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Erschienen in: Rheumatology International 4/2012

01.04.2012 | Short Communication

Extremely high serum ferritin levels as a main diagnostic tool of adult-onset Still’s disease

verfasst von: Srdan Novak, Felina Anic, Tea Schnurrerer Luke-Vrbanić

Erschienen in: Rheumatology International | Ausgabe 4/2012

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Abstract

Adult-onset Still’s disease is a rare systemic inflammatory disease of unknown aetiology characterised by typical symptoms including daily high spiking fever, evanescent salmon-pink rash, sore throat, arthritis/arthralgias and polyserositis. The laboratory findings usually show neutrophilic leucocytosis, seronegativity and raised serum transaminases. We describe six typical cases. All of them had serum ferritin above 5,000 µg/L. Although there are few theories about the origin of the high ferritin level, an extremely high serum ferritin above 5,000 µg/L should be the main diagnostic tool of adult-onset Still’s disease.
Literatur
1.
Zurück zum Zitat Yamaguchi M, Ohta A, Tsunematsu T et al (1992) Preliminary criteria for classification of adult Still’s disease. J Rheumatol 19:424–430PubMed Yamaguchi M, Ohta A, Tsunematsu T et al (1992) Preliminary criteria for classification of adult Still’s disease. J Rheumatol 19:424–430PubMed
2.
3.
4.
Zurück zum Zitat Prieto J, Barry M, Sherlock S (1965) Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology 68:526–533 Prieto J, Barry M, Sherlock S (1965) Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology 68:526–533
5.
Zurück zum Zitat Schwarz-Eywill M, Heilig B, Bauer H, Breitbart A, Pezzutto A (1992) Evaluation of serum ferritin as a marker for adult Still’s disease activity. Ann Rheum Dis 51:683–685PubMedCrossRef Schwarz-Eywill M, Heilig B, Bauer H, Breitbart A, Pezzutto A (1992) Evaluation of serum ferritin as a marker for adult Still’s disease activity. Ann Rheum Dis 51:683–685PubMedCrossRef
6.
Zurück zum Zitat Hoshino T, Ohta A, Yang D, Kawamoto M, Kikuchi M, Inoue Y et al (1998) Elevated serum interleukin 6, inteferon-y, and tumor necrosis factor α levels in patients with adult Still’s disease. J Rheumatol 25:396–398PubMed Hoshino T, Ohta A, Yang D, Kawamoto M, Kikuchi M, Inoue Y et al (1998) Elevated serum interleukin 6, inteferon-y, and tumor necrosis factor α levels in patients with adult Still’s disease. J Rheumatol 25:396–398PubMed
7.
Zurück zum Zitat Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE, Munro HN (1990) Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem 265:14572–14578PubMed Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE, Munro HN (1990) Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem 265:14572–14578PubMed
8.
Zurück zum Zitat Kawashima M, Yamamura M, Taniai M et al (2001) Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still’s disease. Arthritis Rheum 44:550–560PubMedCrossRef Kawashima M, Yamamura M, Taniai M et al (2001) Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still’s disease. Arthritis Rheum 44:550–560PubMedCrossRef
9.
Zurück zum Zitat Van Reeth C, le Moel G, Lasne Y, Revenant MC, Agneray J, Kahn MF et al (1994) Serum ferritin and isoferritins are tools for diagnosis of active adult Still’s disease. J Rheumatol 21:890–895PubMed Van Reeth C, le Moel G, Lasne Y, Revenant MC, Agneray J, Kahn MF et al (1994) Serum ferritin and isoferritins are tools for diagnosis of active adult Still’s disease. J Rheumatol 21:890–895PubMed
10.
Zurück zum Zitat Kondo H, Saito K, Grasso JP, Aisen P (1988) Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology 8:32–38PubMedCrossRef Kondo H, Saito K, Grasso JP, Aisen P (1988) Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology 8:32–38PubMedCrossRef
11.
Zurück zum Zitat Sibille JC, Kondo H, Aisen P (1988) Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein. Hepatology 8:296–301PubMedCrossRef Sibille JC, Kondo H, Aisen P (1988) Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein. Hepatology 8:296–301PubMedCrossRef
12.
Zurück zum Zitat Campbell CH, Solgonick RM, Linder MC (1989) Translational regulation of ferritin synthesis in rat spleen: effects of iron inflammation. Biochem Biophys Res Commun 160:453–459PubMedCrossRef Campbell CH, Solgonick RM, Linder MC (1989) Translational regulation of ferritin synthesis in rat spleen: effects of iron inflammation. Biochem Biophys Res Commun 160:453–459PubMedCrossRef
13.
Zurück zum Zitat Fautrel B (2002) Ferritin levels in adult Still’s disease: any sugar? Joint Bone Spine 69:355–357PubMedCrossRef Fautrel B (2002) Ferritin levels in adult Still’s disease: any sugar? Joint Bone Spine 69:355–357PubMedCrossRef
14.
Zurück zum Zitat Kirino Y, Takeno M, Iwasaki M et al (2005) Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still’s disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther 7:R616–R624PubMedCrossRef Kirino Y, Takeno M, Iwasaki M et al (2005) Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still’s disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther 7:R616–R624PubMedCrossRef
Metadaten
Titel
Extremely high serum ferritin levels as a main diagnostic tool of adult-onset Still’s disease
verfasst von
Srdan Novak
Felina Anic
Tea Schnurrerer Luke-Vrbanić
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 4/2012
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-011-1834-x

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