The introduction of digital radiography not only has revolutionized communication between radiologists and clinicians, but also has improved image quality and allowed for further reduction of patient exposure. However, digital radiography also poses risks, such as unnoticed increases in patient dose and suboptimum image processing that may lead to suppression of diagnostic information. Advanced processing techniques, such as temporal subtraction, dual-energy subtraction and computer-aided detection (CAD) will play an increasing role in the future and are all targeted to decrease the influence of distracting anatomic background structures and to ease the detection of focal and subtle lesions. This review summarizes the most recent technical developments with regard to new detector techniques, options for dose reduction and optimized image processing. It explains the meaning of the exposure indicator or the dose reference level as tools for the radiologist to control the dose. It also provides an overview over the multitude of studies conducted in recent years to evaluate the options of these new developments to realize the principle of ALARA. The focus of the review is hereby on adult applications, the relationship between dose and image quality and the differences between the various detector systems.
Digital chest radiography: an update on modern technology, dose containment and control of image quality
Chest radiography still remains the mainstay of chest imaging despite the known diagnostic superiority and increasing availability of cross-sectional techniques. The main advantages of chest radiographs are the speed at which they can be acquired and interpreted, the low cost and the low radiation exposure. Upright chest radiographs still play an important role as a fast tool to rule out various chest diseases and cardiac congestion or to monitor response to therapy. Portable radiographs are the main tools to monitor patients in intensive care units (ICU). Chest radiography is responsible for approximately 30–40% of all X-ray examinations performed, regardless of the level of health-care delivery [1].
Chest radiography is subject to a number of technical challenges that include capturing the wide attenuation differences between lungs and mediastinum, a need for depiction of small contrast differences and fine structural detail. As a consequence, a radiographic system needs to a have a wide dynamic range in order to display mediastinal and retrocardiac abnormalities, should provide a high local contrast to detect focal lesions with subtle contrast and should have a high spatial resolution in order to be able to display interstitial lung disease. For portable chest radiographs, which are usually obtained without grid, the scatter within the patient is the main challenge: retaining contrast in high-attenuation areas such as the mediastinum and retrocardiac regions is more important than high spatial resolution or wide dynamic range.
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The introduction of digital radiography not only has revolutionized communication between radiologists and clinicians, but also has improved image quality and allowed for further reduction of the radiation exposure of the patients. However, digital radiography also poses risks: increase in patient dose may go unnoticed because increased dose no longer leads to overexposed films, and suboptimum image processing may lead to suppression of diagnostic information.
Advanced techniques such as temporal subtraction, dual energy subtraction, digital tomosynthesis and computer-aided detection (CAD) may play an increasing role in the future and are all targeted towards better detection and interpretation of chest radiographs in an environment in which time pressure and 24-h availability of constantly high quality image interpretation have a growing importance.
The following article summarizes recent advances in detector technology and discusses radiation-dose control and improvements in image processing.
Developments in detector and readout technology
Main objectives for recent system developments were
1.
to increase dose efficiency,
2.
to increase image quality and
3.
to ease handling and increase image throughput.
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Increased dose efficiency can be used to improve image quality or decrease patient exposure. Ease of handling and increased throughput can be realized through cassette-less handling or instantaneous image availability.
The two most important objective performance measures to describe digital radiography systems with respect to dose requirements and detail resolution are the modulation transfer function (MTF) and the detective quantum efficiency (DQE) [2]. DQE describes the efficiency of a detector to generate signal from X-ray quanta. MTF is a measure of image quality of an imaging system with respect to structural contrast and spatial resolution. Optimizing MTF and DQE simultaneously is a challenge: thicker detector material, for example, will improve absorption (thus, DQE), but generally also will induce more blur (deteriorate MTF).
The following sections discuss recent developments for the three main digital detector technologies: storage phosphors (computed radiography; CR), flat-panel detectors (digital radiography; DR) and CCD detectors.
Computed radiography systems are based on storage phosphor technology that has continuously improved over 25 years. CR systems are relatively inexpensive and versatile: they can be cassette-based and portable, which makes them ideal for bedside imaging, or they can be integrated into a dedicated Bucky system for chest radiography. Standard CR systems use a single laser beam and a detector screen covered with an amorphous (powder-based) detector material (Fig. 1a). These systems require an exposure comparable to a 400 speed film/screen system (detector dose 2.5 μGy). Recently, a number of improvements regarding detector material and read-out technology have been introduced.
