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01.09.2013 | Nuclear Medicine

Comparative diagnostic accuracy of contrast-enhanced MRI and ¹⁸F-FDOPA PET-CT in recurrent glioma

verfasst von: Sellam Karunanithi, Punit Sharma, Abhishek Kumar, Bangkim Chandra Khangembam, Guru Pada Bandopadhyaya, Rakesh Kumar, Ajit Goenka, Deepak Kumar Gupta, Arun Malhotra, Chandrasekhar Bal

Erschienen in: European Radiology | Ausgabe 9/2013

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Abstract

Objectives

To compare the diagnostic accuracy of contrast enhanced magnetic resonance imaging (Ce-MRI) and ¹⁸F-fluorodopa (¹⁸F-FDOPA) positron emission tomography (PET)-computed tomography (CT) for detecting recurrent glioma.

Methods

In this prospective study, 35 patients (age, 36.62 ± 0.86 years; 80 % male) with histopathologically proven glioma with clinical suspicion of recurrence were evaluated using Ce-MRI and ¹⁸F-FDOPA PET-CT. ¹⁸F-FDOPA PET-CT images were evaluated qualitatively and semi-quantitatively. Combination of clinical follow-up (minimum 1 year), repeat imaging and/or biopsy (when available) was taken as the reference standard.

Results

Based on the reference standard, 26 patients were positive and nine were negative for recurrence. The sensitivity, specificity and accuracy of Ce-MRI were 92.3 %, 44.4 % and 80 % respectively, whereas those of ¹⁸F-FDOPA PET-CT were 100 %, 88.89 % and 97.1 % respectively. Results of Ce-MRI and ¹⁸F-FDOPA PET-CT were concordant in 74.3 % (29/35) and discordant in 17.1 % of patients (6/35). On McNemar analysis the difference was not statistically significant overall (P = 0.687), for high-grade tumour (P = 0.5) or low-grade tumours (P = 1.0). However, ¹⁸F-FDOPA PET-CT was more specific than Ce-MRI overall (P = 0.0002), for high-grade tumour (P = 0.006) and low-grade tumours (P = 0.004).

Conclusion

F-FDOPA PET-CT shows a high but comparable diagnostic accuracy to Ce-MRI for the detection of recurrent glioma. However, it is more specific than Ce-MRI.

Key Points

• Recurrent glioma in the postoperative site remains a diagnostic dilemma.

• ¹⁸ F-FDOPA PET-CT shows high diagnostic accuracy for detecting recurrent glioma.

• Diagnostic accuracies for ¹⁸ F-FDOPA PET-CT and contrast enhanced MRI are comparable.

• However, ¹⁸ F-FDOPA PET-CT is more specific than Ce-MRI for recurrent glioma.

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Titel: Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma
verfasst von: Sellam Karunanithi
Punit Sharma
Abhishek Kumar
Bangkim Chandra Khangembam
Guru Pada Bandopadhyaya
Rakesh Kumar
Ajit Goenka
Deepak Kumar Gupta
Arun Malhotra
Chandrasekhar Bal
Publikationsdatum: 01.09.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-2838-6

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Comparative diagnostic accuracy of contrast-enhanced MRI and ¹⁸F-FDOPA PET-CT in recurrent glioma

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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