Skip to main content
Erschienen in: Rheumatology International 6/2006

01.04.2006 | Review

Familial Mediterranean fever

verfasst von: Fatos Onen

Erschienen in: Rheumatology International | Ausgabe 6/2006

Einloggen, um Zugang zu erhalten

Abstract

Familial Mediterranean fever (FMF) is the most frequent hereditary inflammatory disease characterized by self-limited recurrent attacks of fever and serositis. It is transmitted in an autosomal recessive pattern and affects certain ethnic groups mainly Jews, Turks, Arabs, and Armenians. FMF is caused by mutations in MEFV gene, which encodes pyrin. This protein is expressed mainly in myeloid/monocytic cells and modulates IL-1β processing, NF-κB activation, and apoptosis. A mutated pyrin probably results in uncontrolled inflammation. The most devastating complication of FMF is amyloidosis, leading to chronic renal failure. M694V homozygocity, male gender and the α/α genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis. Daily colchicine is the mainstay of the therapy for the disease, resulting in complete remission or marked reduction in the frequency and duration of attacks in most patients. It is also effective in preventing and arresting renal amyloidosis.
Literatur
1.
Zurück zum Zitat Sohar E, Gafni J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 43:227–253CrossRefPubMed Sohar E, Gafni J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 43:227–253CrossRefPubMed
2.
Zurück zum Zitat Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever (1997) The international FMF consortium. Cell 90:797–807 Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever (1997) The international FMF consortium. Cell 90:797–807
3.
Zurück zum Zitat A candidate gene for familial Mediterranean fever (1997) The French FMF consortium. Nat Genet 17:25–31 A candidate gene for familial Mediterranean fever (1997) The French FMF consortium. Nat Genet 17:25–31
4.
Zurück zum Zitat Yilmaz E, Ozen S, Balci B, Duzova A, Topaloglu R, Besbas N, Saatci U, Bakkaloglu A, Ozguc M (2001) Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 9:553–555CrossRefPubMed Yilmaz E, Ozen S, Balci B, Duzova A, Topaloglu R, Besbas N, Saatci U, Bakkaloglu A, Ozguc M (2001) Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 9:553–555CrossRefPubMed
5.
Zurück zum Zitat Shohat M, Magal N, Shohat T, Chen X, Dagan T, Mimouni A, Danon Y, Lotan R, Ogur G, Sirin A, Schlezinger M, Halpern GJ, Schwabe A, Kastner D, Rotter JI, Fischel-Ghodsian N (1999) Phenotype–genotype correlation in familial Mediterranean fever: evidence for an association between Met694Val and amyloidosis. Eur J Hum Genet 7:287–292CrossRefPubMed Shohat M, Magal N, Shohat T, Chen X, Dagan T, Mimouni A, Danon Y, Lotan R, Ogur G, Sirin A, Schlezinger M, Halpern GJ, Schwabe A, Kastner D, Rotter JI, Fischel-Ghodsian N (1999) Phenotype–genotype correlation in familial Mediterranean fever: evidence for an association between Met694Val and amyloidosis. Eur J Hum Genet 7:287–292CrossRefPubMed
6.
Zurück zum Zitat Livneh A, Langevitz P, Shinar Y, Zaks N, Kastner DL, Pras M, Pras E (1999) MEFV mutation analysis in patients suffering from amyloidosis of familial Mediterranean fever. Amyloid 6:1–6PubMed Livneh A, Langevitz P, Shinar Y, Zaks N, Kastner DL, Pras M, Pras E (1999) MEFV mutation analysis in patients suffering from amyloidosis of familial Mediterranean fever. Amyloid 6:1–6PubMed
7.
Zurück zum Zitat Ben-Chetrit E, Urieli-Shoval S, Calko S, Abeliovich D, Matzner Y (2002) Molecular diagnosis of FMF: lessons from a study of 446 unrelated individuals. Clin Exp Rheumatol 20:S25–S29PubMed Ben-Chetrit E, Urieli-Shoval S, Calko S, Abeliovich D, Matzner Y (2002) Molecular diagnosis of FMF: lessons from a study of 446 unrelated individuals. Clin Exp Rheumatol 20:S25–S29PubMed
8.
Zurück zum Zitat Majeed HA, El-Shanti H, Al-Khateeb MS, Rabaiha ZA (2002) Genotype/phenotype correlations in Arab patients with familial Mediterranean fever. Semin Arthritis Rheum 31:371–376CrossRefPubMed Majeed HA, El-Shanti H, Al-Khateeb MS, Rabaiha ZA (2002) Genotype/phenotype correlations in Arab patients with familial Mediterranean fever. Semin Arthritis Rheum 31:371–376CrossRefPubMed
9.
Zurück zum Zitat Brik R, Shinawi M, Kepten I, Berant M, Gershoni-Baruch R (1999) Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients. Pediatrics 103:e70CrossRefPubMed Brik R, Shinawi M, Kepten I, Berant M, Gershoni-Baruch R (1999) Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients. Pediatrics 103:e70CrossRefPubMed
10.
Zurück zum Zitat Cattan D, Dervichian M, Thomas M, Dode C, Touitou I (2001) MEFV mutations and phenotype-genotype correlations in North African Jews and Armenians with familial Mediterranean fever. Isr Med Assoc J 3:803–804PubMed Cattan D, Dervichian M, Thomas M, Dode C, Touitou I (2001) MEFV mutations and phenotype-genotype correlations in North African Jews and Armenians with familial Mediterranean fever. Isr Med Assoc J 3:803–804PubMed
11.