Fig. 1
Electron microscopic views from a powder- (a) and a needle-structured (b) storage phosphor plate (courtesy of Dr. Schaetzing, Agfa, Mortsel, Belgium)
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Dual-reading CR
Dual-reading CR systems are based on transparent detector material and employ light collection optics in the front and the back side of the detector (Fig. 2). Combining these signals improves quantum detection (DQE) and has only a minimum deteriorating effect on spatial resolution (MTF) [3].
Fig. 2
Schematic view from a single read out (a) and a dual read-out (b) system of a storage phosphor plate
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Dual-reading CR was shown to provide better detection of (simulated) chest lesions than single-reading CR [4]. In the lung fields, but not the mediastinum, detection was even found to be similar to that with high-end DR systems [CsI-photodiode/TFT-(thin-film transistors) detector].
Parallel reading (line scanning)
Traditional CR scanners use for read-out the principle of flying spot scanning: a tightly focused laser beam stimulates the latent image in a moving storage phosphor plate one point at a time over the entire screen surface. Parallel reading employs a linear array of laser diodes (linear-line laser diode) that reads out all pixels in one line simultaneously, therefore speeding up the process tremendously. A light collection system with dedicated optics and multiple linear asymmetric CCDs also makes the read-out process more effective in terms of photon collection [5].
Needle-crystalline CR detectors
A new crystalline detector material (CsBr:Eu2+) for storage phosphor systems allows for creating a thicker detector layer (better DQE) without deteriorating spatial resolution (MTF). This is possible because of the structure of the detector material: crystalline needles serve as light pipes and substantially reduce lateral diffusion of photons. The principle is similar to that of indirect flat panel systems (CsI-photodiode/TFT detectors). Quantum efficiency and detail resolution (sensitivity and sharpness) of a 500-μm-thick CsBr:Eu2+ needle detector, which was read out by the new line scanner, were superior to standard CR systems and matched the values of a CsI-photodiode/TFT detector [6, 7].
Initial clinical experience at the bedside and a contrast-detail study found a superior low-contrast resolution and a potential for dose reduction without loss of image quality with the new needle-image-plate/line scanner (NI) as compared to the standard powder image plate/flying spot scanner (PIP) [8, 9] (Figs. 1b, 3).
Fig. 3
Postero-anterior radiograph of 3-year-old boy obtained with a needle-structured phosphor plate at 30% reduced acquisition dose (speed 600) (courtesy of Dr. Koerner, Grosshadern, Munich, Germany)
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4K matrix size
CR systems with a pixel size of 200 μm result in an image matrix of approximately 2,150×1,750 for a 35×43-cm radiograph. The cut-off frequency of the MTF for these standard ‘2k matrices’ is 2.5 cycles/mm (mm−1). To allow for a higher spatial resolution with a cut-off frequency of five cycles/mm (mm−1), all vendors now offer also ‘4k matrices’ with a pixel size of 100 μm. If pixel size was the limiting factor for image quality, then these systems should provide better clinical results. However, the MTF and DQE above 2.5 cycles/mm (mm−1) are both relatively poor for CR systems [10, 11]. In the low and medium frequency range representing larger, but ill-defined and potentially low contrast structures in the chest, such as infiltrates or tumors, the MTF for 4k images was even lower than that of 2k images (Fig. 4).
Fig. 4
Storage phosphor radiographs of a patient with right-sided upper-lobe infiltrate obtained with 2K and 4K matrix size: there is no visually appreciable difference between the images
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These experimental data explain that a number of clinical studies could not find an advantage of 4k matrices for detection of a broad range of intrapulmonary lesions [12, 13], delineation of anatomical landmarks [13] or interstitial diseases [14].
Flat-panel direct detector systems (DR)
Electronic flat panel detector (DR) systems have been introduced in the past decade. Compared to CR, dedicated Bucky chest units based on DR provide superior image quality and require no transport to an external read-out unit so that the image is instantly available. Recently, a mobile DR system for portable imaging has been introduced. It also offers immediate read-out for visual control of image quality, but suffers from a relatively bulky read-out unit that has to be managed within the patient room.
Two different DR technologies are available, both of which are based on TFT matrix arrays.
