Skip to main content
Erschienen in: European Radiology 10/2013

01.10.2013 | Magnetic Resonance

Intravoxel incoherent motion model-based liver lesion characterisation from three b-value diffusion-weighted MRI

verfasst von: A.-H. Penner, A. M. Sprinkart, G. M. Kukuk, I. Gütgemann, J. Gieseke, H. H. Schild, W. A. Willinek, P. Mürtz

Erschienen in: European Radiology | Ausgabe 10/2013

Einloggen, um Zugang zu erhalten

Abstract

Objective

To evaluate intravoxel incoherent motion (IVIM) model-based liver lesion characterisation from three b-value diffusion-weighted imaging (DWI).

Methods

The 1.5-T DWI data from a respiratory gated spin-echo echo-planar magnetic resonance imaging sequence (b = 0, 50, 800 s/mm2) were retrospectively analysed in 38 patients with different liver lesions. Conventional apparent diffusion coefficient ADC = ADC(0,800) as well as IVIM-based parameters D′ = ADC(50,800), ADC_low = ADC(0,50), and f′ were calculated voxel-wise. Sixty-one regions of interest in hepatocellular carcinomas (HCCs, n = 24), haemangiomas (HEMs, n = 11), focal nodular hyperplasias (FNHs, n = 11), and healthy liver tissue (REFs, n = 15) were analysed. Group differences were investigated using Student’s t-test and receiver-operating characteristic (ROC) analysis.

Results

Mean values ± standard deviations of ADC, D′, ADC_low (in 10-5 mm2/s), and f′ (in %) for REFs/FNHs/HEMs/HCCs were 130 ± 11/143 ± 27/168 ± 16/113 ± 25, 104 ± 12/123 ± 25/162 ± 18/102 ± 23, 518 ± 66/437 ± 97/268 ± 69/283 ± 120, and 18 ± 3/14 ± 4/6 ± 3/9 ± 5, respectively. Differences between lesions and REFs were more significant for IVIM-based parameters than for conventional ADC. ROC analysis showed the best discriminability between HCCs and FNHs for ADC_low and f′ and between HEMs and FNHs or HCCs for D′.

Conclusion

Three instead of two b-value DWI enables a numerically stable and voxel-wise IVIM-based analysis for improved liver lesion characterisation with tolerable acquisition time.

