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European Radiology

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01.09.2008 | Breast

Accuracy of ultrasound-guided, large-core needle breast biopsy

verfasst von: G. Schueller, C. Schueller-Weidekamm, T. H. Helbich

Erschienen in: European Radiology | Ausgabe 9/2008

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Abstract

Ultrasound-guided, large-core needle biopsy (US-LCNB) of suspicious breast lesions is acknowledged as less invasive and less expensive and less time consuming than surgical biopsy, and provides a histologic diagnosis with a comparable high degree. US-LCNB has been proven to help reduce the number of unnecessary surgeries for benign disease. Its limitations, however, are false-negative results and underestimation of disease. Thus, the demand for breast teams is to carefully adhere to the principles of triple assessment and imaging-histologic correlation, and follow-up of lesions with a specific benign histology after biopsy. Also, the acceptance of guidelines and rigorous quality controls help to reliably minimize the delay in the diagnosis of breast cancer in patients with false-negative biopsies. This paper aims to summarize the equipment and methods as well as the benefits and limitations of US-LCNB. Also, guidelines of quality assessment are suggested. Finally, recent developments which may help to overcome the limitations of US-LCNB will be discussed, i.e., directional vacuum-assisted biopsy (VAB), three-dimensional (3D) US-guided biopsy, as well as the use of tissue harmonic imaging (THI) and compound imaging (CI) during biopsy.

American Cancer Society (2006) Cancer facts & figures. American Cancer Society, Oakland

Parikh J, Tickman R (2005) Image-guided tissue sampling: where radiology meets pathology. Breast J 11:403–409PubMedCrossRef

Tabar L, Vitak B, Chen HH, Yen MF, Duffy SW, Smith RA (2001) Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer 91:1724–1731PubMedCrossRef

Leconte I, Feger C, Galant C et al (2003) Mammography and subsequent whole-breast sonography of nonpalpable breast cancers: the importance of radiologic breast density. AJR Am J Roentgenol 180:1675–1679PubMed

Kolb TM, Lichy J, Newhouse JH (2002) Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. Radiology 225:165–175PubMedCrossRef

American College of Radiology (2003) Illustrated breast imaging reporting and data system (BI-RADS), 4th edn. ACR, Reston

Pijnappel RM, van den Donk M, Holland R et al (2004) Diagnostic accuracy for different strategies of image-guided breast intervention in cases of nonpalpable breast lesions. Br J Cancer 90:595–600PubMedCrossRef

Parker SH, Burbank F, Jackman RJ et al (1994) Percutaneous large-core breast biopsy: a multi-institutional study. Radiology 193:359–364PubMed

Helbich TH, Mayr W, Schick S et al (1997) Coaxial technique: approach to breast core biopsies. Radiology 203:684–690PubMed

10.

Smith DN, Rosenfield Darling ML, Meyer JE et al (2001) The utility of ultrasonographically guided large-core needle biopsy: results from 500 consecutive breast biopsies. J Ultrasound Med 20:43–49PubMed

11.

Sauer G, Deissler H, Strunz K et al (2005) Ultrasound-guided large-core needle biopsies of breast lesions: analysis of 962 cases to determine the number of samples for reliable tumour classification. Br J Cancer 92:231–235PubMed

12.

Liberman L, Feng TL, Dershaw DD, Morris EA, Abramson AF (1998) US-guided core breast biopsy: use and cost-effectiveness. Radiology 208:717–723PubMed

13.

Crystal P, Koretz M, Shcharynsky S, Makarov V, Strano S (2005) Accuracy of sonographically guided 14-gauge core-needle biopsy: results of 715 consecutive breast biopsies with at least two-year follow-up of benign lesions. J Clin Ultrasound 33:47–52PubMedCrossRef

14.

Mainiero MB, Gareen IF, Bird CE, Smith W, Cobb C, Schepps B (2002) Preferential use of sonographically guided biopsy to minimize patient discomfort and procedure time in a percutaneous image-guided breast biopsy program. J Ultrasound Med 21:1221–1226PubMed

15.

