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Baculovirus-Encoded MicroRNAs: A Brief Overview and Future Prospects

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Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs with ∼22 nucleotides, which are able to regulate various biological processes, including the viral life cycle and host–pathogen interactions. Long primary transcripts (pri-miRNAs) are initially transcribed in nucleus, and subsequently processed by Dicer in cytoplasm to generate mature miRNAs. Baculoviruses consist of large, enveloped, insect-pathogenic viruses with a double-stranded circular DNA genome. Recent studies suggest that baculoviruses encode some miRNAs to manipulate expression regulation of host genes, whereas host modulate viral gene expression via miRNAs to limit viral infection. In the review, we will focus on the biogenesis and functions of miRNAs and the interactions between baculoviruses, insect, and miRNAs. It will be helpful to delve into the related mechanisms of BmNPV-encoded miRNAs that contribute to infection and pathogenesis.

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Acknowledgements

This study was supported by National Natural Science Foundation of China (31402016, 81402840); Postdoctoral Research in Jiangsu Province (1501070C), a project supported by the Youth Foundation of Jiangsu University (FCJJ2015028), and Natural Science Foundation of Jiangsu Province of China (BK20130495).

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Authors and Affiliations

  1. Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, Jiangsu, China

    Qi Tang, Lipeng Qiu & Guohui Li

  2. School of Public Health, University of California, Berkeley, CA, USA

    Guohui Li

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  1. Qi Tang
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  2. Lipeng Qiu
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Correspondence to Guohui Li.

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Tang, Q., Qiu, L. & Li, G. Baculovirus-Encoded MicroRNAs: A Brief Overview and Future Prospects. Curr Microbiol 76, 738–743 (2019). https://doi.org/10.1007/s00284-018-1443-y

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  • DOI: https://doi.org/10.1007/s00284-018-1443-y

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