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Erschienen in: Rheumatology International 3/2010

01.01.2010 | Case Report

Late infection of total knee arthroplasty inflamed by anti-TNFα, Infliximab therapy in rheumatoid arthritis

verfasst von: Takashi Yurube, Koichiro Takahi, Hajime Owaki, Takeshi Fuji, Masahiro Kurosaka, Minoru Doita

Erschienen in: Rheumatology International | Ausgabe 3/2010

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Abstract

We report a case of sudden onset of late infection after TKA inflamed by anti-TNFα therapy, Infliximab, in a 54-year-old woman with RA. Infliximab therapy was started 3 years and 8 months after TKAs as a result of multiple arthritides showing high inflammation of RA. One week after the third administration of Infliximab, the patient suffered sudden knee pain and infectious clinical symptoms, and bacteria (MSSA) were detected by joint effusion culture. She was successfully treated by open debridement with antibiotics-loaded calcium phosphate bone paste and cement and the prostheses were retained. Early diagnosis and operative treatment might be the key to controlling infected TKA without removing the implant. This present case might indicate a serious risk of immunosuppressive effects caused by Infliximab.
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Metadaten
Titel
Late infection of total knee arthroplasty inflamed by anti-TNFα, Infliximab therapy in rheumatoid arthritis
verfasst von
Takashi Yurube
Koichiro Takahi
Hajime Owaki
Takeshi Fuji
Masahiro Kurosaka
Minoru Doita
Publikationsdatum
01.01.2010
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 3/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-0948-x

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