Skip to main content
Erschienen in: Seminars in Immunopathology 1/2012

01.01.2012 | Review

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

verfasst von: Adriana Vieira-de-Abreu, Robert A. Campbell, Andrew S. Weyrich, Guy A. Zimmerman

Erschienen in: Seminars in Immunopathology | Ausgabe 1/2012

Einloggen, um Zugang zu erhalten

Abstract

Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on interactions between inflammatory, immune, and hemostatic activities of these anucleate but complex and versatile cells. The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.
Literatur
1.
Zurück zum Zitat Coller BS (2007) A brief history of ideas about platelets in health and disease. In: Alan D, Michelson MD (eds) Platelets, 2nd edn. Elsevier, London, pp xxiii–xlii Coller BS (2007) A brief history of ideas about platelets in health and disease. In: Alan D, Michelson MD (eds) Platelets, 2nd edn. Elsevier, London, pp xxiii–xlii
2.
Zurück zum Zitat Coller BS, Shattil SJ (2008) The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood 112:3011–3025PubMed Coller BS, Shattil SJ (2008) The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood 112:3011–3025PubMed
3.
Zurück zum Zitat Weyrich AS, Lindemann S, Zimmerman GA (2003) The evolving role of platelets in inflammation. J Thromb Haemost 1:1897–1905PubMed Weyrich AS, Lindemann S, Zimmerman GA (2003) The evolving role of platelets in inflammation. J Thromb Haemost 1:1897–1905PubMed
4.
Zurück zum Zitat Weyrich AS, Zimmerman GA (2004) Platelets: signaling cells in the immune continuum. Trends Immunol 25:489–495PubMed Weyrich AS, Zimmerman GA (2004) Platelets: signaling cells in the immune continuum. Trends Immunol 25:489–495PubMed
5.
Zurück zum Zitat Iwasaki A, Medzhitov R (2010) Regulation of adaptive immunity by the innate immune system. Science 327:291–295PubMed Iwasaki A, Medzhitov R (2010) Regulation of adaptive immunity by the innate immune system. Science 327:291–295PubMed
6.
Zurück zum Zitat Danese S, Dejana E, Fiocchi C (2007) Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 178:6017–6022PubMed Danese S, Dejana E, Fiocchi C (2007) Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 178:6017–6022PubMed
7.
Zurück zum Zitat Pober JS, Sessa WC (2007) Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 7:803–815PubMed Pober JS, Sessa WC (2007) Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 7:803–815PubMed
8.
Zurück zum Zitat Zimmerman GA, Weyrich AS (2008) Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol 28:s17–s24PubMed Zimmerman GA, Weyrich AS (2008) Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol 28:s17–s24PubMed
9.
Zurück zum Zitat Zimmerman GA, Weyrich AS (2010) Immunology. Arsonists in rheumatoid arthritis. Science 327:528–529PubMed Zimmerman GA, Weyrich AS (2010) Immunology. Arsonists in rheumatoid arthritis. Science 327:528–529PubMed
10.
Zurück zum Zitat Junt T, Schulze H, Chen Z et al (2007) Dynamic visualization of thrombopoiesis within bone marrow. Science 317:1767–1770PubMed Junt T, Schulze H, Chen Z et al (2007) Dynamic visualization of thrombopoiesis within bone marrow. Science 317:1767–1770PubMed
11.
Zurück zum Zitat Watkins NA, Gusnanto A, de Bono B et al (2009) A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 113:e1–e9PubMed Watkins NA, Gusnanto A, de Bono B et al (2009) A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 113:e1–e9PubMed
12.
Zurück zum Zitat O'Connor MN, Salles II, Cvejic A et al (2009) Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood 113:4754–4762PubMed O'Connor MN, Salles II, Cvejic A et al (2009) Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood 113:4754–4762PubMed
13.
Zurück zum Zitat Weyrich AS, Zimmerman GA (2009) Comparative genomics: fishing nets hemostatic catch. Blood 113:4479–4480PubMed Weyrich AS, Zimmerman GA (2009) Comparative genomics: fishing nets hemostatic catch. Blood 113:4479–4480PubMed
14.
Zurück zum Zitat Denis MM, Tolley ND, Bunting M et al (2005) Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122:379–391PubMed Denis MM, Tolley ND, Bunting M et al (2005) Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122:379–391PubMed
15.
Zurück zum Zitat Patel SR, Hartwig JH, Italiano JE Jr (2005) The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 115:3348–3354PubMed Patel SR, Hartwig JH, Italiano JE Jr (2005) The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 115:3348–3354PubMed
16.
Zurück zum Zitat Schwertz H, Tolley ND, Foulks JM et al (2006) Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 203:2433–2440PubMed Schwertz H, Tolley ND, Foulks JM et al (2006) Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 203:2433–2440PubMed
17.
Zurück zum Zitat Landry P, Plante I, Ouellet DL et al (2009) Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol 16:961–966PubMed Landry P, Plante I, Ouellet DL et al (2009) Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol 16:961–966PubMed
18.
Zurück zum Zitat Schwertz H, Koster S, Kahr WH et al (2010) Anucleate platelets generate progeny. Blood 115:3801–3809PubMed Schwertz H, Koster S, Kahr WH et al (2010) Anucleate platelets generate progeny. Blood 115:3801–3809PubMed
19.
Zurück zum Zitat Quintana-Murci L, Alcais A, Abel L et al (2007) Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases. Nat Immunol 8:1165–1171PubMed Quintana-Murci L, Alcais A, Abel L et al (2007) Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases. Nat Immunol 8:1165–1171PubMed
20.
Zurück zum Zitat Nachman RL, Polley M (1979) The platelet as an inflammatory cell. In: Weissmann G et al (eds) Advances in inflammation research, vol 1. Raven, New York, pp 169–173 Nachman RL, Polley M (1979) The platelet as an inflammatory cell. In: Weissmann G et al (eds) Advances in inflammation research, vol 1. Raven, New York, pp 169–173
21.
Zurück zum Zitat Herd CM, Page CP (1995) Do platelets have a role as inflammatory cells? In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 1–20 Herd CM, Page CP (1995) Do platelets have a role as inflammatory cells? In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 1–20
22.
Zurück zum Zitat Klinger MH (1997) Platelets and inflammation. Anat Embryol (Berl) 196:1–11 Klinger MH (1997) Platelets and inflammation. Anat Embryol (Berl) 196:1–11
23.
Zurück zum Zitat Diaz-Gonzalez F, Ginsberg MH (2005) Platelets and rheumatic diseases. In: Harris ED et al (eds) Kelley's textbook of rheumatology. Elsevier Saunders, Philadelphia, pp 252–259 Diaz-Gonzalez F, Ginsberg MH (2005) Platelets and rheumatic diseases. In: Harris ED et al (eds) Kelley's textbook of rheumatology. Elsevier Saunders, Philadelphia, pp 252–259
24.
Zurück zum Zitat Gawaz M, Langer H, May AE (2005) Platelets in inflammation and atherogenesis. J Clin Invest 115:3378–3384PubMed Gawaz M, Langer H, May AE (2005) Platelets in inflammation and atherogenesis. J Clin Invest 115:3378–3384PubMed
25.
Zurück zum Zitat Fitzgerald JR, Foster TJ, Cox D (2006) The interaction of bacterial pathogens with platelets. Nat Rev Microbiol 4:445–457PubMed Fitzgerald JR, Foster TJ, Cox D (2006) The interaction of bacterial pathogens with platelets. Nat Rev Microbiol 4:445–457PubMed
26.
Zurück zum Zitat von Hundelshausen P, Weber C (2007) Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100:27–40 von Hundelshausen P, Weber C (2007) Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100:27–40
27.
Zurück zum Zitat Bergmeier W, Wagner DD (2007) Inflammation. In: Alan D, Michelson MD (eds) Platelets, 2nd edn. Elsevier, London, pp 713–726 Bergmeier W, Wagner DD (2007) Inflammation. In: Alan D, Michelson MD (eds) Platelets, 2nd edn. Elsevier, London, pp 713–726
28.
Zurück zum Zitat Yeaman MR, Bayer AS (2007) Antimicrobial host defense. In: Alan D, Michelson MD (eds) Platelets, 2nd edn. Elsevier, London, pp 727–755 Yeaman MR, Bayer AS (2007) Antimicrobial host defense. In: Alan D, Michelson MD (eds) Platelets, 2nd edn. Elsevier, London, pp 727–755
29.
Zurück zum Zitat Bozza FA, Shah AM, Weyrich AS et al (2009) Amicus or adversary: platelets in lung biology, acute injury, and inflammation. Am J Respir Cell Mol Biol 40:123–134PubMed Bozza FA, Shah AM, Weyrich AS et al (2009) Amicus or adversary: platelets in lung biology, acute injury, and inflammation. Am J Respir Cell Mol Biol 40:123–134PubMed
30.
Zurück zum Zitat Smyth SS, McEver RP, Weyrich AS et al (2009) Platelet functions beyond hemostasis. J Thromb Haemost 7:1759–1766PubMed Smyth SS, McEver RP, Weyrich AS et al (2009) Platelet functions beyond hemostasis. J Thromb Haemost 7:1759–1766PubMed
31.
Zurück zum Zitat Semple JW, Freedman J (2010) Platelets and innate immunity. Cell Mol Life Sci 67:499–511PubMed Semple JW, Freedman J (2010) Platelets and innate immunity. Cell Mol Life Sci 67:499–511PubMed
32.
Zurück zum Zitat Peerschke EI, Yin W, Ghebrehiwet B (2010) Complement activation on platelets: implications for vascular inflammation and thrombosis. Mol Immunol 47:2170–2175PubMed Peerschke EI, Yin W, Ghebrehiwet B (2010) Complement activation on platelets: implications for vascular inflammation and thrombosis. Mol Immunol 47:2170–2175PubMed
33.
Zurück zum Zitat Shi G, Morrell CN (2011) Platelets as initiators and mediators of inflammation at the vessel wall. Thromb Res 127:387–390PubMed Shi G, Morrell CN (2011) Platelets as initiators and mediators of inflammation at the vessel wall. Thromb Res 127:387–390PubMed
34.
Zurück zum Zitat Li Z, Yang F, Dunn S et al (2011) Platelets as immune mediators: their role in host defense responses and sepsis. Thromb Res 127:184–188PubMed Li Z, Yang F, Dunn S et al (2011) Platelets as immune mediators: their role in host defense responses and sepsis. Thromb Res 127:184–188PubMed
35.