Zurück zum Zitat Gershoni-Baruch R, Shinawi M, Leah K, Badarnah K, Brik R (2001) Familial Mediterranean fever: prevalence, penetrance and genetic drift. Eur J Hum Genet 9:634–637CrossRefPubMed Gershoni-Baruch R, Shinawi M, Leah K, Badarnah K, Brik R (2001) Familial Mediterranean fever: prevalence, penetrance and genetic drift. Eur J Hum Genet 9:634–637CrossRefPubMed
12.
Zurück zum Zitat Yalcinkaya F, Cakar N, Misirlioglu M, Tumer N, Akar N, Tekin M, Tastan H, Kocak H, Ozkaya N, Elhan AH (2000) Genotype–phenotype correlation in a large group of Turkish patients with familial mediterranean fever: evidence for mutation-independent amyloidosis. Rheumatology (Oxford) 39:67–72CrossRef Yalcinkaya F, Cakar N, Misirlioglu M, Tumer N, Akar N, Tekin M, Tastan H, Kocak H, Ozkaya N, Elhan AH (2000) Genotype–phenotype correlation in a large group of Turkish patients with familial mediterranean fever: evidence for mutation-independent amyloidosis. Rheumatology (Oxford) 39:67–72CrossRef
13.
Zurück zum Zitat Akar N, Misiroglu M, Yalcinkaya F, Akar E, Cakar N, Tumer N, Akcakus M, Tastan H, Matzner Y (2000) MEFV mutations in Turkish patients suffering from familial Mediterranean fever. Hum Mutat 15:118–119CrossRefPubMed Akar N, Misiroglu M, Yalcinkaya F, Akar E, Cakar N, Tumer N, Akcakus M, Tastan H, Matzner Y (2000) MEFV mutations in Turkish patients suffering from familial Mediterranean fever. Hum Mutat 15:118–119CrossRefPubMed
14.
Zurück zum Zitat Touitou I (2001) The spectrum of familial Mediterranean fever (FMF) mutations. Eur J Hum Genet 9:473–483CrossRefPubMed Touitou I (2001) The spectrum of familial Mediterranean fever (FMF) mutations. Eur J Hum Genet 9:473–483CrossRefPubMed
15.
Zurück zum Zitat Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, Tutar E, Ozen S, Topaloglu R, Yilmaz E, Arici M, Bakkaloglu A, Besbas N, Akpolat T, Dinc A, Erken E (2005) Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore) 84:1–11CrossRef Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, Tutar E, Ozen S, Topaloglu R, Yilmaz E, Arici M, Bakkaloglu A, Besbas N, Akpolat T, Dinc A, Erken E (2005) Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore) 84:1–11CrossRef
16.
Zurück zum Zitat Mansfield E, Chae JJ, Komarow HD, Brotz TM, Frucht DM, Aksentijevich I, Kastner DL (2001) The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments. Blood 98:851–859CrossRefPubMed Mansfield E, Chae JJ, Komarow HD, Brotz TM, Frucht DM, Aksentijevich I, Kastner DL (2001) The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments. Blood 98:851–859CrossRefPubMed
17.
Zurück zum Zitat Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, Hidaka E, Katsuyama T, Higuchi T, Sagara J (1999) ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 274:33835–33838CrossRefPubMed Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, Hidaka E, Katsuyama T, Higuchi T, Sagara J (1999) ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 274:33835–33838CrossRefPubMed
18.
Zurück zum Zitat Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 277:21119–21122CrossRefPubMed Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 277:21119–21122CrossRefPubMed
19.
Zurück zum Zitat Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417–426CrossRefPubMed Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417–426CrossRefPubMed
20.
Zurück zum Zitat Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL (2003) Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell 11:591–604CrossRefPubMed Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL (2003) Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell 11:591–604CrossRefPubMed
21.
Zurück zum Zitat Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Nunez G, Inohara N (2003) ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 303:69–73CrossRefPubMed Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Nunez G, Inohara N (2003) ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 303:69–73CrossRefPubMed
22.
Zurück zum Zitat Gumucio DL, Diaz A, Schaner P, Richards N, Babcock C, Schaller M, Cesena T (2002) Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis. Clin Exp Rheumatol 20:S45–S53PubMed Gumucio DL, Diaz A, Schaner P, Richards N, Babcock C, Schaller M, Cesena T (2002) Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis. Clin Exp Rheumatol 20:S45–S53PubMed
23.
Zurück zum Zitat Ozen S, Uckan D, Baskin E, Besbas N, Okur H, Saatci U, Bakkaloglu A (2001) Increased neutrophil apoptosis during attacks of familial Mediterranean fever. Clin Exp Rheumatol 19:S68–S71PubMed Ozen S, Uckan D, Baskin E, Besbas N, Okur H, Saatci U, Bakkaloglu A (2001) Increased neutrophil apoptosis during attacks of familial Mediterranean fever. Clin Exp Rheumatol 19:S68–S71PubMed
24.
Zurück zum Zitat Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL (2003) Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci USA 100:13501–13506CrossRefPubMed Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL (2003) Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci USA 100:13501–13506CrossRefPubMed
25.
Zurück zum Zitat Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, Lovett M (2002) Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Hum Mol Genet 11:961–969CrossRefPubMed Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, Lovett M (2002) Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Hum Mol Genet 11:961–969CrossRefPubMed
26.
Zurück zum Zitat Daniels M, Shohat T, Brenner-Ullman A, Shohat M (1995) Familial Mediterranean fever: high gene frequency among the non-Ashkenazic and Ashkenazic Jewish populations in Israel. Am J Med Genet 55:311–314CrossRefPubMed Daniels M, Shohat T, Brenner-Ullman A, Shohat M (1995) Familial Mediterranean fever: high gene frequency among the non-Ashkenazic and Ashkenazic Jewish populations in Israel. Am J Med Genet 55:311–314CrossRefPubMed
27.
