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Erschienen in: European Radiology 6/2004

01.06.2004 | Oncology

Interstitial photodynamic laser therapy in interventional oncology

verfasst von: Thomas J. Vogl, Katrin Eichler, Martin G. Mack, Stephan Zangos, Christopher Herzog, Axel Thalhammer, Kerstin Engelmann

Erschienen in: European Radiology | Ausgabe 6/2004

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Abstract

Photodynamic therapy (PDT) is a well-investigated locoregional cancer treatment in which a systemically administered photosensitizer is activated locally by illuminating the diseased tissue with light of a suitable wavelength. PDT offers various treatment strategies in oncology, especially palliative ones. This article focuses on the development and evaluation of interstitial PDT for the treatment of solid tumors, particularly liver tumors. The PDT is mostly used for superficial and endoluminal lesions like skin or bladder malignancies and also more frequently applied for the treatment of lung, esophageal, and head and neck cancer. With the help of specially designed application systems, PDT is now becoming a practicable option for solid lesions, including those in parenchymal organs such as the liver. After intravenous treatment with the photosensitizer followed by interstitial light activation, contrast-enhanced computed tomography shows the development of therapy-induced necrosis around the light-guiding device. With the use of multiple devices, ablation of liver tumors seems to be possible, and no severe side effects or toxicities related to the treatment are reported. PDT can become a clinically relevant adjunct in the locoregional therapy strategies.
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Metadaten
Titel
Interstitial photodynamic laser therapy in interventional oncology
verfasst von
Thomas J. Vogl
Katrin Eichler
Martin G. Mack
Stephan Zangos
Christopher Herzog
Axel Thalhammer
Kerstin Engelmann
Publikationsdatum
01.06.2004
Erschienen in
European Radiology / Ausgabe 6/2004
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-004-2290-8

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