Zurück zum Zitat Baldwin WM III, Kuo H-H, Morrell CN (2011) Platelets: versatile modifiers of innate and adaptive immune responses to transplants. Curr Opin Org Trans 16:41–46 Baldwin WM III, Kuo H-H, Morrell CN (2011) Platelets: versatile modifiers of innate and adaptive immune responses to transplants. Curr Opin Org Trans 16:41–46
36.
Zurück zum Zitat Freedman JE (2005) Molecular regulation of platelet-dependent thrombosis. Circulation 112:2725–2734PubMed Freedman JE (2005) Molecular regulation of platelet-dependent thrombosis. Circulation 112:2725–2734PubMed
37.
Zurück zum Zitat Bouchard BA, Tracy PB (2001) Platelets, leukocytes, and coagulation. Curr Opin Hematol 8:263–269PubMed Bouchard BA, Tracy PB (2001) Platelets, leukocytes, and coagulation. Curr Opin Hematol 8:263–269PubMed
38.
Zurück zum Zitat Ruggeri ZM, Mendolicchio GL (2007) Adhesion mechanisms in platelet function. Circ Res 100:1673–1685PubMed Ruggeri ZM, Mendolicchio GL (2007) Adhesion mechanisms in platelet function. Circ Res 100:1673–1685PubMed
39.
Zurück zum Zitat Furie B, Furie BC (2008) Mechanisms of thrombus formation. N Engl J Med 359:938–949PubMed Furie B, Furie BC (2008) Mechanisms of thrombus formation. N Engl J Med 359:938–949PubMed
40.
Zurück zum Zitat Rivera J, Lozano ML, Navarro-Nunez L et al (2009) Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 94:700–711PubMed Rivera J, Lozano ML, Navarro-Nunez L et al (2009) Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 94:700–711PubMed
41.
Zurück zum Zitat Smyth SS, Woulfe DS, Weitz JI et al (2009) G-protein-coupled receptors as signaling targets for antiplatelet therapy. Arterioscler Thromb Vasc Biol 29:449–457PubMed Smyth SS, Woulfe DS, Weitz JI et al (2009) G-protein-coupled receptors as signaling targets for antiplatelet therapy. Arterioscler Thromb Vasc Biol 29:449–457PubMed
42.
Zurück zum Zitat Davi G, Patrono C (2007) Platelet activation and atherothrombosis. N Engl J Med 357:2482–2494PubMed Davi G, Patrono C (2007) Platelet activation and atherothrombosis. N Engl J Med 357:2482–2494PubMed
43.
Zurück zum Zitat Perez-Pujol S, Marker PH, Key NS (2007) Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytometry A 71:38–45PubMed Perez-Pujol S, Marker PH, Key NS (2007) Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytometry A 71:38–45PubMed
44.
Zurück zum Zitat McIntyre TM, Prescott SM, Weyrich AS et al (2003) Cell–cell interactions: leukocyte–endothelial interactions. Curr Opin Hematol 10:150–158PubMed McIntyre TM, Prescott SM, Weyrich AS et al (2003) Cell–cell interactions: leukocyte–endothelial interactions. Curr Opin Hematol 10:150–158PubMed
45.
Zurück zum Zitat Mackman N (2008) Triggers, targets and treatments for thrombosis. Nature 451:914–918PubMed Mackman N (2008) Triggers, targets and treatments for thrombosis. Nature 451:914–918PubMed
46.
Zurück zum Zitat Panes O, Matus V, Saez CG et al (2007) Human platelets synthesize and express functional tissue factor. Blood 109:5242–5250PubMed Panes O, Matus V, Saez CG et al (2007) Human platelets synthesize and express functional tissue factor. Blood 109:5242–5250PubMed
47.
Zurück zum Zitat Massberg S, Grahl L, von Bruehl ML et al (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16:887–896PubMed Massberg S, Grahl L, von Bruehl ML et al (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16:887–896PubMed
48.
Zurück zum Zitat Goerge T, Ho-Tin-Noe B, Carbo C et al (2008) Inflammation induces hemorrhage in thrombocytopenia. Blood 111:4958–4964PubMed Goerge T, Ho-Tin-Noe B, Carbo C et al (2008) Inflammation induces hemorrhage in thrombocytopenia. Blood 111:4958–4964PubMed
49.
Zurück zum Zitat Washington AV, Gibot S, Acevedo I et al (2009) TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest 119:1489–1501PubMed Washington AV, Gibot S, Acevedo I et al (2009) TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest 119:1489–1501PubMed
50.
Zurück zum Zitat Tucker EI, Marzec UM, Berny MA et al (2010) Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. Sci Transl Med 2:37ra45PubMed Tucker EI, Marzec UM, Berny MA et al (2010) Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. Sci Transl Med 2:37ra45PubMed
51.
Zurück zum Zitat London NR, Zhu W, Bozza FA et al (2010) Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med 2:23ra19PubMed London NR, Zhu W, Bozza FA et al (2010) Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med 2:23ra19PubMed
52.
Zurück zum Zitat Schaphorst KL, Chiang E, Jacobs KN et al (2003) Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. Am J Physiol Lung Cell Mol Physiol 285:L258–L267PubMed Schaphorst KL, Chiang E, Jacobs KN et al (2003) Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. Am J Physiol Lung Cell Mol Physiol 285:L258–L267PubMed
53.
Zurück zum Zitat Camerer E, Regard JB, Cornelissen I et al (2009) Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119:1871–1879PubMed Camerer E, Regard JB, Cornelissen I et al (2009) Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119:1871–1879PubMed
54.
Zurück zum Zitat Brinkmann V, Cyster JG, Hla T (2004) FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 4:1019–1025PubMed Brinkmann V, Cyster JG, Hla T (2004) FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 4:1019–1025PubMed
55.
Zurück zum Zitat Clawson CC (1995) Platelets in bacterial infections. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 83–124 Clawson CC (1995) Platelets in bacterial infections. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 83–124
56.
Zurück zum Zitat Pancre V, Auriault C (1995) Platelets in parasitic diseases. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 125–135 Pancre V, Auriault C (1995) Platelets in parasitic diseases. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 125–135
57.
Zurück zum Zitat Zucker-Franklin D (1995) Platelets in viral infections. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 137–149 Zucker-Franklin D (1995) Platelets in viral infections. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 137–149
58.
Zurück zum Zitat Hickey MJ, Kubes P (2009) Intravascular immunity: the host–pathogen encounter in blood vessels. Nat Rev Immunol 9:364–375PubMed Hickey MJ, Kubes P (2009) Intravascular immunity: the host–pathogen encounter in blood vessels. Nat Rev Immunol 9:364–375PubMed
59.
Zurück zum Zitat Mueller KL (2010) Innate immunity. Recognizing the first responders. Introduction. Science 327:283PubMed Mueller KL (2010) Innate immunity. Recognizing the first responders. Introduction. Science 327:283PubMed
60.
Zurück zum Zitat Yeaman MR (2010) Platelets in defense against bacterial pathogens. Cell Mol Life Sci 67:525–544PubMed Yeaman MR (2010) Platelets in defense against bacterial pathogens. Cell Mol Life Sci 67:525–544PubMed
61.
Zurück zum Zitat Lekstrom-Himes JA, Gallin JI (2000) Immunodeficiency diseases caused by defects in phagocytes. N Engl J Med 343:1703–1714PubMed Lekstrom-Himes JA, Gallin JI (2000) Immunodeficiency diseases caused by defects in phagocytes. N Engl J Med 343:1703–1714PubMed
62.
Zurück zum Zitat Zimmerman GA (2009) LAD syndromes: FERMT3 kindles the signal. Blood 113:4485–4486PubMed Zimmerman GA (2009) LAD syndromes: FERMT3 kindles the signal. Blood 113:4485–4486PubMed
63.
Zurück zum Zitat Youssefian T, Drouin A, Masse JM et al (2002) Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 99:4021–4029PubMed Youssefian T, Drouin A, Masse JM et al (2002) Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 99:4021–4029PubMed
64.
Zurück zum Zitat Zander DM, Klinger M (2009) The blood platelets contribution to innate host defense—what they have learned from their big brothers. Biotechnol J 4:914–926PubMed Zander DM, Klinger M (2009) The blood platelets contribution to innate host defense—what they have learned from their big brothers. Biotechnol J 4:914–926PubMed
65.
Zurück zum Zitat Sun H, Wang X, Degen JL et al (2009) Reduced thrombin generation increases host susceptibility to group A streptococcal infection. Blood 113:1358–1364PubMed Sun H, Wang X, Degen JL et al (2009) Reduced thrombin generation increases host susceptibility to group A streptococcal infection. Blood 113:1358–1364PubMed
66.
Zurück zum Zitat McRedmond JP, Fitzgerald DJ (2002) A growing set of platelet-activating bacterial proteins. Blood 99:387–388PubMed McRedmond JP, Fitzgerald DJ (2002) A growing set of platelet-activating bacterial proteins. Blood 99:387–388PubMed
67.
Zurück zum Zitat White JG (2006) Why human platelets fail to kill bacteria. Platelets 17:191–200PubMed White JG (2006) Why human platelets fail to kill bacteria. Platelets 17:191–200PubMed
68.
Zurück zum Zitat Clark SR, Ma AC, Tavener SA et al (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13:463–469PubMed Clark SR, Ma AC, Tavener SA et al (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13:463–469PubMed
69.
Zurück zum Zitat Brinkmann V, Reichard U, Goosmann C et al (2004) Neutrophil extracellular traps kill bacteria. Science 303:1532–1535PubMed Brinkmann V, Reichard U, Goosmann C et al (2004) Neutrophil extracellular traps kill bacteria. Science 303:1532–1535PubMed
70.
Zurück zum Zitat Fuchs TA, Abed U, Goosmann C et al (2007) Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176:231–241PubMed Fuchs TA, Abed U, Goosmann C et al (2007) Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176:231–241PubMed
71.
Zurück zum Zitat Wartha F, Henriques-Normark B (2008) ETosis: a novel cell death pathway. Sci Signal 1:pe25PubMed Wartha F, Henriques-Normark B (2008) ETosis: a novel cell death pathway. Sci Signal 1:pe25PubMed
72.
