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Seminars in Immunopathology
Erschienen in: Seminars in Immunopathology 3/2017

27.10.2016 | Review

Myeloid-derived suppressor cells and tumor escape from immune surveillance

verfasst von: Viktor Umansky, Carolin Blattner, Viktor Fleming, Xiaoying Hu, Christoffer Gebhardt, Peter Altevogt, Jochen Utikal

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2017

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Abstract

Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.
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Metadaten
Titel
Myeloid-derived suppressor cells and tumor escape from immune surveillance
verfasst von
Viktor Umansky
Carolin Blattner
Viktor Fleming
Xiaoying Hu
Christoffer Gebhardt
Peter Altevogt
Jochen Utikal
Publikationsdatum
27.10.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Seminars in Immunopathology / Ausgabe 3/2017
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-016-0597-6

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