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Erschienen in: European Radiology 1/2009

01.01.2009 | Musculoskeletal

T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients—a 3.0-Tesla MRI study

verfasst von: Robert Stahl, Anthony Luke, Xiaojuan Li, Julio Carballido-Gamio, C. Benjamin Ma, Sharmila Majumdar, Thomas M. Link

Erschienen in: European Radiology | Ausgabe 1/2009

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Abstract

(1) To assess the degree of focal cartilage abnormalities in physically active and sedentary healthy subjects as well as in patients with early osteoarthritis (OA). (2) To determine the diagnostic value of T2 and T1rho measurements in identifying asymptomatic physically active subjects with focal cartilage lesions. Thirteen asymptomatic physically active subjects, 7 asymptomatic sedentary subjects, and 17 patients with mild OA underwent 3.0-T MRI of the knee joint. T1rho and T2 values, cartilage volume and thickness, as well as the WORMS scores were obtained. Nine out of 13 active healthy subjects had focal cartilage abnormalities. T1rho and T2 values in active subjects with and without focal cartilage abnormalities differed significantly (p < 0.05). T1rho and T2 values were significantly higher (p < 0.05) in early OA patients compared to healthy subjects. T1rho measurements were superior to T2 in differentiating OA patients from healthy subjects, yet T1rho was moderately age-dependent. (1) Active subjects showed a high prevalence of focal cartilage abnormalities and (2) active subjects with and without focal cartilage abnormalities had different T1rho and T2 composition of cartilage. Thus, T1rho and T2 could be a parameter suited to identify active healthy subjects at higher risk for developing cartilage pathology.
Literatur
1.
Zurück zum Zitat Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F (1998) Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41:778–799PubMedCrossRef Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F (1998) Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41:778–799PubMedCrossRef
2.
Zurück zum Zitat Peyron JG (1984) The epidemiology of osteoarthritis. WB Sanders, Philadelphia, pp 9–27 Peyron JG (1984) The epidemiology of osteoarthritis. WB Sanders, Philadelphia, pp 9–27
3.
Zurück zum Zitat Sharma L, Kapoor D, Issa S (2006) Epidemiology of osteoarthritis: an update. Curr Opin Rheumatol 18:147–156PubMedCrossRef Sharma L, Kapoor D, Issa S (2006) Epidemiology of osteoarthritis: an update. Curr Opin Rheumatol 18:147–156PubMedCrossRef
4.
Zurück zum Zitat Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, Wolfe F, Schnitzer TJ, Moreland LW, Manzi S, Bradley JD, Sharma L, Oddis CV, Hugenberg ST, Heck LW (2005) Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 52:2015–2025PubMedCrossRef Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, Wolfe F, Schnitzer TJ, Moreland LW, Manzi S, Bradley JD, Sharma L, Oddis CV, Hugenberg ST, Heck LW (2005) Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 52:2015–2025PubMedCrossRef
5.
Zurück zum Zitat Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O (2007) A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at 5 years. J Bone Joint Surg Am 89:2105–2112CrossRef Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O (2007) A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at 5 years. J Bone Joint Surg Am 89:2105–2112CrossRef
6.
Zurück zum Zitat Felson DT, McLaughlin S, Goggins J, LaValley MP, Gale ME, Totterman S, Li W, Hill C, Gale D (2003) Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 139:330–336PubMed Felson DT, McLaughlin S, Goggins J, LaValley MP, Gale ME, Totterman S, Li W, Hill C, Gale D (2003) Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 139:330–336PubMed
7.
Zurück zum Zitat Link TM, Steinbach LS, Ghosh S, Ries M, Lu Y, Lane N, Majumdar S (2003) Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226:373–381PubMedCrossRef Link TM, Steinbach LS, Ghosh S, Ries M, Lu Y, Lane N, Majumdar S (2003) Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226:373–381PubMedCrossRef
8.
Zurück zum Zitat Bruyere O, Genant H, Kothari M, Zaim S, White D, Peterfy C, Burlet N, Richy F, Ethgen D, Montague T, Dabrowski C, Reginster JY (2007) Longitudinal study of magnetic resonance imaging and standard X-rays to assess disease progression in osteoarthritis. Osteoarthr Cartil 15(1):98–103, Epub 2006 Aug 4PubMedCrossRef Bruyere O, Genant H, Kothari M, Zaim S, White D, Peterfy C, Burlet N, Richy F, Ethgen D, Montague T, Dabrowski C, Reginster JY (2007) Longitudinal study of magnetic resonance imaging and standard X-rays to assess disease progression in osteoarthritis. Osteoarthr Cartil 15(1):98–103, Epub 2006 Aug 4PubMedCrossRef
9.
