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Erschienen in: Rheumatology International 2/2005

01.03.2005 | Original Article

Synovial membrane enhancement and bone erosion by magnetic resonance imaging for prediction of radiologic progression in patients with early rheumatoid arthritis

verfasst von: Nobuyuki Tanaka, Hisashi Sakahashi, Seiichi Ishii, Eiichi Sato, Kazuya Hirose, Takumi Ishima

Erschienen in: Rheumatology International | Ausgabe 2/2005

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Abstract

Objective

The aim of this study was to determine the prognostic factors related to radiographic progression in patients with early rheumatoid arthritis (RA) (less than 1 year after onset) undergoing enhanced MRI at entry.

Methods

Demographic characteristics, disease duration, and enhanced MRI of the dominant wrists were recorded at entry. Duration of morning stiffness, number of swollen joints, serum rheumatoid factor (RF), erythrocyte sedimentation rate, C-reactive protein (CRP) level, and radiographs of hands and feet (Sharp/van der Heijde score) were assessed at each follow-up. Outcome was defined as damage seen on radiography.

Results

One hundred fourteen patients were followed up for 10 years. Logistic regression analysis showed that high MRI score, CRP, and RF positivity were associated with radiologic progression. The MRI score at baseline was a better predictor than CRP level and RF positivity at entry.

Conclusion

The assessment of synovial membrane enhancement and bone erosion by MRI of the wrist in early RA is very helpful to predict erosive outcome.
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Metadaten
Titel
Synovial membrane enhancement and bone erosion by magnetic resonance imaging for prediction of radiologic progression in patients with early rheumatoid arthritis
verfasst von
Nobuyuki Tanaka
Hisashi Sakahashi
Seiichi Ishii
Eiichi Sato
Kazuya Hirose
Takumi Ishima
Publikationsdatum
01.03.2005
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 2/2005
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-003-0404-2

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