nach oben

Erschienen in:

05.02.2018 | Original Article

Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants

verfasst von: Nuria Aranda, Cristina Bedmar, Victoria Arija, Cristina Jardí, Rosa Jimenez-Feijoo, Natalia Ferré, Monica Tous, Defensas Study investigators

Erschienen in: Annals of Hematology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

The aims of this study were to describe hepcidin levels and to assess their associations with iron status and the main variants in the HFE gene in healthy and full-term newborns during the first year of life, as a longitudinal study conducted on 140 infants. Anthropometric and biochemical parameters, hepcidin, hemoglobin (Hb), serum ferritin (SF), transferrin saturation (TS), mean corpuscular volume (MCV), and C-reactive protein (CRP), were assessed in 6- and 12-month-olds. Infants were genotyped for the three main HFE variants: C282Y, H63D, and S65C. Hepcidin levels increased from 6 to 12 months of age (43.7 ± 1.5 to 52.0 ± 1.5 ng/mL; p < 0.001), showing higher levels in infants with better iron status compared to those with iron deficiency (ID) (44.8 ± 1.5 vs 37.9 ± 1.3 ng/mL, p < 0.018, and 54.3 ± 1.5 vs 44.0 ± 1.4 ng/mL, p < 0.038, in 6- and 12-month-olds, respectively). In multivariate linear regression models, iron status was found to be associated with hepcidin levels in infants with wild-type HFE gene (p = 0.046 and p = 0.048 in 6- and 12-month-olds, respectively). However, this association was not found in HFE-alteration-carrying infants. Hepcidin levels increased in healthy infants during the first year of life and were positively associated with iron levels only in infants with wild-type HFE gene, a situation that requires further investigation.

Nur mit Berechtigung zugänglich

Durá T, Díaz L (2002) Prevalencia de la deficiencia de hierro en lactantes sanos de 12 meses de edad. An Esp Pediatr 57(3):209–214. https://doi.org/10.1016/s1695-4033(02)77907-1 CrossRef

McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B (2009) Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005. Public Health Nutr 12(04):444–454. https://doi.org/10.1017/s1368980008002401 CrossRefPubMed

Roncagliolo M, Garrido M, Walter T, Peirano P, Lozoff B (1998) Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses. Am J Clin Nutr 68(3):683–690. https://doi.org/10.1093/ajcn/68.3.683 CrossRefPubMed

Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64:S34–S91CrossRefPubMedPubMedCentral

Thomas DG, Grant SL, Aubuchon-Endsley NL (2009) The role of iron in neurocognitive development. Dev Neurophsychol 34(2):196–122. https://doi.org/10.1080/87565640802646767 CrossRef

Beard J (2007) Recent evidence from human and animal studies regarding iron status and infant development. J Nutr 137(2):524S–530S. https://doi.org/10.1093/jn/137.2.524S CrossRefPubMed

Chaparro CM (2008) Setting the stage for child health and development: prevention of iron deficiency in early infancy. J Nutr 138(12):2529–2533. https://doi.org/10.1093/jn/138.12.2529 CrossRefPubMed

Moráis A, Dalmau J (2011) Importancia de la ferropenia en el niño pequeño: Repercusiones y prevención. An Pediatr 74(6):415.e1–415.e10. https://doi.org/10.1016/j.anpedi.2011.01.036

Demircioglu F, Gorunmez G, Dagıstan E et al (2014) Serum hepcidin levels and iron metabolism in obese children with and without fatty liver: case-control study. Eur J Pediatr 173:947–951. https://doi.org/10.1007/s00431-014-2268-8 CrossRefPubMed

10.

Galesloot TE, Janss LL, Burgess S et al (2015) Iron and hepcidin as risk factors in atherosclerosis: what do the genes say? BMC Genet 16(7):79. https://doi.org/10.1186/s12863-015-0246-4 CrossRefPubMedPubMedCentral

11.

