Erschienen in:
01.06.2003 | Laboratory Investigations
Systemic Pulsatile Pressure in Type II Endoleaks
After Stent Grafting of Experimental Abdominal Aortic Aneurysms
verfasst von:
Michael Bernhard Pitton, Patrick Schmenger, Christoph Düber, Achim Neufang, Manfred Thelen
Erschienen in:
CardioVascular and Interventional Radiology
|
Ausgabe 3/2003
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Abstract
Purpose: To investigate pressure and
maximum rate of rise of systolic pressure (peak dP/dt) in completely
excluded aneurysms and endoleaks to determine the hemodynamic impact of
endoleaks.
Methods: In mongrel dogs (n =
36) experimental aneurysms were created by insertion of a
patch (portion of rectus abdominis muscle sheath) into the infrarenal
aorta. In group I (n = 18), all aortic branches of the
aneurysm were ligated and all aneurysms were completely excluded by
stent grafts. Group II (n = 18) consisted of aneurysms
with patent aortic side branches that represented sources of endoleaks.
One week (n = 12), six weeks (n = 12),
and six months (n = 12) after stent grafting,
hemodynamic measurements were obtained in thrombosed aneurysms and
proved endoleaks. Systemic blood pressure and intraaneurysmal pressure
were simultaneously measured and the respective peak dP/dt were
computed.
Results: At the six-month follow-up, the
systolic-pressure ratio (intraaneurysmatic pressure: systemic pressure)
was significantly increased in endoleaks compared to non-perfused areas
(0.879 ± 0.042 versus 0.438 ± 0.176, p <
0.01, group II) or completely excluded aneurysms (0.385 ±
0.221, group I). Peak dP/dt ratio (intraaneurysmal peak dP/dt: systemic
peak dP/dt) was 0.922 ± 0.154 in endoleaks, compared to
0.084 ± 0.080 in non-perfused areas (group II, p <
0.01), and was 0.146 ± 0.121 in completely excluded
aneurysms (group I). The diastolic-pressure ratio was also increased in
endoleaks compared to non-perfused areas (0.929 ± 0.088 versus
0.655 ± 0.231, p < 0.01, group II) or completely
excluded aneurysms (0.641 ± 0.278, group I). In excluded
aneurysms, pressure exposure declined as the length of the follow-up
period increased.
Conclusion: Type II endoleaks transmit
pulsatile pressure of near systemic level and indicate insufficient
treatment result. In contrast, complete endovascular exclusion of
aneurysms results in significantly reduced pressure exposure.