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Erschienen in: Rheumatology International 10/2019

05.08.2019 | Observational Research

Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies

verfasst von: Adam Maundrell, Susanna Proudman, Vidya Limaye

Erschienen in: Rheumatology International | Ausgabe 10/2019

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Abstract

We sought to determine the prevalence of additional connective tissue diseases (CTDs) in patients with idiopathic inflammatory myopathies (IIM), and to study the muscle biopsy patterns in various clinico-serologic subsets of myositis. We undertook a retrospective cohort study of 648 patients with a histological diagnosis of IIM. The following was determined from the South Australian Myositis Database: presence of associated CTDs, histological details and presence of myositis-specific (MSA) or myositis-associated (MAA) antibodies. Among patients with IIM, a significantly greater proportion had systemic sclerosis 32/648 (4.9%) than mixed connective tissue disease (12/648, p = 0.003), primary Sjogren’s syndrome (12/648, p = 0.003), systemic lupus erythematosus (10/648, p < 0.001) or rheumatoid arthritis (6/648, p = 0.0001). Polymyositis was the most common IIM diagnosis regardless of the presence or absence of CTD. MSA/MAA was more commonly detected in those with systemic sclerosis than those with IIM alone (OR 5.35, p < 0.005). The higher prevalence of SSc (compared with other CTDs) in IIM, together with the more frequent detection of autoantibodies in this group, suggests that these conditions may be linked.
Literatur
1.
Zurück zum Zitat Limaye VS, Blumbergs P, Roberts-Thomson PJ (2009) Idiopathic inflammatory myopathies. Intern Med J 39:179–190CrossRefPubMed Limaye VS, Blumbergs P, Roberts-Thomson PJ (2009) Idiopathic inflammatory myopathies. Intern Med J 39:179–190CrossRefPubMed
2.
Zurück zum Zitat Ghirardello A, Bassi N, Palma L, Borella E, Domeneghetti M, Punzi L et al (2013) Autoantibodies in polymyositis and dermatomyositis. Curr Rheumatol Rep 15:335CrossRefPubMed Ghirardello A, Bassi N, Palma L, Borella E, Domeneghetti M, Punzi L et al (2013) Autoantibodies in polymyositis and dermatomyositis. Curr Rheumatol Rep 15:335CrossRefPubMed
3.
Zurück zum Zitat Gunawardena H, Betteridge ZE, McHugh NJ (2009) Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. Rheumatology (Oxford) 48:607–612CrossRef Gunawardena H, Betteridge ZE, McHugh NJ (2009) Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. Rheumatology (Oxford) 48:607–612CrossRef
4.
Zurück zum Zitat Tansley S, Gunawardena H (2014) The evolving spectrum of polymyositis and dermatomyositis—moving towards clinicoserological syndromes: a critical review. Clin Rev Allergy Immunol 47:264–273CrossRefPubMed Tansley S, Gunawardena H (2014) The evolving spectrum of polymyositis and dermatomyositis—moving towards clinicoserological syndromes: a critical review. Clin Rev Allergy Immunol 47:264–273CrossRefPubMed
5.
Zurück zum Zitat Limaye VS, Lester S, Bardy P, Thompson P, Cox S, Blumbergs P et al (2012) A three-way interplay of DR4, autoantibodies and synovitis in biopsy-proven idiopathic inflammatory myositis. Rheumatol Int 32:611–619CrossRefPubMed Limaye VS, Lester S, Bardy P, Thompson P, Cox S, Blumbergs P et al (2012) A three-way interplay of DR4, autoantibodies and synovitis in biopsy-proven idiopathic inflammatory myositis. Rheumatol Int 32:611–619CrossRefPubMed
6.