Pechlaner R, Kiechl S, Mayr M, Santer P, Weger S, Haschka D, Bansal SS, Willeit J, Weiss G (2016) Correlates of serum hepcidin levels and its association with cardiovascular disease in an elderly general population. Clin Chem Lab Med 54(1):151–161. https://doi.org/10.1515/cclm-2015-0068 CrossRefPubMed

12.

Berglund S, Lonnerdal B, Westrup B, Domellof M (2011) Effects of iron supplementation on serum hepcidin in low birth weight infants. Am J Clin Nutr 94(6):1553–1561. https://doi.org/10.3945/ajcn.111.013938 CrossRefPubMed

13.

Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M (2008) Immunoassay for human serum hepcidin. Blood 112(10):4292–4297. https://doi.org/10.1182/blood-2008-02-139915 CrossRefPubMed

14.

Ganz T, Nemeth E (2012) Hepcidin and iron homeostasis. Biochim Biophys Acta 1823(9):1434–1443. https://doi.org/10.1016/j.bbamcr.2012.01.014 CrossRefPubMedPubMedCentral

15.

Dogan A, Alioglu B, Dindar N, Dallar Y (2013) Increased serum hepcidin and ghrelin levels in children treated for iron deficiency anemia. J Clin Lab Anal 27(1):81–85. https://doi.org/10.1002/jcla.21566 CrossRefPubMed

16.

Galesloot TE, Vermeulen SH, Geurts-Moespot AJ, Klaver SM, Kroot JJ, van Tienoven D, Wetzels JFM, Kiemeney LALM, Sweep FC, den Heijer M, Swinkels DW (2011) Serum hepcidin: reference ranges and biochemical correlates in the general population. Blood 117(25):218–226. https://doi.org/10.1182/blood-2011-02-337907 CrossRef

17.

Rochette L, Gudjoncik A, Guenancia C, Zeller M, Cottin Y, Vergely C (2015) The iron-regulatory hormone hepcidin: a possible therapeutic target? Pharmacol Ther 146:35–52. https://doi.org/10.1016/j.pharmthera.2014.09.004 CrossRefPubMed

18.

Aranda N, Viteri FE, Fernández-Ballart J, Murphy M, Arija V (2007) Frequency of the hemochromatosis gene (HFE) 282C→Y, 63H→D, and 65S→C mutations in a general Mediterranean population from Tarragona, Spain. Ann Hematol 86:17–21. https://doi.org/10.1007/s00277-006-0179-0 CrossRefPubMed

19.

Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E (2005) Hepcidin in iron overload disorders. Blood 105(10):4103–4105. https://doi.org/10.1182/blood-2004-12-4844 CrossRefPubMedPubMedCentral

20.

Fairbanks VF, Klee GG (1999) Biochemical aspects of haematology, 3rd edn. Saunders, Philadelphia

21.

Aranda N, Viteri FE, Montserrat C, Arija V (2010) Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain. Ann Hematol 89(8):767–773. https://doi.org/10.1007/s00277-010-0901-9 CrossRefPubMedPubMedCentral

22.

Hollingshead AB (2011) Four factor index of social status. Yale J Sociol 8:21–52 http://www.yale.edu/sociology/yjs/yjs_fall_2011.pdf. Accessed 19 March 2017

23.

Choi HS, Song SH, Lee JH, Kim HJ, Yang HR (2012) Serum hepcidin levels and iron parameters in children with iron deficiency. Korean J Hematol 47(4):286–292. https://doi.org/10.5045/kjh.2012.47.4.286 CrossRefPubMedPubMedCentral

24.

Muller KF, Lorenz L, Poets CF, Westerman M, Franz AR (2012) Hepcidin concentrations in serum and urine correlate with iron homeostasis in preterm infants. J Pediatr 160(6):949–953. https://doi.org/10.1016/j.jpeds.2011.12.030 CrossRefPubMed

25.

Mupfudze TG, Stoltzfus RJ, Rukobo S, Moulton LH, Humphrey JH, Prendergast AJ (2014) Hepcidin decreases over the first year of life in healthy African infants. Br J Haematol 164(1):150–153. https://doi.org/10.1111/bjh.12567 CrossRefPubMed

26.

