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CardioVascular and Interventional Radiology

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01.04.2015 | Review/State of the Arti

Radioembolization Dosimetry: The Road Ahead

verfasst von: Maarten L. J. Smits, Mattijs Elschot, Daniel Y. Sze, Yung H. Kao, Johannes F. W. Nijsen, Andre H. Iagaru, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 2/2015

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Abstract

Methods for calculating the activity to be administered during yttrium-90 radioembolization (RE) are largely based on empirical toxicity and efficacy analyses, rather than dosimetry. At the same time, it is recognized that treatment planning based on proper dosimetry is of vital importance for the optimization of the results of RE. The heterogeneous and often clustered intrahepatic biodistribution of millions of point-source radioactive particles poses a challenge for dosimetry. Several studies found a relationship between absorbed doses and treatment outcome, with regard to both toxicity and efficacy. This should ultimately lead to improved patient selection and individualized treatment planning. New calculation methods and imaging techniques and a new generation of microspheres for image-guided RE will all contribute to these improvements. The aim of this review is to give insight into the latest and most important developments in RE dosimetry and to suggest future directions on patient selection, individualized treatment planning, and study designs.

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Titel: Radioembolization Dosimetry: The Road Ahead
verfasst von: Maarten L. J. Smits
Mattijs Elschot
Daniel Y. Sze
Yung H. Kao
Johannes F. W. Nijsen
Andre H. Iagaru
Hugo W. A. M. de Jong
Maurice A. A. J. van den Bosch
Marnix G. E. H. Lam
Publikationsdatum: 01.04.2015
Verlag: Springer US
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 2/2015
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-014-1042-7

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Radioembolization Dosimetry: The Road Ahead

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