Key Points

Quantitative analysis of diffusion-weighted MRI helps liver lesion characterisation.
Analysis of intravoxel incoherent motion is superior to apparent diffusion coefficient determination.
Only three b-values enable separation of diffusion and microcirculation effects.
The method presented is numerically stable, with voxel-wise results and short acquisition times.
Literatur
1.
Zurück zum Zitat Padhani AR, Liu G, Koh DM et al (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: Consensus and recommendations. Neoplasia 11:102–125PubMed Padhani AR, Liu G, Koh DM et al (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: Consensus and recommendations. Neoplasia 11:102–125PubMed
2.
3.
Zurück zum Zitat Taouli B (2012) Diffusion-weighted MR imaging for liver lesion characterization: A critical look. Radiology 262:378–380PubMedCrossRef Taouli B (2012) Diffusion-weighted MR imaging for liver lesion characterization: A critical look. Radiology 262:378–380PubMedCrossRef
4.
Zurück zum Zitat Sinkus R, Van Beers BE, Vilgrain V, DeSouza N, Waterton JC (2012) Apparent diffusion coefficient from magnetic resonance imaging as a biomarker in oncology drug development. Eur J Cancer 48:425–431PubMedCrossRef Sinkus R, Van Beers BE, Vilgrain V, DeSouza N, Waterton JC (2012) Apparent diffusion coefficient from magnetic resonance imaging as a biomarker in oncology drug development. Eur J Cancer 48:425–431PubMedCrossRef
5.
Zurück zum Zitat Takahara T, Kwee TC (2012) Low b-value diffusion-weighted imaging: Emerging applications in the body. J Magn Reson Imaging 35:1266–1273PubMedCrossRef Takahara T, Kwee TC (2012) Low b-value diffusion-weighted imaging: Emerging applications in the body. J Magn Reson Imaging 35:1266–1273PubMedCrossRef
6.
Zurück zum Zitat Kwee TC, Takahara T (2011) Diffusion-weighted MRI for detecting liver metastases: Importance of the b-value. Eur Radiol 21:150PubMedCrossRef Kwee TC, Takahara T (2011) Diffusion-weighted MRI for detecting liver metastases: Importance of the b-value. Eur Radiol 21:150PubMedCrossRef
7.
Zurück zum Zitat Goshima S, Kanematsu M, Kondo H et al (2008) Diffusion-weighted imaging of the liver: Optimizing b value for the detection and characterization of benign and malignant hepatic lesions. J Magn Reson Imaging 28:691–697PubMedCrossRef Goshima S, Kanematsu M, Kondo H et al (2008) Diffusion-weighted imaging of the liver: Optimizing b value for the detection and characterization of benign and malignant hepatic lesions. J Magn Reson Imaging 28:691–697PubMedCrossRef
8.
Zurück zum Zitat Parikh T, Drew SJ, Lee VS et al (2008) Focal liver lesion detection and characterization with diffusion-weighted MR imaging: Comparison with standard breath-hold T2-weighted imaging. Radiology 246:812–822PubMedCrossRef Parikh T, Drew SJ, Lee VS et al (2008) Focal liver lesion detection and characterization with diffusion-weighted MR imaging: Comparison with standard breath-hold T2-weighted imaging. Radiology 246:812–822PubMedCrossRef
9.
Zurück zum Zitat Gourtsoyianni S, Papanikolaou N, Yarmenitis S, Maris T, Karantanas A, Gourtsoyiannis N (2008) Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions. Eur Radiol 18:486–492PubMedCrossRef Gourtsoyianni S, Papanikolaou N, Yarmenitis S, Maris T, Karantanas A, Gourtsoyiannis N (2008) Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions. Eur Radiol 18:486–492PubMedCrossRef
10.
Zurück zum Zitat Coenegrachts K, Delanote J, Ter BL et al (2007) Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques. Br J Radiol 80:524–531PubMedCrossRef Coenegrachts K, Delanote J, Ter BL et al (2007) Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques. Br J Radiol 80:524–531PubMedCrossRef
11.
Zurück zum Zitat Koh DM, Collins DJ, Orton MR (2011) Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges. AJR Am J Roentgenol 196:1351–1361PubMedCrossRef Koh DM, Collins DJ, Orton MR (2011) Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges. AJR Am J Roentgenol 196:1351–1361PubMedCrossRef
12.
Zurück zum Zitat Guiu B, Cercueil JP (2011) Liver diffusion-weighted MR imaging: The tower of Babel? Eur Radiol 21:463–467PubMedCrossRef Guiu B, Cercueil JP (2011) Liver diffusion-weighted MR imaging: The tower of Babel? Eur Radiol 21:463–467PubMedCrossRef
13.
Zurück zum Zitat Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMed Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMed
14.
Zurück zum Zitat Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: Application to diffusion and perfusion in neurologic disorders. Radiology 161:401–407PubMed Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: Application to diffusion and perfusion in neurologic disorders. Radiology 161:401–407PubMed
15.
Zurück zum Zitat Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H (1999) Diffusion coefficients in abdominal organs and hepatic lesions: Evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 210:617–623PubMed Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H (1999) Diffusion coefficients in abdominal organs and hepatic lesions: Evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 210:617–623PubMed