Zurück zum Zitat Yost CC, Cody MJ, Harris ES et al (2009) Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood 113:6419–6427PubMed Yost CC, Cody MJ, Harris ES et al (2009) Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood 113:6419–6427PubMed
73.
Zurück zum Zitat Papayannopoulos V, Zychlinsky A (2009) NETs: a new strategy for using old weapons. Trends Immunol 30:513–521PubMed Papayannopoulos V, Zychlinsky A (2009) NETs: a new strategy for using old weapons. Trends Immunol 30:513–521PubMed
74.
Zurück zum Zitat Fuchs TA, Brill A, Duerschmied D et al (2010) Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A 107:15880–15885PubMed Fuchs TA, Brill A, Duerschmied D et al (2010) Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A 107:15880–15885PubMed
75.
Zurück zum Zitat Kessenbrock K, Krumbholz M, Schonermarck U et al (2009) Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15:623–625PubMed Kessenbrock K, Krumbholz M, Schonermarck U et al (2009) Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15:623–625PubMed
76.
Zurück zum Zitat Hakkim A, Furnrohr BG, Amann K et al (2010) Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A 107:9813–9818PubMed Hakkim A, Furnrohr BG, Amann K et al (2010) Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A 107:9813–9818PubMed
77.
Zurück zum Zitat Klinger MH, Jelkmann W (2002) Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 22:913–922PubMed Klinger MH, Jelkmann W (2002) Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 22:913–922PubMed
78.
Zurück zum Zitat Dominguez M, Torano A (2001) Leishmania immune adherence reaction in vertebrates. Parasite Immunol 23:259–265PubMed Dominguez M, Torano A (2001) Leishmania immune adherence reaction in vertebrates. Parasite Immunol 23:259–265PubMed
79.
Zurück zum Zitat Yong EC, Chi EY, Fritsche TR et al (1991) Human platelet-mediated cytotoxicity against Toxoplasma gondii: role of thromboxane. J Exp Med 173:65–78PubMed Yong EC, Chi EY, Fritsche TR et al (1991) Human platelet-mediated cytotoxicity against Toxoplasma gondii: role of thromboxane. J Exp Med 173:65–78PubMed
80.
Zurück zum Zitat McMorran BJ, Marshall VM, de Graaf C et al (2009) Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323:797–800PubMed McMorran BJ, Marshall VM, de Graaf C et al (2009) Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323:797–800PubMed
81.
Zurück zum Zitat Peyron F, Polack B, Lamotte D et al (1989) Plasmodium falciparum growth inhibition by human platelets in vitro. Parasitology 99(Pt 3):317–322PubMed Peyron F, Polack B, Lamotte D et al (1989) Plasmodium falciparum growth inhibition by human platelets in vitro. Parasitology 99(Pt 3):317–322PubMed
82.
Zurück zum Zitat Cox D, McConkey S (2010) The role of platelets in the pathogenesis of cerebral malaria. Cell Mol Life Sci 67:557–568PubMed Cox D, McConkey S (2010) The role of platelets in the pathogenesis of cerebral malaria. Cell Mol Life Sci 67:557–568PubMed
83.
Zurück zum Zitat Elzey BD, Tian J, Jensen RJ et al (2003) Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 19:9–19PubMed Elzey BD, Tian J, Jensen RJ et al (2003) Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 19:9–19PubMed
84.
Zurück zum Zitat Iannacone M, Sitia G, Isogawa M et al (2008) Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A 105:629–634PubMed Iannacone M, Sitia G, Isogawa M et al (2008) Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A 105:629–634PubMed
85.
Zurück zum Zitat Iannacone M, Sitia G, Isogawa M et al (2005) Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med 11:1167–1169PubMed Iannacone M, Sitia G, Isogawa M et al (2005) Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med 11:1167–1169PubMed
86.
Zurück zum Zitat Lang PA, Contaldo C, Georgiev P et al (2008) Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 14:756–761PubMed Lang PA, Contaldo C, Georgiev P et al (2008) Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 14:756–761PubMed
87.
Zurück zum Zitat Lisman T, Porte RJ (2010) The role of platelets in liver inflammation and regeneration. Semin Thromb Hemost 36:170–174PubMed Lisman T, Porte RJ (2010) The role of platelets in liver inflammation and regeneration. Semin Thromb Hemost 36:170–174PubMed
88.
Zurück zum Zitat Boukour S, Masse JM, Benit L et al (2006) Lentivirus degradation and DC-SIGN expression by human platelets and megakaryocytes. J Thromb Haemost 4:426–435PubMed Boukour S, Masse JM, Benit L et al (2006) Lentivirus degradation and DC-SIGN expression by human platelets and megakaryocytes. J Thromb Haemost 4:426–435PubMed
89.
Zurück zum Zitat Chaipan C, Soilleux EJ, Simpson P et al (2006) DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol 80:8951–8960PubMed Chaipan C, Soilleux EJ, Simpson P et al (2006) DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol 80:8951–8960PubMed
90.
Zurück zum Zitat Torre D, Pugliese A (2008) Platelets and HIV-1 infection: old and new aspects. Curr HIV Res 6:411–418PubMed Torre D, Pugliese A (2008) Platelets and HIV-1 infection: old and new aspects. Curr HIV Res 6:411–418PubMed
91.
Zurück zum Zitat Ghosh K, Gangodkar S, Jain P et al (2008) Imaging the interaction between dengue 2 virus and human blood platelets using atomic force and electron microscopy. J Electron Microsc (Tokyo) 57:113–118 Ghosh K, Gangodkar S, Jain P et al (2008) Imaging the interaction between dengue 2 virus and human blood platelets using atomic force and electron microscopy. J Electron Microsc (Tokyo) 57:113–118
92.
Zurück zum Zitat Mourao MP, Lacerda MV, Macedo VO et al (2007) Thrombocytopenia in patients with dengue virus infection in the Brazilian Amazon. Platelets 18:605–612PubMed Mourao MP, Lacerda MV, Macedo VO et al (2007) Thrombocytopenia in patients with dengue virus infection in the Brazilian Amazon. Platelets 18:605–612PubMed
93.
Zurück zum Zitat Gavrilovskaya IN, Brown EJ, Ginsberg MH et al (1999) Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol 73:3951–3959PubMed Gavrilovskaya IN, Brown EJ, Ginsberg MH et al (1999) Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol 73:3951–3959PubMed
94.
Zurück zum Zitat Hamaia S, Li C, Allain JP (2001) The dynamics of hepatitis C virus binding to platelets and 2 mononuclear cell lines. Blood 98:2293–2300PubMed Hamaia S, Li C, Allain JP (2001) The dynamics of hepatitis C virus binding to platelets and 2 mononuclear cell lines. Blood 98:2293–2300PubMed
95.
Zurück zum Zitat Zahn A, Jennings N, Ouwehand WH et al (2006) Hepatitis C virus interacts with human platelet glycoprotein VI. J Gen Virol 87:2243–2251PubMed Zahn A, Jennings N, Ouwehand WH et al (2006) Hepatitis C virus interacts with human platelet glycoprotein VI. J Gen Virol 87:2243–2251PubMed
96.
Zurück zum Zitat de Almeida AJ, Campos-de-Magalhaes M, Brandao-Mello CE et al (2007) Detection of hepatitis C virus in platelets: evaluating its relationship to viral and host factors. Hepatogastroenterology 54:964–968PubMed de Almeida AJ, Campos-de-Magalhaes M, Brandao-Mello CE et al (2007) Detection of hepatitis C virus in platelets: evaluating its relationship to viral and host factors. Hepatogastroenterology 54:964–968PubMed
97.
Zurück zum Zitat Pugliese A, Gennero L, Cutufia M et al (2004) HCV infective virions can be carried by human platelets. Cell Biochem Funct 22:353–358PubMed Pugliese A, Gennero L, Cutufia M et al (2004) HCV infective virions can be carried by human platelets. Cell Biochem Funct 22:353–358PubMed
98.
Zurück zum Zitat Tareda H, Baldini M, Ebbe S et al (1966) Interaction of influenza viruses with blood platelets. Blood 28:213–227 Tareda H, Baldini M, Ebbe S et al (1966) Interaction of influenza viruses with blood platelets. Blood 28:213–227
99.
Zurück zum Zitat Rocca B, Secchiero P, Ciabattoni G et al (2002) Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A 99:7634–7639PubMed Rocca B, Secchiero P, Ciabattoni G et al (2002) Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A 99:7634–7639PubMed
100.
Zurück zum Zitat Freishtat RJ, Natale J, Benton AS et al (2009) Sepsis alters the megakaryocyte–platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med 179:467–473PubMed Freishtat RJ, Natale J, Benton AS et al (2009) Sepsis alters the megakaryocyte–platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med 179:467–473PubMed
101.
Zurück zum Zitat Kasirer-Friede A, Kahn ML, Shattil SJ (2007) Platelet integrins and immunoreceptors. Immunol Rev 218:247–264PubMed Kasirer-Friede A, Kahn ML, Shattil SJ (2007) Platelet integrins and immunoreceptors. Immunol Rev 218:247–264PubMed
102.
Zurück zum Zitat Qian K, Xie F, Gibson AW et al (2008) Functional expression of IgA receptor FcalphaRI on human platelets. J Leukoc Biol 84:1492–1500PubMed Qian K, Xie F, Gibson AW et al (2008) Functional expression of IgA receptor FcalphaRI on human platelets. J Leukoc Biol 84:1492–1500PubMed
103.
Zurück zum Zitat Falet H, Pollitt AY, Begonja AJ et al (2010) A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med 207:1967–1979PubMed Falet H, Pollitt AY, Begonja AJ et al (2010) A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med 207:1967–1979PubMed
104.
Zurück zum Zitat Tomer A (2004) Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes. Blood 104:2722–2727PubMed Tomer A (2004) Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes. Blood 104:2722–2727PubMed
105.
Zurück zum Zitat Calverley DC, Hacker MR, Loda KA et al (2003) Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus. Br J Haematol 121:139–142PubMed Calverley DC, Hacker MR, Loda KA et al (2003) Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus. Br J Haematol 121:139–142PubMed
106.
Zurück zum Zitat Moroi M, Jung SM (2004) Platelet glycoprotein VI: its structure and function. Thromb Res 114:221–233PubMed Moroi M, Jung SM (2004) Platelet glycoprotein VI: its structure and function. Thromb Res 114:221–233PubMed
107.
