Skip to main content
Erschienen in: Rheumatology International 8/2006

01.06.2006 | Original Article

Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India

verfasst von: R. Venkatraman, S. Singh, R.W. Minz

Erschienen in: Rheumatology International | Ausgabe 8/2006

Einloggen, um Zugang zu erhalten

Abstract

A study of organ-specific and organ-nonspecific autoantibodies was carried out in 21 children being followed up after a diagnosis of Kawasaki disease at a tertiary care center of North India. Anti-nuclear antibodies were detected in 9.5% patients while anti-thyroid microsomal antibodies were detected in 23.9% patients. Other autoantibodies (e.g. anti-parietal cell antibody, anti-liver kidney microsomal antibody anti-neutrophil cytoplasmic antibody, anti-mitochondrial antibody and anti-smooth muscle antibody) were not detected in any of our patients. Children with Kawasaki disease need to be monitored for the development of autoantibodies during follow-up.
Literatur
1.
Zurück zum Zitat Cassidy JT, Petty RE (2001) Vasculitis. Kawasaki disease. In: Cassidy JT, Petty RE (eds) Textbook of pediatric rheumatology, 4th edn. W.B. Saunders Company, Philadelphia Cassidy JT, Petty RE (2001) Vasculitis. Kawasaki disease. In: Cassidy JT, Petty RE (eds) Textbook of pediatric rheumatology, 4th edn. W.B. Saunders Company, Philadelphia
2.
Zurück zum Zitat Soppi E, Salo E, Pelkonen P (1992) Antibodies against neutrophil cytoplasmic components in Kawasaki disease. Acta Pathol Microbiol Immunol Scand 100(3):369–372 Soppi E, Salo E, Pelkonen P (1992) Antibodies against neutrophil cytoplasmic components in Kawasaki disease. Acta Pathol Microbiol Immunol Scand 100(3):369–372
3.
Zurück zum Zitat Savage CO, Tizard J, Jayne D, Lockwood CM, Dillon MJ (1989) Antineutrophilic cytoplasmic antibodies in Kawasaki disease. Arch Dis Child 64:360–363PubMed Savage CO, Tizard J, Jayne D, Lockwood CM, Dillon MJ (1989) Antineutrophilic cytoplasmic antibodies in Kawasaki disease. Arch Dis Child 64:360–363PubMed
4.
Zurück zum Zitat Tizard EJ, Baguley E, Hughes GR, Dillon M (1991) Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease. Arch Dis Child 66:189–192PubMedCrossRef Tizard EJ, Baguley E, Hughes GR, Dillon M (1991) Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease. Arch Dis Child 66:189–192PubMedCrossRef
5.
Zurück zum Zitat Salo E, Kekomaki R, Pelkonen P, Ruuskanen O, Viander M, Wagner O (1988) Kawasaki disease: monitoring of circulating immune complexes. Eur J Pediatr 147:377–380PubMedCrossRef Salo E, Kekomaki R, Pelkonen P, Ruuskanen O, Viander M, Wagner O (1988) Kawasaki disease: monitoring of circulating immune complexes. Eur J Pediatr 147:377–380PubMedCrossRef
6.
Zurück zum Zitat Cunningham MW, Meissner CH, Heuser JS, Pietra BA, Kurahara DK, Leung DYM (1999) Anti-human cardiac myosin autoantibodies in Kawasaki syndrome. J Immunol 163:1060–1065PubMed Cunningham MW, Meissner CH, Heuser JS, Pietra BA, Kurahara DK, Leung DYM (1999) Anti-human cardiac myosin autoantibodies in Kawasaki syndrome. J Immunol 163:1060–1065PubMed
7.
Zurück zum Zitat Guzman J, Fung M, Petty RE (1994) Diagnostic value of anti-neutrophil cytoplasmic and anti-endothelial cell antibodies in early Kawasaki disease. J Pediatr 124:917–920PubMedCrossRef Guzman J, Fung M, Petty RE (1994) Diagnostic value of anti-neutrophil cytoplasmic and anti-endothelial cell antibodies in early Kawasaki disease. J Pediatr 124:917–920PubMedCrossRef
8.
Zurück zum Zitat Gupta M, Johann-Liang R, Bussel JB, Gersony WM, Lehman TJ (2002) Elevated IgA and IgM anticardiolipin antibodies in acute Kawasaki disease. Cardiology 97:180–182PubMedCrossRef Gupta M, Johann-Liang R, Bussel JB, Gersony WM, Lehman TJ (2002) Elevated IgA and IgM anticardiolipin antibodies in acute Kawasaki disease. Cardiology 97:180–182PubMedCrossRef
9.