Uijterschout L, Swinkels DW, Domellof M et al (2014) Serum hepcidin measured by immunochemical and mass-spectrometric methods and their correlation with iron status indicators in healthy children aged 0.5–3 y. Pediatr Res 76(4):409–414. https://doi.org/10.1038/pr.2014.109 CrossRefPubMed

27.

Viatte L, Vaulont S (2009) Hepcidin, the iron watcher. Biochimie 91:1223–1228. https://doi.org/10.1016/j.biochi.2009.06.012 CrossRefPubMed

28.

Dahlfors G, Stal P, Hansson EC et al (2015) Validation of a competitive ELISA assay for the quantification of human serum hepcidin. Scand J Clin Lab Invest 75(10):652–658PubMed

29.

Domellöf M, Dewey KG, Lönnerdal B, Cohen RJ, Hernell O (2002) The diagnostic criteria for iron deficiency in infants should be reevaluated. J Nutr 132(12):3680–3686. https://doi.org/10.1093/jn/132.12.3680 CrossRefPubMed

30.

Emond AM, Hawkins N, Pennock C, Golding J (1996) Haemoglobin and ferritin concentrations in infants at 8 months of age. Arch Dis Child 74(1):36–39. https://doi.org/10.1136/adc.74.1.36 CrossRefPubMedPubMedCentral

31.

Yalçin SS, Dut R, Yurdakok K, Ozmert E (2009) Seasonal and gender differences in hemoglobin value in infants at 5–7 months of age. Turk J Pediatr 51(6):572–577PubMed

32.

Sherriff A, Emond A, Bell JC, Golding J (2001) Should infants be screened for anaemia? A prospective study investigating the relation between haemoglobin at 8, 12, and 18 months and development at 18 months. Arch Dis Child 84(6):480–485. https://doi.org/10.1136/adc.84.6.480 CrossRefPubMedPubMedCentral

33.

Domellof M, Hernell O (2002) Iron-deficiency anaemia during the first two years of life. Scand J Nutr 46(1):20–30. https://doi.org/10.1080/110264802753704091 CrossRef

34.

Makrides M, Leeson R, Gibson RA, Simmer K (1998) A randomized controlled clinical trial of increased dietary iron in breastfed infants. J Pediatr 133(4):559–562. https://doi.org/10.1016/S0022-3476(98)70069-1 CrossRefPubMed

35.

Hay G, Sandstad B, Whitelaw A, Borch-Iohnsen B (2004) Iron status in a group of Norwegian children aged 6-24 months. Acta Paediatr 93(5):592–598. https://doi.org/10.1111/j.1651-2227.2004.tb02983.x CrossRefPubMed

36.

Beristain R, Pasquetti A, Meléndez G, Sánchez-Escobar O, Cuevas-Covarrubias S (2010) Evaluation of iron status in healthy six-month-old infants in Mexican population: evidence of a high prevalence of iron deficiency. e- Spen, Eur e-J Clin Nutr Metab 5(1):37–39. https://doi.org/10.1016/j.eclnm.2010.01.001 CrossRef

37.

Trowbridge F, Martorell R (2002) Forging effective strategies to combat iron deficiency. Summ Recomm J Nutr 132(4 Suppl):875S–879S

38.

Male C, Persson LA, Freeman V, Guerra A, van't Hof MA, Haschke F (2001) Prevalence of iron deficiency in 12-mo-old infants from 11 European areas and influence of dietary factors on iron status (Euro-Growth study). Acta Paediatr 90(5):492–498. https://doi.org/10.1080/080352501750197601 CrossRefPubMed

39.

Vila Sanchez M et al (2003) Population screening for hemochromatosis: a study in 5370 Spanish blood donors. J Hepatol 38(6):745–750. https://doi.org/10.1016/S0168-8278(03)00123-5 CrossRef

40.

Altes A, Ruiz A et al (2004) Frequency of the C282Y and H63D mutations of the hemochromatosis gene (HFE) in a cohort of 1,000 neonates in Madrid (Spain). Genet Test. Winter 8:407–410CrossRef

41.