Zurück zum Zitat Boilard E, Nigrovic PA, Larabee K et al (2010) Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327:580–583PubMed Boilard E, Nigrovic PA, Larabee K et al (2010) Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327:580–583PubMed
108.
Zurück zum Zitat Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800–1814PubMed Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800–1814PubMed
109.
Zurück zum Zitat Weyrich AS, Dixon DA, Pabla R et al (1998) Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A 95:5556–5561PubMed Weyrich AS, Dixon DA, Pabla R et al (1998) Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A 95:5556–5561PubMed
110.
Zurück zum Zitat Weyrich AS, Denis MM, Schwertz H et al (2007) mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 109:1975–1983PubMed Weyrich AS, Denis MM, Schwertz H et al (2007) mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 109:1975–1983PubMed
111.
Zurück zum Zitat Thomson AW, Turnquist HR, Raimondi G (2009) Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol 9:324–337PubMed Thomson AW, Turnquist HR, Raimondi G (2009) Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol 9:324–337PubMed
112.
Zurück zum Zitat Michelson AD (2008) P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol 28:s33–s38PubMed Michelson AD (2008) P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol 28:s33–s38PubMed
113.
Zurück zum Zitat Evangelista V, Manarini S, Dell'Elba G et al (2005) Clopidogrel inhibits platelet–leukocyte adhesion and platelet-dependent leukocyte activation. Thromb Haemost 94:568–577PubMed Evangelista V, Manarini S, Dell'Elba G et al (2005) Clopidogrel inhibits platelet–leukocyte adhesion and platelet-dependent leukocyte activation. Thromb Haemost 94:568–577PubMed
114.
Zurück zum Zitat Duffau P, Seneschal J, Nicco C et al (2010) Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci Transl Med 2:47ra63PubMed Duffau P, Seneschal J, Nicco C et al (2010) Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci Transl Med 2:47ra63PubMed
115.
Zurück zum Zitat Graff J, Harder S, Wahl O et al (2005) Anti-inflammatory effects of clopidogrel intake in renal transplant patients: effects on platelet–leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers. Clin Pharmacol Ther 78:468–476PubMed Graff J, Harder S, Wahl O et al (2005) Anti-inflammatory effects of clopidogrel intake in renal transplant patients: effects on platelet–leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers. Clin Pharmacol Ther 78:468–476PubMed
116.
Zurück zum Zitat Narumiya S, FitzGerald GA (2001) Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 108:25–30PubMed Narumiya S, FitzGerald GA (2001) Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 108:25–30PubMed
117.
Zurück zum Zitat Petrucci G, De Cristofaro R, Rutella S et al (2011) Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors. J Pharmacol Exp Ther 336:391–402PubMed Petrucci G, De Cristofaro R, Rutella S et al (2011) Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors. J Pharmacol Exp Ther 336:391–402PubMed
118.
Zurück zum Zitat Tilley SL, Coffman TM, Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108:15–23PubMed Tilley SL, Coffman TM, Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108:15–23PubMed
119.
Zurück zum Zitat Muhlestein JB (2010) Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients. Thromb Haemost 103:71–82PubMed Muhlestein JB (2010) Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients. Thromb Haemost 103:71–82PubMed
120.
Zurück zum Zitat Prescott SM, Zimmerman GA, Stafforini DM et al (2000) Platelet-activating factor and related lipid mediators. Annu Rev Biochem 69:419–445PubMed Prescott SM, Zimmerman GA, Stafforini DM et al (2000) Platelet-activating factor and related lipid mediators. Annu Rev Biochem 69:419–445PubMed
121.
Zurück zum Zitat Groscurth P, Huracek J, Filgueira L et al (1988) Effects of platelet activating factor (PAF) on human citrated whole blood. Eur J Haematol 41:37–416PubMed Groscurth P, Huracek J, Filgueira L et al (1988) Effects of platelet activating factor (PAF) on human citrated whole blood. Eur J Haematol 41:37–416PubMed
122.
Zurück zum Zitat Lindemann S, Tolley ND, Dixon DA et al (2001) Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 154:485–490PubMed Lindemann S, Tolley ND, Dixon DA et al (2001) Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 154:485–490PubMed
123.
Zurück zum Zitat Keating FK, Schneider DJ (2009) The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro. J Thromb Thrombolysis 28:38–45PubMed Keating FK, Schneider DJ (2009) The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro. J Thromb Thrombolysis 28:38–45PubMed
124.
Zurück zum Zitat Harris ES, Rondina MT, Schwertz H et al (2010) Pathogenesis of sepsis and sepsis-induced acute lung injury. In: Choi AMK (ed) Acute respiratory distress syndrome, 2nd edn. Informa, Zug, pp 369–419 Harris ES, Rondina MT, Schwertz H et al (2010) Pathogenesis of sepsis and sepsis-induced acute lung injury. In: Choi AMK (ed) Acute respiratory distress syndrome, 2nd edn. Informa, Zug, pp 369–419
125.
Zurück zum Zitat Coyle AJ, Vargaftig BB (1995) Animal models for investigating the allergic and inflammatory properties of platelets. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 21–30 Coyle AJ, Vargaftig BB (1995) Animal models for investigating the allergic and inflammatory properties of platelets. In: Joseph M (ed) Immunopharmacology of platelets. Academic, San Diego, pp 21–30
126.
Zurück zum Zitat Yost CC, Weyrich AS, Zimmerman GA (2010) The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie 92:692–697PubMed Yost CC, Weyrich AS, Zimmerman GA (2010) The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie 92:692–697PubMed
127.
Zurück zum Zitat Brass LF, Stalker TJ, Zhu L et al (2007) Signal transduction during platelet plug formation. In: Michelson AD (ed) Platelets, 2nd edn. Elsevier, London, pp 319–346 Brass LF, Stalker TJ, Zhu L et al (2007) Signal transduction during platelet plug formation. In: Michelson AD (ed) Platelets, 2nd edn. Elsevier, London, pp 319–346
128.
Zurück zum Zitat Boehlen F, Clemetson KJ (2001) Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfus Med 11:403–417PubMed Boehlen F, Clemetson KJ (2001) Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfus Med 11:403–417PubMed
129.
Zurück zum Zitat Brass LF, Zhu L, Stalker TJ (2008) Novel therapeutic targets at the platelet vascular interface. Arterioscler Thromb Vasc Biol 28:s43–s50PubMed Brass LF, Zhu L, Stalker TJ (2008) Novel therapeutic targets at the platelet vascular interface. Arterioscler Thromb Vasc Biol 28:s43–s50PubMed
130.
Zurück zum Zitat Clemetson JK, Clemetson JM (2007) Platelet receptors. In: Michelson AD (ed) Platelets, 2nd edn. Elsevier, London, pp 117–143 Clemetson JK, Clemetson JM (2007) Platelet receptors. In: Michelson AD (ed) Platelets, 2nd edn. Elsevier, London, pp 117–143
131.
Zurück zum Zitat Garraud O, Cognasse F (2010) Platelet Toll-like receptor expression: the link between “danger” ligands and inflammation. Inflamm Allergy Drug Targets 9:322–333PubMed Garraud O, Cognasse F (2010) Platelet Toll-like receptor expression: the link between “danger” ligands and inflammation. Inflamm Allergy Drug Targets 9:322–333PubMed
132.
Zurück zum Zitat Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805–820PubMed Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805–820PubMed
133.
Zurück zum Zitat Blasius AL, Beutler B (2010) Intracellular toll-like receptors. Immunity 32:305–315PubMed Blasius AL, Beutler B (2010) Intracellular toll-like receptors. Immunity 32:305–315PubMed
134.
Zurück zum Zitat Zhang Q, Raoof M, Chen Y et al (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104–107PubMed Zhang Q, Raoof M, Chen Y et al (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104–107PubMed
135.
Zurück zum Zitat Des Prez RM, Horowitz HI, Hook EW (1961) Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro. J Exp Med 114:857–874PubMed Des Prez RM, Horowitz HI, Hook EW (1961) Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro. J Exp Med 114:857–874PubMed
136.
Zurück zum Zitat Ginsberg MH, Henson PM (1978) Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. J Exp Med 147:207–217PubMed Ginsberg MH, Henson PM (1978) Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. J Exp Med 147:207–217PubMed
137.
Zurück zum Zitat Romano M, Hawiger J (1990) Interaction of endotoxic lipid A and lipid X with purified human platelet protein kinase C. J Biol Chem 265:1765–1770PubMed Romano M, Hawiger J (1990) Interaction of endotoxic lipid A and lipid X with purified human platelet protein kinase C. J Biol Chem 265:1765–1770PubMed
138.
Zurück zum Zitat Berg M, Offermanns S, Seifert R et al (1994) Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. Am J Physiol 266:C1684–C1691PubMed Berg M, Offermanns S, Seifert R et al (1994) Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets. Am J Physiol 266:C1684–C1691PubMed
139.
Zurück zum Zitat Zhao L, Ohtaki Y, Yamaguchi K et al (2002) LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system. Blood 100:3233–3239PubMed Zhao L, Ohtaki Y, Yamaguchi K et al (2002) LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system. Blood 100:3233–3239PubMed
140.
Zurück zum Zitat Shiraki R, Inoue N, Kawasaki S et al (2004) Expression of Toll-like receptors on human platelets. Thromb Res 113:379–385PubMed Shiraki R, Inoue N, Kawasaki S et al (2004) Expression of Toll-like receptors on human platelets. Thromb Res 113:379–385PubMed
141.
Zurück zum Zitat Cognasse F, Hamzeh H, Chavarin P et al (2005) Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol 83:196–198PubMed Cognasse F, Hamzeh H, Chavarin P et al (2005) Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol 83:196–198PubMed
142.
Zurück zum Zitat Andonegui G, Kerfoot SM, McNagny K et al (2005) Platelets express functional Toll-like receptor-4. Blood 106:2417–2423PubMed Andonegui G, Kerfoot SM, McNagny K et al (2005) Platelets express functional Toll-like receptor-4. Blood 106:2417–2423PubMed
143.
Zurück zum Zitat Aslam R, Speck ER, Kim M et al (2006) Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood 107:637–641PubMed Aslam R, Speck ER, Kim M et al (2006) Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood 107:637–641PubMed
144.
Zurück zum Zitat Freedman JE, Larson MG, Tanriverdi K et al (2010) Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham Heart Study. Circulation 122:119–129PubMed Freedman JE, Larson MG, Tanriverdi K et al (2010) Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham Heart Study. Circulation 122:119–129PubMed
145.