Zurück zum Zitat Ozen S, Karaaslan Y, Ozdemir O, Saatci U, Bakkaloglu A, Koroglu E, Tezcan S (1998) Prevalence of juvenile chronic arthritis and familial Mediterranean fever in Turkey: a field study. J Rheumatol 25:2445–2449PubMed Ozen S, Karaaslan Y, Ozdemir O, Saatci U, Bakkaloglu A, Koroglu E, Tezcan S (1998) Prevalence of juvenile chronic arthritis and familial Mediterranean fever in Turkey: a field study. J Rheumatol 25:2445–2449PubMed
28.
Zurück zum Zitat Onen F, Sumer H, Turkay S, Akyurek O, Tunca M, Ozdogan H (2004) Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clin Exp Rheumatol 22:S31–S33PubMed Onen F, Sumer H, Turkay S, Akyurek O, Tunca M, Ozdogan H (2004) Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clin Exp Rheumatol 22:S31–S33PubMed
29.
Zurück zum Zitat Rogers DB, Shohat M, Petersen GM, Bickal J, Congleton J, Schwabe AD, Rotter JI (1989) Familial Mediterranean fever in Armenians: autosomal recessive inheritance with high gene frequency. Am J Med Genet 34:168–172CrossRefPubMed Rogers DB, Shohat M, Petersen GM, Bickal J, Congleton J, Schwabe AD, Rotter JI (1989) Familial Mediterranean fever in Armenians: autosomal recessive inheritance with high gene frequency. Am J Med Genet 34:168–172CrossRefPubMed
30.
Zurück zum Zitat Livneh A, Langevitz P, Zemer D, Padeh S, Migdal A, Sohar E, Pras M (1996) The changing face of familial Mediterranean fever. Semin Arthritis Rheum 26:612–627CrossRefPubMed Livneh A, Langevitz P, Zemer D, Padeh S, Migdal A, Sohar E, Pras M (1996) The changing face of familial Mediterranean fever. Semin Arthritis Rheum 26:612–627CrossRefPubMed
31.
Zurück zum Zitat Schwabe AD, Peters RS (1974) Familial Mediterranean fever in Armenians. Analysis of 100 cases. Medicine (Baltimore) 53:453–462CrossRef Schwabe AD, Peters RS (1974) Familial Mediterranean fever in Armenians. Analysis of 100 cases. Medicine (Baltimore) 53:453–462CrossRef
32.
Zurück zum Zitat Heller H, Gafni J, Michaeli D, Shahin N, Sohar E, Ehrlich G, Karten I, Sokoloff L (1966) The arthritis of familial Mediterranean fever (FMF). Arthritis Rheum 9:1–17PubMedCrossRef Heller H, Gafni J, Michaeli D, Shahin N, Sohar E, Ehrlich G, Karten I, Sokoloff L (1966) The arthritis of familial Mediterranean fever (FMF). Arthritis Rheum 9:1–17PubMedCrossRef
33.
Zurück zum Zitat Majeed HA, Rawashdeh M (1997) The clinical patterns of arthritis in children with familial Mediterranean fever. QJM 90:37–43PubMed Majeed HA, Rawashdeh M (1997) The clinical patterns of arthritis in children with familial Mediterranean fever. QJM 90:37–43PubMed
34.
Zurück zum Zitat Sneh E, Pras M, Michaeli D, Shanin N, Gafni J (1997) Protracted arthritis in familial Mediterranean fever. Rheumatol Rehabil X 16:102–106CrossRef Sneh E, Pras M, Michaeli D, Shanin N, Gafni J (1997) Protracted arthritis in familial Mediterranean fever. Rheumatol Rehabil X 16:102–106CrossRef
35.
Zurück zum Zitat Salai M, Langevitz P, Blankstein A, Zemmer D, Chechick A, Pras M, Horoszowski H (1993) Total hip replacement in familial Mediterranean fever. Bull Hosp Jt Dis 53:25–28PubMed Salai M, Langevitz P, Blankstein A, Zemmer D, Chechick A, Pras M, Horoszowski H (1993) Total hip replacement in familial Mediterranean fever. Bull Hosp Jt Dis 53:25–28PubMed
36.
Zurück zum Zitat Besbas N, Ozdemir S, Saatci I, Bakkaloglu A, Ozen S, Saatci U (1999) Sacroiliitis in familial Mediterranean fever: an unusual presentation in childhood. Turk J Pediatr 41:387–390PubMed Besbas N, Ozdemir S, Saatci I, Bakkaloglu A, Ozen S, Saatci U (1999) Sacroiliitis in familial Mediterranean fever: an unusual presentation in childhood. Turk J Pediatr 41:387–390PubMed
37.
Zurück zum Zitat Langevitz P, Zemer D, Livneh A, Shemer J, Pras M (1994) Protracted febrile myalgia in patients with familial Mediterranean fever. J Rheumatol 21:1708–1709PubMed Langevitz P, Zemer D, Livneh A, Shemer J, Pras M (1994) Protracted febrile myalgia in patients with familial Mediterranean fever. J Rheumatol 21:1708–1709PubMed
38.
Zurück zum Zitat Pras M, Bronshpigel N, Zemer D, Gafni J (1982) Variable incidence of amyloidosis in familial Mediterranean fever among different ethnic groups. Johns Hopkins Med J 150:22–26PubMed Pras M, Bronshpigel N, Zemer D, Gafni J (1982) Variable incidence of amyloidosis in familial Mediterranean fever among different ethnic groups. Johns Hopkins Med J 150:22–26PubMed
39.
Zurück zum Zitat Konstantopoulos K, Kanta A, Tzoulianos M, Dimou S, Sotsiou F, Politou M, Loukopoulos D (2001) Familial Mediterranean fever phenotype II in Greece. Isr Med Assoc J 3:862–863PubMed Konstantopoulos K, Kanta A, Tzoulianos M, Dimou S, Sotsiou F, Politou M, Loukopoulos D (2001) Familial Mediterranean fever phenotype II in Greece. Isr Med Assoc J 3:862–863PubMed
40.