Zurück zum Zitat Mimura Y, Ihn H, Jinnin M et al (2005) Clinical and laboratory features of scleroderma patients developing skeletal myopathy. Clin Rheumatol 24:99–102CrossRefPubMed Mimura Y, Ihn H, Jinnin M et al (2005) Clinical and laboratory features of scleroderma patients developing skeletal myopathy. Clin Rheumatol 24:99–102CrossRefPubMed
7.
Zurück zum Zitat Balbir-Gurman A, Braun-Moscovici Y (2011) Scleroderma overlap syndrome. Isr Med Assoc J 13:14–20PubMed Balbir-Gurman A, Braun-Moscovici Y (2011) Scleroderma overlap syndrome. Isr Med Assoc J 13:14–20PubMed
8.
Zurück zum Zitat Muangchan C, Canadian Scleroderma Research Group, Baron M, Pope J (2013) The 15% rule in scleroderma: the frequency of severe organ complications in systemic sclerosis A systematic review. J Rheumatol 40:1545–1556CrossRefPubMed Muangchan C, Canadian Scleroderma Research Group, Baron M, Pope J (2013) The 15% rule in scleroderma: the frequency of severe organ complications in systemic sclerosis A systematic review. J Rheumatol 40:1545–1556CrossRefPubMed
9.
Zurück zum Zitat Hausmanowa-Petrusewicz I, Kowalska-Oledzka E, Miller FW, Jarzabek-Chorzelska M, Targoff IN, Blaszczyk-Kostanecka M et al (1997) Clinical, serologic and immunogenetic features in Polish patients with idiopathic inflammatory myopathies. Arthritis Rheum 40:1257–1266CrossRefPubMed Hausmanowa-Petrusewicz I, Kowalska-Oledzka E, Miller FW, Jarzabek-Chorzelska M, Targoff IN, Blaszczyk-Kostanecka M et al (1997) Clinical, serologic and immunogenetic features in Polish patients with idiopathic inflammatory myopathies. Arthritis Rheum 40:1257–1266CrossRefPubMed
10.
Zurück zum Zitat Vansca A, Gergely L, Ponyi A, Lakos G, Nemeth J, Szodoray P et al (2010) Myositis-specific and myositis-associated antibodies in overlap myositis in comparison to primary dermatopolymyositis: relevance for clinical classification: retrospective study of 169 patients. Jt Bone Spine 77:125–130CrossRef Vansca A, Gergely L, Ponyi A, Lakos G, Nemeth J, Szodoray P et al (2010) Myositis-specific and myositis-associated antibodies in overlap myositis in comparison to primary dermatopolymyositis: relevance for clinical classification: retrospective study of 169 patients. Jt Bone Spine 77:125–130CrossRef
11.
Zurück zum Zitat Dalakas MC (2011) Pathophysiology of inflammatory and autoimmune myopathies. Presse Med 40:e237–e247CrossRefPubMed Dalakas MC (2011) Pathophysiology of inflammatory and autoimmune myopathies. Presse Med 40:e237–e247CrossRefPubMed
12.
Zurück zum Zitat Mastaglia FL, Phillips BA (2002) Idiopathic inflammatory myopathies, epidemiology, classification and diagnostic criteria. Rheum Dis Clin N Am 28:723–741CrossRef Mastaglia FL, Phillips BA (2002) Idiopathic inflammatory myopathies, epidemiology, classification and diagnostic criteria. Rheum Dis Clin N Am 28:723–741CrossRef
13.
Zurück zum Zitat Hochberg MC, Feldman D, Stevens MB (1986) Adult onset polymyositis/dermatomyositis: an analysis of clinical and laboratory features and survival in 76 patients with a review of the literature. Semin Arthritis Rheum 15:168–178CrossRefPubMed Hochberg MC, Feldman D, Stevens MB (1986) Adult onset polymyositis/dermatomyositis: an analysis of clinical and laboratory features and survival in 76 patients with a review of the literature. Semin Arthritis Rheum 15:168–178CrossRefPubMed
14.