Zurück zum Zitat Coban C, Igari Y, Yagi M et al (2010) Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe 7:50–61PubMed Coban C, Igari Y, Yagi M et al (2010) Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe 7:50–61PubMed
146.
Zurück zum Zitat Rumbaut RE, Bellera RV, Randhawa JK et al (2006) Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290:H1671–H1679PubMed Rumbaut RE, Bellera RV, Randhawa JK et al (2006) Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290:H1671–H1679PubMed
147.
Zurück zum Zitat Shashkin PN, Brown GT, Ghosh A et al (2008) Lipopolysaccharide is a direct agonist for platelet RNA splicing. J Immunol 181:3495–3502PubMed Shashkin PN, Brown GT, Ghosh A et al (2008) Lipopolysaccharide is a direct agonist for platelet RNA splicing. J Immunol 181:3495–3502PubMed
148.
Zurück zum Zitat Ward JR, Bingle L, Judge HM et al (2005) Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. Thromb Haemost 94:831–838PubMed Ward JR, Bingle L, Judge HM et al (2005) Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. Thromb Haemost 94:831–838PubMed
149.
Zurück zum Zitat Rondina MT, Schwertz H, Harris ES et al (2011) The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost 9:748–758PubMed Rondina MT, Schwertz H, Harris ES et al (2011) The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost 9:748–758PubMed
150.
Zurück zum Zitat Stahl AL, Svensson M, Morgelin M et al (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108:167–176PubMed Stahl AL, Svensson M, Morgelin M et al (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108:167–176PubMed
151.
Zurück zum Zitat Cognasse F, Hamzeh-Cognasse H, Lafarge S et al (2008) Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets. Br J Haematol 141:84–91PubMed Cognasse F, Hamzeh-Cognasse H, Lafarge S et al (2008) Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets. Br J Haematol 141:84–91PubMed
152.
Zurück zum Zitat Zhang G, Han J, Welch EJ et al (2009) Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol 182:7997–8004PubMed Zhang G, Han J, Welch EJ et al (2009) Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol 182:7997–8004PubMed
153.
Zurück zum Zitat Smiley ST, King JA, Hancock WW (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167:2887–2894PubMed Smiley ST, King JA, Hancock WW (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167:2887–2894PubMed
154.
Zurück zum Zitat Kuhns DB, Priel DA, Gallin JI (2007) Induction of human monocyte interleukin (IL)-8 by fibrinogen through the toll-like receptor pathway. Inflammation 30:178–188PubMed Kuhns DB, Priel DA, Gallin JI (2007) Induction of human monocyte interleukin (IL)-8 by fibrinogen through the toll-like receptor pathway. Inflammation 30:178–188PubMed
155.
Zurück zum Zitat Blair P, Rex S, Vitseva O et al (2009) Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res 104:346–354PubMed Blair P, Rex S, Vitseva O et al (2009) Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res 104:346–354PubMed
156.
Zurück zum Zitat Rex S, Beaulieu LM, Perlman DH et al (2009) Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein–protein interactions, and alpha-granule release. Thromb Haemost 102:97–110PubMed Rex S, Beaulieu LM, Perlman DH et al (2009) Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein–protein interactions, and alpha-granule release. Thromb Haemost 102:97–110PubMed
157.
Zurück zum Zitat Blumberg N, Spinelli SL, Francis CW et al (2009) The platelet as an immune cell-–CD40 ligand and transfusion immunomodulation. Immunol Res 45:251–260 Blumberg N, Spinelli SL, Francis CW et al (2009) The platelet as an immune cell-–CD40 ligand and transfusion immunomodulation. Immunol Res 45:251–260
158.
Zurück zum Zitat Phipps RP, Kaufman J, Blumberg N (2001) Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet 357:2023–2024PubMed Phipps RP, Kaufman J, Blumberg N (2001) Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet 357:2023–2024PubMed
159.
Zurück zum Zitat Blumberg N, Gettings KF, Turner C et al (2006) An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion 46:1813–1821PubMed Blumberg N, Gettings KF, Turner C et al (2006) An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion 46:1813–1821PubMed
160.
Zurück zum Zitat Damas JK, Jensenius M, Ueland T et al (2006) Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol 177:2699–2706PubMed Damas JK, Jensenius M, Ueland T et al (2006) Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol 177:2699–2706PubMed
161.
Zurück zum Zitat Amelot AA, Tagzirt M, Ducouret G et al (2007) Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin. J Biol Chem 282:710–720PubMed Amelot AA, Tagzirt M, Ducouret G et al (2007) Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin. J Biol Chem 282:710–720PubMed
162.
Zurück zum Zitat Deuel TF, Senior RM, Chang D et al (1981) Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A 78:4584–4587PubMed Deuel TF, Senior RM, Chang D et al (1981) Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A 78:4584–4587PubMed
163.
Zurück zum Zitat Scheuerer B, Ernst M, Durrbaum-Landmann I et al (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95:1158–1166PubMed Scheuerer B, Ernst M, Durrbaum-Landmann I et al (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95:1158–1166PubMed
164.
Zurück zum Zitat Gleissner CA, Shaked I, Little KM et al (2010) CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages. J Immunol 184:4810–4818PubMed Gleissner CA, Shaked I, Little KM et al (2010) CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages. J Immunol 184:4810–4818PubMed
165.
Zurück zum Zitat Srivastava K, Cockburn IA, Swaim A et al (2008) Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe 4:179–187PubMed Srivastava K, Cockburn IA, Swaim A et al (2008) Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe 4:179–187PubMed
166.
Zurück zum Zitat Srivastava K, Field DJ, Aggrey A et al (2010) Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. PLoS One 5:e10413PubMed Srivastava K, Field DJ, Aggrey A et al (2010) Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. PLoS One 5:e10413PubMed
167.
Zurück zum Zitat Essien EM, Ebhota MI (1983) Platelet secretory activities in acute malaria (Plasmodium falciparum) infection. Acta Haematol 70:183–188PubMed Essien EM, Ebhota MI (1983) Platelet secretory activities in acute malaria (Plasmodium falciparum) infection. Acta Haematol 70:183–188PubMed
168.
Zurück zum Zitat Greinacher A (2009) Heparin-induced thrombocytopenia. J Thromb Haemost 7(Suppl 1):9–12PubMed Greinacher A (2009) Heparin-induced thrombocytopenia. J Thromb Haemost 7(Suppl 1):9–12PubMed
169.
Zurück zum Zitat Levy JA (2009) The unexpected pleiotropic activities of RANTES. J Immunol 182:3945–3946PubMed Levy JA (2009) The unexpected pleiotropic activities of RANTES. J Immunol 182:3945–3946PubMed
170.
Zurück zum Zitat Kameyoshi Y, Dorschner A, Mallet AI et al (1992) Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176:587–592PubMed Kameyoshi Y, Dorschner A, Mallet AI et al (1992) Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176:587–592PubMed
171.
Zurück zum Zitat Weyrich AS, Elstad MR, McEver RP et al (1996) Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest 97:1525–1534PubMed Weyrich AS, Elstad MR, McEver RP et al (1996) Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest 97:1525–1534PubMed
172.
Zurück zum Zitat Klinger MH, Wilhelm D, Bubel S et al (1995) Immunocytochemical localization of the chemokines RANTES and MIP-1 alpha within human platelets and their release during storage. Int Arch Allergy Immunol 107:541–546PubMed Klinger MH, Wilhelm D, Bubel S et al (1995) Immunocytochemical localization of the chemokines RANTES and MIP-1 alpha within human platelets and their release during storage. Int Arch Allergy Immunol 107:541–546PubMed
173.
Zurück zum Zitat Pabla R, Weyrich AS, Dixon DA et al (1999) Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. J Cell Biol 144:175–184PubMed Pabla R, Weyrich AS, Dixon DA et al (1999) Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. J Cell Biol 144:175–184PubMed
174.
Zurück zum Zitat Mause SF, von Hundelshausen P, Zernecke A et al (2005) Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol 25:1512–1518PubMed Mause SF, von Hundelshausen P, Zernecke A et al (2005) Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol 25:1512–1518PubMed
175.
Zurück zum Zitat Danese S, de la Motte C, Reyes BM et al (2004) Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification. J Immunol 172:2011–2015PubMed Danese S, de la Motte C, Reyes BM et al (2004) Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification. J Immunol 172:2011–2015PubMed
176.
Zurück zum Zitat Hawrylowicz CM, Santoro SA, Platt FM et al (1989) Activated platelets express IL-1 activity. J Immunol 143:4015–4018PubMed Hawrylowicz CM, Santoro SA, Platt FM et al (1989) Activated platelets express IL-1 activity. J Immunol 143:4015–4018PubMed
177.
Zurück zum Zitat Hawrylowicz CM, Howells GL, Feldmann M (1991) Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 174:785–790PubMed Hawrylowicz CM, Howells GL, Feldmann M (1991) Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 174:785–790PubMed
178.
Zurück zum Zitat Kaplanski G, Porat R, Aiura K et al (1993) Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood 81:2492–2495PubMed Kaplanski G, Porat R, Aiura K et al (1993) Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood 81:2492–2495PubMed
179.
Zurück zum Zitat Loppnow H, Bil R, Hirt S et al (1998) Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells. Blood 91:134–141PubMed Loppnow H, Bil R, Hirt S et al (1998) Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells. Blood 91:134–141PubMed
180.
Zurück zum Zitat Braddock M, Quinn A (2004) Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention. Nat Rev Drug Discov 3:330–339PubMed Braddock M, Quinn A (2004) Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention. Nat Rev Drug Discov 3:330–339PubMed
181.
Zurück zum Zitat Gawaz M, Brand K, Dickfeld T et al (2000) Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis. Atherosclerosis 148:75–85PubMed Gawaz M, Brand K, Dickfeld T et al (2000) Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis. Atherosclerosis 148:75–85PubMed
182.
Zurück zum Zitat Henn V, Slupsky JR, Grafe M et al (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391:591–594PubMed Henn V, Slupsky JR, Grafe M et al (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391:591–594PubMed
183.
Zurück zum Zitat Weber C, Springer TA (1997) Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest 100:2085–2093PubMed Weber C, Springer TA (1997) Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest 100:2085–2093PubMed
184.