Collins LC, Connolly JL, Page DL et al (2004) Diagnostic agreement in the evaluation of image-guided breast core needle biopsies: results from a randomized clinical trial. Am J Surg Pathol 28:126–131PubMedCrossRef

16.

Vargas HI, Vargas MP, Gonzalez KD et al (2004) Diagnosis of palpable breast masses: ultrasound-guided large core biopsy in a multidisciplinary setting. Am Surg 70:867–871PubMed

17.

Helbich TH, Matzek W, Fuchsjager MH (2004) Stereotactic and ultrasound-guided breast biopsy. Eur Radiol 14:383–393PubMedCrossRef

18.

Shulman SG, March DE (2006) Ultrasound-guided breast interventions: accuracy of biopsy techniques and applications in patient management. Semin Ultrasound CT MR 27:298–307PubMedCrossRef

19.

Dillon MF, Hill AD, Quinn CM, O’Doherty A, McDermott EW, O’Higgins N (2005) The accuracy of ultrasound, stereotactic, and clinical core biopsies in the diagnosis of breast cancer, with an analysis of false-negative cases. Ann Surg 242:701–707PubMedCrossRef

20.

Schulz-Wendtland R, Kramer S, Lang N, Bautz W (1998) Ultrasonic guided microbiopsy in mammary diagnosis: indications, technique and results. Anticancer Res 18:2145–2146PubMed

21.

Schoonjans JM, Brem RF (2001) Fourteen-gauge ultrasonographically guided large-core needle biopsy of breast masses. J Ultrasound Med 20:967–972PubMed

22.

Buchberger W, Niehoff A, Obrist P, Rettl G, Dunser M (2002) [Sonographically guided core needle biopsy of the breast: technique, accuracy and indications]. Radiologe 42:25–32PubMedCrossRef

23.

Perry NM (2001) Quality assurance in the diagnosis of breast disease. EUSOMA Working Party. Eur J Cancer 37:159–172PubMedCrossRef

24.

Helbich TH, Rudas M, Haitel A et al (1998) Evaluation of needle size for breast biopsy: comparison of 14-, 16-, and 18-gauge biopsy needles. AJR Am J Roentgenol 171:59–63PubMed

25.

Helbich TH, Rudas M, Bohm G et al (1999) Randomized in vitro and in vivo evaluation of different biopsy needles and devices for breast biopsy. Clin Radiol 54:56–62PubMedCrossRef

26.

Memarsadeghi M, Pfarl G, Riedl C, Wagner T, Rudas M, Helbich TH (2003) [Value of 14-gauge ultrasound-guided large-core needle biopsy of breast lesions: own results in comparison with the literature]. Rofo 175:374–380PubMed

27.

Liberman L (2000) Clinical management issues in percutaneous core breast biopsy. Radiol Clin North Am 38:791–807PubMedCrossRef

28.

Schueller G, Jaromi S, Ponhold L et al (2008) Ultrasound-guided, 14-gauge, core needle breast biopsy: a validation study in 1,352 cases. Radiology (in press)

29.

Heywang-Köbrunner SH (2001) Diagnostic Breast Imaging. Thieme, Stuttgart New York

30.

Youk JH, Kim EK, Kim MJ, Lee JY, Oh KK (2007) Missed breast cancers at US-guided core needle biopsy: how to reduce them. Radiographics 27:79–94PubMedCrossRef

31.

Liberman L, LaTrenta LR, Dershaw DD (1997) Impact of core biopsy on the surgical management of impalpable breast cancer: another look at margins. AJR Am J Roentgenol 169:1464–1465PubMed

32.

Wu YC, Chen DR, Kuo SJ (2006) Personal experience of ultrasound-guided 14-gauge core biopsy of breast tumor. Eur J Surg Oncol 32:715–718PubMedCrossRef

33.

