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Erschienen in: Annals of Hematology 4/2011

01.04.2011 | Review Article

Anemia—still a major health problem in many parts of the world!

verfasst von: Nils Milman

Erschienen in: Annals of Hematology | Ausgabe 4/2011

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Abstract

Anemia is a major global health problem, especially in developing countries. This fundamental health issue still has not been solved and continues to exist affecting the health, quality of life, and working capacity in billions of people all over the world. This paper gives a review on the prevalence and major causes of anemia seen on a global scale. Most cases of anemia are due to iron deficiency, which often work in symphony with folate deficiency and/or vitamin B12 deficiency as well as with infections. More efforts should be dedicated to tackle this massive problem—we have the tools, and we know the ways. Iron fortification of appropriate food items combined with iron supplements in specific population groups has proven to be efficient. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e., young children, adolescent females, women of reproductive age, as well as pregnant women and postpartum lactating mothers.
Literatur
1.
Zurück zum Zitat Greer JP, Foerrster J, Rodgers G, Paraskevas F, Glader B, Arber DA, Means RT Jr (2008) Wintrobe's Clinical Hematology, 12th edition. Lippincott, Williams and Wilkins, Baltimore, MD Greer JP, Foerrster J, Rodgers G, Paraskevas F, Glader B, Arber DA, Means RT Jr (2008) Wintrobe's Clinical Hematology, 12th edition. Lippincott, Williams and Wilkins, Baltimore, MD
4.
Zurück zum Zitat Milman N, Byg K-E, Ovesen L, Kirchhoff M, Jürgensen KS-L (2002) Iron status in Danish men 1984–94: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. Eur J Haematol 68:332–340PubMedCrossRef Milman N, Byg K-E, Ovesen L, Kirchhoff M, Jürgensen KS-L (2002) Iron status in Danish men 1984–94: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. Eur J Haematol 68:332–340PubMedCrossRef
5.
Zurück zum Zitat Milman N, Byg K-E, Ovesen L, Kirchhoff M, Jürgensen KS-L (2003) Iron status in Danish women, 1984–1994: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. Eur J Haematol 71:51–61PubMedCrossRef Milman N, Byg K-E, Ovesen L, Kirchhoff M, Jürgensen KS-L (2003) Iron status in Danish women, 1984–1994: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. Eur J Haematol 71:51–61PubMedCrossRef
6.
8.
Zurück zum Zitat Pedersen AN, Fagt S, Groth MV et al (2010) National food agency of Denmark. Danish dietary habits 2003–2008. National Food Institute. Danish Technical University Copenhagen Pedersen AN, Fagt S, Groth MV et al (2010) National food agency of Denmark. Danish dietary habits 2003–2008. National Food Institute. Danish Technical University Copenhagen
9.
Zurück zum Zitat Nordic Council of Ministers (2004) Nordic nutrition recommendations 2004. Nordic Council of Ministers, Copenhagen Nordic Council of Ministers (2004) Nordic nutrition recommendations 2004. Nordic Council of Ministers, Copenhagen
10.
Zurück zum Zitat Semba RD, Bloem MW (2002) The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr 56:271–281PubMedCrossRef Semba RD, Bloem MW (2002) The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr 56:271–281PubMedCrossRef
11.
Zurück zum Zitat Ozsoylu S, Aytekin MN (2010) Vitamin D deficiency and anemia. Ann Hematol Sep 17 (in press) Ozsoylu S, Aytekin MN (2010) Vitamin D deficiency and anemia. Ann Hematol Sep 17 (in press)
12.
Zurück zum Zitat Alexandrescu DT, Dasanu CA, Kauffman CL (2009) Acute scurvy during treatment with interleukin-2. Clin Exp Dermatol 34:811–814PubMedCrossRef Alexandrescu DT, Dasanu CA, Kauffman CL (2009) Acute scurvy during treatment with interleukin-2. Clin Exp Dermatol 34:811–814PubMedCrossRef
13.
Zurück zum Zitat Benoist B (2008) Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 29(suppl):S238–S244PubMed Benoist B (2008) Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 29(suppl):S238–S244PubMed
14.
Zurück zum Zitat Khatib LA, Obeid O, Sibai A-M, Batal M, Adra N, Hwalla N (2006) Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age. Public Health Nutr 9:921–927PubMedCrossRef Khatib LA, Obeid O, Sibai A-M, Batal M, Adra N, Hwalla N (2006) Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age. Public Health Nutr 9:921–927PubMedCrossRef