Zurück zum Zitat Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Beaudoin G, Choquette D, Haraoui B, Tannenbaum H, Meyer JM, Beary JF, Cline GA, Pelletier JP (2006) Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes. Arthritis Res Ther 8:R21PubMedCrossRef Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Beaudoin G, Choquette D, Haraoui B, Tannenbaum H, Meyer JM, Beary JF, Cline GA, Pelletier JP (2006) Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes. Arthritis Res Ther 8:R21PubMedCrossRef
10.
Zurück zum Zitat Dijkgraaf LC, de Bont LG, Boering G, Liem RS (1995) The structure, biochemistry, and metabolism of osteoarthritic cartilage: a review of the literature. J Oral Maxillofac Surg 53:1182–1192PubMedCrossRef Dijkgraaf LC, de Bont LG, Boering G, Liem RS (1995) The structure, biochemistry, and metabolism of osteoarthritic cartilage: a review of the literature. J Oral Maxillofac Surg 53:1182–1192PubMedCrossRef
11.
Zurück zum Zitat Lammentausta E, Kiviranta P, Nissi MJ, Laasanen MS, Kiviranta I, Nieminen MT, Jurvelin JS (2006) T2 relaxation time and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of human patellar cartilage at 1.5 T and 9.4 T: relationships with tissue mechanical properties. J Orthop Res 24:366–374PubMedCrossRef Lammentausta E, Kiviranta P, Nissi MJ, Laasanen MS, Kiviranta I, Nieminen MT, Jurvelin JS (2006) T2 relaxation time and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of human patellar cartilage at 1.5 T and 9.4 T: relationships with tissue mechanical properties. J Orthop Res 24:366–374PubMedCrossRef
12.
Zurück zum Zitat Link TM, Sell CA, Masi JN, Phan C, Newitt D, Lu Y, Steinbach L, Majumdar S (2006) 3.0 vs 1.5 T MRI in the detection of focal cartilage pathology-ROC analysis in an experimental model. Osteoarthr Cartil 14:63–70PubMedCrossRef Link TM, Sell CA, Masi JN, Phan C, Newitt D, Lu Y, Steinbach L, Majumdar S (2006) 3.0 vs 1.5 T MRI in the detection of focal cartilage pathology-ROC analysis in an experimental model. Osteoarthr Cartil 14:63–70PubMedCrossRef
13.
Zurück zum Zitat Bashir A, Gray ML, Hartke J, Burstein D (1999) Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 41:857–865PubMedCrossRef Bashir A, Gray ML, Hartke J, Burstein D (1999) Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 41:857–865PubMedCrossRef
14.
Zurück zum Zitat Fragonas E, Mlynarik V, Jellus V, Micali F, Piras A, Toffanin R, Rizzo R, Vittur F (1998) Correlation between biochemical composition and magnetic resonance appearance of articular cartilage. Osteoarthr Cartil 6:24–32PubMedCrossRef Fragonas E, Mlynarik V, Jellus V, Micali F, Piras A, Toffanin R, Rizzo R, Vittur F (1998) Correlation between biochemical composition and magnetic resonance appearance of articular cartilage. Osteoarthr Cartil 6:24–32PubMedCrossRef
15.
Zurück zum Zitat Liess C, Lusse S, Karger N, Heller M, Gluer CC (2002) Detection of changes in cartilage water content using MRI T2-mapping in vivo. Osteoarthr Cartil 10:907–913PubMedCrossRef Liess C, Lusse S, Karger N, Heller M, Gluer CC (2002) Detection of changes in cartilage water content using MRI T2-mapping in vivo. Osteoarthr Cartil 10:907–913PubMedCrossRef
16.
Zurück zum Zitat Lusse S, Claassen H, Gehrke T, Hassenpflug J, Schunke M, Heller M, Gluer CC (2000) Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage. Magn Reson Imaging 18:423–430PubMedCrossRef Lusse S, Claassen H, Gehrke T, Hassenpflug J, Schunke M, Heller M, Gluer CC (2000) Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage. Magn Reson Imaging 18:423–430PubMedCrossRef
17.