Zurück zum Zitat Kutlay S, Yilmaz E, Koytak ES, Tulunay OO, Keven K, Ozcan M, Erturk S (2001) A case of familial Mediterranean fever with amyloidosis as the first manifestation. Am J Kidney Dis 38:E34PubMed Kutlay S, Yilmaz E, Koytak ES, Tulunay OO, Keven K, Ozcan M, Erturk S (2001) A case of familial Mediterranean fever with amyloidosis as the first manifestation. Am J Kidney Dis 38:E34PubMed
41.
Zurück zum Zitat Melikoglu M, Ozdogan H, Korkmaz C, Kasapcopur O, Arisoy N, Akkus S, Fresko Z, Yazici H (2000) A survey of phenotype II in familial Mediterranean fever. Ann Rheum Dis 59:910–913CrossRefPubMed Melikoglu M, Ozdogan H, Korkmaz C, Kasapcopur O, Arisoy N, Akkus S, Fresko Z, Yazici H (2000) A survey of phenotype II in familial Mediterranean fever. Ann Rheum Dis 59:910–913CrossRefPubMed
42.
Zurück zum Zitat Cazeneuve C, Ajrapetyan H, Papin S, Roudot-Thoraval F, Genevieve D, Mndjoyan E, Papazian M, Sarkisian A, Babloyan A, Boissier B, Duquesnoy P, Kouyoumdjian JC, Girodon-Boulandet E, Grateau G, Sarkisian T, Amselem S (2000) Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever. Am J Hum Genet 67:1136–1143PubMed Cazeneuve C, Ajrapetyan H, Papin S, Roudot-Thoraval F, Genevieve D, Mndjoyan E, Papazian M, Sarkisian A, Babloyan A, Boissier B, Duquesnoy P, Kouyoumdjian JC, Girodon-Boulandet E, Grateau G, Sarkisian T, Amselem S (2000) Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever. Am J Hum Genet 67:1136–1143PubMed
43.
Zurück zum Zitat Booth DR, Gillmore JD, Booth SE, Pepys MB, Hawkins PN (1998) Pyrin/marenostrin mutations in familial Mediterranean fever. QJM 91:603–606CrossRefPubMed Booth DR, Gillmore JD, Booth SE, Pepys MB, Hawkins PN (1998) Pyrin/marenostrin mutations in familial Mediterranean fever. QJM 91:603–606CrossRefPubMed
44.
Zurück zum Zitat Samuels J, Aksentijevich I, Torosyan Y, Centola M, Deng Z, Sood R, Kastner DL (1998) Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine (Baltimore) 77:268–297CrossRef Samuels J, Aksentijevich I, Torosyan Y, Centola M, Deng Z, Sood R, Kastner DL (1998) Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine (Baltimore) 77:268–297CrossRef
45.
Zurück zum Zitat Yalcinkaya F, Akar N, Misirlioglu M (1998) Familial Mediterranean fever—amyloidosis and the Val726Ala mutation. N Engl J Med 338:993–994CrossRefPubMed Yalcinkaya F, Akar N, Misirlioglu M (1998) Familial Mediterranean fever—amyloidosis and the Val726Ala mutation. N Engl J Med 338:993–994CrossRefPubMed
46.
Zurück zum Zitat Tekin M, Yalcinkaya F, Cakar N, Akar N, Misirlioglu M, Tastan H, Tumer N (2000) MEFV mutations in multiplex families with familial Mediterranean fever: is a particular genotype necessary for amyloidosis? Clin Genet 57:430–434CrossRefPubMed Tekin M, Yalcinkaya F, Cakar N, Akar N, Misirlioglu M, Tastan H, Tumer N (2000) MEFV mutations in multiplex families with familial Mediterranean fever: is a particular genotype necessary for amyloidosis? Clin Genet 57:430–434CrossRefPubMed
47.
Zurück zum Zitat Yilmaz E, Balci B, Kutlay S, Ozen S, Erturk S, Oner A, Besbas N, Bakkaloglu A (2003) Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients. Turk J Pediatr 45:198–202PubMed Yilmaz E, Balci B, Kutlay S, Ozen S, Erturk S, Oner A, Besbas N, Bakkaloglu A (2003) Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients. Turk J Pediatr 45:198–202PubMed
48.
Zurück zum Zitat Bakkaloglu A, Duzova A, Ozen S, Balci B, Besbas N, Topaloglu R, Ozaltin F, Yilmaz E (2004) Influence of serum amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. J Rheumatol 31:1139–1142PubMed Bakkaloglu A, Duzova A, Ozen S, Balci B, Besbas N, Topaloglu R, Ozaltin F, Yilmaz E (2004) Influence of serum amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. J Rheumatol 31:1139–1142PubMed
49.
Zurück zum Zitat Touitou I, Picot MC, Domingo C, Notarnicola C, Cattan D, Demaille J, Kone-Paut I (2001) The MICA region determines the first modifier locus in familial Mediterranean fever. Arthritis Rheum 44:163–169CrossRefPubMed Touitou I, Picot MC, Domingo C, Notarnicola C, Cattan D, Demaille J, Kone-Paut I (2001) The MICA region determines the first modifier locus in familial Mediterranean fever. Arthritis Rheum 44:163–169CrossRefPubMed
50.
Zurück zum Zitat Flatau E, Kohn D, Schiller D, Lurie M, Levy E (1982) Schonlein-Henoch syndrome in patients with familial Mediterranean fever. Arthritis Rheum 25:42–47PubMedCrossRef Flatau E, Kohn D, Schiller D, Lurie M, Levy E (1982) Schonlein-Henoch syndrome in patients with familial Mediterranean fever. Arthritis Rheum 25:42–47PubMedCrossRef
51.