Indirect conversion systems or opto-direct systems use a scintillator (e.g., cesium iodide, CsI or gadolinium oxysulphide, GOS or Gadox) layered on top of an array with light-sensitive photodiodes with thin-film transistors (TFTs). The scintillator converts radiation into light that is detected by the photodiode/TFT array. Crystalline scintillators (e.g., CsI) guide the scintillation light through crystalline needles, allowing for thicker detector layers without deteriorating MTF. CsI-photodiode/TFT systems are widely used for chest radiography and provide better DQE than standard CR or Gadox-TFT systems (Fig. 5) [15, 16].
Fig. 5
DQE curves for various detector systems: note the superiority of CsI-TFT over Se- and Gadox-TFT for spatial frequencies below two cycles/mm (source NHS/Kcare UK 2005)
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Direct conversion systems or electro-direct systems use a photoconducting layer (amorphous selenium, a-Se), in which the absorbed X-ray energy is directly converted into charge on top of a TFT array. These systems are excellent for the high spatial frequencies required for mammography, but because they absorb less X-ray energy, they suffer from a lower dose efficiency (DQE) for structures such as vascular or interstitial structures or infiltrates in the lung represented by frequencies below four cycles/mm (factor of 2 compared to CsI-photodiode/TFT), which makes them less suited for chest radiography [15, 17].
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CCD detector technology
Charge-coupled devices (CCDs) used to be less well suited for chest radiography because CCDs are much smaller (2–4 cm2) than the exposed chest region. The light emitted by a scintillator screen has to be collimated to the CCD by optical coupling (demagnification), which can reduce dose efficiency and degrade image quality [18]. Recent improvements in coupling mechanism and use of larger CCD sensors have made these systems more attractive for chest radiography [19]. Systems are more frequently used in the US than in Western Europe.
Slot-scanning CCD technology
No demagnification is required for slot-scanning CCD technology: a CsI scintillator is coupled to a linear array of CCDs that covers the whole slot that is used to scan the chest (Fig. 6). The slot-scan technology provides excellent scatter rejection by irradiating the body by a sliding slit beam instead of irradiating the whole body at once. The increased signal to noise yielded by scatter reduction effectively compensates for the 2.5 times lower intrinsic DQE of CCD technology [20]. The increased SNR can be used to improve image quality or to reduce patient dose. In a comparison study of eight digital chest systems, CCD slot-scan technology performed equivalently to CsI-DR. Despite a 75% dose reduction for CsI-DR and a 50% reduction for CCD slot scanning, both outperformed a standard CR system [21, 22]. Advantages of the CCD technology were especially prominent for the mediastinum [23].
Fig. 6
Considerably increased transparency of high absorption areas in the PA chest radiograph obtained with the slot-scan CCD technique (b) compared to the film/screen radiograph (a) (courtesy of Dr. L. Kroft, LUMC, Leiden, The Netherlands)
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Dose control: why and how?
Dose creep
The automatic optimization of image contrast and density in digital radiography systems makes it impossible to determine if a radiograph was over- or underexposed by judging its density. Instead, underexposure manifests itself as an increased image noise while overexposure is rewarded by high image quality. When exposure parameters are chosen manually, such as in portable chest radiography or pediatric exams, radiographers tend to favor overexposure over underexposure because the latter will lead to complaints, while the former will not. The resulting ‘dose creep’ will cause a gradual increase in exposure parameters over time. This is less important for a single exposure given the relatively low dose of 0.03 mSv for a posteroanterior and lateral chest X-ray compared to the natural burden of radiation, which amounts in most European countries to some 2–3 mSv/year. Nevertheless, dose creep is very important when multiple follow-up examinations are performed (e.g., on intensive care units) or when patients are especially vulnerable (as the pediatric age group).
Compared to conventional radiography, a study in 269 patients admitted to the ICU found that technologists used a significantly higher entrance dose (median 0.21 vs. 0.16 mGy) for CR [24]. This was seen despite the fact that radiologists will only complain about the noise in CR images when images were underexposed by considerably more than 50% of the appropriate level [25]. On the other hand, standard CR systems will not profit from an increase in dose level beyond that of a 400 speed film/screen system for imaging tasks such as detection of catheters in the mediastinum [26]. These examples illustrate that there is a need for an exposure indicator that allows for controlling dose in an individual patient as well as for a certain type of examination in a whole patient group.