Zurück zum Zitat Lee LA, Burns J, Glode M, Harmon C, Weston WL (1983) No autoantibodies to nuclear antigens in the Kawasaki disease. N Engl J Med 308:1034PubMed Lee LA, Burns J, Glode M, Harmon C, Weston WL (1983) No autoantibodies to nuclear antigens in the Kawasaki disease. N Engl J Med 308:1034PubMed
10.
Zurück zum Zitat Birdi N, Laxer RM, Silverman ED (1991) Antineutrophil cytoplasmic antibodies in Kawasaki disease. Arthritis Rheum 34(Suppl):70 Birdi N, Laxer RM, Silverman ED (1991) Antineutrophil cytoplasmic antibodies in Kawasaki disease. Arthritis Rheum 34(Suppl):70
11.
Zurück zum Zitat Serodia-AMC. Semi-quantitative microtiter particle agglutination test for in vitro diagnostic detection and titration of microsomal antibodies in human serum. Fujirebio Inc., Tokyo, Japan Serodia-AMC. Semi-quantitative microtiter particle agglutination test for in vitro diagnostic detection and titration of microsomal antibodies in human serum. Fujirebio Inc., Tokyo, Japan
12.
Zurück zum Zitat Shulman ST, Bass JL, Bierman F, Burns JC, Chung K, Dillon MJ, et al (1989) Management of Kawasaki syndrome: a consensus statement prepared by North American participants of the third international Kawasaki disease symposium, Tokyo, Japan, December 1988. Pediatr Infect Dis J 8(Suppl):663–667 Shulman ST, Bass JL, Bierman F, Burns JC, Chung K, Dillon MJ, et al (1989) Management of Kawasaki syndrome: a consensus statement prepared by North American participants of the third international Kawasaki disease symposium, Tokyo, Japan, December 1988. Pediatr Infect Dis J 8(Suppl):663–667
13.
Zurück zum Zitat Kato H, Inoue O, Akagi T (1988) Kawasaki disease: cardiac problems and management. Pediatr Rev 9:209–217PubMedCrossRef Kato H, Inoue O, Akagi T (1988) Kawasaki disease: cardiac problems and management. Pediatr Rev 9:209–217PubMedCrossRef
14.
Zurück zum Zitat Leung DY (1989) The immunologic effects of IVIG in Kawasaki disease. Int Rev Immunol 5:197–202PubMedCrossRef Leung DY (1989) The immunologic effects of IVIG in Kawasaki disease. Int Rev Immunol 5:197–202PubMedCrossRef
15.
Zurück zum Zitat Rowley AH, Shulman ST (1987) The search for the etiology of Kawasaki disease. Pediatr Infect Dis J 6:506–508PubMed Rowley AH, Shulman ST (1987) The search for the etiology of Kawasaki disease. Pediatr Infect Dis J 6:506–508PubMed
16.
Zurück zum Zitat Leung DY, Siege RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha RS (1982) Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol 23:100–112PubMedCrossRef Leung DY, Siege RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha RS (1982) Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol 23:100–112PubMedCrossRef
17.
Zurück zum Zitat Leung DY, Collins T, Lapierre LF, et al (1986) IgM antibodies in the acute phase of KD lysed cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest 77:1428–1435PubMedCrossRef Leung DY, Collins T, Lapierre LF, et al (1986) IgM antibodies in the acute phase of KD lysed cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest 77:1428–1435PubMedCrossRef
18.
Zurück zum Zitat Suzuki H, Noda E, Miyawaki M, Takeuchi T, Uemura S, Koike M (2001) Serum levels of neutrophil activation cytokines in Kawasaki disease. Pediatr Int 43(2):115–119PubMedCrossRef Suzuki H, Noda E, Miyawaki M, Takeuchi T, Uemura S, Koike M (2001) Serum levels of neutrophil activation cytokines in Kawasaki disease. Pediatr Int 43(2):115–119PubMedCrossRef
19.
Zurück zum Zitat Falcini TF, Trapani S, Turchini S, et al (1997) Immunological findings in Kawasaki disease: an evaluation in a cohort of Italian children. Clin Exp Rheumatol 15(6):685–689PubMed Falcini TF, Trapani S, Turchini S, et al (1997) Immunological findings in Kawasaki disease: an evaluation in a cohort of Italian children. Clin Exp Rheumatol 15(6):685–689PubMed
20.
Zurück zum Zitat Nonoyama S (1991) Immunological abnormalities and endothelial cell injury in Kawasaki disease. Acta Pediatr Jpn 33:752 Nonoyama S (1991) Immunological abnormalities and endothelial cell injury in Kawasaki disease. Acta Pediatr Jpn 33:752
21.
