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Erschienen in: Rheumatology International 10/2010

01.08.2010 | Original Article

High frequencies of HLA-B27 in Chinese patients with suspected of ankylosing spondylitis

verfasst von: Xiang Liu, Yi-Rong Li, Li-Hua Hu, Zhi-Ming Zhou, Feng-Hua Chen, Yong Ning, Qun-Feng Yao

Erschienen in: Rheumatology International | Ausgabe 10/2010

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Abstract

This study was performed to investigate the frequency of human leukocyte antigen (HLA)-B27 in Chinese patients with suspected of ankylosing spondylitis (AS) and to assess the clinical significance of HLA-B27 typing. A total of 1,016 patients suspected of AS were classified into six groups based on one major AS-related clinical manifestation. HLA-B27 was determined by polymerase chain reaction using sequence-specific primers. The frequency of B27 ranged between 24.3 and 46.7% among the patient groups, significantly higher than in healthy controls (2.4%). In the same group, the frequency of B27 in young (≤40 years) and in male patients was significantly higher than in the old and in female (P < 0.01). During a 1-year follow-up, 102 subjects were definitely diagnosed as AS, but only one B27(−) patient. Of the 102 definite patients, 69 (67.6%) definite patients were distributed in group 1 (low back pain and stiffness) with the higher incidence (28.5%) of AS. The incidence of AS in the same group was found with a similar pattern to the frequency of B27, in male and young patients significantly greater, except groups 4 and 6 (peripheral arthritis and alteration of skin). These findings confirm that HLA-B27 is one of sensitive diagnostic tools for early AS and suggest that there was a remarkable clinical significance of HLA-B27 typing in Chinese patients suspected of AS, particularly a young man who presents with low back pain and stiffness for >3 months.
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Metadaten
Titel
High frequencies of HLA-B27 in Chinese patients with suspected of ankylosing spondylitis
verfasst von
Xiang Liu
Yi-Rong Li
Li-Hua Hu
Zhi-Ming Zhou
Feng-Hua Chen
Yong Ning
Qun-Feng Yao
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 10/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-1148-4

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