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Exposure indicators
An exposure indicator or exposure index (EI) gives the user feedback about the actual detector dose level of a digital clinical radiograph. The exposure indicator is always a measure for the air kerma at the detector surface and therefore describes the detector dose and not the patient entrance dose. Unfortunately, the definition of exposure indicators varies between vendors (Fig. 7), which makes it difficult to compare exposure values across systems. Presently, the American Association of Physics in Medicine (AAPM) and the International Electrotechnical Committee (IEC) attempt standardization of the exposure indicator.
Fig. 7
Exposure indices for various manufacturers: note the different definitions using linear and logarithmic scales
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The exposure indicator provides a composite measure of radiation exposure and patient-related features. Variation of the EI may be due to varying radiation exposure, but can also be caused by varying clinical conditions (e.g., resolution of pneumonia), patient positioning, and variable focus-detector distance or beam collimation. With automatic exposure control, the EI was shown to be constant within a narrow range [27]. In an ICU setting where automatic exposure control is not available, our own measurements found that the S-value, which is the exposure indicator in Fuji-based CR systems, vary up to 50% in follow-up images of the same patient, obtained with the same skin entrance dose, but under varying clinical conditions [28].
The EI value may be therefore used for dose containment not on a short-term individual basis, but on a longitudinal scale: while exposure indicators in individual patients may vary up to 50% despite identical skin entrance dose, the mean exposure indicator over a larger number of consecutive patients should remain constant. In case of dose creep, therefore, the mean EI will provide early feedback about changes in average patient exposure.
Kilovoltage and beam filtration
There are a number of recent studies that evaluated how far techniques assumed to be optimum for conventional imaging need to be revisited for digital radiography.
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In upright film/screen chest radiography, high kilovoltage settings are used to improve penetration of the mediastinum and to reduce the attenuation of the ribs superimposing over the lung fields. Digital radiography no longer suffers from underpenetration of the mediastinum, which makes it possible to re-think the conventional approach. Image contrast increases with low kVp, which could improve signal-to-noise ratios. In addition, detector mediums have, to an extent that depends on their absorption characteristics, a higher dose efficiency (DQE) at lower kVp ranges that again could be translated into improved signal to noise [29, 30, 31]. At identical effective dose to the patient, low kVp settings were found to increase SNR and significantly increase image quality, both in a phantom setup [30, 31, 32, 33] as well as in clinical studies [16, 32]. Despite this, chest radiography at lower kVp has not seen broad clinical application. Potential downsides include increased exposure time and resulting blurring artifacts at the heart borders and increased contrast not only of pathology, but also of soft tissue compared to bones resulting in an increased visualization of anatomical background structures (such as ribs) [33].
Diagnostic reference (dose) levels
The concept of reference doses or ‘diagnostic reference levels’ (DRL) was introduced by the International Commission for Radiation Protection (ICRP) in the 1990s [34, 35]. DRLs are defined as patient entrance dose levels for typical examinations for groups of standard-sized patients or standard phantoms for broadly defined types of equipment [34]. DRLs vary slightly for different countries and represent “state of practice” and not “state of the art.” For a PA chest radiograph, the DRL varies between 0.2 and 0.3 mGy, and for the lateral projection from 1.0 to 1.5 mGy [27, 36]. The DRL are advisory and therefore do not distinguish between acceptable and unacceptable practice. However, if local dose values consistently exceed the DRL, an investigation into the cause should be initiated. It has to be noted that the reference levels proposed by the ICRP do not yet take into account the dose-saving potential of modern CR and DR detector technology. The chest DRL should therefore be considered an upper threshold for skin entrance exposure in digital radiography.
Dose reduction: how much is possible?
ALARA principle
In the past decades a shift has taken place from the principle of ‘image quality as good as possible’ to ‘image quality as good as needed.’ Radiation dose to patients should be as low as reasonably achievable (ALARA), while still providing image quality adequate to enable an accurate diagnosis [37, 38]. Image quality requirements depend on the clinical question that has to be answered and therefore vary with the size, density and contrast of objects of interest relative to their background. The flexibility offered by digital radiographic systems places a lot of responsibility on technicians, physicists and radiologists for optimizing the trade-off between image quality and dose. The principle of ALARA includes the critical weighting of the indication and determining the required image quality. It also requires reorganization of the workflow because, unlike CT and fluoroscopic examinations, ordinary radiographic examinations are usually performed without the knowledge or input of the radiologist.
