nach oben

Erschienen in:

01.08.2013 | Chest

Tomosynthesis for the early detection of pulmonary emphysema: diagnostic performance compared with chest radiography, using multidetector computed tomography as reference

verfasst von: Yoshitake Yamada, Masahiro Jinzaki, Masahiro Hashimoto, Eisuke Shiomi, Takayuki Abe, Sachio Kuribayashi, Kenji Ogawa

Erschienen in: European Radiology | Ausgabe 8/2013

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To compare the diagnostic performance of tomosynthesis with that of chest radiography for the detection of pulmonary emphysema, using multidetector computed tomography (MDCT) as reference.

Methods

Forty-eight patients with and 63 without pulmonary emphysema underwent chest MDCT, tomosynthesis and radiography on the same day. Two blinded radiologists independently evaluated the tomosynthesis images and radiographs for the presence of pulmonary emphysema. Axial and coronal MDCT images served as the reference standard and the percentage lung volume with attenuation values of −950 HU or lower (LAA₋₉₅₀) was evaluated to determine the extent of emphysema. Receiver-operating characteristic (ROC) analysis and generalised estimating equations model were used.

Results

ROC analysis revealed significantly better performance (P < 0.0001) of tomosynthesis than radiography for the detection of pulmonary emphysema. The average sensitivity, specificity, positive predictive value and negative predictive value of tomosynthesis were 0.875, 0.968, 0.955 and 0.910, respectively, whereas the values for radiography were 0.479, 0.913, 0.815 and 0.697, respectively. For both tomosynthesis and radiography, the sensitivity increased with increasing LAA₋₉₅₀.

Conclusions

The diagnostic performance of tomosynthesis was significantly superior to that of radiography for the detection of pulmonary emphysema. In both tomosynthesis and radiography, the sensitivity was affected by the LAA₋₉₅₀.

Key Points

• Tomosynthesis showed significantly better diagnostic performance for pulmonary emphysema than radiography.

• Interobserver agreement for tomosynthesis was significantly higher than that for radiography.

• Sensitivity increased with increasing LAA ₋₉₅₀ in both tomosynthesis and radiography.

• Tomosynthesis imparts a similar radiation dose to two projection chest radiography.

• Radiation dose and cost of tomosynthesis are lower than those of MDCT.

Litmanovich D, Boiselle PM, Bankier AA (2009) CT of pulmonary emphysema—current status, challenges, and future directions. Eur Radiol 19:537–551PubMedCrossRef

Geitung JT, Skjaerstad LM, Gothlin JH (1999) Clinical utility of chest roentgenograms. Eur Radiol 9:721–723PubMedCrossRef

Speets AM, van der Graaf Y, Hoes AW et al (2006) Chest radiography in general practice: indications, diagnostic yield and consequences for patient management. Br J Gen Pract 56:574–578PubMed

Washko GR (2010) Diagnostic imaging in COPD. Semin Respir Crit Care Med 31:276–285PubMedCrossRef

Coxson HO, Rogers RM (2005) Quantitative computed tomography of chronic obstructive pulmonary disease. Acad Radiol 12:1457–1463PubMedCrossRef

Mets OM, de Jong PA, van Ginneken B, Gietema HA, Lammers JW (2012) Quantitative computed tomography in COPD: possibilities and limitations. Lung 190:133–145PubMedCrossRef

Mayo JR, Aldrich J, Muller NL (2003) Radiation exposure at chest CT: a statement of the Fleischner Society. Radiology 228:15–21PubMedCrossRef

Payne JT (2005) CT radiation dose and image quality. Radiol Clin North Am 43:953–962, viiPubMedCrossRef

Grant DG (1972) Tomosynthesis: a three-dimensional radiographic imaging technique. IEEE Trans Biomed Eng 19:20–28PubMedCrossRef

10.

McAdams HP, Samei E, Dobbins J III, Tourassi GD, Ravin CE (2006) Recent advances in chest radiography. Radiology 241:663–683PubMedCrossRef

11.

Sone S, Kasuga T, Sakai F et al (1991) Development of a high-resolution digital tomosynthesis system and its clinical application. Radiographics 11:807–822PubMed

12.

Dobbins JT III, Godfrey DJ (2003) Digital x-ray tomosynthesis: current state of the art and clinical potential. Phys Med Biol 48:R65–R106PubMedCrossRef

13.

Dobbins JT III, McAdams HP, Godfrey DJ, Li CM (2008) Digital tomosynthesis of the chest. J Thorac Imaging 23:86–92PubMedCrossRef

14.

Dobbins JT, McAdams HP, Song JW et al (2008) Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Med Phys 35:2554–2557CrossRef

15.

Johnsson AA, Vikgren J, Svalkvist A et al (2010) Overview of two years of clinical experience of chest tomosynthesis at Sahlgrenska University Hospital. Radiat Prot Dosim 139:124–129CrossRef

16.

Vikgren J, Zachrisson S, Svalkvist A et al (2008) Comparison of chest tomosynthesis and chest radiography for detection of pulmonary nodules: human observer study of clinical cases. Radiology 249:1034–1041PubMedCrossRef

17.

Dobbins JT 3rd, McAdams HP (2009) Chest tomosynthesis: technical principles and clinical update. Eur J Radiol 72:244–251PubMedCrossRef

18.