Zurück zum Zitat Mlynarik V, Trattnig S, Huber M, Zembsch A, Imhof H (1999) The role of relaxation times in monitoring proteoglycan depletion in articular cartilage. J Magn Reson Imaging 10:497–502PubMedCrossRef Mlynarik V, Trattnig S, Huber M, Zembsch A, Imhof H (1999) The role of relaxation times in monitoring proteoglycan depletion in articular cartilage. J Magn Reson Imaging 10:497–502PubMedCrossRef
18.
Zurück zum Zitat Menezes NM, Gray ML, Hartke JR, Burstein D (2004) T2 and T1rho MRI in articular cartilage systems. Magn Reson Med 51:503–509PubMedCrossRef Menezes NM, Gray ML, Hartke JR, Burstein D (2004) T2 and T1rho MRI in articular cartilage systems. Magn Reson Med 51:503–509PubMedCrossRef
19.
Zurück zum Zitat Goodwin DW, Wadghiri YZ, Zhu H, Vinton CJ, Smith ED, Dunn JF (2004) Macroscopic structure of articular cartilage of the tibial plateau: influence of a characteristic matrix architecture on MRI appearance. AJR Am J Roentgenol 182:311–318PubMed Goodwin DW, Wadghiri YZ, Zhu H, Vinton CJ, Smith ED, Dunn JF (2004) Macroscopic structure of articular cartilage of the tibial plateau: influence of a characteristic matrix architecture on MRI appearance. AJR Am J Roentgenol 182:311–318PubMed
20.
Zurück zum Zitat Goodwin DW, Zhu H, Dunn JF (2000) In vitro MR imaging of hyaline cartilage: correlation with scanning electron microscopy. AJR Am J Roentgenol 174:405–409PubMed Goodwin DW, Zhu H, Dunn JF (2000) In vitro MR imaging of hyaline cartilage: correlation with scanning electron microscopy. AJR Am J Roentgenol 174:405–409PubMed
21.
Zurück zum Zitat Xia Y, Moody JB, Burton-Wurster N, Lust G (2001) Quantitative in situ correlation between microscopic MRI and polarized light microscopy studies of articular cartilage. Osteoarthr Cartil 9:393–406PubMedCrossRef Xia Y, Moody JB, Burton-Wurster N, Lust G (2001) Quantitative in situ correlation between microscopic MRI and polarized light microscopy studies of articular cartilage. Osteoarthr Cartil 9:393–406PubMedCrossRef
22.
Zurück zum Zitat Bachmann GF, Basad E, Rauber K, Damian MS, Rau WS (1999) Degenerative joint disease on MRI and physical activity: a clinical study of the knee joint in 320 patients. Eur Radiol 9:145–152PubMedCrossRef Bachmann GF, Basad E, Rauber K, Damian MS, Rau WS (1999) Degenerative joint disease on MRI and physical activity: a clinical study of the knee joint in 320 patients. Eur Radiol 9:145–152PubMedCrossRef
23.
Zurück zum Zitat Blumenkrantz G, Lindsey CT, Dunn TC, Jin H, Ries MD, Link TM, Steinbach LS, Majumdar S (2004) A pilot, 2-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee. Osteoarthr Cartil 12:997–1005PubMedCrossRef Blumenkrantz G, Lindsey CT, Dunn TC, Jin H, Ries MD, Link TM, Steinbach LS, Majumdar S (2004) A pilot, 2-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee. Osteoarthr Cartil 12:997–1005PubMedCrossRef
24.
Zurück zum Zitat Regatte RR, Akella SV, Lonner JH, Kneeland JB, Reddy R (2006) T1rho relaxation mapping in human osteoarthritis (OA) cartilage: comparison of T1rho with T2. J Magn Reson Imaging 23:547–553PubMedCrossRef Regatte RR, Akella SV, Lonner JH, Kneeland JB, Reddy R (2006) T1rho relaxation mapping in human osteoarthritis (OA) cartilage: comparison of T1rho with T2. J Magn Reson Imaging 23:547–553PubMedCrossRef
25.
Zurück zum Zitat David-Vaudey E, Ghosh S, Ries M, Majumdar S (2004) T2 relaxation time measurements in osteoarthritis. Magn Reson Imaging 22:673–682PubMedCrossRef David-Vaudey E, Ghosh S, Ries M, Majumdar S (2004) T2 relaxation time measurements in osteoarthritis. Magn Reson Imaging 22:673–682PubMedCrossRef
26.
