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01.02.2012 | Short Communication

Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

verfasst von: Trine Bay Laurberg, Torkell Ellingsen, Jonas Thorsen, Bjarne Kuno Møller, Ib Hansen, Ulrik Tarp, Merete Lund Hetland, Kim Hørslev-Petersen, Allan Flyvbjerg, Jan Frystyk, Kristian Stengaard-Pedersen

Erschienen in: Rheumatology International | Ausgabe 2/2012

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Abstract

The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naïve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.

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Titel: Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment
verfasst von: Trine Bay Laurberg
Torkell Ellingsen
Jonas Thorsen
Bjarne Kuno Møller
Ib Hansen
Ulrik Tarp
Merete Lund Hetland
Kim Hørslev-Petersen
Allan Flyvbjerg
Jan Frystyk
Kristian Stengaard-Pedersen
Publikationsdatum: 01.02.2012
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 2/2012
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-010-1683-z

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Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

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