Zurück zum Zitat Ostrovsky L, King AJ, Bond S et al (1998) A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process. Blood 91:3028–3036PubMed Ostrovsky L, King AJ, Bond S et al (1998) A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process. Blood 91:3028–3036PubMed
185.
Zurück zum Zitat Zarbock A, Muller H, Kuwano Y et al (2009) PSGL-1-dependent myeloid leukocyte activation. J Leukoc Biol 86:1119–1124PubMed Zarbock A, Muller H, Kuwano Y et al (2009) PSGL-1-dependent myeloid leukocyte activation. J Leukoc Biol 86:1119–1124PubMed
186.
Zurück zum Zitat Kornerup KN, Salmon GP, Pitchford SC et al (2010) Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration. J Appl Physiol 109:758–767PubMed Kornerup KN, Salmon GP, Pitchford SC et al (2010) Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration. J Appl Physiol 109:758–767PubMed
187.
Zurück zum Zitat Flick MJ, Du X, Witte DP et al (2004) Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest 113:1596–1606PubMed Flick MJ, Du X, Witte DP et al (2004) Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest 113:1596–1606PubMed
188.
Zurück zum Zitat Hara T, Shimizu K, Ogawa F et al (2010) Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. Am J Pathol 176:259–269PubMed Hara T, Shimizu K, Ogawa F et al (2010) Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. Am J Pathol 176:259–269PubMed
189.
Zurück zum Zitat Keating FK, Fung MK, Schneider DJ (2008) Induction of platelet white blood cell (WBC) aggregate formation by platelets and WBCs in red blood cell units. Transfusion 48:1099–1105PubMed Keating FK, Fung MK, Schneider DJ (2008) Induction of platelet white blood cell (WBC) aggregate formation by platelets and WBCs in red blood cell units. Transfusion 48:1099–1105PubMed
190.
Zurück zum Zitat Evangelista V, Pamuklar Z, Piccoli A et al (2007) Src family kinases mediate neutrophil adhesion to adherent platelets. Blood 109:2461–2469PubMed Evangelista V, Pamuklar Z, Piccoli A et al (2007) Src family kinases mediate neutrophil adhesion to adherent platelets. Blood 109:2461–2469PubMed
191.
Zurück zum Zitat Lorant DE, Patel KD, McIntyre TM et al (1991) Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils. J Cell Biol 115:223–234PubMed Lorant DE, Patel KD, McIntyre TM et al (1991) Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils. J Cell Biol 115:223–234PubMed
192.
Zurück zum Zitat Simon DI, Chen Z, Xu H et al (2000) Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med 192:193–204PubMed Simon DI, Chen Z, Xu H et al (2000) Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med 192:193–204PubMed
193.
Zurück zum Zitat Santoso S, Sachs UJ, Kroll H et al (2002) The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 196:679–691PubMed Santoso S, Sachs UJ, Kroll H et al (2002) The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 196:679–691PubMed
194.
Zurück zum Zitat Ehlers R, Ustinov V, Chen Z et al (2003) Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med 198:1077–1088PubMed Ehlers R, Ustinov V, Chen Z et al (2003) Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med 198:1077–1088PubMed
195.
Zurück zum Zitat Li N, Hu H, Lindqvist M et al (2000) Platelet–leukocyte cross talk in whole blood. Arterioscler Thromb Vasc Biol 20:2702–2708PubMed Li N, Hu H, Lindqvist M et al (2000) Platelet–leukocyte cross talk in whole blood. Arterioscler Thromb Vasc Biol 20:2702–2708PubMed
196.
Zurück zum Zitat Hidari KI, Weyrich AS, Zimmerman GA et al (1997) Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem 272:28750–28756PubMed Hidari KI, Weyrich AS, Zimmerman GA et al (1997) Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem 272:28750–28756PubMed
197.
Zurück zum Zitat Lindemann SW, Yost CC, Denis MM et al (2004) Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A 101:7076–7081PubMed Lindemann SW, Yost CC, Denis MM et al (2004) Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A 101:7076–7081PubMed
198.
Zurück zum Zitat Goel MS, Diamond SL (2001) Neutrophil enhancement of fibrin deposition under flow through platelet-dependent and -independent mechanisms. Arterioscler Thromb Vasc Biol 21:2093–2098PubMed Goel MS, Diamond SL (2001) Neutrophil enhancement of fibrin deposition under flow through platelet-dependent and -independent mechanisms. Arterioscler Thromb Vasc Biol 21:2093–2098PubMed
199.
Zurück zum Zitat McCarty OJ, Tien N, Bochner BS et al (2003) Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow. Am J Physiol Cell Physiol 284:C1223–C1234PubMed McCarty OJ, Tien N, Bochner BS et al (2003) Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow. Am J Physiol Cell Physiol 284:C1223–C1234PubMed
200.
Zurück zum Zitat de Bruijne-Admiraal LG, Modderman PW, Von dem Borne AE et al (1992) P-selectin mediates Ca(2+)-dependent adhesion of activated platelets to many different types of leukocytes: detection by flow cytometry. Blood 80:134–142PubMed de Bruijne-Admiraal LG, Modderman PW, Von dem Borne AE et al (1992) P-selectin mediates Ca(2+)-dependent adhesion of activated platelets to many different types of leukocytes: detection by flow cytometry. Blood 80:134–142PubMed
201.
Zurück zum Zitat Michetti N, Weyrich AS, Zimmerman GA (2009) Platelet–leukocyte interactions in inflammation and thrombosis. US Hematology 2:24–27 Michetti N, Weyrich AS, Zimmerman GA (2009) Platelet–leukocyte interactions in inflammation and thrombosis. US Hematology 2:24–27
202.
Zurück zum Zitat van Gils JM, Zwaginga JJ, Hordijk PL (2009) Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 85:195–204PubMed van Gils JM, Zwaginga JJ, Hordijk PL (2009) Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 85:195–204PubMed
203.
Zurück zum Zitat Kirchhofer D, Riederer MA, Baumgartner HR (1997) Specific accumulation of circulating monocytes and polymorphonuclear leukocytes on platelet thrombi in a vascular injury model. Blood 89:1270–1278PubMed Kirchhofer D, Riederer MA, Baumgartner HR (1997) Specific accumulation of circulating monocytes and polymorphonuclear leukocytes on platelet thrombi in a vascular injury model. Blood 89:1270–1278PubMed
204.
Zurück zum Zitat Rinder HM, Bonan JL, Rinder CS et al (1991) Dynamics of leukocyte–platelet adhesion in whole blood. Blood 78:1730–1737PubMed Rinder HM, Bonan JL, Rinder CS et al (1991) Dynamics of leukocyte–platelet adhesion in whole blood. Blood 78:1730–1737PubMed
205.
Zurück zum Zitat Li N (2008) Platelet–lymphocyte cross-talk. J Leukoc Biol 83:1069–1078PubMed Li N (2008) Platelet–lymphocyte cross-talk. J Leukoc Biol 83:1069–1078PubMed
206.
Zurück zum Zitat Rinder HM, Tracey JL, Rinder CS et al (1994) Neutrophil but not monocyte activation inhibits P-selectin-mediated platelet adhesion. Thromb Haemost 72:750–756PubMed Rinder HM, Tracey JL, Rinder CS et al (1994) Neutrophil but not monocyte activation inhibits P-selectin-mediated platelet adhesion. Thromb Haemost 72:750–756PubMed
207.
Zurück zum Zitat Lorant DE, McEver RP, McIntyre TM et al (1995) Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces. J Clin Invest 96:171–182PubMed Lorant DE, McEver RP, McIntyre TM et al (1995) Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces. J Clin Invest 96:171–182PubMed
208.
Zurück zum Zitat Michelson AD, Barnard MR, Krueger LA et al (2001) Circulating monocyte–platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 104:1533–1537PubMed Michelson AD, Barnard MR, Krueger LA et al (2001) Circulating monocyte–platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 104:1533–1537PubMed
209.
Zurück zum Zitat Larsen E, Celi A, Gilbert GE et al (1989) PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 59:305–312PubMed Larsen E, Celi A, Gilbert GE et al (1989) PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 59:305–312PubMed
210.
Zurück zum Zitat Weyrich AS, McIntyre TM, McEver RP et al (1995) Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. J Clin Invest 95:2297–2303PubMed Weyrich AS, McIntyre TM, McEver RP et al (1995) Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. J Clin Invest 95:2297–2303PubMed
211.
Zurück zum Zitat Silverstein RL, Asch AS, Nachman RL (1989) Glycoprotein IV mediates thrombospondin-dependent platelet–monocyte and platelet–U937 cell adhesion. J Clin Invest 84:546–552PubMed Silverstein RL, Asch AS, Nachman RL (1989) Glycoprotein IV mediates thrombospondin-dependent platelet–monocyte and platelet–U937 cell adhesion. J Clin Invest 84:546–552PubMed
212.
Zurück zum Zitat Gawaz MP, Loftus JC, Bajt ML et al (1991) Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell–cell interactions. J Clin Invest 88:1128–1134PubMed Gawaz MP, Loftus JC, Bajt ML et al (1991) Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell–cell interactions. J Clin Invest 88:1128–1134PubMed
213.
Zurück zum Zitat da Costa Martins PA, van Gils JM, Mol A et al (2006) Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol 79:499–507PubMed da Costa Martins PA, van Gils JM, Mol A et al (2006) Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol 79:499–507PubMed
214.
Zurück zum Zitat Fernandes LS, Conde ID, Smith CW et al (2003) Platelet–monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting. Thromb Res 111:171–177PubMed Fernandes LS, Conde ID, Smith CW et al (2003) Platelet–monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting. Thromb Res 111:171–177PubMed
215.
Zurück zum Zitat Ahn KC, Jun AJ, Pawar P et al (2005) Preferential binding of platelets to monocytes over neutrophils under flow. Biochem Biophys Res Commun 329:345–355PubMed Ahn KC, Jun AJ, Pawar P et al (2005) Preferential binding of platelets to monocytes over neutrophils under flow. Biochem Biophys Res Commun 329:345–355PubMed
216.
Zurück zum Zitat Galt SW, Lindemann S, Medd D et al (2001) Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets. Circ Res 89:509–516PubMed Galt SW, Lindemann S, Medd D et al (2001) Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets. Circ Res 89:509–516PubMed
217.
