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Erschienen in: CardioVascular and Interventional Radiology 6/2012

01.12.2012 | Laboratory Investigation

Ghrelin Suppression and Fat Loss after Left Gastric Artery Embolization in Canine Model

verfasst von: Dilmurat Bawudun, Yan Xing, Wen-Ya Liu, Yu-Jie Huang, Wei-Xin Ren, Mei Ma, Xiao-Dong Xu, Gao-Jun Teng

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 6/2012

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Abstract

Purpose

To evaluate the effects of left gastric artery embolization (LGAE) on plasma ghrelin levels, abdominal fat, and body weight in beagles.

Methods

The institutional animal care and use committee approved this study. Fifteen healthy adult beagles (12 male and three female animals) were randomly divided into three experimental groups: LGAE was proceeded with mixed emulsion of bleomycin A5 hydrochloride and lipiodol (group A), and polyvinyl alcohol particles (group B). Transcatheter saline injections in the left gastric artery were performed as a control. Weight and fasting plasma ghrelin levels were obtained at baseline and at weekly intervals for 8 weeks after the procedure in all animals. All animals were scanned and measured by multidetector computed tomography at baseline and at week 8 for evaluation of abdominal fat.

Results

In LGAE-treated animals, plasma ghrelin and body weight significantly decreased compared to control animals (group A: P = 0.007 and P = 0.000; group B: P = 0.004 and P = 0.000, respectively). Subcutaneous fat size was also significantly reduced (P = 0.011 and P = 0.027 for groups A and B, respectively). The decreasing percentage in ghrelin levels at week 6 (peak of recovery) of LGAE-treated animals were negatively correlated with the size of area supplied by left gastric artery (r = −0.693, P = 0.026).

Conclusion

LGAE could suppress the plasma concentration of ghrelin, which results in subcutaneous fat size reduction and weight loss. Compensatory ghrelin production might occur in the remnant gastric fundus after LGAE.
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Metadaten
Titel
Ghrelin Suppression and Fat Loss after Left Gastric Artery Embolization in Canine Model
verfasst von
Dilmurat Bawudun
Yan Xing
Wen-Ya Liu
Yu-Jie Huang
Wei-Xin Ren
Mei Ma
Xiao-Dong Xu
Gao-Jun Teng
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 6/2012
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-012-0362-8

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