dermatol.26880PubMed
78.
Neifeld, JP, Lee, HM, Hutcher, NE 1975Lack of effect of vitamin A on corticosteroid-induced immunosuppressionJ. Surg. Res.19225228PubMed
79.
Stephens, FO,  et al. 1971Effect of cortisone and vitamin A on wound infectionAm. J. Surg.121569571PubMed
80.
Thomas, DR 1997The role of nutrition in prevention and healing of pressure ulcersClin. Geriatr. Med.13497511PubMed
81.
Ueng, SW,  et al. 1997Effect of intermittent cigarette smoke inhalation on tibial lengthening: experimental study on rabbitsJ. Trauma42231238PubMed
82.
Broadley, KN,  et al. 1989Monospecific antibodies implicate basic fibroblast growth factor in normal wound repairLab. Invest.61571575PubMed
83.
Mustoe, TA,  et al. 1987Accelerated healing of incisional wounds in rats induced by transforming growth factor-betaScience23713331336PubMed
84.
Ashcroft, GS,  et al. 1997Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levelsNat. Med.312091215PubMed
85.
Ashcroft, GS, Mills, SJ 2002Androgen receptor-mediated inhibition of cutaneous wound healingJ. Clin. Invest.110615624CrossRefPubMed
86.
Falanga, V 1992Growth factors and chronic wounds: the need to understand the microenvironmentJ. Dermatol.19667672PubMed
87.
Falanga, V 1993Chronic wounds: pathophysiologic and experimental considerationsJ. Invest. Dermatol.100721725PubMed
88.
Wu, L, Mustoe, TA 1995Effect of ischemia on growth factor enhancement of incisional wound healingSurgery117570576PubMed
89.
Pierce, GF,  et al. 1989Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factorProc. Natl. Acad. Sci. U. S. A.8622292233PubMed
90.
Mustoe, TA,  et al. 1989Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BBAm. J. Surg.158345350PubMed
91.
Wu, L,  et al. 1999Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and ageAm. J. Pathol.154301309CrossRefPubMed
92.
Mogford, JE,  et al. 2002Effect of age and hypoxia on TGFbeta1 receptor expression and signal transduction in human dermal fibroblasts: impact on cell migrationJ. Cell. Physiol.190259265CrossRefPubMed
93.
Reed, MJ, Koike, T, Puolakkainen, P 2003Wound repair in aging. A reviewMeth. Mol. Med.78217237CrossRef
Metadaten
Titel
Aging and Wound Healing
verfasst von
Ankush Gosain, M.D.
Luisa A. DiPietro, D.D.S., Ph.D.
Publikationsdatum
01.03.2004
Erschienen in
World Journal of Surgery / Ausgabe 3/2004
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-003-7397-6

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