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Erschienen in: European Radiology 1/2011

01.01.2011 | Urogenital

Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation

verfasst von: Kazuhiro Katahira, Taro Takahara, Thomas C. Kwee, Seitaro Oda, Yasuko Suzuki, Shoji Morishita, Kosuke Kitani, Yasuyuki Hamada, Mitsuhiko Kitaoka, Yasuyuki Yamashita

Erschienen in: European Radiology | Ausgabe 1/2011

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Abstract

Purpose

To assess the diagnostic performance of diffusion-weighted magnetic resonance (MR) imaging (DWI) for prostate cancer detection, using different b-values.

Methods

A total of 201 patients who underwent MR imaging before total prostatectomy were evaluated. MR images were independently assessed by three radiologists. Three combinations of sequences were separately evaluated, as follows: group 1 [T2-weighted images (T2WI) alone], group 2 (T2WI and DWI with a b-value of 1,000 s/mm2), group 3 (T2WI and DWI with a b-value of 2,000 s/mm2). Whole-mount-section histopathological examination was the reference standard. Areas under the receiver operating characteristic curve (AUCs) and diagnostic performance parameters were determined.

Results

The sensitivity, specificity, and AUC for the detection of prostate cancer were as follows: 52.2%, 80.7%, and 0.694 in group 1; 61.2%, 82.6%, and 0.755 in group 2; 73.2%, 89.7%, and 0.842 in group 3. Group 3 achieved the highest diagnostic performance, followed by group 2 (P < 0.05). In the transition zone, the specificity was lower (P < 0.001) for group 2 (82.2%) than for group 1 (86.2%).

Conclusion

The addition of diffusion-weighted images with a b-value of 2,000 s/mm2 to T2WI can improve the diagnostic performance of MR imaging in prostate cancer detection.
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Metadaten
Titel
Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation
verfasst von
Kazuhiro Katahira
Taro Takahara
Thomas C. Kwee
Seitaro Oda
Yasuko Suzuki
Shoji Morishita
Kosuke Kitani
Yasuyuki Hamada
Mitsuhiko Kitaoka
Yasuyuki Yamashita
Publikationsdatum
01.01.2011
Verlag
Springer-Verlag
Erschienen in
European Radiology / Ausgabe 1/2011
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1883-7

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