15.
Zurück zum Zitat Karaoglu L, Pehlivan E, Egri M, Deprem C, Gunes G, Genc MF, Temel I (2010) The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey. BMC Public Health 10:329PubMedCrossRef Karaoglu L, Pehlivan E, Egri M, Deprem C, Gunes G, Genc MF, Temel I (2010) The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey. BMC Public Health 10:329PubMedCrossRef
16.
Zurück zum Zitat Groenen PM, van Rooij IA, Peer PG, Gooskens RH, Zielhuis GA, Steegers-Theunissen RP (2004) Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida. Am J Obstet Gynecol 191:11–17PubMedCrossRef Groenen PM, van Rooij IA, Peer PG, Gooskens RH, Zielhuis GA, Steegers-Theunissen RP (2004) Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida. Am J Obstet Gynecol 191:11–17PubMedCrossRef
17.
Zurück zum Zitat Smith JL, Brooker S (2010) Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review. Trop Med Int Health 15:776–795PubMedCrossRef Smith JL, Brooker S (2010) Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review. Trop Med Int Health 15:776–795PubMedCrossRef
18.
Zurück zum Zitat Hung LQ, de Vries P, Giao PT, Binh TQ, Nam NV, Kager PA (2005) Anemia, malaria and hookworm infections in a Vietnamese ethnic minority. Southeast Asian J Trop Med Public Health 36:816–821PubMed Hung LQ, de Vries P, Giao PT, Binh TQ, Nam NV, Kager PA (2005) Anemia, malaria and hookworm infections in a Vietnamese ethnic minority. Southeast Asian J Trop Med Public Health 36:816–821PubMed
19.
Zurück zum Zitat Mousa SA, Qari MH (2010) Diagnosis and management of sickle cell disorders. Methods Mol Biol 663:291–307PubMedCrossRef Mousa SA, Qari MH (2010) Diagnosis and management of sickle cell disorders. Methods Mol Biol 663:291–307PubMedCrossRef
20.
Zurück zum Zitat Marsella M, Pepe A, Borgna-Pignatti C (2010) Better survival and less cardiac morbidity in female patients with thalassemia major: a review of the literature. Ann NY Acad Sci 1202:129–133PubMedCrossRef Marsella M, Pepe A, Borgna-Pignatti C (2010) Better survival and less cardiac morbidity in female patients with thalassemia major: a review of the literature. Ann NY Acad Sci 1202:129–133PubMedCrossRef
21.
Zurück zum Zitat Sukrat B, Suwathanapisate P, Siritawee S, Poungthong T, Phupongpankul K (2010) The prevalence of iron deficiency anemia in pregnant women in Nakhonsawan, Thailand. J Med Assos Thail 93:765–770 Sukrat B, Suwathanapisate P, Siritawee S, Poungthong T, Phupongpankul K (2010) The prevalence of iron deficiency anemia in pregnant women in Nakhonsawan, Thailand. J Med Assos Thail 93:765–770
22.
Zurück zum Zitat Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM (2003) Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr 78:773–781PubMed Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM (2003) Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr 78:773–781PubMed
23.
Zurück zum Zitat Milman N, Backer V, Laursen EM, Graudal N, Ibsen KK, Jordal R (1994) Serum ferritin in children and adolescents. Results from population surveys in 1979 and 1986 comprising 1312 individuals. Eur J Haematol 53:16–20PubMedCrossRef Milman N, Backer V, Laursen EM, Graudal N, Ibsen KK, Jordal R (1994) Serum ferritin in children and adolescents. Results from population surveys in 1979 and 1986 comprising 1312 individuals. Eur J Haematol 53:16–20PubMedCrossRef
24.
Zurück zum Zitat Milman N, Clausen J, Byg K-E (1998) Iron status in 268 Danish women aged 18–30 years: influence of menstruation, contraceptive method, and iron supplementation. Ann Hematol 76:13–19CrossRef Milman N, Clausen J, Byg K-E (1998) Iron status in 268 Danish women aged 18–30 years: influence of menstruation, contraceptive method, and iron supplementation. Ann Hematol 76:13–19CrossRef
25.
Zurück zum Zitat Milman N, Agger OA, Nielsen OJ (1991) Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women. Dan Med Bull 38:471–476PubMed Milman N, Agger OA, Nielsen OJ (1991) Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women. Dan Med Bull 38:471–476PubMed
26.
