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Association of anti-CCP positivity with serum ferritin and DAS-28

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Abstract

Antibodies to cyclic citrullinated peptides (anti-CCP) are highly specific for the diagnosis of rheumatoid arthritis (RA) with a marginal increased prediction of the disease. In this study, we aimed to investigate the relation of the presence of anti-CCP with clinical manifestations and disease activity in a cohort of RA patients. A total of 61 RA patients were included in this study. Data of disease-related parameters such as duration of disease, medications, degree of pain (visual analog scale, VAS), disease activity score 28 (DAS-28) and health assessment questionnaire (HAQ) were recorded. Laboratory workup included erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP), rheumatoid factor (RF), anti-CCP, complete blood count and anemia parameters. Anti-CCP positivity was associated with higher scores of DAS-28, longer duration of morning stiffness, serum RF positivity and low levels of serum ferritin, while it was not associated with disease duration, VAS, HAQ, ESR, CRP and hemoglobin.

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Authors and Affiliations

  1. Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey

    Burcu Önder, Aydan Kurtaran, Songül Kimyon, Barın Selçuk & Müfit Akyüz

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  1. Burcu Önder
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  2. Aydan Kurtaran
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  3. Songül Kimyon
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  4. Barın Selçuk
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  5. Müfit Akyüz
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Correspondence to Burcu Önder.

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Önder, B., Kurtaran, A., Kimyon, S. et al. Association of anti-CCP positivity with serum ferritin and DAS-28. Rheumatol Int 30, 223–227 (2009). https://doi.org/10.1007/s00296-009-0941-4

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  • DOI: https://doi.org/10.1007/s00296-009-0941-4

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