Zurück zum Zitat Dunn TC, Lu Y, Jin H, Ries MD, Majumdar S (2004) T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis. Radiology 232:592–598PubMedCrossRef Dunn TC, Lu Y, Jin H, Ries MD, Majumdar S (2004) T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis. Radiology 232:592–598PubMedCrossRef
27.
Zurück zum Zitat Redfield AG (1969) Nuclear Spin Thermodynamics in the Rotating Frame. Science 164:1015–1023PubMedCrossRef Redfield AG (1969) Nuclear Spin Thermodynamics in the Rotating Frame. Science 164:1015–1023PubMedCrossRef
28.
Zurück zum Zitat Makela HI, Grohn OH, Kettunen MI, Kauppinen RA (2001) Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Biochem Biophys Res Commun 289:813–818PubMedCrossRef Makela HI, Grohn OH, Kettunen MI, Kauppinen RA (2001) Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Biochem Biophys Res Commun 289:813–818PubMedCrossRef
29.
Zurück zum Zitat Akella SV, Regatte RR, Gougoutas AJ, Borthakur A, Shapiro EM, Kneeland JB, Leigh JS, Reddy R (2001) Proteoglycan-induced changes in T1rho-relaxation of articular cartilage at 4T. Magn Reson Med 46:419–423PubMedCrossRef Akella SV, Regatte RR, Gougoutas AJ, Borthakur A, Shapiro EM, Kneeland JB, Leigh JS, Reddy R (2001) Proteoglycan-induced changes in T1rho-relaxation of articular cartilage at 4T. Magn Reson Med 46:419–423PubMedCrossRef
30.
Zurück zum Zitat Duvvuri U, Reddy R, Patel SD, Kaufman JH, Kneeland JB, Leigh JS, Nugent AC, Johnson GA, Makela HI, Grohn OH, Kettunen MI, Kauppinen RA (1997) T1rho-relaxation in articular cartilage: effects of enzymatic degradation T1rho imaging using magnetization-prepared projection encoding (MaPPE) Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Magn Reson Med 38:863–867PubMedCrossRef Duvvuri U, Reddy R, Patel SD, Kaufman JH, Kneeland JB, Leigh JS, Nugent AC, Johnson GA, Makela HI, Grohn OH, Kettunen MI, Kauppinen RA (1997) T1rho-relaxation in articular cartilage: effects of enzymatic degradation T1rho imaging using magnetization-prepared projection encoding (MaPPE) Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Magn Reson Med 38:863–867PubMedCrossRef
31.
Zurück zum Zitat Regatte RR, Akella SV, Borthakur A, Kneeland JB, Reddy R (2002) Proteoglycan depletion-induced changes in transverse relaxation maps of cartilage: comparison of T2 and T1rho. Acad Radiol 9:1388–1394PubMedCrossRef Regatte RR, Akella SV, Borthakur A, Kneeland JB, Reddy R (2002) Proteoglycan depletion-induced changes in transverse relaxation maps of cartilage: comparison of T2 and T1rho. Acad Radiol 9:1388–1394PubMedCrossRef
32.
Zurück zum Zitat Wheaton AJ, Dodge GR, Elliott DM, Nicoll SB, Reddy R (2005) Quantification of cartilage biomechanical and biochemical properties via T1rho magnetic resonance imaging. Magn Reson Med 54:1087–1093PubMedCrossRef Wheaton AJ, Dodge GR, Elliott DM, Nicoll SB, Reddy R (2005) Quantification of cartilage biomechanical and biochemical properties via T1rho magnetic resonance imaging. Magn Reson Med 54:1087–1093PubMedCrossRef
33.
Zurück zum Zitat Li X, Benjamin Ma C, Link TM, Castillo DD, Blumenkrantz G, Lozano J, Carballido-Gamio J, Ries M, Majumdar S (2007) In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthr Cartil 15:789–797PubMedCrossRef Li X, Benjamin Ma C, Link TM, Castillo DD, Blumenkrantz G, Lozano J, Carballido-Gamio J, Ries M, Majumdar S (2007) In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthr Cartil 15:789–797PubMedCrossRef
34.