Zurück zum Zitat Lin CY, Hwang B (1987) Serial immunologic studies in patients with mucocutaneous lymph node syndrome (Kawasaki disease). Ann Allergy 59:291–297PubMed Lin CY, Hwang B (1987) Serial immunologic studies in patients with mucocutaneous lymph node syndrome (Kawasaki disease). Ann Allergy 59:291–297PubMed
22.
Zurück zum Zitat Ohshio G, Furukawa F, Khine M, Yoshioka H, Kudo H, Hamashima Y (1987) High levels of IgA-containing circulating immune complexes and secretory IgA in Kawasaki disease. Microbiol Immunol 31:891–898PubMed Ohshio G, Furukawa F, Khine M, Yoshioka H, Kudo H, Hamashima Y (1987) High levels of IgA-containing circulating immune complexes and secretory IgA in Kawasaki disease. Microbiol Immunol 31:891–898PubMed
23.
Zurück zum Zitat Li C, Yang X, Shen J, Li Y, Jiang L (1990) Immunoglobulin G subclasses in serum and circulating immune complexes in patients with Kawasaki syndrome. Pediatr Infect Dis J 9:544–547PubMedCrossRef Li C, Yang X, Shen J, Li Y, Jiang L (1990) Immunoglobulin G subclasses in serum and circulating immune complexes in patients with Kawasaki syndrome. Pediatr Infect Dis J 9:544–547PubMedCrossRef
24.
Zurück zum Zitat Takeshita S, Kawase H, Shimizu T, Yoshida M, Sekine I (2002) Increased production of serum IgA—class antibody to lipid A in Kawasaki disease. Pediatr Int 44:5–11PubMedCrossRef Takeshita S, Kawase H, Shimizu T, Yoshida M, Sekine I (2002) Increased production of serum IgA—class antibody to lipid A in Kawasaki disease. Pediatr Int 44:5–11PubMedCrossRef
25.
Zurück zum Zitat Rowley AH, Shulman ST, Spike BT, Mask CA, Baker SC (2001) Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. J Immunol 166(2):1334–1343PubMed Rowley AH, Shulman ST, Spike BT, Mask CA, Baker SC (2001) Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. J Immunol 166(2):1334–1343PubMed
26.
Zurück zum Zitat Krasovec S, Bezrodnik L, Gaillard MI, et al (2001) Kawasaki disease. Immunological evaluation of 26 cases. Medicina 61(1):8PubMed Krasovec S, Bezrodnik L, Gaillard MI, et al (2001) Kawasaki disease. Immunological evaluation of 26 cases. Medicina 61(1):8PubMed
27.
Zurück zum Zitat Nash MC, Shah V, Reader JA (1995) Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies are not increased in Kawasaki disease. Br J Rheumatol 34(9):882–887PubMedCrossRef Nash MC, Shah V, Reader JA (1995) Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies are not increased in Kawasaki disease. Br J Rheumatol 34(9):882–887PubMedCrossRef
28.
Zurück zum Zitat Rider LG, Wener MH, French J, et al (1993) Autoantibody production in Kawasaki syndrome. Clin Exp Rheumatol 11(4):445–449PubMed Rider LG, Wener MH, French J, et al (1993) Autoantibody production in Kawasaki syndrome. Clin Exp Rheumatol 11(4):445–449PubMed
29.
Zurück zum Zitat Vaarala O, Salo E, Pelkonen P, Palosuo T, Aho K (1990) Anticardiolipin response in Kawasaki disease. Acta Pediatr Scand 79:804–809CrossRef Vaarala O, Salo E, Pelkonen P, Palosuo T, Aho K (1990) Anticardiolipin response in Kawasaki disease. Acta Pediatr Scand 79:804–809CrossRef
30.
Zurück zum Zitat Nomura Y, Yoshinaga M, Oku S, Kono Y, Yuasa Y, Noda T (1993) Estimation of myocardial damage in Kawasaki disease using antimyosin antibody. Acta Paediatr Jpn 35(5):412–417PubMed Nomura Y, Yoshinaga M, Oku S, Kono Y, Yuasa Y, Noda T (1993) Estimation of myocardial damage in Kawasaki disease using antimyosin antibody. Acta Paediatr Jpn 35(5):412–417PubMed
31.
Zurück zum Zitat Singh S, Kumar L, Khetarpal R, Aggarwal P, Marwaha RK, Minz RW, Sehgal S (1997) Clinical and immunological profile of SLE: some unusual features. Indian Pediatr 34:979–986PubMed Singh S, Kumar L, Khetarpal R, Aggarwal P, Marwaha RK, Minz RW, Sehgal S (1997) Clinical and immunological profile of SLE: some unusual features. Indian Pediatr 34:979–986PubMed
32.
Zurück zum Zitat Kumar L, Singh S, Goraya JS, Uppal B, Kakkar S, Walker R, Sehgal S (1998) Henoch-Schonlein purpura: the Chandigarh experience. Indian Pediatr 35(1):19–25PubMed Kumar L, Singh S, Goraya JS, Uppal B, Kakkar S, Walker R, Sehgal S (1998) Henoch-Schonlein purpura: the Chandigarh experience. Indian Pediatr 35(1):19–25PubMed