16.
Zurück zum Zitat Le Bihan D (2008) Intravoxel incoherent motion perfusion MR imaging: A wake-up call. Radiology 249:748–752PubMedCrossRef Le Bihan D (2008) Intravoxel incoherent motion perfusion MR imaging: A wake-up call. Radiology 249:748–752PubMedCrossRef
17.
Zurück zum Zitat Dyvorne HA, Galea N, Nevers T et al (2013) Diffusion-weighted imaging of the liver with multiple b values: Effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters—a pilot study. Radiology 266:920–929 Dyvorne HA, Galea N, Nevers T et al (2013) Diffusion-weighted imaging of the liver with multiple b values: Effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters—a pilot study. Radiology 266:920–929
18.
Zurück zum Zitat Andreou A, Koh DM, Collins DJ et al (2013) Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases. Eur Radiol 23:428–434PubMedCrossRef Andreou A, Koh DM, Collins DJ et al (2013) Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases. Eur Radiol 23:428–434PubMedCrossRef
19.
Zurück zum Zitat Leitao HS, Doblas S, D’Assignies G et al (2013) Fat deposition decreases diffusion parameters at MRI: a study in phantoms and patients with liver steatosis. Eur Radiol 23:461–467PubMedCrossRef Leitao HS, Doblas S, D’Assignies G et al (2013) Fat deposition decreases diffusion parameters at MRI: a study in phantoms and patients with liver steatosis. Eur Radiol 23:461–467PubMedCrossRef
20.
Zurück zum Zitat Guiu B, Petit JM, Capitan V et al (2012) Intravoxel incoherent motion diffusion-weighted imaging in nonalcoholic fatty liver disease: A 3.0-T MR study. Radiology 265:96–103PubMedCrossRef Guiu B, Petit JM, Capitan V et al (2012) Intravoxel incoherent motion diffusion-weighted imaging in nonalcoholic fatty liver disease: A 3.0-T MR study. Radiology 265:96–103PubMedCrossRef
21.
Zurück zum Zitat Lee JT, Liau J, Murphy P, Schroeder ME, Sirlin CB, Bydder M (2012) Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging. Magn Reson Imaging 30:572–578PubMedCrossRef Lee JT, Liau J, Murphy P, Schroeder ME, Sirlin CB, Bydder M (2012) Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging. Magn Reson Imaging 30:572–578PubMedCrossRef
22.
Zurück zum Zitat Dijkstra H, Baron P, Kappert P, Oudkerk M, Sijens PE (2012) Effects of microperfusion in hepatic diffusion weighted imaging. Eur Radiol 22:891–899PubMedCrossRef Dijkstra H, Baron P, Kappert P, Oudkerk M, Sijens PE (2012) Effects of microperfusion in hepatic diffusion weighted imaging. Eur Radiol 22:891–899PubMedCrossRef
23.
Zurück zum Zitat Lewin M, Arrive L, Lacombe C et al (2010) Diffusion-weighted MR imaging of liver pathology: Principles and clinical applications. J Radiol 91:11–26PubMedCrossRef Lewin M, Arrive L, Lacombe C et al (2010) Diffusion-weighted MR imaging of liver pathology: Principles and clinical applications. J Radiol 91:11–26PubMedCrossRef
24.
Zurück zum Zitat Luciani A, Vignaud A, Cavet M et al (2008) Liver cirrhosis: intravoxel incoherent motion MR imaging–pilot study. Radiology 249:891–899PubMedCrossRef Luciani A, Vignaud A, Cavet M et al (2008) Liver cirrhosis: intravoxel incoherent motion MR imaging–pilot study. Radiology 249:891–899PubMedCrossRef
25.
Zurück zum Zitat Patel J, Sigmund EE, Rusinek H, Oei M, Babb JS, Taouli B (2010) Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging 31:589–600PubMedCrossRef Patel J, Sigmund EE, Rusinek H, Oei M, Babb JS, Taouli B (2010) Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging 31:589–600PubMedCrossRef
26.
Zurück zum Zitat Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: An update. Hepatology 53:1020–1022PubMedCrossRef Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: An update. Hepatology 53:1020–1022PubMedCrossRef
27.
Zurück zum Zitat Steudel A, Träber F, Reiser M (1993) Hepatic tumors: relaxometry and quantitative tissue characterization with magnetic resonance imaging. Frontiers Eur Radiol 9:45–61CrossRef Steudel A, Träber F, Reiser M (1993) Hepatic tumors: relaxometry and quantitative tissue characterization with magnetic resonance imaging. Frontiers Eur Radiol 9:45–61CrossRef
28.
Zurück zum Zitat Stanisz GJ, Odrobina EE, Pun J et al (2005) T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med 54:507–512PubMedCrossRef Stanisz GJ, Odrobina EE, Pun J et al (2005) T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med 54:507–512PubMedCrossRef
29.
Zurück zum Zitat Lewin M, Fartoux L, Vignaud A, Arrive L, Menu Y, Rosmorduc O (2011) The diffusion-weighted imaging perfusion fraction f is a potential marker of sorafenib treatment in advanced hepatocellular carcinoma: A pilot study. Eur Radiol 21:281–290PubMedCrossRef Lewin M, Fartoux L, Vignaud A, Arrive L, Menu Y, Rosmorduc O (2011) The diffusion-weighted imaging perfusion fraction f is a potential marker of sorafenib treatment in advanced hepatocellular carcinoma: A pilot study. Eur Radiol 21:281–290PubMedCrossRef