What constitutes ‘adequate image quality’ is still under discussion. Usually studies compare the performance of a new system with a ‘reference system’ to define the dose required with the new system for retaining equivalent image quality (Table 1). Research, however, is needed to determine the minimum level of image quality needed to reliably make or exclude a certain diagnosis. Since multiple patient exposures are not acceptable, dose reduction will have to be simulated by adding noise to a reference image. Such techniques have been published for CT [39, 40], but only start to be applied to chest radiography [41].
Table 1
List of observer studies using a CD phantom or simulated lesions to compare various chest detector systems at different dose levels
Literature reference (journal and year of publication)
Study design*
Reference for comparison
Statistics
Dose level (speed **)
Results (dose savings with CsI-DR in %)
Aufrichtig Med Phys 1999
Contrast-detail
SFR vs. CsI-DR
70
Chotas 2001
Contrast-detail
CR vs. CsI-DR
ROC
20%
Rong Med Phys 2000
Contrast-detail
CR vs. SFR
CD curves
70–90%
PeerIEEE Trans Med Imag 2001
Contrast-detail
CR vs. CsI-DR
Sensitivity, CD curves
50, 100, 200, 400, 800
CsI-DR superior to DR for low-contrast structures at lower dose levels
Geijer ER 2001
Contrast-detail
SFR vs. CR vs. CsI-DR
CD curves
SFR 160, CR 200,DR 400, 600, 800
CsI-DR vs. CR 30% CsI-DR vs. SFR <20%
De Hauwere Rad Prot Dosim 2005
Contrast-detail
SFR vs. CR vs. CsI-DR
CD curves
Hard and soft copy
>40%
Strotzer Inv Rad 1998
Simulated chest lesion
SFR vs. CsI-DR
Hosch 2002
Phantom, simulated lesions
SFR vs. CsI-DR
Preference study
240 vs. 480 14–332 micro Gy
50%
Goo Radiol 2002
Phantom, simulated lesions
CsI-DR vs. CR softcopy
Uffmann Invest Rad 2005
Phantomsimulated chest lesions
CR (dual und single reading) vs. DR
ROC
250 vs. 500; 400 vs. 800
Dual > single CRDual CR = CsI-DR
Redlich Radiat Prot Dosim 2005
Phantomsimulated chest lesions
CR (2K), CR (4K), CsI-DR, SFR, SE
ROC
400
CsI-DR superior CR-4K superior for reticular lesions
Rapp-Bernhardt Radiol 2003
Phantomsimulated chest lesions
CsI-DR vs. SFR asymm
ROC
SFR 400 DR 400, 800, 1,600
CsI-DR 50% 400 vs. 800 CsI-DR 1,600 inferior
Busch ROEFO 2003
Contrast-detail and a chest phantom
CsI-DR vs. CR vs. SFR, different CR systems
CD curves
200, 400, 800, 1,600
>50%
KroftAJR 2005
Simulated chest lesions
CR vs. CsI-DR vs. Se-DR vs. CCD
Sensitivity
AEC
Dose diff 1:4
Metz Radiol 2005
Simultaed chest lesions
CsI-DR
ROC
400, 640, 800, 100, 120, 140 kV
50% reduction for the lung, not for the mediastinum
**Based on its definition in film/screen “speed” should not be used to describe the dose that was applied to acquire digital radiographs. Yet, it is frequently used in publications and means that the exposure parameters or the automatic exposure control (AEC) were set as for images with a conventional film of the corresponding speed
Implementation of ALARA was subject of international workgroups of physicists and radiologists [37, 38] who suggested three levels of image quality (high, medium and low), depending on the clinical question. A low quality level, for example, was suggested for follow-up of pneumonia in adults (see www.icrp.org) [37, 38, 42]. Because of the varying detector efficiencies, however, the actual exposure dose connected to these quality levels will vary substantially with the detector system used. Experimental evaluations showed that a medium quality level could be reached with a 400 speed film/screen system, but required a higher dose, equivalent to a speed of 200–400, for standard CR systems and a much lower dose (equivalent to a speed of 1,600) for a CsI-photodiode/TFT DR system [43].
Dose and image quality in digital radiography
The relationship between dose and image quality can be assessed quantitatively and qualitatively. The spectrum reaches from objective measurements of physical characteristics, such as modulation-transfer function (MTF), detective quantum efficiency (DQE) or contrast-noise ratio (CNR) over contrast-detail studies, anthropomorphic phantom studies to clinical studies. Studies differ in how much a radiologist’s perception and abilities are involved and how well they represent the clinical situation.
