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Cancer Chemotherapy and Pharmacology

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21.08.2018 | Original Article

Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment

verfasst von: Kelong Tao, Meng He, Feng Tao, Guangen Xu, Minfeng Ye, Yuanyuan Zheng, Yaoqing Li

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 5/2018

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Abstract

Gastric cancer is the third leading cause of cancer-related mortalities worldwide and mostly incurable. It remains an urgent need for novel strategies in the management of patients with advanced gastric cancer. Chimeric antigen receptor (CAR) T therapy has shown unprecedented clinical success in hematological malignancies and potential utility is going on various solid tumors like gastric cancer. In this study, a broad expression of NKG2D ligands was observed in gastric cancer cell lines, making them suitable targets for gastric cancer therapy. T cells were engineered with an NKG2D-based second-generation CAR and the resulting NKG2D-CAR-T cells showed significantly increased cytolytic activity against gastric cancer compared to untransduced T cells. In vivo, these cells can significantly suppressed the growth of established gastric cancer xenografts. Besides, cisplatin was shown to upregulate NKG2D ligand expression in gastric cancer cells and enhance the susceptibility to NKG2D-CAR-T-cell-mediated cytotoxicity. In conclusion, NKG2D-based CAR-T cells have potent in vivo and in vitro anti-tumor activities against gastric cancer and could be a new paradigm for patients with gastric cancer, either used alone or combined with chemotherapy.

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Titel: Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment
verfasst von: Kelong Tao
Meng He
Feng Tao
Guangen Xu
Minfeng Ye
Yuanyuan Zheng
Yaoqing Li
Publikationsdatum: 21.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 5/2018
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-018-3670-0

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24.04.2024 | DGIM 2024 | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment

Abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

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