Zurück zum Zitat Glikson M, Galun E, Schlesinger M, Cohen D, Haskell L, Rubinow A, Eliakim M (1989) Polyarteritis nodosa and familial Mediterranean fever: a report of 2 cases and review of the literature. J Rheumatol 16:536–539PubMed Glikson M, Galun E, Schlesinger M, Cohen D, Haskell L, Rubinow A, Eliakim M (1989) Polyarteritis nodosa and familial Mediterranean fever: a report of 2 cases and review of the literature. J Rheumatol 16:536–539PubMed
52.
Zurück zum Zitat Ozen S, Ben-Chetrit E, Bakkaloglu A, Gur H, Tinaztepe K, Calguneri M, Turgan C, Turkmen A, Akpolat I, Danaci M, Besbas N, Akpolat T (2001) Polyarteritis nodosa in patients with familial Mediterranean fever (FMF): a concomitant disease or a feature of FMF? Semin Arthritis Rheum 30:281–287CrossRefPubMed Ozen S, Ben-Chetrit E, Bakkaloglu A, Gur H, Tinaztepe K, Calguneri M, Turgan C, Turkmen A, Akpolat I, Danaci M, Besbas N, Akpolat T (2001) Polyarteritis nodosa in patients with familial Mediterranean fever (FMF): a concomitant disease or a feature of FMF? Semin Arthritis Rheum 30:281–287CrossRefPubMed
53.
Zurück zum Zitat Akar S, Goktay Y, Akinci B, Tekis D, Biberoglu K, Birlik M, Onen F, Tunca M, Akkoc N (2005) A case of familial Mediterranean fever and polyarteritis nodosa complicated by spontaneous perirenal and subcapsular hepatic hemorrhage requiring multiple arterial embolizations. Rheumatol Int 25:60–64CrossRefPubMed Akar S, Goktay Y, Akinci B, Tekis D, Biberoglu K, Birlik M, Onen F, Tunca M, Akkoc N (2005) A case of familial Mediterranean fever and polyarteritis nodosa complicated by spontaneous perirenal and subcapsular hepatic hemorrhage requiring multiple arterial embolizations. Rheumatol Int 25:60–64CrossRefPubMed
54.
Zurück zum Zitat Schwartz T, Langevitz P, Zemer D, Gazit E, Pras M, Livneh A (2000) Behcet’s disease in familial Mediterranean fever: characterization of the association between the two diseases. Semin Arthritis Rheum 29:286–295CrossRefPubMed Schwartz T, Langevitz P, Zemer D, Gazit E, Pras M, Livneh A (2000) Behcet’s disease in familial Mediterranean fever: characterization of the association between the two diseases. Semin Arthritis Rheum 29:286–295CrossRefPubMed
55.
Zurück zum Zitat Touitou I, Magne X, Molinari N, Navarro A, Quellec AL, Picco P, Seri M, Ozen S, Bakkaloglu A, Karaduman A, Garnier JM, Demaille J, Kone-Paut I (2000) MEFV mutations in Behcet’s disease. Hum Mutat 16:271–272CrossRefPubMed Touitou I, Magne X, Molinari N, Navarro A, Quellec AL, Picco P, Seri M, Ozen S, Bakkaloglu A, Karaduman A, Garnier JM, Demaille J, Kone-Paut I (2000) MEFV mutations in Behcet’s disease. Hum Mutat 16:271–272CrossRefPubMed
56.
Zurück zum Zitat Atagunduz P, Ergun T, Direskeneli H (2003) MEFV mutations are increased in Behcet’s disease (BD) and are associated with vascular involvement. Clin Exp Rheumatol 21:S35–S37PubMed Atagunduz P, Ergun T, Direskeneli H (2003) MEFV mutations are increased in Behcet’s disease (BD) and are associated with vascular involvement. Clin Exp Rheumatol 21:S35–S37PubMed
57.
Zurück zum Zitat Gershoni-Baruch R, Broza Y, Brik R (2003) Prevalence and significance of mutations in the familial Mediterranean fever gene in Henoch-Schonlein purpura. J Pediatr 143:658–661CrossRefPubMed Gershoni-Baruch R, Broza Y, Brik R (2003) Prevalence and significance of mutations in the familial Mediterranean fever gene in Henoch-Schonlein purpura. J Pediatr 143:658–661CrossRefPubMed
58.
Zurück zum Zitat Ozen S, Bakkaloglu A, Yilmaz E, Duzova A, Balci B, Topaloglu R, Besbas N (2003) Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation? J Rheumatol 30:2014–2018PubMed Ozen S, Bakkaloglu A, Yilmaz E, Duzova A, Balci B, Topaloglu R, Besbas N (2003) Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation? J Rheumatol 30:2014–2018PubMed
59.
Zurück zum Zitat Ehrenfeld M, Brzezinski A, Levy M, Eliakim M (1987) Fertility and obstetric history in patients with familial Mediterranean fever on long-term colchicine therapy. Br J Obstet Gynaecol 94:1186–1191PubMed Ehrenfeld M, Brzezinski A, Levy M, Eliakim M (1987) Fertility and obstetric history in patients with familial Mediterranean fever on long-term colchicine therapy. Br J Obstet Gynaecol 94:1186–1191PubMed
60.
Zurück zum Zitat Ehrenfeld EN, Polishuk WZ (1970) Gynecological aspects of recurrent polyserositis (familial Mediterranean fever, periodic disease). Isr J Med Sci 6:9–13PubMed Ehrenfeld EN, Polishuk WZ (1970) Gynecological aspects of recurrent polyserositis (familial Mediterranean fever, periodic disease). Isr J Med Sci 6:9–13PubMed
61.