Objective physical measurements in principle contain all necessary information, but they do not consider the influence of the human observer and in general it is difficult to translate the extent of differences in physical parameters into differences in clinical performance. Contrast-detail studies make it possible to compare the dose levels required to reach a certain detection level [4, 22,44], but the validity of these tests rely on how well they simulate reality. Anthropomorphic phantoms better approximate the clinical reality with respect to human anatomy and lesion characteristics, but cannot display the whole range of diseases. Clinical studies frequently rely on subjective scoring only and lack a good gold standard.
The majority of published studies (Table 1) apply only one methodology. There is increasing interest in how well objective measures reflect the subjective grading of image quality and how much small differences in visual grading affect diagnostic performance under clinical conditions. There are only few studies that have applied two methods such as objective measures and human observer (phantom) studies [45, 46] or objective measures and visual grading [47, 48]. In most [45, 46, 47] but not all [48] studies, the ranking of system performance was identical for both methodologies.
Comparison of detector systems
Comparison studies for dose requirements with various digital systems for chest radiography are summarized in Table 1. Differences in results appear to be dependent on the dose level, the reference technique (film/screen or CR), the statistical analysis (ROC or preference study), the type of lesions to be depicted and the study methodology (phantom or clinical study). Results can be summarized as follows:
1.
Even the most recent generation of single-sided read storage phosphor plates does not allow for dose reduction relative to a 400 speed film/screen system [44].
2.
Dual-readout CR is more dose-efficient than single read-out CR. Detection of simulated lesions in the lung fields were as high as in CsI-DR, but lesion detection in high absorption areas was inferior to DR [44].
3.
DR systems based on indirect conversion (CsI-photodiode/TFT technology) are more dose-efficient than direct-conversion systems (a-Se/TFT technology) by a factor of 2 for frequencies below 4 cycles/mm [17].
4.
In clinical settings, dose savings with CsI-based DR are 30–50% compared to a 400-speed film/screen system (2.5 μGy detector dose) (Table 1) (Fig. 8). Dose savings are limited by the performance in high absorption areas (retro-cardiac, infra-diaphragmatic areas), but can exceed 50% in the lung fields (Table 1).
5.
Due to effective scatter reduction CCD slot scanning techniques provide an image quality comparable to that of CsI-DR systems. Dose requirements of CCD slot scanning techniques are higher than those of CsI-based DR systems, but lower than those of standard CR or screen/film radiography [22, 23].
Fig. 8
Two follow-up bed-side chest radiographs in the same ICU patient obtained with standard dose CR (single read-out, a) and 50% dose reduced DR (CsI-TFT, b)
×
When interpreting and comparing these results, it is important to consider the following aspects:
Specification of an imaging system as ‘CR’ or ‘DR’ is not enough: more information is needed because of the varying dose efficiency (e.g., indirect versus direct conversion DR, CsI versus Gadox scintillator, dual versus single read-out CR, needle versus amorphous detector).
Comparison of performance vary with the dose level at which images were obtained: while comparison at high dose levels may not reveal a difference, relevant differences may become apparent at low dose levels. For example, CsI-based DR showed its superiority over standard-CR for the detection of low-density lesions, especially at lower dose levels [49].
Type of lesion (e.g., interstitial versus patchy lung infiltration), location in a low or high absorption areas (lung fields versus retrocardiac area) and lesion conspicuity (obvious versus subtle) greatly influence lesion detectability and therefore performance measures.
The impact of digital image processing on the visibility of lesions is well known. In any study-whether phantom or clinical study-the applied processing has to be clearly defined.
Advances in image processing
Image processing critically influences image quality: automated windowing can provide optimum image density independent of exposure, adjustments of the gradation curves can simulate the characteristics of arbitrary film/screen systems, and frequency processing can enhance local contrast or even selectively enhance structures of a certain size or contrast.
Unsharp mask filtering is the simplest type of frequency processing, but has the disadvantage that stronger filter settings lead to (edge) artifacts. Most vendors have made the transition to multi-frequency processing algorithms (e.g., MUSICA, UNIQUE, MFP), which better achieve enhancement of low-density structures and subtle pathology [50, 51]. Multifrequency processing makes it possible to separately enhance and suppress image structures dependent on their contrast (amplitude), their size (spatial frequency bands) and their background density (mediastinum versus lung). The result is an ‘image harmonization’ with a more transparent mediastinum and improved visualization of low-contrast structures throughout the chest [52] (Fig. 9).