Ropero P, Briceño O, Mateo M, Polo M, Mora A, González FA, Villegas A (2006) Frequency of the C282Y and H63D mutations of the hemochromatosis gene (HFE) in a cohort of 1,000 neonates in Madrid (Spain). Ann Hematol 85(5):323–326. https://doi.org/10.1007/s00277-006-0094-4 CrossRefPubMed

42.

Hentze MW, Muckenthaler MU, Galy B, Camaschella C (2010) Two to tango: regulation of mammalian iron metabolism. Cell 142(1):24–38. https://doi.org/10.1016/j.cell.2010.06.028 CrossRefPubMed

43.

Rossi E (2005) Hepcidin—the iron regulatory hormone. Clin Biochem Rev 26:47–49PubMedPubMedCentral

44.

Sdogou T, Tsentidis C, Gourgiotis D, Marmarinos A, Gkourogianni A, Papassotiriou I, Anastasiou T, Kossiva L (2015) Immunoassay-based serum hepcidin reference range measurements in healthy children: differences among age groups. J Clin Lab Anal 29(1):10–14. https://doi.org/10.1002/jcla.21719 CrossRefPubMed

45.

Schaap CC, Hendriks JC, Kortman GA et al (2013) Diurnal rhythm rather than dietary iron mediates daily hepcidin variations. Clin Chem 59(3):527–535. https://doi.org/10.1373/clinchem.2012.194977 CrossRefPubMed

46.

Kroot JJ, Hendriks J, Laarakkers CM et al (2009) Pre-analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: implications for clinical studies. Anal Biochem 389(2):124–129. https://doi.org/10.1016/j.ab.2009.03.039 CrossRefPubMed

47.

Cangemi G, Pistorio A, Miano M, Gattorno M, Acquila M, Bicocchi MP, Gastaldi R, Riccardi F, Gatti C, Fioredda F, Calvillo M, Melioli G, Martini A, Dufour C (2013) Diagnostic potential of hepcidin testing in pediatrics. Eur J Haematol 90(4):323–330. https://doi.org/10.1111/ejh.12081 CrossRefPubMed

48.

Bhatia P, Marathe R, Hegde A, Bhardwaj D, Jain R (2017) Plasma hepcidin levels in healthy children from Chandigarh, Northern India. Indian Pediatr 54(7):599–600. https://doi.org/10.1007/s13312-017-1078-2 CrossRefPubMed

49.

Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110(7):1037–1044. https://doi.org/10.1172/JCI0215686 CrossRefPubMedPubMedCentral

50.

Cherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP (2008) An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study. PLoS ONE 3(12):e4030. https://doi.org/10.1371/journal.pone.0004030 CrossRefPubMedPubMedCentral

51.

Vujić M (2014) Molecular basis of HFE-hemochromatosis. Front Pharmacol 5:42. https://doi.org/10.3389/fphar.2014.00042 PubMedPubMedCentral

52.

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU (2007) STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109(12):353–358. https://doi.org/10.1371/journal.pone.0004030 CrossRefPubMed

Titel: Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants
verfasst von: Nuria Aranda
Cristina Bedmar
Victoria Arija
Cristina Jardí
Rosa Jimenez-Feijoo
Natalia Ferré
Monica Tous
Defensas Study investigators
Publikationsdatum: 05.02.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Annals of Hematology / Ausgabe 6/2018
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-018-3256-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2018

Extramedullary involvement of the stomach presenting as multiple white elevations in the initial diagnosis of chronic myeloid leukemia treated with dasatinib

Impact of pre-transplantation minimal residual disease determined by multiparameter flow cytometry on the outcome of AML patients with FLT3-ITD after allogeneic stem cell transplantation

High PD-L1 expression predicts poor prognosis in diffuse large B-cell lymphoma

Immunomodulatory drugs and the risk of serious infection in multiple myeloma: systematic review and meta-analysis of randomized and observational studies

Prognostic meaning of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ration (LMR) in newly diagnosed Hodgkin lymphoma patients treated upfront with a PET-2 based strategy

Progressive transformation of germinal centers: an illustration of two clinical cases

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin