Viral infection and inflammation result in lung damage. Damaged lung tissues and pulmonary endothelial cells may activate platelets in the lungs, resulting in aggregation and formation of microthrombi, which increases platelet consumption. Most patients with COVID-19 who have thrombocytopenia have elevated D-dimer levels and impaired coagulation time, which further proves the above hypothesis that there is low intravascular coagulation. Therefore, it is still unclear which drugs used for the treatment of patients with COVID-19 having thrombocytopenia resulted in recovery. SARS-CoV-2, MERS-CoV, and SARS-CoV are all β-coronaviruses. Previously, a patient with MERS received large doses of corticosteroids by intravenous infusion to treat thrombocytopenia, and their platelet counts improved [
19]. This classical method has been shown to correct thrombocytopenia in patients infected with HIV [
20]. Therefore, it is speculated that the intravenous injection of human immunoglobulin, corticosteroids, and platelets may be effective in patients under certain circumstances. In the treatment measures of Diagnosis and Treatment Protocol for COVID-19 (Trial Version 7) [
21], it is pointed out that for patients with excessive activation of inflammatory response, the recommended dose of glucocorticoid can be used in a short period of time. This is consistent with the above studies to improve the thrombocytopenia. Reverse transcriptase inhibitors are effective in the treatment of HIV-related thrombocytopenia. For example, zidovudine increased platelet synthesis. In addition, drug stimulation of megakaryocyte synthesis can increase platelet synthesis. Evidence shows that the chemokine CXCR4 can be expressed in megakaryocytes. Because SARS-CoV-2 and HIV are both RNA viruses, reverse transcriptase inhibitors and chemokine receptor antagonists may improve the disease course of COVID-19. At the same time, it is suggested that Shenmai injection can be used to treat immunosuppression in the treatment of traditional Chinese medicine in Diagnosis and Treatment Protocol for COVID-19 (Trial Version 7) [
21]. Shenmai injection has a scavenging effect on all kinds of pathological substances. It can improve anticoagulation and thrombocytopenia in patients with COVID-19 effectively. Additionally, the immunotherapy scheme of “monoclonal antibody drug topirazumab + routine therapy” is also included in the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 7) [
21] as an valid option treating severe and critical COVID-19 cases. The monoclonal antibody against IL-6 receptor tocilizumab can effectively block COVID-19’s inflammatory storm, thus improving the prognosis of the patients.