Fig. 9
Two postero-anterior chest radiographs of a patient after pacemaker implantation: a was processed using simple unsharp masking, b was processed using an elaborate non-linear multifrequency processing
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The most advanced processing algorithms aim at analyzing images (CAD), selectively enhancing bones and soft tissues (dual-energy subtraction), and at visualizing change at follow-up (temporal subtraction) [53]. They are described below.
Computer-aided diagnosis (CAD)
Computer-aided diagnosis (CAD) programs have the goal to aid the radiologist in detecting or differentiating various disease entities in the chest. Usually the system suggests a lesion or abnormal region that then has to be verified by the radiologist. Early versions of CAD systems suffered from unacceptably high false-positive rates. Recent results with nodule CAD (Fig. 10), however, demonstrated increased sensitivity for small lung nodules (5–15 mm) and decreased inter-observer variability at false-positive rates of two or three lesions per PA radiograph [54, 55, 56].
Fig. 10
PA chest radiograph with computer-aided detection (CAD) marks: catch of an obvious nodule in the left lung and two subtle nodules in the right lung. One false-positive mark in the right lung apex on crossing of bone structures
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The role of CAD is continuously evolving. In an environment with ever-increasing time pressure on radiologists, CAD may assume the role of a control mechanism that alerts radiologists to potential abnormalities. Impact of CAD on radiologist’s behavior and the role of reader experience are currently under discussion [57].
Dual-energy subtraction
Dual-energy subtraction radiography involves taking a chest exposure at two different X-ray energies. By exploiting the difference in energy dependence of attenuation between bone and soft tissue, either bone or soft tissues can be eliminated by locally weighted subtraction of the two images. In order to get optimum separation of bone and soft tissues, scatter and beam hardening has to be corrected for. Subtraction increases the noise in the images substantially; this increase is less when the energy separation is good, but even then sophisticated noise reduction techniques are required to achieve diagnostic quality [58, 59]. Dual-energy subtration was found to increase the detection rate of intrapulmonary nodules by ‘subtracting’ overlying and potentially distracting rib structures [60].
Two acquisition techniques are available. The single-exposure technique uses a stack of two detectors (usually storage phosphor screens) with a beam-hardening filter (usually copper) in between. Energy separation between the front low-energy and the back high-energy image is modest and results in higher image noise, but there are no misregistration problems. The dual-exposure technique relies on two separate chest exposures in rapid succession (200 ms) at low and high kVp settings. It has a better energy separation, but suffers from slight misregistration artifacts.
Dual-energy subtraction allows for differentiation of calcified and non-calcified lesions, improved detection of nodules and masses, especially in critical areas, and improved detection of rib lesions [58, 59]. Although all results of clinical studies are positive, dual-energy subtraction has not yet seen widespread use in routine practice. The artifacts seen in earlier versions are now less of a problem, but the fact that a dual-energy technique requires the radiologist to routinely view three images (standard, bone and soft tissue) instead of one radiograph may explain the reluctance to use it. With better integration into monitor reading on PACS workstations, this problem may be overcome soon.
Temporal subtraction
Temporal subtraction is a processing technique based on the matching and subsequent subtraction of a follow-up radiograph and a baseline image. Because the rib cage moves differently than the lungs, the matching process is complex and can induce misregistration artifacts. The technique is powerful in revealing subtle interval changes and improves detection of nodules and hazy infiltrates [61, 62]. A recent publication reported reduction of subtraction artifacts when combining dual-energy soft tissue images with temporal subtraction [63]. At present, temporal subtraction algorithms are commercially available only in Japan.
Digital tomosynthesis
Digital tomosynthesis evolved from conventional tomography: during motion of the X-ray tube, multiple projection images from the patient are obtained. These projection images are subsequently shifted and added to bring objects in a given plane into focus, while other structures are spread across the image and are rendered with varying amounts of blur [64]. Tomosynthesis has been shown to improve visibility of intrapulmonary nodules, but this technique is so far limited to few institutions. The assessment of its role in a larger patient group is the topic of an ongoing study in the US.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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