Cardenosa G (1999) Needle choice for sonographically guided core biopsy. AJR Am J Roentgenol 173:845–846PubMed

34.

Fishman JE, Milikowski C, Ramsinghani R, Velasquez MV, Aviram G (2003) US-guided core-needle biopsy of the breast: how many specimens are necessary? Radiology 226:779–782PubMedCrossRef

35.

Helbich TH, Buchberger W, Rudas M (2002) [Stereotactically and sonographically guided vacuum-assisted breast biopsy: a national consensus for Austria]. Rofo 174:517–522PubMed

36.

Liberman L, LaTrenta LR, Dershaw DD et al (1997) Impact of core biopsy on the surgical management of impalpable breast cancer. AJR Am J Roentgenol 168:495–499PubMed

37.

Simon JR, Kalbhen CL, Cooper RA, Flisak ME (2000) Accuracy and complication rates of US-guided vacuum-assisted core breast biopsy: initial results. Radiology 215:694–697PubMed

38.

Philpotts LE, Hooley RJ, Lee CH (2003) Comparison of automated versus vacuum-assisted biopsy methods for sonographically guided core biopsy of the breast. AJR Am J Roentgenol 180:347–351PubMed

39.

Cho N, Moon WK, Cha JH et al (2005) Sonographically guided core biopsy of the breast: comparison of 14-gauge automated gun and 11-gauge directional vacuum-assisted biopsy methods. Korean J Radiol 6:102–109PubMedCrossRef

40.

Sperber F, Blank A, Metser U, Flusser G, Klausner JM, Lev-Chelouche D (2003) Diagnosis and treatment of breast fibroadenomas by ultrasound-guided vacuum-assisted biopsy. Arch Surg 138:796–800PubMedCrossRef

41.

Alonso-Bartolome P, Vega-Bolivar A, Torres-Tabanera M et al (2004) Sonographically guided 11-G directional vacuum-assisted breast biopsy as an alternative to surgical excision: utility and cost study in probably benign lesions. Acta Radiol 45:390–396PubMedCrossRef

42.

Kim MJ, Kim EK, Lee JY et al (2007) Breast lesions with imaging-histologic discordance during US-guided 14G automated core biopsy: can the directional vacuum-assisted removal replace the surgical excision? Initial findings. Eur Radiol 17:2376–2383PubMedCrossRef

43.

Fine RE, Whitworth PW, Kim JA, Harness JK, Boyd BA, Burak WE Jr. (2003) Low-risk palpable breast masses removed using a vacuum-assisted hand-held device. Am J Surg 186:362–367PubMedCrossRef

44.

March DE, Coughlin BF, Barham RB et al (2003) Breast masses: removal of all US evidence during biopsy by using a handheld vacuum-assisted device—initial experience. Radiology 227:549–555PubMedCrossRef

45.

Parker SH, Klaus AJ, McWey PJ et al (2001) Sonographically guided directional vacuum-assisted breast biopsy using a handheld device. AJR Am J Roentgenol 177:405–408PubMed

46.

Chen SC, Yang HR, Hwang TL, Chen MF, Cheung YC, Hsueh S (2003) Intraoperative ultrasonographically guided excisional biopsy or vacuum-assisted core needle biopsy for nonpalpable breast lesions. Ann Surg 238:738–742PubMedCrossRef

47.

Huber S, Wagner M, Medl M, Czembirek H (2003) Benign breast lesions: minimally invasive vacuum-assisted biopsy with 11-gauge needles patient acceptance and effect on follow-up imaging findings. Radiology 226:783–790PubMedCrossRef

48.

Cassano E, Urban LA, Pizzamiglio M et al (2007) Ultrasound-guided vacuum-assisted core breast biopsy: experience with 406 cases. Breast Cancer Res Treat 102:103–110PubMedCrossRef

49.

