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Rheumatology International

Erschienen in:

01.07.2007 | Original Article

The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor

verfasst von: Young Hee Rho, Seong Jae Choi, Young Ho Lee, Jong Dae Ji, Gwan Gyu Song

Erschienen in: Rheumatology International | Ausgabe 9/2007

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Abstract

The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0%, 34.0%, 2.0%) and 154, 45, and 4 (75.9%, 22.2%, 2.0%) (P = 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95% CI (1.167–2.827), P = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95% CI (1.149–3.266), P = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.

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Titel: The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor
verfasst von: Young Hee Rho
Seong Jae Choi
Young Ho Lee
Jong Dae Ji
Gwan Gyu Song
Publikationsdatum: 01.07.2007
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 9/2007
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-006-0300-7

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