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01.06.2012 | Musculoskeletal

Improved assessment of cartilage repair tissue using fluid-suppressed ²³Na inversion recovery MRI at 7 Tesla: preliminary results

verfasst von: Gregory Chang, Guillaume Madelin, Orrin H. Sherman, Eric J. Strauss, Ding Xia, Michael P. Recht, Alexej Jerschow, Ravinder R. Regatte

Erschienen in: European Radiology | Ausgabe 6/2012

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Abstract

Objectives

To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) ²³Na MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T).

Methods

This study had institutional review board approval. We recruited 11 consecutive patients (41.5 ± 11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median = 26 weeks) with 7-T MRI using: proton-T2 (TR/TE = 3,000 ms/60 ms); sodium UTE (TR/TE = 100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na⁺]_R), adjacent native cartilage ([Na⁺]_N), and native cartilage within the opposite, non-surgical compartment ([Na⁺]_N2) were calculated using external NaCl phantoms.

Results

For conventional sodium imaging, mean [Na⁺]_R, [Na⁺]_N, [Na⁺]_N2 were 177.8 ± 54.1 mM, 170.1 ± 40.7 mM, 172.2 ± 30 mM respectively. Differences in [Na⁺]_R versus [Na⁺]_N (P = 0.59) and [Na⁺]_N versus [Na⁺]_N2 (P = 0.89) were not significant. For sodium IR imaging, mean [Na⁺]_R, [Na⁺]_N, [Na⁺]_N2 were 108.9 ± 29.8 mM, 204.6 ± 34.7 mM, 249.9 ± 44.6 mM respectively. Decreases in [Na⁺]_R versus [Na⁺]_N (P = 0.0.0000035) and [Na⁺]_N versus [Na⁺]_N2 (P = 0.015) were significant.

Conclusions

Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na⁺] within cartilage repair and native tissue.

Key Points

• NaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid.

• NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone.

• This may facilitate more accurate assessment of repair tissue composition and quality.

Williams RJ (2007) Cartilage repair strategies. Humana Press, TotowaCrossRef

Trattnig S, Domayer S, Welsch GW, Mosher T, Eckstein F (2009) MR imaging of cartilage and its repair in the knee – a review. Eur Radiol 19:1582–1594PubMedCrossRef

Marlovits S, Striessnig G, Resinger CT et al (2004) Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging. Eur J Radiol 52:310–319PubMedCrossRef

Potter HG, Foo LF (2006) Magnetic resonance imaging of articular cartilage: trauma, degeneration, and repair. Am J Sports Med 34:661–677PubMedCrossRef

Trattnig S, Mamisch TC, Welsch GH et al (2007) Quantitative T2 mapping of matrix-associated autologous chondrocyte transplantation at 3 Tesla: an in vivo cross-sectional study. Invest Radiol 42:442–448PubMedCrossRef

Trattnig S, Mamisch TC, Pinker K et al (2008) Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla. Eur Radiol 18:1251–1259PubMedCrossRef

White LM, Sussman MS, Hurtig M, Probyn L, Tomlinson G, Kandel R (2006) Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects. Radiology 241:407–414PubMedCrossRef

Trattnig S, Welsch GH, Juras V et al (2010) 23Na MR imaging at 7 T after knee matrix-associated autologous chondrocyte transplantation preliminary results. Radiology 257:175–184PubMedCrossRef

Schmitt B, Zbyn S, Stelzeneder D et al (2011) Cartilage quality assessment by using glycosaminoglycan chemical exchange saturation transfer and 23Na MR imaging at 7 T. Radiology 260:257–264PubMedCrossRef

10.

Trattnig S, Marlovits S, Gebetsroither S et al (2007) Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3.0 T: preliminary results. J Magn Reson Imaging 26:974–982PubMedCrossRef

11.

Mosher TJ, Dardzinski BJ (2004) Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol 8:355–368PubMedCrossRef

12.

Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R (2006) Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 19:781–821PubMedCrossRef

13.

Li X, Benjamin Ma C, Link TM et al (2007) In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthr Cart 15:789–797CrossRef

14.

Burstein D, Gray M, Mosher T, Dardzinski B (2009) Measures of molecular composition and structure in osteoarthritis. Radiol Clin North Am 47:675–686PubMedCrossRef

15.