Zurück zum Zitat Milman N, Bergholt T, Eriksen L, Byg K-E, Graudal N, Pedersen P, Hertz J (2005) Iron prophylaxis during pregnancy-how much iron is needed? A randomised, controlled study of 20 to 80 mg ferrous iron daily to pregnant women. Acta Obstet Gynecol Scand 84:238–247PubMed Milman N, Bergholt T, Eriksen L, Byg K-E, Graudal N, Pedersen P, Hertz J (2005) Iron prophylaxis during pregnancy-how much iron is needed? A randomised, controlled study of 20 to 80 mg ferrous iron daily to pregnant women. Acta Obstet Gynecol Scand 84:238–247PubMed
27.
Zurück zum Zitat Milman N, Pedersen P (2003) Evidence that the Cys282Tyr mutation of the HFE gene originated from a population in Southern Scandinavia and spread with the Vikings. Clin Genet 64:36–47PubMedCrossRef Milman N, Pedersen P (2003) Evidence that the Cys282Tyr mutation of the HFE gene originated from a population in Southern Scandinavia and spread with the Vikings. Clin Genet 64:36–47PubMedCrossRef
28.
Zurück zum Zitat Milman N, Pedersen P, á Steig T, Byg K-E, Graudal N, Fenger K (2001) Clinically overt hereditary hemochromatosis in Denmark 1948–1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients. Ann Hematol 80:737–744PubMedCrossRef Milman N, Pedersen P, á Steig T, Byg K-E, Graudal N, Fenger K (2001) Clinically overt hereditary hemochromatosis in Denmark 1948–1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients. Ann Hematol 80:737–744PubMedCrossRef
29.
Zurück zum Zitat Thuy PV, Berger J, Davidsson L, Khan NC, Lam NT, Cook JD, Hurrell RF, Khoi HH (2003) Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. Am J Clin Nutr 78:284–290PubMed Thuy PV, Berger J, Davidsson L, Khan NC, Lam NT, Cook JD, Hurrell RF, Khoi HH (2003) Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. Am J Clin Nutr 78:284–290PubMed
30.
Zurück zum Zitat Hurrell RF (2007) Iron fortification: its efficacy and safety in relation to infections. Food Nutr Bull 28:S585–S594PubMed Hurrell RF (2007) Iron fortification: its efficacy and safety in relation to infections. Food Nutr Bull 28:S585–S594PubMed
31.
Zurück zum Zitat Ojukwu JU, Okebe JU, Yahav D, Paul M (2009) Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database of Systematic Reviews, Issue 3. Art. No.: CD006589. doi: 10.1002/14651858.CD006589.pub2 Ojukwu JU, Okebe JU, Yahav D, Paul M (2009) Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database of Systematic Reviews, Issue 3. Art. No.: CD006589. doi: 10.​1002/​14651858.​CD006589.​pub2
32.
Zurück zum Zitat Milman N (2006) Iron prophylaxis in pregnancy—general or individual and in which dose? Ann Hematol 85:821–828PubMedCrossRef Milman N (2006) Iron prophylaxis in pregnancy—general or individual and in which dose? Ann Hematol 85:821–828PubMedCrossRef
33.
Zurück zum Zitat Breymann C, Honegger C, Holzgreve W, Surbek D (2007) Diagnostik und Therapie der Anämie in der Schwangerschaft und postpartal. Schweizerische Gesellschaft für Gynäkologie und Geburtshilfe. Expertenbrief, no. 22 Breymann C, Honegger C, Holzgreve W, Surbek D (2007) Diagnostik und Therapie der Anämie in der Schwangerschaft und postpartal. Schweizerische Gesellschaft für Gynäkologie und Geburtshilfe. Expertenbrief, no. 22
34.
Zurück zum Zitat Boris P, Maniatis A, on behalf of the NATA working group on intravenous iron therapy (2007) Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. TATM transfus Altern Transfus Med 9(Suppl 1):29 Boris P, Maniatis A, on behalf of the NATA working group on intravenous iron therapy (2007) Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. TATM transfus Altern Transfus Med 9(Suppl 1):29
36.
38.
Zurück zum Zitat Kladny B (2005) Systematic follow-up and case management of the abnormal newborn screen can improve acceptance of genetic counseling for sickle cell or other hemoglobinopathy trait. Genet Med 7:139–142 Accessed January 4th 2011PubMedCrossRef Kladny B (2005) Systematic follow-up and case management of the abnormal newborn screen can improve acceptance of genetic counseling for sickle cell or other hemoglobinopathy trait. Genet Med 7:139–142 Accessed January 4th 2011PubMedCrossRef
Metadaten
Titel
Anemia—still a major health problem in many parts of the world!
verfasst von
Nils Milman
Publikationsdatum
01.04.2011
Verlag
Springer-Verlag
Erschienen in
Annals of Hematology / Ausgabe 4/2011
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-010-1144-5

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