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Rheumatology International

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30.01.2021 | COVID-19 | Review Zur Zeit gratis

SARS-CoV-2 vaccines and autoimmune diseases amidst the COVID-19 crisis

verfasst von: Tsvetelina Velikova, Tsvetoslav Georgiev

Erschienen in: Rheumatology International | Ausgabe 3/2021

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Abstract

Coronavirus disease 2019 (COVID-19) pandemic has become challenging even for the most durable healthcare systems. It seems that vaccination, one of the most effective public-health interventions, presents a ray of hope to end the pandemic by achieving herd immunity. In this review, we aimed to cover aspects of the current knowledge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and vaccine candidates in the light of autoimmune inflammatory diseases (AIIDs) and to analyze their potential in terms of safety and effectiveness in patients with AIIDs. Therefore, a focused narrative review was carried out to predict the possible implications of different types of SARS-CoV-2 vaccines which confer distinct immune mechanisms to establish immune response and protection against COVID-19: whole virus (inactivated or weakened), viral vector (replicating and non-replicating), nucleic acid (RNA, DNA), and protein-based (protein subunit, virus-like particle). Still, there is uncertainty among patients with AIIDs and clinicians about the effectiveness and safety of the new vaccines. There are a variety of approaches towards building a protective immunity against SARS-CoV-2. Only high-quality clinical trials would clarify the underlying immunological mechanisms of the newly implemented vaccines/adjuvants in patients living with AIIDs.

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Titel: SARS-CoV-2 vaccines and autoimmune diseases amidst the COVID-19 crisis
verfasst von: Tsvetelina Velikova
Tsvetoslav Georgiev
Publikationsdatum: 30.01.2021
Verlag: Springer Berlin Heidelberg
Schlagwort: COVID-19
Erschienen in: Rheumatology International / Ausgabe 3/2021
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-021-04792-9

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