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Rheumatology International

Erschienen in:

01.07.2010 | Short Communication

Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province

verfasst von: Bingrong Zheng, Qin Li, Chuanyu Wei, Jiao Qin, Tao Shou, Ruoyu Zhou, Jingru Shao, Yan Yang, Chunjie Xiao

Erschienen in: Rheumatology International | Ausgabe 9/2010

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Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovium and subsequent joint destruction. Recently, genetic polymorphisms within the toll-like receptor 4 (TLR4) genes have been reported to be associated with RA. To analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to RA in Chinese people, two functional variants, Asp299Gly and Thr399Ile, in the TLR4 gene were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and direct sequencing techniques from 213 RA patients and 247 ethnically matched controls. None polymorphisms of Asp299Gly and Thr399Ile were detected in all RA cases and controls, which indicates that there is no relevance between these two SNPs and RA in the Chinese Han population. Further studies with extended single nucleotide polymorphisms (SNP) should be performed.

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Titel: Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province
verfasst von: Bingrong Zheng
Qin Li
Chuanyu Wei
Jiao Qin
Tao Shou
Ruoyu Zhou
Jingru Shao
Yan Yang
Chunjie Xiao
Publikationsdatum: 01.07.2010
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 9/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-010-1400-y

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Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province

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