Kim EY, Chung MJ, Lee HY, Koh WJ, Jung HN, Lee KS (2010) Pulmonary mycobacterial disease: diagnostic performance of low-dose digital tomosynthesis as compared with chest radiography. Radiology 257:269–277PubMedCrossRef

19.

Quaia E, Baratella E, Cioffi V et al (2010) The value of digital tomosynthesis in the diagnosis of suspected pulmonary lesions on chest radiography: analysis of diagnostic accuracy and confidence. Acad Radiol 17:1267–1274PubMedCrossRef

20.

Yamada Y, Jinzaki M, Hasegawa I et al (2011) Fast scanning tomosynthesis for the detection of pulmonary nodules: diagnostic performance compared with chest radiography, using multidetector-row computed tomography as the reference. Invest Radiol 46:471–477PubMedCrossRef

21.

Servomaa A, Tapiovaara M (1998) Organ dose calculation in medical X ray examinations by the program PCXMC. Radiat Prot Dosim 80:213–219CrossRef

22.

(2007) The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. Ann ICRP 37:1–332

23.

European Guidelines on Quality Criteria for Computed Tomography (1999) Report EUR 16262. European Commission, Brussels. Available at: http://www.drs.dk/guidelines/ct/quality/index.htm. Accessed 18 Aug 2012

24.

Sutinen S, Christoforidis AJ, Klugh GA, Pratt PC (1965) Roentgenologic criteria for the recognition of nonsymptomatic pulmonary emphysema. Correlation between roentgenologic findings and pulmonary pathology. Am Rev Respir Dis 91:69–76PubMed

25.

Nicklaus TM, Stowell DW, Christiansen WR, Renzetti AD Jr (1966) The accuracy of the roentgenologic diagnosis of chronic pulmonary emphysema. Am Rev Respir Dis 93:889–899PubMed

26.

Washko GR, Hunninghake GM, Fernandez IE et al (2011) Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 364:897–906PubMedCrossRef

27.

Kim WJ, Silverman EK, Hoffman E et al (2009) CT metrics of airway disease and emphysema in severe COPD. Chest 136:396–404PubMedCrossRef

28.

Gierada DS, Guniganti P, Newman BJ et al (2011) Quantitative CT assessment of emphysema and airways in relation to lung cancer risk. Radiology 261:950–959PubMedCrossRef

29.

Brenner DJ, Hall EJ (2007) Computed tomography—an increasing source of radiation exposure. N Engl J Med 357:2277–2284PubMedCrossRef

30.

Quaia E, Baratella E, Cernic S et al (2012) Analysis of the impact of digital tomosynthesis on the radiological investigation of patients with suspected pulmonary lesions on chest radiography. Eur Radiol 22:1912–1922PubMedCrossRef

31.

Friedman PJ (2008) Imaging studies in emphysema. Proc Am Thorac Soc 5:494–500PubMedCrossRef

32.

Gurney JW (1998) Pathophysiology of obstructive airways disease. Radiol Clin North Am 36:15–27PubMedCrossRef

33.

Uppaluri R, Mitsa T, Sonka M, Hoffman EA, McLennan G (1997) Quantification of pulmonary emphysema from lung computed tomography images. Am J Respir Crit Care Med 156:248–254PubMedCrossRef

34.

Sanders C, Nath PH, Bailey WC (1988) Detection of emphysema with computed tomography. Correlation with pulmonary function tests and chest radiography. Invest Radiol 23:262–266PubMedCrossRef

35.

Price D, Freeman D, Cleland J, Kaplan A, Cerasoli F (2011) Earlier diagnosis and earlier treatment of COPD in primary care. Prim Care Respir J 20:15–22PubMedCrossRef

36.

O’Donnell DE, Hernandez P, Kaplan A et al (2008) Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease—2008 update—highlights for primary care. Can Respir J 15:1A–8APubMed

37.

Yamada Y, Jinzaki M, Tanami Y et al (2012) Model-based iterative reconstruction technique for ultralow-dose computed tomography of the lung: a pilot study. Invest Radiol 47:482–489PubMedCrossRef

Titel: Tomosynthesis for the early detection of pulmonary emphysema: diagnostic performance compared with chest radiography, using multidetector computed tomography as reference
verfasst von: Yoshitake Yamada
Masahiro Jinzaki
Masahiro Hashimoto
Eisuke Shiomi
Takayuki Abe
Sachio Kuribayashi
Kenji Ogawa
Publikationsdatum: 01.08.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 8/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-2814-1

Neu im Fachgebiet Radiologie

18.04.2024 | Pädiatrische Notfallmedizin | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Tomosynthesis for the early detection of pulmonary emphysema: diagnostic performance compared with chest radiography, using multidetector computed tomography as reference

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2013

Planning deep inferior epigastric perforator flaps for breast reconstruction: a comparison between multidetector computed tomography and magnetic resonance angiography

Diffusion-weighted and T2-weighted MR imaging for colorectal liver metastases detection in a rat model at 7 T: a comparative study using histological examination as reference

Detection of residual packets in cocaine body packers: low accuracy of abdominal radiography—a prospective study

Mammographic features of calcifications in DCIS: correlation with oestrogen receptor and human epidermal growth factor receptor 2 status

Perfusion CT allows prediction of therapy response in non-small cell lung cancer treated with conventional and anti-angiogenic chemotherapy

Anatomical study of the dorsal cutaneous branch of the ulnar nerve using ultrasound

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Update Radiologie