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Erschienen in:
20.03.2018 | Original Scientific Report
Significance of Preoperative Systemic Inflammation Score in Short-Term and Long-Term Outcomes of Patients with Pathological T2–4 Gastric Cancer After Radical Gastrectomy
Erschienen in: World Journal of Surgery | Ausgabe 10/2018
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Background
Surgical resection is the mainstay of treatment for patients with gastric cancer (GC). Development of a simple, high-performance, integrated scoring system is needed to provide appropriate management. This study aimed to evaluate predictive values of the systemic inflammation score (SIS) for short- and long-term outcomes of patients who underwent surgery for GC.
Methods
A total of 187 patients who underwent gastrectomy for pT2–4 GC without preoperative treatment were analyzed. SIS was formulated based on serum albumin level and lymphocyte–monocyte ratio, and graded into SIS 0, 1, and 2.
Results
Preoperative SIS was significantly associated with incidence of postoperative complications, showing a stepwise increased incidence in proportion to SIS in the entire cohort and all subgroups according to operative procedure and disease stage. Overall and disease-free survival times of patients in SIS 0, 1, and 2 shortened in a stepwise fashion. SIS was linked to prevalence of hematogenous metastasis as initial recurrence site. Survival differences between patients with SIS 2 and the others were particularly large in patients who underwent adjuvant chemotherapy. The continuation rate of adjuvant S-1 was lower in the SIS 2 group.
Conclusion
SIS represents a simple predictor for incidence of postoperative complications and survival in patients with pT2–4 GC.