Zurück zum Zitat Brittain JE, Knoll CM, Ataga KI et al (2008) Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1. Br J Haematol 141:872–881PubMed Brittain JE, Knoll CM, Ataga KI et al (2008) Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1. Br J Haematol 141:872–881PubMed
218.
Zurück zum Zitat Dixon DA, Tolley ND, Bemis-Standoli K et al (2006) Expression of COX-2 in platelet–monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest 116:2727–2738PubMed Dixon DA, Tolley ND, Bemis-Standoli K et al (2006) Expression of COX-2 in platelet–monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest 116:2727–2738PubMed
219.
Zurück zum Zitat Weyrich AS, Denis MM, Kuhlmann-Eyre JR et al (2005) Dipyridamole selectively inhibits inflammatory gene expression in platelet–monocyte aggregates. Circulation 111:633–642PubMed Weyrich AS, Denis MM, Kuhlmann-Eyre JR et al (2005) Dipyridamole selectively inhibits inflammatory gene expression in platelet–monocyte aggregates. Circulation 111:633–642PubMed
220.
Zurück zum Zitat Mahoney TS, Weyrich AS, Dixon DA et al (2001) Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes. Proc Natl Acad Sci U S A 98:10284–10289PubMed Mahoney TS, Weyrich AS, Dixon DA et al (2001) Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes. Proc Natl Acad Sci U S A 98:10284–10289PubMed
221.
Zurück zum Zitat Neumann FJ, Marx N, Gawaz M et al (1997) Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation 95:2387–2394PubMed Neumann FJ, Marx N, Gawaz M et al (1997) Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation 95:2387–2394PubMed
222.
Zurück zum Zitat Eligini S, Barbieri SS, Arenaz I et al (2007) Paracrine up-regulation of monocyte cyclooxygenase-2 by platelets: role of transforming growth factor-beta1. Cardiovasc Res 74:270–278PubMed Eligini S, Barbieri SS, Arenaz I et al (2007) Paracrine up-regulation of monocyte cyclooxygenase-2 by platelets: role of transforming growth factor-beta1. Cardiovasc Res 74:270–278PubMed
223.
Zurück zum Zitat Christersson C, Johnell M, Siegbahn A (2008) Tissue factor and IL8 production by P-selectin-dependent platelet-monocyte aggregates in whole blood involves phosphorylation of Lyn and is inhibited by IL10. J Thromb Haemost 6:986–994PubMed Christersson C, Johnell M, Siegbahn A (2008) Tissue factor and IL8 production by P-selectin-dependent platelet-monocyte aggregates in whole blood involves phosphorylation of Lyn and is inhibited by IL10. J Thromb Haemost 6:986–994PubMed
224.
Zurück zum Zitat Celi A, Pellegrini G, Lorenzet R et al (1994) P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A 91:8767–8771PubMed Celi A, Pellegrini G, Lorenzet R et al (1994) P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A 91:8767–8771PubMed
225.
Zurück zum Zitat Lindmark E, Tenno T, Siegbahn A (2000) Role of platelet P-selectin and CD40 ligand in the induction of monocytic tissue factor expression. Arterioscler Thromb Vasc Biol 20:2322–2328PubMed Lindmark E, Tenno T, Siegbahn A (2000) Role of platelet P-selectin and CD40 ligand in the induction of monocytic tissue factor expression. Arterioscler Thromb Vasc Biol 20:2322–2328PubMed
226.
Zurück zum Zitat Steiner S, Seidinger D, Huber K et al (2003) Effect of glycoprotein IIb/IIIa antagonist abciximab on monocyte–platelet aggregates and tissue factor expression. Arterioscler Thromb Vasc Biol 23:1697–1702PubMed Steiner S, Seidinger D, Huber K et al (2003) Effect of glycoprotein IIb/IIIa antagonist abciximab on monocyte–platelet aggregates and tissue factor expression. Arterioscler Thromb Vasc Biol 23:1697–1702PubMed
227.
Zurück zum Zitat Barnard MR, Linden MD, Frelinger AL 3rd et al (2005) Effects of platelet binding on whole blood flow cytometry assays of monocyte and neutrophil procoagulant activity. J Thromb Haemost 3:2563–2570PubMed Barnard MR, Linden MD, Frelinger AL 3rd et al (2005) Effects of platelet binding on whole blood flow cytometry assays of monocyte and neutrophil procoagulant activity. J Thromb Haemost 3:2563–2570PubMed
228.
Zurück zum Zitat Brambilla M, Camera M, Colnago D et al (2008) Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet–leukocyte aggregates. Arterioscler Thromb Vasc Biol 28:947–953PubMed Brambilla M, Camera M, Colnago D et al (2008) Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet–leukocyte aggregates. Arterioscler Thromb Vasc Biol 28:947–953PubMed
229.
Zurück zum Zitat Elstad MR, McIntyre TM, Prescott SM et al (1995) The interaction of leukocytes with platelets in blood coagulation. Curr Opin Hematol 2:47–54PubMed Elstad MR, McIntyre TM, Prescott SM et al (1995) The interaction of leukocytes with platelets in blood coagulation. Curr Opin Hematol 2:47–54PubMed
230.
Zurück zum Zitat Freedman JE, Loscalzo J (2002) Platelet–monocyte aggregates: bridging thrombosis and inflammation. Circulation 105:2130–2132PubMed Freedman JE, Loscalzo J (2002) Platelet–monocyte aggregates: bridging thrombosis and inflammation. Circulation 105:2130–2132PubMed
231.
Zurück zum Zitat Ammon C, Kreutz M, Rehli M et al (1998) Platelets induce monocyte differentiation in serum-free coculture. J Leukoc Biol 63:469–476PubMed Ammon C, Kreutz M, Rehli M et al (1998) Platelets induce monocyte differentiation in serum-free coculture. J Leukoc Biol 63:469–476PubMed
232.
Zurück zum Zitat Lang D, Dohle F, Terstesse M et al (2002) Down-regulation of monocyte apoptosis by phagocytosis of platelets: involvement of a caspase-9, caspase-3, and heat shock protein 70-dependent pathway. J Immunol 168:6152–6158PubMed Lang D, Dohle F, Terstesse M et al (2002) Down-regulation of monocyte apoptosis by phagocytosis of platelets: involvement of a caspase-9, caspase-3, and heat shock protein 70-dependent pathway. J Immunol 168:6152–6158PubMed
233.
Zurück zum Zitat Li G, Kim YJ, Mantel C et al (2003) P-selectin enhances generation of CD14 + CD16+ dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes. J Immunol 171:669–677PubMed Li G, Kim YJ, Mantel C et al (2003) P-selectin enhances generation of CD14 + CD16+ dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes. J Immunol 171:669–677PubMed
234.
Zurück zum Zitat Chen J, Lopez JA (2005) Interactions of platelets with subendothelium and endothelium. Microcirculation 12:235–246PubMed Chen J, Lopez JA (2005) Interactions of platelets with subendothelium and endothelium. Microcirculation 12:235–246PubMed
235.
Zurück zum Zitat Diacovo TG, Puri KD, Warnock RA et al (1996) Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273:252–255PubMed Diacovo TG, Puri KD, Warnock RA et al (1996) Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273:252–255PubMed
236.
Zurück zum Zitat Diacovo TG, Catalina MD, Siegelman MH et al (1998) Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice. J Exp Med 187:197–204PubMed Diacovo TG, Catalina MD, Siegelman MH et al (1998) Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice. J Exp Med 187:197–204PubMed
237.
Zurück zum Zitat Pitchford SC, Momi S, Giannini S et al (2005) Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood 105:2074–2081PubMed Pitchford SC, Momi S, Giannini S et al (2005) Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood 105:2074–2081PubMed
238.
Zurück zum Zitat Diacovo TG, deFougerolles AR, Bainton DF et al (1994) A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. J Clin Invest 94:1243–1251PubMed Diacovo TG, deFougerolles AR, Bainton DF et al (1994) A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. J Clin Invest 94:1243–1251PubMed
239.
Zurück zum Zitat Atarashi K, Hirata T, Matsumoto M et al (2005) Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J Immunol 174:1424–1432PubMed Atarashi K, Hirata T, Matsumoto M et al (2005) Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J Immunol 174:1424–1432PubMed
240.
Zurück zum Zitat Li N, Ji Q, Hjemdahl P (2006) Platelet–lymphocyte conjugation differs between lymphocyte subpopulations. J Thromb Haemost 4:874–881PubMed Li N, Ji Q, Hjemdahl P (2006) Platelet–lymphocyte conjugation differs between lymphocyte subpopulations. J Thromb Haemost 4:874–881PubMed
241.
Zurück zum Zitat Katz IR, Hoffmann MK, Zucker MB et al (1985) A platelet-derived immunoregulatory serum factor with T cell affinity. J Immunol 134:3199–3203PubMed Katz IR, Hoffmann MK, Zucker MB et al (1985) A platelet-derived immunoregulatory serum factor with T cell affinity. J Immunol 134:3199–3203PubMed
242.
Zurück zum Zitat Matsuda H, Ushio H, Geba GP et al (1997) Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. J Immunol 158:2891–2897PubMed Matsuda H, Ushio H, Geba GP et al (1997) Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. J Immunol 158:2891–2897PubMed
243.
Zurück zum Zitat Weyrich AS, Schwertz H, Kraiss LW et al (2009) Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost 7:241–246PubMed Weyrich AS, Schwertz H, Kraiss LW et al (2009) Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost 7:241–246PubMed
244.
Zurück zum Zitat Santoso S, Kalb R, Kiefel V et al (1993) The presence of messenger RNA for HLA class I in human platelets and its capability for protein biosynthesis. Br J Haematol 84:451–456PubMed Santoso S, Kalb R, Kiefel V et al (1993) The presence of messenger RNA for HLA class I in human platelets and its capability for protein biosynthesis. Br J Haematol 84:451–456PubMed
245.
Zurück zum Zitat Wang L, Erling P, Bengtsson AA et al (2004) Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus. J Thromb Haemost 2:1436–1442PubMed Wang L, Erling P, Bengtsson AA et al (2004) Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus. J Thromb Haemost 2:1436–1442PubMed
246.
Zurück zum Zitat Healy AM, Pickard MD, Pradhan AD et al (2006) Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 113:2278–2284PubMed Healy AM, Pickard MD, Pradhan AD et al (2006) Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 113:2278–2284PubMed
247.