Zurück zum Zitat Ben-Chetrit E, Levy M (2003) Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 62:916–919CrossRefPubMed Ben-Chetrit E, Levy M (2003) Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 62:916–919CrossRefPubMed
62.
Zurück zum Zitat Gang N, Drenth JP, Langevitz P, Zemer D, Brezniak N, Pras M, van der Meer JW, Livneh A (1999) Activation of the cytokine network in familial Mediterranean fever. J Rheumatol 26:890–897PubMed Gang N, Drenth JP, Langevitz P, Zemer D, Brezniak N, Pras M, van der Meer JW, Livneh A (1999) Activation of the cytokine network in familial Mediterranean fever. J Rheumatol 26:890–897PubMed
63.
Zurück zum Zitat Frensdorff A, Sohar E, Heller H (1961) Plasma fibrinogen in familial Mediterranean fever. Ann Intern Med 55:448–455PubMed Frensdorff A, Sohar E, Heller H (1961) Plasma fibrinogen in familial Mediterranean fever. Ann Intern Med 55:448–455PubMed
64.
Zurück zum Zitat Moutereau S, Narwa R, Matheron C, Vongmany N, Simon E, Goossens M (2004) An improved electronic microarray-based diagnostic assay for identification of MEFV mutations. Hum Mutat 23:621–628CrossRefPubMed Moutereau S, Narwa R, Matheron C, Vongmany N, Simon E, Goossens M (2004) An improved electronic microarray-based diagnostic assay for identification of MEFV mutations. Hum Mutat 23:621–628CrossRefPubMed
65.
Zurück zum Zitat Delague V, Kriegshauser G, Oberkanins C, Megarbane A (2004) Reverse hybridization vs. DNA sequencing in the molecular diagnosis of Familial Mediterranean fever. Genet Test 8:65–68CrossRefPubMed Delague V, Kriegshauser G, Oberkanins C, Megarbane A (2004) Reverse hybridization vs. DNA sequencing in the molecular diagnosis of Familial Mediterranean fever. Genet Test 8:65–68CrossRefPubMed
66.
67.
Zurück zum Zitat Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome. Nat Genet 29:301–305CrossRefPubMed Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome. Nat Genet 29:301–305CrossRefPubMed
68.
Zurück zum Zitat McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Gadina M, Karenko L, Pettersson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaarslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos CI, Mulley J, Quane KA, Molloy MG, Ranki A, Powell RJ, Hitman GA, O’Shea JJ, Kastner DL (1999) Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97:133–144CrossRefPubMed McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Gadina M, Karenko L, Pettersson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaarslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos CI, Mulley J, Quane KA, Molloy MG, Ranki A, Powell RJ, Hitman GA, O’Shea JJ, Kastner DL (1999) Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97:133–144CrossRefPubMed
69.
Zurück zum Zitat Aksentijevich I, Galon J, Soares M, Mansfield E, Hull K, Oh HH, Goldbach-Mansky R, Dean J, Athreya B, Reginato AJ, Henrickson M, Pons-Estel B, O’Shea JJ, Kastner DL (2001) The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype–phenotype studies, and evidence for further genetic heterogeneity of periodic fevers. Am J Hum Genet 69:301–314CrossRefPubMed Aksentijevich I, Galon J, Soares M, Mansfield E, Hull K, Oh HH, Goldbach-Mansky R, Dean J, Athreya B, Reginato AJ, Henrickson M, Pons-Estel B, O’Shea JJ, Kastner DL (2001) The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype–phenotype studies, and evidence for further genetic heterogeneity of periodic fevers. Am J Hum Genet 69:301–314CrossRefPubMed
70.
Zurück zum Zitat Dode C, Andre M, Bienvenu T, Hausfater P, Pecheux C, Bienvenu J, Lecron JC, Reinert P, Cattan D, Piette JC, Szajnert MF, Delpech M, Grateau G (2002) The enlarging clinical, genetic, and population spectrum of tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 46:2181–2188CrossRefPubMed Dode C, Andre M, Bienvenu T, Hausfater P, Pecheux C, Bienvenu J, Lecron JC, Reinert P, Cattan D, Piette JC, Szajnert MF, Delpech M, Grateau G (2002) The enlarging clinical, genetic, and population spectrum of tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 46:2181–2188CrossRefPubMed
71.
Zurück zum Zitat Aganna E, Hammond L, Hawkins PN, Aldea A, McKee SA, van Amstel HK, Mischung C, Kusuhara K, Saulsbury FT, Lachmann HJ, Bybee A, McDermott EM, La Regina M, Arostegui JI, Campistol JM, Worthington S, High KP, Molloy MG, Baker N, Bidwell JL, Castaner JL, Whiteford ML, Janssens-Korpola PL, Manna R, Powell RJ, Woo P, Solis P, Minden K, Frenkel J, Yague J, Mirakian RM, Hitman GA, McDermott MF (2003) Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes. Arthritis Rheum 48:2632–2644CrossRefPubMed Aganna E, Hammond L, Hawkins PN, Aldea A, McKee SA, van Amstel HK, Mischung C, Kusuhara K, Saulsbury FT, Lachmann HJ, Bybee A, McDermott EM, La Regina M, Arostegui JI, Campistol JM, Worthington S, High KP, Molloy MG, Baker N, Bidwell JL, Castaner JL, Whiteford ML, Janssens-Korpola PL, Manna R, Powell RJ, Woo P, Solis P, Minden K, Frenkel J, Yague J, Mirakian RM, Hitman GA, McDermott MF (2003) Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes. Arthritis Rheum 48:2632–2644CrossRefPubMed
72.