Grady I, Gorsuch H, Wilburn-Bailey S (2005) Ultrasound-guided, vacuum-assisted, percutaneous excision of breast lesions: an accurate technique in the diagnosis of atypical ductal hyperplasia. J Am Coll Surg 201:14–17PubMedCrossRef

50.

Wallis M, Tardivon A, Helbich T, Schreer I (2007) Guidelines from the European Society of Breast Imaging for diagnostic interventional breast procedures. Eur Radiol 17:581–588PubMedCrossRef

51.

Golub RM, Bennett CL, Stinson T, Venta L, Morrow M (2004) Cost minimization study of image-guided core biopsy versus surgical excisional biopsy for women with abnormal mammograms. J Clin Oncol 22:2430–2437PubMedCrossRef

52.

Gruber R, Bernt R, Helbich TH (2008) [Cost-Effectiveness of Percutaneous Core Needle Breast Biopsy (CNBB) Versus Open Surgical Biopsy (OSB) of Nonpalpable Breast Lesions: Metaanalysis and Cost Evaluation for German-Speaking Countries.]. Rofo 180:134–142PubMed

53.

Liberman L, Goodstine SL, Dershaw DD et al (2002) One operation after percutaneous diagnosis of nonpalpable breast cancer: frequency and associated factors. AJR Am J Roentgenol 178:673–679PubMed

54.

Lannin DR, Ponn T, Andrejeva L, Philpotts L (2006) Should all breast cancers be diagnosed by needle biopsy? Am J Surg 192:450–454PubMedCrossRef

55.

Whitten TM, Wallace TW, Bird RE, Turk PS (1997) Image-guided core biopsy has advantages over needle localization biopsy for the diagnosis of nonpalpable breast cancer. Am Surg 63:1072–1077 discussion 1077-1078PubMed

56.

Kopans DB (1994) Caution on core. Radiology 193:325–326, discussion 326-328PubMed

57.

Jackman RJ, Marzoni FA Jr. (1997) Needle-localized breast biopsy: why do we fail? Radiology 204:677–684PubMed

58.

Meyer JE, Smith DN, Lester SC et al (1998) Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy. Radiology 206:717–720PubMed

59.

Mueller-Holzner E, Frede T, Daniaux M et al (2007) Ultrasound-guided core needle biopsy of the breast: does frozen section give an accurate diagnosis? Breast Cancer Res Treat 106:399–406PubMedCrossRef

60.

Verkooijen HM, Peeters PH, Buskens E et al (2000) Diagnostic accuracy of large-core needle biopsy for nonpalpable breast disease: a meta-analysis. Br J Cancer 82:1017–1021PubMedCrossRef

61.

Jackman RJ, Birdwell RL, Ikeda DM (2002) Atypical ductal hyperplasia: can some lesions be defined as probably benign after stereotactic 11-gauge vacuum-assisted biopsy, eliminating the recommendation for surgical excision? Radiology 224:548–554PubMedCrossRef

62.

Diaz LK, Wiley EL, Venta LA (1999) Are malignant cells displaced by large-gauge needle core biopsy of the breast? AJR Am J Roentgenol 173:1303–1313PubMed

63.

Hoorntje LE, Schipper ME, Kaya A, Verkooijen HM, Klinkenbijl JG, Borel Rinkes IH (2004) Tumour cell displacement after 14G breast biopsy. Eur J Surg Oncol 30:520–525PubMedCrossRef

64.

Comstock CE (2005) US-guided interventional procedures. In: Feiss SA (ed) Categorial course in diagnostic radiology-breast imaging. RSNA, Oak Brook

65.

Pisano ED, Fajardo LL, Caudry DJ et al (2001) Fine-needle aspiration biopsy of nonpalpable breast lesions in a multicenter clinical trial: results from the radiologic diagnostic oncology group V. Radiology 219:785–792PubMed

66.

