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Immunometabolism, pregnancy, and nutrition

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Abstract

The emerging field of immunometabolism has substantially progressed over the last years and provided pivotal insights into distinct metabolic regulators and reprogramming pathways of immune cell populations in various immunological settings. However, insights into immunometabolic reprogramming in the context of reproduction are still enigmatic. During pregnancy, the maternal immune system needs to actively adapt to the presence of the fetal antigens, i.e., by functional modifications of distinct innate immune cell subsets, the generation of regulatory T cells, and the suppression of an anti-fetal effector T cell response. Considering that metabolic pathways have been shown to affect the functional role of such immune cells in a number of settings, we here review the potential role of immunometabolism with regard to the molecular and cellular mechanisms necessary for successful reproduction. Since immunometabolism holds the potential for a therapeutic approach to alter the course of immune diseases, we further highlight how a targeted metabolic reprogramming of immune cells may be triggered by maternal anthropometric or nutritional aspects.

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Acknowledgments

The writing of this review and reference to the authors’ own work were made possible through funding by the Deutsche Forschungsgemeinschaft (KFO296 and AR232/27-1 to P.C.A. and TH2126/1-1 to K.T.) and Special Funds for Science and Technology Development of Guangdong Province (2017A020214006 to LH.D).

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  1. Department of Obstetrics and Fetal Medicine, Laboratory for Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Kristin Thiele, Lianghui Diao & Petra Clara Arck

  2. Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China

    Lianghui Diao

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  1. Kristin Thiele
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Correspondence to Petra Clara Arck.

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This article is a contribution to the special issue on Dietary Control of Immunometabolism - Guest Editors: Joerg Heeren and Ludger Scheja

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Thiele, K., Diao, L. & Arck, P.C. Immunometabolism, pregnancy, and nutrition. Semin Immunopathol 40, 157–174 (2018). https://doi.org/10.1007/s00281-017-0660-y

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