33.
Zurück zum Zitat Singh S, Salaria M, Kumar L, Minz R, Datta U, Sehgal S (1999) Clinico-immunological profile of juvenile rheumatoid arthritis at Chandigarh. Indian Pediatr 36(5):449–454PubMed Singh S, Salaria M, Kumar L, Minz R, Datta U, Sehgal S (1999) Clinico-immunological profile of juvenile rheumatoid arthritis at Chandigarh. Indian Pediatr 36(5):449–454PubMed
34.
Zurück zum Zitat Singh S, Kumar L, Shankar KR (1997) Juvenile dermatomyositis in North India. Indian Pediatr 34(3):193–198PubMed Singh S, Kumar L, Shankar KR (1997) Juvenile dermatomyositis in North India. Indian Pediatr 34(3):193–198PubMed
35.
Zurück zum Zitat Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Immunofluroscent antinuclear antibody test. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp724–729 Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Immunofluroscent antinuclear antibody test. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp724–729
36.
Zurück zum Zitat Sehgal S, Aikat BK, Pasricha N (1978) Diagnostic significance of antinuclear antibodies. Indian J Med Res 67:116–128PubMed Sehgal S, Aikat BK, Pasricha N (1978) Diagnostic significance of antinuclear antibodies. Indian J Med Res 67:116–128PubMed
37.
Zurück zum Zitat Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Antibodies to tissue specific endocrine, gastrointestinal and surface receptor antigen. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp765–774 Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Antibodies to tissue specific endocrine, gastrointestinal and surface receptor antigen. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp765–774
38.
Zurück zum Zitat Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Antineutrophil cytoplasmic autoantibodies. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp781–785 Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Antineutrophil cytoplasmic autoantibodies. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp781–785
39.
Zurück zum Zitat Burek CL (1992) Autoantibodies, test for. In: Roitt IM, Delves PJ (eds) Encyclopedia of immunology, Academic Press, London, pp176–180 Burek CL (1992) Autoantibodies, test for. In: Roitt IM, Delves PJ (eds) Encyclopedia of immunology, Academic Press, London, pp176–180
40.
Zurück zum Zitat Lahita RG, Chiorazzi N, Reeves WH (2000) How to interpret autoimmune tests. In: textbook of autoimmune disease. Lippincot Williams and Wilkins, Philadelphia, pp727–752 Lahita RG, Chiorazzi N, Reeves WH (2000) How to interpret autoimmune tests. In: textbook of autoimmune disease. Lippincot Williams and Wilkins, Philadelphia, pp727–752
41.
Zurück zum Zitat Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al (1999) International consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol 111(4):507–513PubMed Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al (1999) International consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol 111(4):507–513PubMed
42.
Zurück zum Zitat Newburger JW, Sanders SP, Burns JC, Parmess IA, Beiser AS Colan SD (1989) Left ventricular contractility and function in Kawasaki syndrome. Effect of intravenous γ-globulin. Circulation 79:1237–1246PubMed Newburger JW, Sanders SP, Burns JC, Parmess IA, Beiser AS Colan SD (1989) Left ventricular contractility and function in Kawasaki syndrome. Effect of intravenous γ-globulin. Circulation 79:1237–1246PubMed
Metadaten
Titel
Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India
verfasst von
R. Venkatraman
S. Singh
R.W. Minz
Publikationsdatum
01.06.2006
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 8/2006
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-005-0050-y

Weitere Artikel der Ausgabe 8/2006

Rheumatology International 8/2006 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.