Kanz KG, Linsenmaier U, Pfeifer KJ, Mutschler W (2002) [Standardized evaluation of trauma patients: requirements for diagnostic imaging]. Radiologe 42:515–521PubMedCrossRef

67.

Rosen EL, Bentley RC, Baker JA, Soo MS (2002) Imaging-guided core needle biopsy of papillary lesions of the breast. AJR Am J Roentgenol 179:1185–1192PubMed

68.

Liberman L, Kaplan JB, Morris EA, Abramson AF, Menell JH, Dershaw DD (2002) To excise or to sample the mammographic target: what is the goal of stereotactic 11-gauge vacuum-assisted breast biopsy? AJR Am J Roentgenol 179:679–683PubMed

69.

Bonifacino A, Petrocelli V, Pisani T et al (2005) Accuracy rates of US-guided vacuum-assisted breast biopsy. Anticancer Res 25:2465–2470PubMed

70.

Gruber R, Jaromi S, Floery D, Memarsadeghi M, Helbich TH (2006) Cost-effectiveness of US-guided 14-G core needle breast biopsy (CNBB) versus open surgical excision. In: Cost-effectiveness of US-guided 14-G core needle breast biopsy (CNBB) versus open surgical excision: Medical University of Vienna, Vienna

71.

Reiner C, Helbich TH, Floery D, Jaromi S, Riedl CC, Fuchsjager MH (2006) Galactography-guided stereotactic 11-gauge vacuum-assisted directional biopsy of intraductal lesions: no alternative to open surgery. Eur Radiol 316

72.

Weismann CF, Forstner R, Prokop E, Rettenbacher T (2000) Three-dimensional targeting: a new three-dimensional ultrasound technique to evaluate needle position during breast biopsy. Ultrasound Obstet Gynecol 16:359–364PubMedCrossRef

73.

Surry KJ, Smith WL, Campbell LJ, Mills GR, Downey DB, Fenster A (2002) The development and evaluation of a three-dimensional ultrasound-guided breast biopsy apparatus. Med Image Anal 6:301–312PubMedCrossRef

74.

Lell M, Wenkel E, Aichinger U, Schulz-Wendtland R, Bautz W (2004) [3D ultrasound in core breast biopsy]. Ultraschall Med 25:126–130PubMedCrossRef

75.

Delle Chiaie L, Terinde R (2004) Three-dimensional ultrasound-validated large-core needle biopsy: is it a reliable method for the histological assessment of breast lesions? Ultrasound Obstet Gynecol 23:393–397PubMedCrossRef

76.

Wunderbaldinger P, Helbich TH, Partik B, Turetschek K, Wolf G (2001) First experience with a new dedicated ultrasound system for computer-guided large-core breast biopsy. Eur Radiol 11:2460–2464PubMedCrossRef

77.

Stuhlfaut JW, Lucey BC, Varghese JC, Soto JA (2006) Blunt abdominal trauma: utility of 5-minute delayed CT with a reduced radiation dose. Radiology 238:473–479PubMedCrossRef

78.

Jung EM, Jungius KP, Lenhart M, Dengler M, Becker H, Rupp N (2004) [Tissue harmonic imaging (THI) and contrast harmonic imaging (CHI) for sonographically guided vacuum-assisted biopsy of mammographically occult breast tumors]. Rofo 176:1416–1422PubMed

79.

Sehgal CM, Weinstein SP, Arger PH, Conant EF (2006) A review of breast ultrasound. J Mammary Gland Biol Neoplasia 11:113–123PubMedCrossRef

80.

Mesurolle B, Bining HJ, El Khoury M, Barhdadi A, Kao E (2006) Contribution of tissue harmonic imaging and frequency compound imaging in interventional breast sonography. J Ultrasound Med 25:845–855PubMed

81.

Huber S, Wagner M, Medl M, Czembirek H (2002) Real-time spatial compound imaging in breast ultrasound. Ultrasound Med Biol 28:155–163PubMedCrossRef

82.

