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European Radiology

Erschienen in:

01.09.2011 | Cardiac

Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis

verfasst von: Peter Schlattmann, Georg M. Schuetz, Marc Dewey

Erschienen in: European Radiology | Ausgabe 9/2011

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Abstract

Objective

To evaluate the impact of coronary artery disease (CAD) prevalence on the predictive values of coronary CT angiography.

Methods

We performed a meta-regression based on a generalised linear mixed model using the binomial distribution and a logit link to analyse the influence of the prevalence of CAD in published studies on the per-patient negative and positive predictive values of CT in comparison to conventional coronary angiography as the reference standard. A prevalence range in which the negative predictive value was higher than 90%, while at the same time the positive predictive value was higher than 70% was considered appropriate.

Results

The summary negative and positive predictive values of coronary CT angiography were 93.7% (95% confidence interval [CI] 92.8–94.5%) and 87.5% (95% CI, 86.5–88.5%), respectively. With 95% confidence, negative and positive predictive values higher than 90% and 70% were available with CT for a CAD prevalence of 18–63%. CT systems with >16 detector rows met these requirements for the positive (P < 0.01) and negative (P < 0.05) predictive values in a significantly broader range than systems with ≤16 detector rows.

Conclusion

It is reasonable to perform coronary CT angiography as a rule-out test in patients with a low-to-intermediate likelihood of disease.

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Titel: Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis
verfasst von: Peter Schlattmann
Georg M. Schuetz
Marc Dewey
Publikationsdatum: 01.09.2011
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 9/2011
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2142-2

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Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis

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Weitere Artikel der Ausgabe 9/2011

ECG-Triggered Non-Contrast-Enhanced MR Angiography (TRANCE) versus Digital Subtraction Angiography (DSA) in patients with peripheral arterial occlusive disease of the lower extremities

Multidetector-CT angiography in pulmonary embolism—can image parameters predict clinical outcome?

64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement

Dynamic telecytologic evaluation of imprint cytology samples from CT-guided lung biopsies: A feasibility study

Accuracy of coronary artery stenosis detection with CT versus conventional coronary angiography compared with composite findings from both tests as an enhanced reference standard

Oedema and fatty degeneration of the soleus and gastrocnemius muscles on MR images in patients with achilles tendon abnormalities

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie