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Erschienen in: Rheumatology International 3/2005

01.04.2005 | Original Article

Hydrotherapy, balneotherapy, and spa treatment in pain management

Erschienen in: Rheumatology International | Ausgabe 3/2005

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Abstract

The use of water for medical treatment is probably as old as mankind. Until the middle of the last century, spa treatment, including hydrotherapy and balneotherapy, remained popular but went into decline especially in the Anglo-Saxon world with the development of effective analgesics. However, no analgesic, regardless of its potency, is capable of eliminating pain, and reports of life-threatening adverse reactions to the use of these drugs led to renewed interest in spa therapy. Because of methodologic difficulties and lack of research funding, the effects of ‘water treatments’ in the relief of pain have rarely been subjected to rigorous assessment by randomised, controlled trials. It is our opinion that the three therapeutic modalities must be considered separately, and this was done in the present paper. In addition, we review the research on the mechanism of action and cost effectiveness of such treatments and examine what research might be useful in the future.
Literatur
1.
Zurück zum Zitat Genesis 14–24, Chap. 3. The New American Bible. Fireside, Wichita Genesis 14–24, Chap. 3. The New American Bible. Fireside, Wichita
2.
Zurück zum Zitat Stevens MJ, Heise RA, Pfost KS (1989) Consumption of attention versus affect elicited by cognition in modifying acute pain. Psychol Rep 64:284–286PubMed Stevens MJ, Heise RA, Pfost KS (1989) Consumption of attention versus affect elicited by cognition in modifying acute pain. Psychol Rep 64:284–286PubMed
3.
Zurück zum Zitat Andersson HI, Ejlertsson G, Leden I, Rosenberg C (1993) Chronic pain in a geographically defined general population: studies of differences in age, gender, social class and pain localisation. Clin J Pain 9:174–182PubMed Andersson HI, Ejlertsson G, Leden I, Rosenberg C (1993) Chronic pain in a geographically defined general population: studies of differences in age, gender, social class and pain localisation. Clin J Pain 9:174–182PubMed
4.
Zurück zum Zitat Macfarlane GJ (1999) Generalized pain, fibromyalgia and regional pain: an epidemiological view. Baillieres Best Pract Res Clin Rheumatol 13:403–414CrossRefPubMed Macfarlane GJ (1999) Generalized pain, fibromyalgia and regional pain: an epidemiological view. Baillieres Best Pract Res Clin Rheumatol 13:403–414CrossRefPubMed
5.
Zurück zum Zitat van Tubergen A, van der Linden S (2002) A brief history of spa therapy. Ann Rheum Dis 61:273–275CrossRefPubMed van Tubergen A, van der Linden S (2002) A brief history of spa therapy. Ann Rheum Dis 61:273–275CrossRefPubMed
6.
Zurück zum Zitat Verhagen AP, de Vet HC, de Bie RA, Kessels AGA, Boers M, Knipschild PG (1997) Taking baths: the efficacy of balneotherapy in patients with arthritis. A systematic review. J Rheumatol 24:1964–1971PubMed Verhagen AP, de Vet HC, de Bie RA, Kessels AGA, Boers M, Knipschild PG (1997) Taking baths: the efficacy of balneotherapy in patients with arthritis. A systematic review. J Rheumatol 24:1964–1971PubMed
7.
Zurück zum Zitat Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Knipschild PG (2000) Balneotherapy for rheumatoid arthritis and osteoarthritis. Cochrane Database Syst Rev 2:CD000518PubMed Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Knipschild PG (2000) Balneotherapy for rheumatoid arthritis and osteoarthritis. Cochrane Database Syst Rev 2:CD000518PubMed
8.
Zurück zum Zitat Balint G, Bender T, Szabó E (1993) Spa treatment in arthritis. J Rheumatol 20:1623–1625 Balint G, Bender T, Szabó E (1993) Spa treatment in arthritis. J Rheumatol 20:1623–1625
9.
Zurück zum Zitat Sukenik S, Flusser D, Abu-Shakra M (1999) The role of spa therapy in various rheumatic diseases. Rheum Dis Clin North Am 25:883–897PubMed Sukenik S, Flusser D, Abu-Shakra M (1999) The role of spa therapy in various rheumatic diseases. Rheum Dis Clin North Am 25:883–897PubMed
10.
Zurück zum Zitat Bender T, Balint PV, Balint GP (2002) A brief history of spa therapy. Ann Rheum Dis:61:949 Bender T, Balint PV, Balint GP (2002) A brief history of spa therapy. Ann Rheum Dis:61:949
11.
Zurück zum Zitat Jackson R (1990) Waters and spas in the classical world. Med Hist Suppl 10:1–13PubMed Jackson R (1990) Waters and spas in the classical world. Med Hist Suppl 10:1–13PubMed
12.
Zurück zum Zitat Kjelllgren A, Sundequist U, Norlander T, Archer T (2001) Effects of flotation-REST on muscle tension pain. Pain Res Manag 6:181–189PubMed Kjelllgren A, Sundequist U, Norlander T, Archer T (2001) Effects of flotation-REST on muscle tension pain. Pain Res Manag 6:181–189PubMed
13.
Zurück zum Zitat Garrett G (1997) Hydrotherapeutic applications in arthritis rehabilitation. In: Becker BE, Cole AJ (eds) Comprehensive aquatic therapy. First edn. Butterworth-Heinemann, Boston, pp 103–122 Garrett G (1997) Hydrotherapeutic applications in arthritis rehabilitation. In: Becker BE, Cole AJ (eds) Comprehensive aquatic therapy. First edn. Butterworth-Heinemann, Boston, pp 103–122
14.
Zurück zum Zitat De Vierville JP (1997) Aquatic rehabilitation: an historical perspective. In: Becker BE, Cole AJ (eds) Comprehensive aquatic therapy. First edn. Butterworth-Heinemann, Boston, pp 1–16 De Vierville JP (1997) Aquatic rehabilitation: an historical perspective. In: Becker BE, Cole AJ (eds) Comprehensive aquatic therapy. First edn. Butterworth-Heinemann, Boston, pp 1–16
15.
Zurück zum Zitat Becker BE (1997) Biophysiologic aspects of hydrotherapy. In Becker BE, Cole AJ (eds) Comprehensive aquatic therapy. First edn. Butterworth-Heinemann, Boston, pp 17–48 Becker BE (1997) Biophysiologic aspects of hydrotherapy. In Becker BE, Cole AJ (eds) Comprehensive aquatic therapy. First edn. Butterworth-Heinemann, Boston, pp 17–48
16.
Zurück zum Zitat Melzack R, Wall PD (1965) Pain mechanism: a new theory. Science 150:971–979PubMed Melzack R, Wall PD (1965) Pain mechanism: a new theory. Science 150:971–979PubMed
17.
Zurück zum Zitat Geytenbeek J (2002) Evidence for effective hydrotherapy Physiotherapy 88:514–529 Geytenbeek J (2002) Evidence for effective hydrotherapy Physiotherapy 88:514–529
18.
Zurück zum Zitat Grahame R, Hunt JN, Kitchen S, Gabell A (1978) The diuretic and natriuretic effect of water immersion—a possible rationale for balneotherapy. Ann Rheum Dis 37:567 Grahame R, Hunt JN, Kitchen S, Gabell A (1978) The diuretic and natriuretic effect of water immersion—a possible rationale for balneotherapy. Ann Rheum Dis 37:567
19.
Zurück zum Zitat O’Hare JP, Heywood A, Dodds P, Corral RJM, Dieppe P (1984) Water immersion in rheumatoid arthritis. Br J Rheumatol 23:117–118 O’Hare JP, Heywood A, Dodds P, Corral RJM, Dieppe P (1984) Water immersion in rheumatoid arthritis. Br J Rheumatol 23:117–118
20.
Zurück zum Zitat Hall J, Skevington SM, Maddison PJ, Chapman K (1996) A randomized and controlled trial of hydrotherapy in rheumatoid arthritis. Arthritis Care Res 9:206–215PubMed Hall J, Skevington SM, Maddison PJ, Chapman K (1996) A randomized and controlled trial of hydrotherapy in rheumatoid arthritis. Arthritis Care Res 9:206–215PubMed
21.
Zurück zum Zitat Gutenbrunner C, Hildebrandt G (1998) Textbook of balneology and medical climatology [German]. Springer, Berlin Heidelberg New York Tokyo Gutenbrunner C, Hildebrandt G (1998) Textbook of balneology and medical climatology [German]. Springer, Berlin Heidelberg New York Tokyo
22.
Zurück zum Zitat O’Hare JP, Heywood A, Summerhayes C et al (1985) Observations on the effect of immersion in Bath spa water. Br Med J (Clin Res Ed) 291:1747–1751 O’Hare JP, Heywood A, Summerhayes C et al (1985) Observations on the effect of immersion in Bath spa water. Br Med J (Clin Res Ed) 291:1747–1751
23.
Zurück zum Zitat Szucs L, Ratko I, Lesko T, Szoor I, Genti G, Balint G (1989) Double-blind trial on the effectiveness of the Puspokladany thermal water on arthrosis of the knee-joints. J R Soc Health 109:7–9PubMed Szucs L, Ratko I, Lesko T, Szoor I, Genti G, Balint G (1989) Double-blind trial on the effectiveness of the Puspokladany thermal water on arthrosis of the knee-joints. J R Soc Health 109:7–9PubMed
24.
Zurück zum Zitat Kovacs I, Bender T (2002) The therapeutic effects of Cserkeszolo thermal water in osteoarthritis of the knee: a double blind, controlled, follow-up study. Rheumatol Int 21:218–221CrossRefPubMed Kovacs I, Bender T (2002) The therapeutic effects of Cserkeszolo thermal water in osteoarthritis of the knee: a double blind, controlled, follow-up study. Rheumatol Int 21:218–221CrossRefPubMed
25.
Zurück zum Zitat Sukenik S, Neumann L, Buskila D, Kleiner-Baumgarten A, Zimlichman S, Horowitz J (1990) Dead Sea bath salts for the treatment of rheumatoid arthritis. Clin Exp Rheumatol 8:353–357PubMed Sukenik S, Neumann L, Buskila D, Kleiner-Baumgarten A, Zimlichman S, Horowitz J (1990) Dead Sea bath salts for the treatment of rheumatoid arthritis. Clin Exp Rheumatol 8:353–357PubMed
26.
Zurück zum Zitat Konrad K, Tatrai T, Hunka A, Vereckei E, Korondi I (1992) Controlled trial of balneotherapy in treatment of low back pain. Ann Rheum Dis 51:820–822PubMed Konrad K, Tatrai T, Hunka A, Vereckei E, Korondi I (1992) Controlled trial of balneotherapy in treatment of low back pain. Ann Rheum Dis 51:820–822PubMed
27.
Zurück zum Zitat Guillemin F, Constant F, Collin JF, Boulange M (1994) Short and long-term effect of spa therapy in chronic low back pain. Br J Rheumatol 33:148–151PubMed Guillemin F, Constant F, Collin JF, Boulange M (1994) Short and long-term effect of spa therapy in chronic low back pain. Br J Rheumatol 33:148–151PubMed
28.
Zurück zum Zitat Constant F, Collin JF, Guillemin F, Boulange (1995) Effectiveness of spa therapy in chronic low back pain: a randomized clinical trial. J Rheumatol 22:1315–1320PubMed Constant F, Collin JF, Guillemin F, Boulange (1995) Effectiveness of spa therapy in chronic low back pain: a randomized clinical trial. J Rheumatol 22:1315–1320PubMed
29.
Zurück zum Zitat Evcik D, Kızılay B, Gokçen E (2002) The effects of balneotherapy on fibromyalgia patients. Rheumatol Int 22:56–59CrossRefPubMed Evcik D, Kızılay B, Gokçen E (2002) The effects of balneotherapy on fibromyalgia patients. Rheumatol Int 22:56–59CrossRefPubMed
30.
Zurück zum Zitat Fam AG (1991) Spa treatment in arthritis: a rheumatologist’s view. J Rheumatol 18:1775–1777PubMed Fam AG (1991) Spa treatment in arthritis: a rheumatologist’s view. J Rheumatol 18:1775–1777PubMed
31.
Zurück zum Zitat Bell MJ (1991) Spa therapy in arthritis: a trialist’s view. J Rheumatol 18:1778–1779PubMed Bell MJ (1991) Spa therapy in arthritis: a trialist’s view. J Rheumatol 18:1778–1779PubMed
32.
Zurück zum Zitat Nguyen M, Revel M, Dougados M (1997) Prolonged effects of 3 week therapy in a spa resort on lumbar spine, knee and hip osteoarthritis: follow-up after 6 months. A randomised controlled trial. Br J Rheumatol 36:77–81CrossRefPubMed Nguyen M, Revel M, Dougados M (1997) Prolonged effects of 3 week therapy in a spa resort on lumbar spine, knee and hip osteoarthritis: follow-up after 6 months. A randomised controlled trial. Br J Rheumatol 36:77–81CrossRefPubMed
33.
Zurück zum Zitat Wigler I, Elkayam O, Paran D, Yaron M (1995) Spa therapy for gonarthrosis: a prospective study. Rheumatol Int 15:65–68PubMed Wigler I, Elkayam O, Paran D, Yaron M (1995) Spa therapy for gonarthrosis: a prospective study. Rheumatol Int 15:65–68PubMed
34.
Zurück zum Zitat Yurtkuran M, Çeliktaş M (1996) A randomized, controlled trial of balneotherapy in the treatment of patients with primary fibromyalgia. Phys Rehab Kur Med 6:109–112 Yurtkuran M, Çeliktaş M (1996) A randomized, controlled trial of balneotherapy in the treatment of patients with primary fibromyalgia. Phys Rehab Kur Med 6:109–112
35.
Zurück zum Zitat Neumann L, Sukenik S, Bolotin A et al (2001) The effect of balneotherapy at the Dead Sea on the quality of life of patients with fibromyalgia syndrome. Clin Rheumatol 20:15–19CrossRefPubMed Neumann L, Sukenik S, Bolotin A et al (2001) The effect of balneotherapy at the Dead Sea on the quality of life of patients with fibromyalgia syndrome. Clin Rheumatol 20:15–19CrossRefPubMed
36.
Zurück zum Zitat Buskila D, Abu-Shakra M, Neumann L et al (2001) Balneotherapy for fibromyalgia at the Dead Sea. Rheumatol Int 20:105–108CrossRefPubMed Buskila D, Abu-Shakra M, Neumann L et al (2001) Balneotherapy for fibromyalgia at the Dead Sea. Rheumatol Int 20:105–108CrossRefPubMed
37.
Zurück zum Zitat Elkayam O, Ophir J, Brener S et al (2000) Immediate and delayed effects of treatment at the Dead Sea in patients with psoriatic arthritis. Rheumatol Int 19:77–82CrossRefPubMed Elkayam O, Ophir J, Brener S et al (2000) Immediate and delayed effects of treatment at the Dead Sea in patients with psoriatic arthritis. Rheumatol Int 19:77–82CrossRefPubMed
38.
Zurück zum Zitat van Tubergen A, Landewe R, van der Heijde D et al (2001) Combined spa-exercise therapy is effective in patients with ankylosing spondylitis: a randomized controlled trial. Arthritis Rheum 45:430–438CrossRefPubMed van Tubergen A, Landewe R, van der Heijde D et al (2001) Combined spa-exercise therapy is effective in patients with ankylosing spondylitis: a randomized controlled trial. Arthritis Rheum 45:430–438CrossRefPubMed
39.
Zurück zum Zitat Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (2000) Long-term efficacy of radon spa therapy in rheumatoid arthritis--a randomized, sham-controlled study and follow-up. Rheumatology (Oxford) 39:894–902 Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (2000) Long-term efficacy of radon spa therapy in rheumatoid arthritis--a randomized, sham-controlled study and follow-up. Rheumatology (Oxford) 39:894–902
40.
Zurück zum Zitat Sukenik S, Buskila D, Neumann L, Kleiner-Baumgarten A, Zimlichman S, Horowitz J (1990) Sulphur bath and mud pack treatment for rheumatoid arthritis at the Dead Sea area. Ann Rheum Dis 49:99–102PubMed Sukenik S, Buskila D, Neumann L, Kleiner-Baumgarten A, Zimlichman S, Horowitz J (1990) Sulphur bath and mud pack treatment for rheumatoid arthritis at the Dead Sea area. Ann Rheum Dis 49:99–102PubMed
41.
Zurück zum Zitat Elkayam O, Wigler I, Tishler M et al (1991) Effect of spa therapy in Tiberias on patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 18:1799–1803PubMed Elkayam O, Wigler I, Tishler M et al (1991) Effect of spa therapy in Tiberias on patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 18:1799–1803PubMed
42.
Zurück zum Zitat Yurtkuran M, Yurtkuran MA, Dilek K et al (1999) A randomised controlled study of balneotherapy in patients with rheumatoid arthritis. Phys Rehab Kur Med 9:92–96 Yurtkuran M, Yurtkuran MA, Dilek K et al (1999) A randomised controlled study of balneotherapy in patients with rheumatoid arthritis. Phys Rehab Kur Med 9:92–96
43.
Zurück zum Zitat Coruzzi P, Ravanetti C, Musiari L, Biggi A, Vescovi PP, Novarini A (1988) Circulating opioid peptides during water immersion in normal man. Clin Sci (Lond) 74:133–136 Coruzzi P, Ravanetti C, Musiari L, Biggi A, Vescovi PP, Novarini A (1988) Circulating opioid peptides during water immersion in normal man. Clin Sci (Lond) 74:133–136
44.
Zurück zum Zitat Reilly KA, Bird HA (2001) Prophylactic hydrotherapy. Rheumatology (Oxford) 40:4–6 Reilly KA, Bird HA (2001) Prophylactic hydrotherapy. Rheumatology (Oxford) 40:4–6
45.
Zurück zum Zitat Shani J, Barak S, Levi D et al (1985) Skin penetration of minerals in psoriatics and guinea-pigs bathing in hypertonic salt solutions. Pharmacol Res Commun 17:501–512PubMed Shani J, Barak S, Levi D et al (1985) Skin penetration of minerals in psoriatics and guinea-pigs bathing in hypertonic salt solutions. Pharmacol Res Commun 17:501–512PubMed
46.
Zurück zum Zitat Andrejew SV, Selenskaja VS (1991) Das Verhalten des in den Körper aus dem Sulfidbad eindringenden Schwefels. In: Pratzel HG, .Bühring M, Evers A (eds) Schwefel in der Medizin. Demeter, Gräfelfing, pp 35–41 Andrejew SV, Selenskaja VS (1991) Das Verhalten des in den Körper aus dem Sulfidbad eindringenden Schwefels. In: Pratzel HG, .Bühring M, Evers A (eds) Schwefel in der Medizin. Demeter, Gräfelfing, pp 35–41
47.
Zurück zum Zitat Pratzel HG, Aigner UM, Weinert D, Limbach B (1992) .Zur analgetischen Wirksamkeit eines Schwefelmoorbades bei weichteilreumatischen Beschwerden. Eine randomisierte Doppelblindstudie. Phys Rehab Kur Med 2:92–97 Pratzel HG, Aigner UM, Weinert D, Limbach B (1992) .Zur analgetischen Wirksamkeit eines Schwefelmoorbades bei weichteilreumatischen Beschwerden. Eine randomisierte Doppelblindstudie. Phys Rehab Kur Med 2:92–97
48.
Zurück zum Zitat Gutenbrunner C, Kopetzki K, Neues-Lahusen M, Gehrke A (1999) Wirkungen natürlicher thermoindifferenter Schwefelbäder auf Hautdurchblutung und Schmerzempfindlichkeit bei Gesunden und Patienten mit chronisher Polyarthitis. Akt Reumatol 24:117–123 Gutenbrunner C, Kopetzki K, Neues-Lahusen M, Gehrke A (1999) Wirkungen natürlicher thermoindifferenter Schwefelbäder auf Hautdurchblutung und Schmerzempfindlichkeit bei Gesunden und Patienten mit chronisher Polyarthitis. Akt Reumatol 24:117–123
49.
Zurück zum Zitat Karagülle MZ, Tütüncü ZN, Aslan O, Basak E, Mutlu A (1996) Effects of thermal sulphur bath cure on adjuvant arthritic rats. Phys Rehab Kur Med 6:53–57 Karagülle MZ, Tütüncü ZN, Aslan O, Basak E, Mutlu A (1996) Effects of thermal sulphur bath cure on adjuvant arthritic rats. Phys Rehab Kur Med 6:53–57
50.
Zurück zum Zitat Jöckel H (1997) Praktische Erfahrungen mit der Radontherapie. In: Pratzel HG, Deetjen P (eds) Radon in der Kurortmedizin. Geretsried:ISMH 84–91 Jöckel H (1997) Praktische Erfahrungen mit der Radontherapie. In: Pratzel HG, Deetjen P (eds) Radon in der Kurortmedizin. Geretsried:ISMH 84–91
51.
Zurück zum Zitat Kappel M, Gyhrs A, Galbo H, Pedersen BK (1997) The response on glucoregulatory hormones of in vivo whole body hyperthermia. Int.J Hyperthermia 13:413–421 Kappel M, Gyhrs A, Galbo H, Pedersen BK (1997) The response on glucoregulatory hormones of in vivo whole body hyperthermia. Int.J Hyperthermia 13:413–421
52.
Zurück zum Zitat Bellometti S, Galzigna L (1998) Serum levels of a prostaglandin and a leukotriene after thermal mud pack therapy. J Investig Med 46:140–145PubMed Bellometti S, Galzigna L (1998) Serum levels of a prostaglandin and a leukotriene after thermal mud pack therapy. J Investig Med 46:140–145PubMed
53.
Zurück zum Zitat Lee P, Kennedy AC, Anderson J, Buchanan WW (1974) Benefits of hospitalization in rheumatoid arthritis. Q J Med 43:205–214PubMed Lee P, Kennedy AC, Anderson J, Buchanan WW (1974) Benefits of hospitalization in rheumatoid arthritis. Q J Med 43:205–214PubMed
54.
Zurück zum Zitat Strauss-Blasche G, Ekmekcioglu C, Leibetseder V, Melchart H, Marktl W (2002) Seasonal variation in effect of spa therapy on chronic pain. Chronobiol Int 19:483–495CrossRefPubMed Strauss-Blasche G, Ekmekcioglu C, Leibetseder V, Melchart H, Marktl W (2002) Seasonal variation in effect of spa therapy on chronic pain. Chronobiol Int 19:483–495CrossRefPubMed
55.
Zurück zum Zitat Lee P, Webb J, Anderson J, Buchanan WW (1973) Method for assessing therapeutic potential of anti-inflammatory drugs in rheumatoid arthritis. Br Med J 2:685–688PubMed Lee P, Webb J, Anderson J, Buchanan WW (1973) Method for assessing therapeutic potential of anti-inflammatory drugs in rheumatoid arthritis. Br Med J 2:685–688PubMed
56.
Zurück zum Zitat Helliwell PS (1989) An appraisal of medicinal spa therapy for rheumatological disorders. J R Soc Health 109:3–7PubMed Helliwell PS (1989) An appraisal of medicinal spa therapy for rheumatological disorders. J R Soc Health 109:3–7PubMed
57.
Zurück zum Zitat Kersly G (1989) The history of spas. J R Soc Health109:2–3 Kersly G (1989) The history of spas. J R Soc Health109:2–3
58.
Zurück zum Zitat Hildebrandt G, Gutenbrunner C (1996) Über adaptive Normalisierung. Forsch Komplementärmed 3:236–243 Hildebrandt G, Gutenbrunner C (1996) Über adaptive Normalisierung. Forsch Komplementärmed 3:236–243
59.
Zurück zum Zitat Allard P, Deligne J, Van Bockstael V, Duquesnoy B (1998) Is spa therapy cost-effective in rheumatic disorders? Rev Rhum Engl Ed 65:173–180PubMed Allard P, Deligne J, Van Bockstael V, Duquesnoy B (1998) Is spa therapy cost-effective in rheumatic disorders? Rev Rhum Engl Ed 65:173–180PubMed
60.
Zurück zum Zitat van Tubergen A, Boonen A, Landewe R et al (2002) Cost effectiveness of combined spa-exercise therapy in ankylosing spondylitis: a randomized controlled trial. Arthritis Rheum 47:459–467CrossRefPubMed van Tubergen A, Boonen A, Landewe R et al (2002) Cost effectiveness of combined spa-exercise therapy in ankylosing spondylitis: a randomized controlled trial. Arthritis Rheum 47:459–467CrossRefPubMed
61.
Zurück zum Zitat Huskisson EC, Scott J (1976) How double-blind is double blind? And does it matter? Br J Clin Pharmacol 3:331–332PubMed Huskisson EC, Scott J (1976) How double-blind is double blind? And does it matter? Br J Clin Pharmacol 3:331–332PubMed
Metadaten
Titel
Hydrotherapy, balneotherapy, and spa treatment in pain management
Publikationsdatum
01.04.2005
Erschienen in
Rheumatology International / Ausgabe 3/2005
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-004-0487-4

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