Zurück zum Zitat Li X, Han ET, Ma CB, Link TM, Newitt DC, Majumdar S (2005) In vivo 3T spiral imaging based multi-slice T(1rho) mapping of knee cartilage in osteoarthritis. Magn Reson Med 54:929–536PubMedCrossRef Li X, Han ET, Ma CB, Link TM, Newitt DC, Majumdar S (2005) In vivo 3T spiral imaging based multi-slice T(1rho) mapping of knee cartilage in osteoarthritis. Magn Reson Med 54:929–536PubMedCrossRef
35.
Zurück zum Zitat Regatte RR, Akella SV, Wheaton AJ, Lech G, Borthakur A, Kneeland JB, Reddy R (2004) 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects. Acad Radiol 11:741–749PubMed Regatte RR, Akella SV, Wheaton AJ, Lech G, Borthakur A, Kneeland JB, Reddy R (2004) 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects. Acad Radiol 11:741–749PubMed
36.
37.
Zurück zum Zitat Kaplan LD, Schurhoff MR, Selesnick H, Thorpe M, Uribe JW (2005) Magnetic resonance imaging of the knee in asymptomatic professional basketball players. Arthroscopy 21:557–561PubMedCrossRef Kaplan LD, Schurhoff MR, Selesnick H, Thorpe M, Uribe JW (2005) Magnetic resonance imaging of the knee in asymptomatic professional basketball players. Arthroscopy 21:557–561PubMedCrossRef
38.
Zurück zum Zitat Major NM, Helms CA (2002) MR imaging of the knee: findings in asymptomatic collegiate basketball players. AJR Am J Roentgenol 179:641–644PubMed Major NM, Helms CA (2002) MR imaging of the knee: findings in asymptomatic collegiate basketball players. AJR Am J Roentgenol 179:641–644PubMed
39.
Zurück zum Zitat Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502PubMedCrossRef Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502PubMedCrossRef
40.
Zurück zum Zitat Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M et al (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 29:1039–1049PubMedCrossRef Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M et al (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 29:1039–1049PubMedCrossRef
41.
Zurück zum Zitat Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 43–49 Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 43–49
42.
Zurück zum Zitat Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840PubMed Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840PubMed
43.
Zurück zum Zitat Krug R, Han ET, Banerjee S, Majumdar S (2006) Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla. Magn Reson Med 56:1033–1040PubMedCrossRef Krug R, Han ET, Banerjee S, Majumdar S (2006) Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla. Magn Reson Med 56:1033–1040PubMedCrossRef
44.
Zurück zum Zitat Oh J, Cha S, Aiken AH, Han ET, Crane JC, Stainsby JA, Wright GA, Dillon WP, Nelson SJ (2005) Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edema. J Magn Reson Imaging 21:701–708PubMedCrossRef Oh J, Cha S, Aiken AH, Han ET, Crane JC, Stainsby JA, Wright GA, Dillon WP, Nelson SJ (2005) Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edema. J Magn Reson Imaging 21:701–708PubMedCrossRef
45.
Zurück zum Zitat Carballido-Gamio J, Bauer JS, Keh-Yang L, Krause S, Majumdar S. Combined Image Processing Techniques for Characterization of MRI Cartilage of the Knee. In: IEEE-EMBS. 2005. Shanghai Carballido-Gamio J, Bauer JS, Keh-Yang L, Krause S, Majumdar S. Combined Image Processing Techniques for Characterization of MRI Cartilage of the Knee. In: IEEE-EMBS. 2005. Shanghai
46.
Zurück zum Zitat Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Hellio Le Graverand-Gastineau MP, Li X, Majumdar S, Link TM (2007) MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthr Cartil 15(11):1225–1234, Epub 2007 Jun 11PubMedCrossRef Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Hellio Le Graverand-Gastineau MP, Li X, Majumdar S, Link TM (2007) MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthr Cartil 15(11):1225–1234, Epub 2007 Jun 11PubMedCrossRef
47.
Zurück zum Zitat Faber SC, Eckstein F, Lukasz S, Muhlbauer R, Hohe J, Englmeier KH, Reiser M (2001) Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging. Skeletal Radiol 30:144–150PubMedCrossRef Faber SC, Eckstein F, Lukasz S, Muhlbauer R, Hohe J, Englmeier KH, Reiser M (2001) Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging. Skeletal Radiol 30:144–150PubMedCrossRef
48.
Zurück zum Zitat Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK (2004) Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthr Cartil 12:177–190PubMedCrossRef Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK (2004) Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthr Cartil 12:177–190PubMedCrossRef
49.
