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01.03.2008 | Hepatobiliary-Pancreas

Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions

verfasst von: Renate Hammerstingl, Alexander Huppertz, Josy Breuer, Thomas Balzer, Anthony Blakeborough, Rick Carter, Lluis Castells Fusté, Gertraud Heinz-Peer, Werner Judmaier, Michael Laniado, Riccardo M. Manfredi, Didier G. Mathieu, Dieter Müller, Koenraad Mortelè, Peter Reimer, Maximilian F. Reiser, Philip J. Robinson, Kohkan Shamsi, Michael Strotzer, Matthias Taupitz, Bernd Tombach, Gianluca Valeri, Bernhard E. van Beers, Thomas J. Vogl, For the European EOB-study group

Erschienen in: European Radiology | Ausgabe 3/2008

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Abstract

A multicenter study has been employed to evaluate the diagnostic efficacy of magnetic resonance imaging (MRI) using the new liver-specific contrast agent gadoxetic acid (Gd-EOB-DTPA, Primovist), as opposed to contrast-enhanced biphasic spiral computed tomography (CT), in the diagnosis of focal liver lesions, compared with a standard of reference (SOR). One hundred and sixty-nine patients with hepatic lesions eligible for surgery underwent Gd-EOB-DTPA-enhanced MRI as well as CT within 6 weeks. Pathologic evaluation of the liver specimen combined with intraoperative ultrasound established the SOR. Data sets were evaluated on-site (14 investigators) and off-site (three independent blinded readers). Gd-EOB-DTPA was well tolerated. Three hundred and two lesions were detected in 131 patients valid for analysis by SOR. The frequency of correctly detected lesions was significantly higher on Gd-EOB-DTPA-enhanced MRI compared with CT in the clinical evaluation [10.44%; 95% confidence interval (CI): 4.88, 16.0]. In the blinded reading there was a trend towards Gd-EOB-DTPA-enhanced MRI, not reaching statistical significance (2.14%; 95% CI: −4.32, 8.6). However, the highest rate of correctly detected lesions with a diameter below 1 cm was achieved by Gd-EOB-DTPA-enhanced MRI. Differential diagnosis was superior for Gd-EOB-DTPA-enhanced MRI (82.1%) versus CT (71.0%). A change in surgical therapy was documented in 19 of 131 patients (14.5%) post Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT.

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Titel: Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions
verfasst von: Renate Hammerstingl
Alexander Huppertz
Josy Breuer
Thomas Balzer
Anthony Blakeborough
Rick Carter
Lluis Castells Fusté
Gertraud Heinz-Peer
Werner Judmaier
Michael Laniado
Riccardo M. Manfredi
Didier G. Mathieu
Dieter Müller
Koenraad Mortelè
Peter Reimer
Maximilian F. Reiser
Philip J. Robinson
Kohkan Shamsi
Michael Strotzer
Matthias Taupitz
Bernd Tombach
Gianluca Valeri
Bernhard E. van Beers
Thomas J. Vogl
For the European EOB-study group
Publikationsdatum: 01.03.2008
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 3/2008
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-007-0716-9

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Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions

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