Ling W, Regatte RR, Navon G, Jerschow A (2008) Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci USA 105:2266–2270PubMedCrossRef

16.

Wang L, Wu Y, Chang G et al (2009) Rapid isotropic 3D-sodium MRI of the knee joint in vivo at 7 T. J Magn Reson Imaging 30:606–614PubMedCrossRef

17.

Staroswiecki E, Bangerter NK, Gurney PT, Grafendorfer T, Gold GE, Hargreaves BA (2010) In vivo sodium imaging of human patellar cartilage with a 3D cones sequence at 3 T and 7 T. J Magn Reson Imaging 32:446–451PubMedCrossRef

18.

Wheaton AJ, Borthakur A, Shapiro EM et al (2004) Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging – feasibility study. Radiology 231:900–905PubMedCrossRef

19.

Madelin G, Lee JS, Inati S, Jerschow A, Regatte RR (2010) Sodium inversion recovery MRI of the knee joint in vivo at 7 T. J Magn Reson 207:42–52PubMedCrossRef

20.

Stobbe R, Beaulieu C (2005) In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation. Magn Reson Med 54:1305–1310PubMedCrossRef

21.

Marlovits S, Singer P, Zeller P, Mandl I, Haller J, Trattnig S (2006) Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol 57:16–23PubMedCrossRef

22.

Madelin G, Jerschow A, Regatte RR (2011) Sodium relaxation times in the knee joint in vivo at 7 T. NMR Biomed. doi:10.1002/nbm.1768

23.

Shapiro EM, Borthakur A, Kaufman JH, Leigh JS, Reddy R (2001) Water distribution patterns inside bovine articular cartilage as visualized by 1H magnetic resonance imaging. Osteoarthr Cart 9:533–538CrossRef

24.

Borthakur A, Shapiro EM, Akella SV, Gougoutas A, Kneeland JB, Reddy R (2002) Quantifying sodium in the human wrist in vivo by using MR imaging. Radiology 224:598–602PubMedCrossRef

25.

Kuettner KE (1992) Biochemistry of articular cartilage in health and disease. Clin Biochem 25:155–163PubMedCrossRef

26.

Madelin G, Babb JS, Xia D, Chang G, Jerschow A, Regatte RR (2011) Reproducibility and repeatibility of quantitative sodium MRI in vivo in articular cartilage at 3 T and 7 T. Magn Reson Med. doi:10.1002/mrm.23307

27.

Glaser C, Mendlik T, Dinges J et al (2006) Global and regional reproducibility of T2 relaxation time measurements in human patellar cartilage. Magn Reson Med 56:527–534PubMedCrossRef

28.

Mosher TJ, Zhang Z, Reddy R et al (2011) Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 multicenter trial. Radiology 258:832–842PubMedCrossRef

29.

Welsch GH, Apprich S, Zbyn S et al (2010) Biochemical (T2, T2* and magnetisation transfer ratio) MRI of knee cartilage: feasibility at ultra-high field (7 T) compared with high field (3 T) strength. Eur Radiol

30.

DiMicco MA, Patwari P, Siparsky PN et al (2004) Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum 50:840–848PubMedCrossRef

31.

Tochigi Y, Buckwalter JA, Martin JA et al (2011) Distribution and progression of chondrocyte damage in a whole-organ model of human ankle intra-articular fracture. J Bone Joint Surg Am 93:533–539PubMedCrossRef

32.

Bansal N, Szczepaniak L, Ternullo D, Fleckenstein JL, Malloy CR (2000) Effect of exercise on (23)Na MRI and relaxation characteristics of the human calf muscle. J Magn Reson Imaging 11:532–538PubMedCrossRef

Titel: Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: preliminary results
verfasst von: Gregory Chang
Guillaume Madelin
Orrin H. Sherman
Eric J. Strauss
Ding Xia
Michael P. Recht
Alexej Jerschow
Ravinder R. Regatte
Publikationsdatum: 01.06.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 6/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2383-8

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Improved assessment of cartilage repair tissue using fluid-suppressed ²³Na inversion recovery MRI at 7 Tesla: preliminary results

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Objectives

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Conclusions

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