Desser TS, Jeffrey RB (2001) Tissue harmonic imaging techniques: physical principles and clinical applications. Semin Ultrasound CT MR 22:1–10PubMedCrossRef

83.

Cha JH, Moon WK, Cho N et al (2007) Characterization of benign and malignant solid breast masses: comparison of conventional US and tissue harmonic imaging. Radiology 242:63–69PubMedCrossRef

84.

Saleh A, Ernst S, Grust A, Furst G, Dall P, Modder U (2001) [Real-time compound imaging: improved visibility of puncture needles and localization wires as compared to single-line ultrasonography]. Rofo 173:368–372PubMed

85.

Ko K, Han BK, Jang KM et al (2007) The value of ultrasound-guided tattooing localization of nonpalpable breast lesions. Korean J Radiol 8:295–301PubMedCrossRef

86.

Viehweg P, Fabel K, Petzold A, Friedrich K, Laniado M (2007) [O-Twist Marker for marking breast cancer under neoadjuvant chemotherapy–first results]. Rofo 179:1055–1060PubMed

87.

Fornage BD, Sneige N, Ross MI et al (2004) Small (< or = 2-cm) breast cancer treated with US-guided radiofrequency ablation: feasibility study. Radiology 231:215–224PubMedCrossRef

88.

Kaufman CS, Bachman B, Littrup PJ et al (2004) Cryoablation treatment of benign breast lesions with 12-month follow-up. Am J Surg 188:340–348PubMedCrossRef

89.

Kaufman CS, Littrup PJ, Freman-Gibb LA et al (2004) Office-based cryoablation of breast fibroadenomas: 12-month followup. J Am Coll Surg 198:914–923PubMedCrossRef

90.

Khatri VP, McGahan JP, Ramsamooj R et al (2007) A phase II trial of image-guided radiofrequency ablation of small invasive breast carcinomas: use of saline-cooled tip electrode. Ann Surg Oncol 14:1644–1652PubMedCrossRef

91.

Littrup PJ, Freeman-Gibb L, Andea A et al (2005) Cryotherapy for breast fibroadenomas. Radiology 234:63–72PubMedCrossRef

92.

Marcy PY, Magne N, Castadot P, Bailet C, Namer M (2007) Ultrasound-guided percutaneous radiofrequency ablation in elderly breast cancer patients: preliminary institutional experience. Br J Radiol 80:267–273PubMedCrossRef

93.

Pfleiderer SO, Freesmeyer MG, Marx C, Kuhne-Heid R, Schneider A, Kaiser WA (2002) Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations. Eur Radiol 12:3009–3014PubMed

94.

Pfleiderer SO, Marx C, Camara O, Gajda M, Kaiser WA (2005) Ultrasound-guided, percutaneous cryotherapy of small (< or = 15 mm) breast cancers. Invest Radiol 40:472–477PubMedCrossRef

95.

Roubidoux MA, Sabel MS, Bailey JE, Kleer CG, Klein KA, Helvie MA (2004) Small (< 2.0-cm) breast cancers: mammographic and US findings at US-guided cryoablation—initial experience. Radiology 233:857–867PubMedCrossRef

96.

Susini T, Nori J, Olivieri S et al (2007) Radiofrequency ablation for minimally invasive treatment of breast carcinoma. A pilot study in elderly inoperable patients. Gynecol Oncol 104:304–310PubMedCrossRef

97.

Boehm T, Malich A, Nahum Goldberg S et al (2001) Vacuum-assisted resection of malignant tumors with and without subsequent radiofrequency ablation: feasibility of complete tumor treatment tested in an animal model. J Vasc Interv Radiol 12:1086–1093PubMedCrossRef

Titel: Accuracy of ultrasound-guided, large-core needle breast biopsy
verfasst von: G. Schueller
C. Schueller-Weidekamm
T. H. Helbich
Publikationsdatum: 01.09.2008
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 9/2008
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-0955-4

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