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Erschienen in: European Radiology 2/2010

01.02.2010 | Magnetic Resonance

Simulation-based comparison of two approaches frequently used for dynamic contrast-enhanced MRI

verfasst von: Stefan Zwick, Gunnar Brix, Paul S. Tofts, Ralph Strecker, Annette Kopp-Schneider, Hendrik Laue, Wolfhard Semmler, Fabian Kiessling

Erschienen in: European Radiology | Ausgabe 2/2010

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Abstract

Purpose

The purpose was to compare two approaches for the acquisition and analysis of dynamic-contrast-enhanced MRI data with respect to differences in the modelling of the arterial input-function (AIF), the dependency of the model parameters on physiological parameters and their numerical stability. Eight hundred tissue concentration curves were simulated for different combinations of perfusion, permeability, interstitial volume and plasma volume based on two measured AIFs and analysed according to the two commonly used approaches. The transfer constants (Approach 1) K trans and (Approach 2) k ep were correlated with all tissue parameters. K trans showed a stronger dependency on perfusion, and k ep on permeability. The volume parameters (Approach 1) v e and (Approach 2) A were mainly influenced by the interstitial and plasma volume. Both approaches allow only rough characterisation of tissue microcirculation and microvasculature. Approach 2 seems to be somewhat more robust than 1, mainly due to the different methods of CA administration.
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Metadaten
Titel
Simulation-based comparison of two approaches frequently used for dynamic contrast-enhanced MRI
verfasst von
Stefan Zwick
Gunnar Brix
Paul S. Tofts
Ralph Strecker
Annette Kopp-Schneider
Hendrik Laue
Wolfhard Semmler
Fabian Kiessling
Publikationsdatum
01.02.2010
Verlag
Springer-Verlag
Erschienen in
European Radiology / Ausgabe 2/2010
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-009-1556-6

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