Zurück zum Zitat Duvvuri U, Charagundla SR, Kudchodkar SB, Kaufman JH, Kneeland JB, Rizi R, Leigh JS, Reddy R (2001) Human knee: in vivo T1(rho)-weighted MR imaging at 1.5 T-preliminary experience. Radiology 220:822–826PubMedCrossRef Duvvuri U, Charagundla SR, Kudchodkar SB, Kaufman JH, Kneeland JB, Rizi R, Leigh JS, Reddy R (2001) Human knee: in vivo T1(rho)-weighted MR imaging at 1.5 T-preliminary experience. Radiology 220:822–826PubMedCrossRef
50.
Zurück zum Zitat Nissi MJ, Rieppo J, Toyras J, Laasanen MS, Kiviranta I, Jurvelin JS, Nieminen MT (2006) T(2) relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage. Osteoarthr Cartil 14(12):1265–1271, Epub 2006 Jul 14PubMedCrossRef Nissi MJ, Rieppo J, Toyras J, Laasanen MS, Kiviranta I, Jurvelin JS, Nieminen MT (2006) T(2) relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage. Osteoarthr Cartil 14(12):1265–1271, Epub 2006 Jul 14PubMedCrossRef
51.
Zurück zum Zitat Nissi MJ, Toyras J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS, Nieminen MT (2004) Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage. J Orthop Res 22:557–564PubMedCrossRef Nissi MJ, Toyras J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS, Nieminen MT (2004) Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage. J Orthop Res 22:557–564PubMedCrossRef
52.
Zurück zum Zitat Akella SV, Regatte RR, Wheaton AJ, Borthakur A, Reddy R (2004) Reduction of residual dipolar interaction in cartilage by spin-lock technique. Magn Reson Med 52:1103–1109PubMedCrossRef Akella SV, Regatte RR, Wheaton AJ, Borthakur A, Reddy R (2004) Reduction of residual dipolar interaction in cartilage by spin-lock technique. Magn Reson Med 52:1103–1109PubMedCrossRef
53.
Zurück zum Zitat Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Labonte F, Beaudoin G, de Guise JA, Bloch DA, Choquette D, Haraoui B, Altman RD, Hochberg MC, Meyer JM, Cline GA, Pelletier JP (2004) Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes. Arthritis Rheum 50:476–487PubMedCrossRef Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Labonte F, Beaudoin G, de Guise JA, Bloch DA, Choquette D, Haraoui B, Altman RD, Hochberg MC, Meyer JM, Cline GA, Pelletier JP (2004) Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes. Arthritis Rheum 50:476–487PubMedCrossRef
54.
Zurück zum Zitat Mosher TJ, Dardzinski BJ, Smith MB (2000) Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2-preliminary findings at 3 T. Radiology 214:259–266PubMed Mosher TJ, Dardzinski BJ, Smith MB (2000) Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2-preliminary findings at 3 T. Radiology 214:259–266PubMed
55.
Zurück zum Zitat Mosher TJ, Liu Y, Yang QX, Yao J, Smith R, Dardzinski BJ, Smith MB (2004) Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum 50:2820–2828PubMedCrossRef Mosher TJ, Liu Y, Yang QX, Yao J, Smith R, Dardzinski BJ, Smith MB (2004) Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum 50:2820–2828PubMedCrossRef
56.
Zurück zum Zitat Baysal O, Baysal T, Alkan A, Altay Z, Yologlu S (2004) Comparison of MRI graded cartilage and MRI based volume measurement in knee osteoarthritis. Swiss Med Wkly 134:283–288PubMed Baysal O, Baysal T, Alkan A, Altay Z, Yologlu S (2004) Comparison of MRI graded cartilage and MRI based volume measurement in knee osteoarthritis. Swiss Med Wkly 134:283–288PubMed
57.
Zurück zum Zitat Cicuttini F, Hankin J, Jones G, Wluka A (2005) Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis. Osteoarthr Cartil 13:722–727PubMedCrossRef Cicuttini F, Hankin J, Jones G, Wluka A (2005) Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis. Osteoarthr Cartil 13:722–727PubMedCrossRef
58.