Zurück zum Zitat Hull KM, Drewe E, Aksentijevich I, Singh HK, Wong K, McDermott EM, Dean J, Powell RJ, Kastner DL (2002) The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder. Medicine (Baltimore) 81:349–368CrossRef Hull KM, Drewe E, Aksentijevich I, Singh HK, Wong K, McDermott EM, Dean J, Powell RJ, Kastner DL (2002) The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder. Medicine (Baltimore) 81:349–368CrossRef
73.
Zurück zum Zitat Drenth JP, Haagsma CJ, van der Meer JW (1994) Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine (Baltimore) 73:133–144 Drenth JP, Haagsma CJ, van der Meer JW (1994) Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine (Baltimore) 73:133–144
74.
Zurück zum Zitat Drenth JP, Cuisset L, Grateau G, Vasseur C, van de Velde-Visser SD, de Jong JG, Beckmann JS, van der Meer JW, Delpech M (1999) Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Nat Genet 22:178–181CrossRefPubMed Drenth JP, Cuisset L, Grateau G, Vasseur C, van de Velde-Visser SD, de Jong JG, Beckmann JS, van der Meer JW, Delpech M (1999) Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Nat Genet 22:178–181CrossRefPubMed
75.
Zurück zum Zitat Muckle TJ, Wellsm (1962) Urticaria, deafness, and amyloidosis: a new heredo-familial syndrome. Q J Med 31:235–248 Muckle TJ, Wellsm (1962) Urticaria, deafness, and amyloidosis: a new heredo-familial syndrome. Q J Med 31:235–248
76.
Zurück zum Zitat Prieur AM, Griscelli C, Lampert F, Truckenbrodt H, Guggenheim MA, Lovell DJ, Pelkonnen P, Chevrant-Breton J, Ansell BM (1987) A chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients. Scand J Rheumatol Suppl 66:57–68PubMedCrossRef Prieur AM, Griscelli C, Lampert F, Truckenbrodt H, Guggenheim MA, Lovell DJ, Pelkonnen P, Chevrant-Breton J, Ansell BM (1987) A chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients. Scand J Rheumatol Suppl 66:57–68PubMedCrossRef
77.
Zurück zum Zitat Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P, Migdal A, Pras M, Passwell JH (1999) Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 135:98–101CrossRefPubMed Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P, Migdal A, Pras M, Passwell JH (1999) Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 135:98–101CrossRefPubMed
78.
Zurück zum Zitat Goldfinger SE (1972) Colchicine for familial Mediterranean fever. N Engl J Med 287:1302PubMed Goldfinger SE (1972) Colchicine for familial Mediterranean fever. N Engl J Med 287:1302PubMed
79.
Zurück zum Zitat Zemer D, Revach M, Pras M, Modan B, Schor S, Sohar E, Gafni J (1974) A controlled trial of colchicine in preventing attacks of familial Mediterranean fever. N Engl J Med 291:932–934PubMedCrossRef Zemer D, Revach M, Pras M, Modan B, Schor S, Sohar E, Gafni J (1974) A controlled trial of colchicine in preventing attacks of familial Mediterranean fever. N Engl J Med 291:932–934PubMedCrossRef
80.
Zurück zum Zitat Livneh A, Zemer D, Langevitz P, Laor A, Sohar E, Pras M (1994) Colchicine treatment of AA amyloidosis of familial Mediterranean fever. An analysis of factors affecting outcome. Arthritis Rheum 37:1804–1811PubMedCrossRef Livneh A, Zemer D, Langevitz P, Laor A, Sohar E, Pras M (1994) Colchicine treatment of AA amyloidosis of familial Mediterranean fever. An analysis of factors affecting outcome. Arthritis Rheum 37:1804–1811PubMedCrossRef
81.
Zurück zum Zitat Zemer D, Pras M, Sohar E, Modan M, Cabili S, Gafni J (1986) Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med 314:1001–1005PubMedCrossRef Zemer D, Pras M, Sohar E, Modan M, Cabili S, Gafni J (1986) Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med 314:1001–1005PubMedCrossRef
82.
Zurück zum Zitat Lidar M, Scherrmann JM, Shinar Y, Chetrit A, Niel E, Gershoni-Baruch R, Langevitz P, Livneh A (2004) Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 33:273–282CrossRefPubMed Lidar M, Scherrmann JM, Shinar Y, Chetrit A, Niel E, Gershoni-Baruch R, Langevitz P, Livneh A (2004) Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 33:273–282CrossRefPubMed
83.
Zurück zum Zitat Lidar M, Kedem R, Langevitz P, Pras M, Livneh A (2003) Intravenous colchicine for treatment of patients with familial Mediterranean fever unresponsive to oral colchicine. J Rheumatol 30:2620–2623PubMed Lidar M, Kedem R, Langevitz P, Pras M, Livneh A (2003) Intravenous colchicine for treatment of patients with familial Mediterranean fever unresponsive to oral colchicine. J Rheumatol 30:2620–2623PubMed
84.
85.
Zurück zum Zitat Amital H, Ben-Chetrit E (2004) Therapeutic approaches to familial Mediterranean fever. What do we know and where are we going to? Clin Exp Rheumatol 22:S4–S7PubMed Amital H, Ben-Chetrit E (2004) Therapeutic approaches to familial Mediterranean fever. What do we know and where are we going to? Clin Exp Rheumatol 22:S4–S7PubMed
86.
Zurück zum Zitat Ozkaya N, Yalcinkaya F (2003) Colchicine treatment in children with familial Mediterranean fever. Clin Rheumatol 22:314–317CrossRefPubMed Ozkaya N, Yalcinkaya F (2003) Colchicine treatment in children with familial Mediterranean fever. Clin Rheumatol 22:314–317CrossRefPubMed
87.
