Erschienen in:
01.07.2009 | Original Article
A phase II randomized trial of gemcitabine-docetaxel versus gemcitabine-cisplatin in patients with advanced non-small cell lung carcinoma
verfasst von:
Joaquín Casal Rubio, S. Vázquez, F. Vázquez, M. Amenedo, J. L. Fírvida, J. R. Mel, G. Huidobro, E. Álvarez, M. Lázaro, G. Alonso, I. Fernández, As representatives of the Galician Group of Lung Cancer (GGCP in the Spanish acronym)
Erschienen in:
Cancer Chemotherapy and Pharmacology
|
Ausgabe 2/2009
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Abstract
Purpose
To test efficacy and tolerability of non-platinum regimens for advanced non-small-cell lung cancer (NSCLC).
Methods
Chemonaive patients with measurable stage IIIB/IV NSCLC treated with gemcitabine and cisplatin (GC), or gemcitabine and docetaxel (GD), maximumsix cycles in a phase IIB trial.
Results
A total of 108 patients were randomized. Response rates (GC vs. GD, respectively): complete 3.6/2.0%, Partial 30.9/38.0%. Median Overall Survival (OS): 8.9 months in both groups (P = 0.53); and median time to progression (TTP): 6.2/5.5 months respectively (P = 0.61). Toxicities included (GC vs. GD, respectively): grade 3–4 neutropenia 49.1/41.2%; grade 3 thrombocytopenia 30.9/3.9%; grade 3 anemia 14.5/3.9%. Non-haematological toxicity was similar, except for nausea and vomiting, (16.3/2%); renal toxicity (3.7/0%) and hepatic toxicity (5.6/12.7%).
Conclusions
With a higher overall response rate and lower toxicity, GD is a good first treatment option for advanced NSCLC.