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Rheumatology International

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01.04.2010 | Review Article

Osteonecrosis secondary to antiphospholipid syndrome: a case report, review of the literature, and treatment strategy

verfasst von: Waqar Haque, Huseyin Kadikoy, Omar Pacha, Joseph Maliakkal, Vu Hoang, Abdul Abdellatif

Erschienen in: Rheumatology International | Ausgabe 6/2010

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Abstract

Osteonecrosis is commonly present in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Treatment of this condition remains extremely controversial. We present a treatment strategy of avascular necrosis of the knee in a patient with catastrophic antiphospholipid syndrome with a history of SLE and APS. Aggressive treatment with 12 rounds of plasmapheresis, intravenous immunoglobulin, rituximab, and cylophosphamide led to the patient’s recovery with no recurrence of symptoms during 16 months of follow up. In this report, we further discuss the pathogenesis of osteonecrosis and current understanding of the treatment of this disease.

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Titel: Osteonecrosis secondary to antiphospholipid syndrome: a case report, review of the literature, and treatment strategy
verfasst von: Waqar Haque
Huseyin Kadikoy
Omar Pacha
Joseph Maliakkal
Vu Hoang
Abdul Abdellatif
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 6/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-1269-9

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