Zurück zum Zitat Ramesha KN, Kuruvilla A, Sarma PS, Radhakrishnan VV (2010) Clinical, electrophysiologic and histopathologic profile, and outcome in idiopathic inflammatory myositis: an analysis of 68 cases. Ann Indian Acad Neurol 13:250–256CrossRefPubMedPubMedCentral Ramesha KN, Kuruvilla A, Sarma PS, Radhakrishnan VV (2010) Clinical, electrophysiologic and histopathologic profile, and outcome in idiopathic inflammatory myositis: an analysis of 68 cases. Ann Indian Acad Neurol 13:250–256CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Aguila LA, Lopes MR, Pretti FZ, Sampaio-Barros PD, Carlos de Souza FH, Borba EF et al (2014) Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. Clin Rheumatol 33:1093–1098CrossRefPubMed Aguila LA, Lopes MR, Pretti FZ, Sampaio-Barros PD, Carlos de Souza FH, Borba EF et al (2014) Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. Clin Rheumatol 33:1093–1098CrossRefPubMed
16.
Zurück zum Zitat Troyanov Y, Targoff IN, Tremblay JL, Goulet JR, Raymond Y, Senecal JL (2005) Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies, Analysis of 100 French Canadian patients. Medicine 84:231–249CrossRefPubMed Troyanov Y, Targoff IN, Tremblay JL, Goulet JR, Raymond Y, Senecal JL (2005) Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies, Analysis of 100 French Canadian patients. Medicine 84:231–249CrossRefPubMed
17.
Zurück zum Zitat Koschik RW, Fertig N, Lucas MR, Domsic RT, Medsger TA Jr (2012) Anti-PM-Scl antibody in patients with systemic sclerosis. Clin Exp Rheumatol 30:S12–S16PubMed Koschik RW, Fertig N, Lucas MR, Domsic RT, Medsger TA Jr (2012) Anti-PM-Scl antibody in patients with systemic sclerosis. Clin Exp Rheumatol 30:S12–S16PubMed
18.
Zurück zum Zitat Schulte-Pelkum J, Fritzler M, Mahler M (2009) Latest update on the Ro/SS-A autoantibody system. Autoimmun Rev 8:632–637CrossRefPubMed Schulte-Pelkum J, Fritzler M, Mahler M (2009) Latest update on the Ro/SS-A autoantibody system. Autoimmun Rev 8:632–637CrossRefPubMed
19.
Zurück zum Zitat Cooley HM, Melny BJ, Gleeson R, Greco T, Kay TW (1999) Clinical and serological associations of anti-Ku antibody. J Rheumatol 26:563PubMed Cooley HM, Melny BJ, Gleeson R, Greco T, Kay TW (1999) Clinical and serological associations of anti-Ku antibody. J Rheumatol 26:563PubMed
20.
Zurück zum Zitat Rozman B, Cucnik S, Sodin-Semrl S, Czirjak L, Varju C, Distler O et al (2008) Prevalence and clinical associations of anti-Ku antibodies in patients with systemic sclerosis: a European EUSTAR-initiated multi-centre case-control study. Ann Rheum Dis 67:1282–1286CrossRefPubMed Rozman B, Cucnik S, Sodin-Semrl S, Czirjak L, Varju C, Distler O et al (2008) Prevalence and clinical associations of anti-Ku antibodies in patients with systemic sclerosis: a European EUSTAR-initiated multi-centre case-control study. Ann Rheum Dis 67:1282–1286CrossRefPubMed
21.
Zurück zum Zitat Suzuki S, Yonekawa T, Kuwana M, Hayashi Y, Okazaki Y, Kawaguchi Y et al (2014) Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies. J Neuroimmunol 274:202–208CrossRefPubMed Suzuki S, Yonekawa T, Kuwana M, Hayashi Y, Okazaki Y, Kawaguchi Y et al (2014) Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies. J Neuroimmunol 274:202–208CrossRefPubMed
Metadaten
Titel
Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies
verfasst von
Adam Maundrell
Susanna Proudman
Vidya Limaye
Publikationsdatum
05.08.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 10/2019
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-019-04411-8

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