Zurück zum Zitat Cicuttini F, Wluka A, Hankin J, Wang Y (2004) Longitudinal study of the relationship between knee angle and tibiofemoral cartilage volume in subjects with knee osteoarthritis. Rheumatology (Oxford) 43:321–324CrossRef Cicuttini F, Wluka A, Hankin J, Wang Y (2004) Longitudinal study of the relationship between knee angle and tibiofemoral cartilage volume in subjects with knee osteoarthritis. Rheumatology (Oxford) 43:321–324CrossRef
59.
Zurück zum Zitat Cicuttini FM, Wluka AE, Wang Y, Stuckey SL (2004) Longitudinal study of changes in tibial and femoral cartilage in knee osteoarthritis. Arthritis Rheum 50:94–97PubMedCrossRef Cicuttini FM, Wluka AE, Wang Y, Stuckey SL (2004) Longitudinal study of changes in tibial and femoral cartilage in knee osteoarthritis. Arthritis Rheum 50:94–97PubMedCrossRef
60.
Zurück zum Zitat Ding C, Cicuttini F, Scott F, Boon C, Jones G (2005) Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal study. Arthritis Rheum 52:3918–3927PubMedCrossRef Ding C, Cicuttini F, Scott F, Boon C, Jones G (2005) Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal study. Arthritis Rheum 52:3918–3927PubMedCrossRef
61.
Zurück zum Zitat Wluka AE, Forbes A, Wang Y, Hanna F, Jones G, Cicuttini FM (2006) Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years. Arthritis Res Ther 8:R90PubMedCrossRef Wluka AE, Forbes A, Wang Y, Hanna F, Jones G, Cicuttini FM (2006) Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years. Arthritis Res Ther 8:R90PubMedCrossRef
62.
Zurück zum Zitat Wluka AE, Stuckey S, Snaddon J, Cicuttini FM (2002) The determinants of change in tibial cartilage volume in osteoarthritic knees. Arthritis Rheum 46:2065–2072PubMedCrossRef Wluka AE, Stuckey S, Snaddon J, Cicuttini FM (2002) The determinants of change in tibial cartilage volume in osteoarthritic knees. Arthritis Rheum 46:2065–2072PubMedCrossRef
63.
Zurück zum Zitat Wluka AE, Wolfe R, Stuckey S, Cicuttini FM (2004) How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis? Ann Rheum Dis 63:264–268PubMedCrossRef Wluka AE, Wolfe R, Stuckey S, Cicuttini FM (2004) How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis? Ann Rheum Dis 63:264–268PubMedCrossRef
64.
Zurück zum Zitat Gandy SJ, Dieppe PA, Keen MC, Maciewicz RA, Watt I, Waterton JC (2002) No loss of cartilage volume over three years in patients with knee osteoarthritis as assessed by magnetic resonance imaging. Osteoarthr Cartil 10:929–937PubMedCrossRef Gandy SJ, Dieppe PA, Keen MC, Maciewicz RA, Watt I, Waterton JC (2002) No loss of cartilage volume over three years in patients with knee osteoarthritis as assessed by magnetic resonance imaging. Osteoarthr Cartil 10:929–937PubMedCrossRef
65.
Zurück zum Zitat Yoshioka H, Stevens K, Hargreaves BA, Steines D, Genovese M, Dillingham MF, Winalski CS, Lang P (2004) Magnetic resonance imaging of articular cartilage of the knee: comparison between fat-suppressed three-dimensional SPGR imaging, fat-suppressed FSE imaging, and fat-suppressed three-dimensional DEFT imaging, and correlation with arthroscopy. J Magn Reson Imaging 20:857–864PubMedCrossRef Yoshioka H, Stevens K, Hargreaves BA, Steines D, Genovese M, Dillingham MF, Winalski CS, Lang P (2004) Magnetic resonance imaging of articular cartilage of the knee: comparison between fat-suppressed three-dimensional SPGR imaging, fat-suppressed FSE imaging, and fat-suppressed three-dimensional DEFT imaging, and correlation with arthroscopy. J Magn Reson Imaging 20:857–864PubMedCrossRef
Metadaten
Titel
T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients—a 3.0-Tesla MRI study
verfasst von
Robert Stahl
Anthony Luke
Xiaojuan Li
Julio Carballido-Gamio
C. Benjamin Ma
Sharmila Majumdar
Thomas M. Link
Publikationsdatum
01.01.2009
Verlag
Springer-Verlag
Erschienen in
European Radiology / Ausgabe 1/2009
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-008-1107-6

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