Zurück zum Zitat Tunca M, Tankurt E, Akbaylar Akpinar H, Akar S, Hizli N, Gonen O (1997) The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study. Br J Rheumatol 36:1005–1008CrossRefPubMed Tunca M, Tankurt E, Akbaylar Akpinar H, Akar S, Hizli N, Gonen O (1997) The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study. Br J Rheumatol 36:1005–1008CrossRefPubMed
88.
Zurück zum Zitat Tunca M, Akar S, Soyturk M, Kirkali G, Resmi H, Akhunlar H, Gonen O, Gallimore JR, Hawkins PN, Tankurt E (2004) The effect of interferon alpha administration on acute attacks of familial Mediterranean fever: a double-blind, placebo-controlled trial. Clin Exp Rheumatol 22:S37–S40PubMed Tunca M, Akar S, Soyturk M, Kirkali G, Resmi H, Akhunlar H, Gonen O, Gallimore JR, Hawkins PN, Tankurt E (2004) The effect of interferon alpha administration on acute attacks of familial Mediterranean fever: a double-blind, placebo-controlled trial. Clin Exp Rheumatol 22:S37–S40PubMed
89.
Zurück zum Zitat Calguneri M, Apras S, Ozbalkan Z, Ozturk MA (2004) The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa. Intern Med 43:612–614CrossRefPubMed Calguneri M, Apras S, Ozbalkan Z, Ozturk MA (2004) The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa. Intern Med 43:612–614CrossRefPubMed
90.
Zurück zum Zitat Seyahi E, Ozdogan H, Masatlioglu S, Yazici H (2002) Successful treatment of familial Mediterranean fever attacks with thalidomide in a colchicine resistant patient. Clin Exp Rheumatol 20:S43–S44PubMed Seyahi E, Ozdogan H, Masatlioglu S, Yazici H (2002) Successful treatment of familial Mediterranean fever attacks with thalidomide in a colchicine resistant patient. Clin Exp Rheumatol 20:S43–S44PubMed
91.
Zurück zum Zitat Drenth JP, Vonk AG, Simon A, Powell R, van der Meer JW (2001) Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. J Pharmacol Exp Ther 298:1221–1226PubMed Drenth JP, Vonk AG, Simon A, Powell R, van der Meer JW (2001) Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. J Pharmacol Exp Ther 298:1221–1226PubMed
92.
Zurück zum Zitat Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G (1991) Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 173:699–703PubMedCrossRef Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G (1991) Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 173:699–703PubMedCrossRef
93.
Zurück zum Zitat Milledge J, Shaw PJ, Mansour A, Williamson S, Bennetts B, Roscioli T, Curtin J, Christodoulou J (2002) Allogeneic bone marrow transplantation: cure for familial Mediterranean fever. Blood 100:774–777CrossRefPubMed Milledge J, Shaw PJ, Mansour A, Williamson S, Bennetts B, Roscioli T, Curtin J, Christodoulou J (2002) Allogeneic bone marrow transplantation: cure for familial Mediterranean fever. Blood 100:774–777CrossRefPubMed
94.
Zurück zum Zitat Touitou I, Ben-Chetrit E, Gershoni-Baruch R, Grateau G, Kastner DL, Kone-Paut I, Livneh A, Manna R, Mansour I, Ozdogan H, Ozen S, Sarkisian T, Tunca M, Yalcinkaya F (2003) Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean fever. Blood 102:409CrossRefPubMed Touitou I, Ben-Chetrit E, Gershoni-Baruch R, Grateau G, Kastner DL, Kone-Paut I, Livneh A, Manna R, Mansour I, Ozdogan H, Ozen S, Sarkisian T, Tunca M, Yalcinkaya F (2003) Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean fever. Blood 102:409CrossRefPubMed
95.
Zurück zum Zitat Keven K, Sengul S, Kutlay S, Ekmekci Y, Anadol E, Nergizoglu G, Ates K, Erturk S, Erbay B (2004) Long-term outcome of renal transplantation in patients with familial Mediterranean fever amyloidosis: a single-center experience. Transplant Proc 36:2632–2634CrossRefPubMed Keven K, Sengul S, Kutlay S, Ekmekci Y, Anadol E, Nergizoglu G, Ates K, Erturk S, Erbay B (2004) Long-term outcome of renal transplantation in patients with familial Mediterranean fever amyloidosis: a single-center experience. Transplant Proc 36:2632–2634CrossRefPubMed
96.
Zurück zum Zitat Altiparmak MR, Pamuk ON, Ataman R, Serdengecti K (2004) Continuous ambulatory peritoneal dialysis in familial Mediterranean fever amyloidosis patients with end-stage renal failure: a single-centre experience from Turkey. Nephron Clin Pract 98:c119–c123CrossRefPubMed Altiparmak MR, Pamuk ON, Ataman R, Serdengecti K (2004) Continuous ambulatory peritoneal dialysis in familial Mediterranean fever amyloidosis patients with end-stage renal failure: a single-centre experience from Turkey. Nephron Clin Pract 98:c119–c123CrossRefPubMed
97.
Zurück zum Zitat Rawashdeh MO, Majeed HA (1996) Familial Mediterranean fever in Arab children: the high prevalence and gene frequency. Eur J Pediatr 155:540–544PubMedCrossRef Rawashdeh MO, Majeed HA (1996) Familial Mediterranean fever in Arab children: the high prevalence and gene frequency. Eur J Pediatr 155:540–544PubMedCrossRef
Metadaten
Titel
Familial Mediterranean fever
verfasst von
Fatos Onen
Publikationsdatum
01.04.2006
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 6/2006
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-005-0074-3

Weitere Artikel der Ausgabe 6/2006

Rheumatology International 6/2006 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.