Zurück zum Zitat Potti A, Bild A, Dressman HK et al (2006) Gene-expression patterns predict phenotypes of immune-mediated thrombosis. Blood 107:1391–1396PubMed Potti A, Bild A, Dressman HK et al (2006) Gene-expression patterns predict phenotypes of immune-mediated thrombosis. Blood 107:1391–1396PubMed
248.
Zurück zum Zitat Raghavachari N, Xu X, Harris A et al (2007) Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 115:1551–1562PubMed Raghavachari N, Xu X, Harris A et al (2007) Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 115:1551–1562PubMed
249.
Zurück zum Zitat Gnatenko DV, Zhu W, Xu X et al (2010) Class prediction models of thrombocytosis using genetic biomarkers. Blood 115:7–14PubMed Gnatenko DV, Zhu W, Xu X et al (2010) Class prediction models of thrombocytosis using genetic biomarkers. Blood 115:7–14PubMed
250.
Zurück zum Zitat Lood C, Amisten S, Gullstrand B et al (2010) Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease. Blood 116:1951–1957PubMed Lood C, Amisten S, Gullstrand B et al (2010) Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease. Blood 116:1951–1957PubMed
251.
Zurück zum Zitat Pawlinski R, Wang JG, Owens AP 3rd et al (2010) Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood 116:806–814PubMed Pawlinski R, Wang JG, Owens AP 3rd et al (2010) Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood 116:806–814PubMed
252.
Zurück zum Zitat Spinelli SL, Maggirwar SB, Blumberg N et al (2010) Nuclear emancipation: a platelet tour de force. Sci Signal 3:pe37PubMed Spinelli SL, Maggirwar SB, Blumberg N et al (2010) Nuclear emancipation: a platelet tour de force. Sci Signal 3:pe37PubMed
253.
Zurück zum Zitat Schubert S, Schwertz H, Weyrich AS et al (2011) Staphylococcus aureus alpha-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins 3:120–133PubMed Schubert S, Schwertz H, Weyrich AS et al (2011) Staphylococcus aureus alpha-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins 3:120–133PubMed
254.
Zurück zum Zitat Gerrits AJ, Koekman CA, van Haeften TW et al (2010) Platelet tissue factor synthesis in type 2 diabetic patients is resistant to inhibition by insulin. Diabetes 59:1487–1495PubMed Gerrits AJ, Koekman CA, van Haeften TW et al (2010) Platelet tissue factor synthesis in type 2 diabetic patients is resistant to inhibition by insulin. Diabetes 59:1487–1495PubMed
255.
Zurück zum Zitat Mezzano D, Matus V, Saez CG et al (2008) Tissue factor storage, synthesis and function in normal and activated human platelets. Thromb Res 122(Suppl 1):S31–S36PubMed Mezzano D, Matus V, Saez CG et al (2008) Tissue factor storage, synthesis and function in normal and activated human platelets. Thromb Res 122(Suppl 1):S31–S36PubMed
256.
Zurück zum Zitat Anthoni C, Russell J, Wood KC et al (2007) Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis. J Exp Med 204:1595–1601PubMed Anthoni C, Russell J, Wood KC et al (2007) Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis. J Exp Med 204:1595–1601PubMed
257.
Zurück zum Zitat Elzey BD, Sprague DL, Ratliff TL (2005) The emerging role of platelets in adaptive immunity. Cell Immunol 238:1–9PubMed Elzey BD, Sprague DL, Ratliff TL (2005) The emerging role of platelets in adaptive immunity. Cell Immunol 238:1–9PubMed
258.
Zurück zum Zitat Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419–426PubMed Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419–426PubMed
259.
Zurück zum Zitat Hilf N, Singh-Jasuja H, Schwarzmaier P et al (2002) Human platelets express heat shock protein receptors and regulate dendritic cell maturation. Blood 99:3676–3682PubMed Hilf N, Singh-Jasuja H, Schwarzmaier P et al (2002) Human platelets express heat shock protein receptors and regulate dendritic cell maturation. Blood 99:3676–3682PubMed
260.
Zurück zum Zitat Kaneider NC, Kaser A, Tilg H et al (2003) CD40 ligand-dependent maturation of human monocyte-derived dendritic cells by activated platelets. Int J Immunopathol Pharmacol 16:225–231PubMed Kaneider NC, Kaser A, Tilg H et al (2003) CD40 ligand-dependent maturation of human monocyte-derived dendritic cells by activated platelets. Int J Immunopathol Pharmacol 16:225–231PubMed
261.
Zurück zum Zitat Czapiga M, Kirk AD, Lekstrom-Himes J (2004) Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation. Exp Hematol 32:135–139PubMed Czapiga M, Kirk AD, Lekstrom-Himes J (2004) Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation. Exp Hematol 32:135–139PubMed
262.
Zurück zum Zitat Martinson J, Bae J, Klingemann HG et al (2004) Activated platelets rapidly up-regulate CD40L expression and can effectively mature and activate autologous ex vivo differentiated DC. Cytotherapy 6:487–497PubMed Martinson J, Bae J, Klingemann HG et al (2004) Activated platelets rapidly up-regulate CD40L expression and can effectively mature and activate autologous ex vivo differentiated DC. Cytotherapy 6:487–497PubMed
263.
Zurück zum Zitat Hagihara M, Higuchi A, Tamura N et al (2004) Platelets, after exposure to a high shear stress, induce IL-10-producing, mature dendritic cells in vitro. J Immunol 172:5297–5303PubMed Hagihara M, Higuchi A, Tamura N et al (2004) Platelets, after exposure to a high shear stress, induce IL-10-producing, mature dendritic cells in vitro. J Immunol 172:5297–5303PubMed
264.
Zurück zum Zitat Kissel K, Berber S, Nockher A et al (2006) Human platelets target dendritic cell differentiation and production of proinflammatory cytokines. Transfusion 46:818–827PubMed Kissel K, Berber S, Nockher A et al (2006) Human platelets target dendritic cell differentiation and production of proinflammatory cytokines. Transfusion 46:818–827PubMed
265.
Zurück zum Zitat Langer HF, Daub K, Braun G et al (2007) Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro. Arterioscler Thromb Vasc Biol 27:1463–1470PubMed Langer HF, Daub K, Braun G et al (2007) Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro. Arterioscler Thromb Vasc Biol 27:1463–1470PubMed
266.
Zurück zum Zitat Hamzeh-Cognasse H, Cognasse F, Palle S et al (2008) Direct contact of platelets and their released products exert different effects on human dendritic cell maturation. BMC Immunol 9:54PubMed Hamzeh-Cognasse H, Cognasse F, Palle S et al (2008) Direct contact of platelets and their released products exert different effects on human dendritic cell maturation. BMC Immunol 9:54PubMed
267.
Zurück zum Zitat Katoh N, Soga F, Nara T et al (2006) Effect of serotonin on the differentiation of human monocytes into dendritic cells. Clin Exp Immunol 146:354–361PubMed Katoh N, Soga F, Nara T et al (2006) Effect of serotonin on the differentiation of human monocytes into dendritic cells. Clin Exp Immunol 146:354–361PubMed
268.
Zurück zum Zitat Suzuki-Inoue K, Fuller GL, Garcia A et al (2006) A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107:542–549PubMed Suzuki-Inoue K, Fuller GL, Garcia A et al (2006) A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107:542–549PubMed
269.
Zurück zum Zitat Suzuki-Inoue K, Inoue O, Ding G et al (2010) Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem 285:24494–24507PubMed Suzuki-Inoue K, Inoue O, Ding G et al (2010) Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem 285:24494–24507PubMed
270.
Zurück zum Zitat Uhrin P, Zaujec J, Breuss JM et al (2010) Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood 115:3997–4005PubMed Uhrin P, Zaujec J, Breuss JM et al (2010) Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood 115:3997–4005PubMed
271.
Zurück zum Zitat Bertozzi CC, Schmaier AA, Mericko P et al (2010) Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 116:661–670PubMed Bertozzi CC, Schmaier AA, Mericko P et al (2010) Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 116:661–670PubMed
272.
Zurück zum Zitat Tammela T, Alitalo K (2010) Lymphangiogenesis: molecular mechanisms and future promise. Cell 140:460–476PubMed Tammela T, Alitalo K (2010) Lymphangiogenesis: molecular mechanisms and future promise. Cell 140:460–476PubMed
273.
Zurück zum Zitat Sprague DL, Elzey BD, Crist SA et al (2008) Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 111:5028–5036PubMed Sprague DL, Elzey BD, Crist SA et al (2008) Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 111:5028–5036PubMed
274.
Zurück zum Zitat Elzey BD, Grant JF, Sinn HW et al (2005) Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation. J Leukoc Biol 78:80–84PubMed Elzey BD, Grant JF, Sinn HW et al (2005) Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation. J Leukoc Biol 78:80–84PubMed
275.
Zurück zum Zitat Italiano JE Jr, Mairuhu AT, Flaumenhaft R (2010) Clinical relevance of microparticles from platelets and megakaryocytes. Curr Opin Hematol 17:578–584PubMed Italiano JE Jr, Mairuhu AT, Flaumenhaft R (2010) Clinical relevance of microparticles from platelets and megakaryocytes. Curr Opin Hematol 17:578–584PubMed
276.
Zurück zum Zitat Elzey BD, Schmidt NW, Crist SA et al (2008) Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood 111:3684–3691PubMed Elzey BD, Schmidt NW, Crist SA et al (2008) Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood 111:3684–3691PubMed
277.
Zurück zum Zitat Lindemann SW, Weyrich AS, Zimmerman GA (2005) Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells. Trends Cardiovasc Med 15:9–17PubMed Lindemann SW, Weyrich AS, Zimmerman GA (2005) Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells. Trends Cardiovasc Med 15:9–17PubMed
278.
Zurück zum Zitat Meshorer E, Misteli T (2005) Splicing misplaced. Cell 122:317–318PubMed Meshorer E, Misteli T (2005) Splicing misplaced. Cell 122:317–318PubMed
Metadaten
Titel
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
verfasst von
Adriana Vieira-de-Abreu
Robert A. Campbell
Andrew S. Weyrich
Guy A. Zimmerman
Publikationsdatum
01.01.2012
Verlag
Springer-Verlag
Erschienen in
Seminars in Immunopathology / Ausgabe 1/2012
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-011-0286-4

Weitere Artikel der Ausgabe 1/2012

Seminars in Immunopathology 1/2012 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.