30.
Zurück zum Zitat Lemke A, Stieltjes B, Schad LR, Laun FB (2011) Toward an optimal distribution of b values for intravoxel incoherent motion imaging. Magn Reson Imaging 29:766–776PubMedCrossRef Lemke A, Stieltjes B, Schad LR, Laun FB (2011) Toward an optimal distribution of b values for intravoxel incoherent motion imaging. Magn Reson Imaging 29:766–776PubMedCrossRef
31.
Zurück zum Zitat Cho GY, Kim S, Jensen JH, Storey P, Sodickson DK, Sigmund EE (2012) A versatile flow phantom for intravoxel incoherent motion MRI. Magn Reson Med 67:1710–1720PubMedCrossRef Cho GY, Kim S, Jensen JH, Storey P, Sodickson DK, Sigmund EE (2012) A versatile flow phantom for intravoxel incoherent motion MRI. Magn Reson Med 67:1710–1720PubMedCrossRef
32.
Zurück zum Zitat Koh DM, Blackledge M, Collins DJ et al (2009) Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial. Eur Radiol 19:2728–2738PubMedCrossRef Koh DM, Blackledge M, Collins DJ et al (2009) Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial. Eur Radiol 19:2728–2738PubMedCrossRef
33.
Zurück zum Zitat Coenegrachts K, Delanote J, Ter BL et al (2009) Evaluation of true diffusion, perfusion factor, and apparent diffusion coefficient in non-necrotic liver metastases and uncomplicated liver hemangiomas using black-blood echo planar imaging. Eur J Radiol 69:131–138PubMedCrossRef Coenegrachts K, Delanote J, Ter BL et al (2009) Evaluation of true diffusion, perfusion factor, and apparent diffusion coefficient in non-necrotic liver metastases and uncomplicated liver hemangiomas using black-blood echo planar imaging. Eur J Radiol 69:131–138PubMedCrossRef
34.
Zurück zum Zitat Schraml C, Schwenzer NF, Martirosian P et al (2009) Diffusion-weighted MRI of advanced hepatocellular carcinoma during sorafenib treatment: initial results. AJR Am J Roentgenol 193:W301–W307PubMedCrossRef Schraml C, Schwenzer NF, Martirosian P et al (2009) Diffusion-weighted MRI of advanced hepatocellular carcinoma during sorafenib treatment: initial results. AJR Am J Roentgenol 193:W301–W307PubMedCrossRef
35.
Zurück zum Zitat Bruegel M, Holzapfel K, Gaa J et al (2008) Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique. Eur Radiol 18:477–485PubMedCrossRef Bruegel M, Holzapfel K, Gaa J et al (2008) Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique. Eur Radiol 18:477–485PubMedCrossRef
36.
Zurück zum Zitat Moteki T, Horikoshi H (2006) Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted echo-planar MR with three values of gradient b-factor. J Magn Reson Imaging 24:637–645PubMedCrossRef Moteki T, Horikoshi H (2006) Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted echo-planar MR with three values of gradient b-factor. J Magn Reson Imaging 24:637–645PubMedCrossRef
37.
Zurück zum Zitat Aoyagi T, Shuto K, Okazumi S et al (2012) Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis. Eur Radiol 22:1172–1177PubMedCrossRef Aoyagi T, Shuto K, Okazumi S et al (2012) Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis. Eur Radiol 22:1172–1177PubMedCrossRef
38.
Zurück zum Zitat Le Bihan D, Turner R (1992) The capillary network: A link between IVIM and classical perfusion. Magn Reson Med 27:171–178PubMedCrossRef Le Bihan D, Turner R (1992) The capillary network: A link between IVIM and classical perfusion. Magn Reson Med 27:171–178PubMedCrossRef
39.
Zurück zum Zitat Duong TQ, Kim SG (2000) In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain. Magn Reson Med 43:393–402PubMedCrossRef Duong TQ, Kim SG (2000) In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain. Magn Reson Med 43:393–402PubMedCrossRef
40.
Zurück zum Zitat Coenegrachts K (2009) Magnetic resonance imaging of the liver: New imaging strategies for evaluating focal liver lesions. World J Radiol 1:72–85PubMedCrossRef Coenegrachts K (2009) Magnetic resonance imaging of the liver: New imaging strategies for evaluating focal liver lesions. World J Radiol 1:72–85PubMedCrossRef
41.
Zurück zum Zitat Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1998) Diffusion-weighted MR imaging with a single-shot echoplanar sequence: Detection and characterization of focal hepatic lesions. AJR Am J Roentgenol 170:397–402PubMedCrossRef Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1998) Diffusion-weighted MR imaging with a single-shot echoplanar sequence: Detection and characterization of focal hepatic lesions. AJR Am J Roentgenol 170:397–402PubMedCrossRef
42.
Zurück zum Zitat Xing D, Papadakis NG, Huang CL, Lee VM, Carpenter TA, Hall LD (1997) Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain. Magn Reson Imaging 15:771–784PubMedCrossRef Xing D, Papadakis NG, Huang CL, Lee VM, Carpenter TA, Hall LD (1997) Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain. Magn Reson Imaging 15:771–784PubMedCrossRef
43.
Zurück zum Zitat Lemke A, Laun FB, Simon D, Stieltjes B, Schad LR (2010) An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen. Magn Reson Med 64:1580–1585PubMedCrossRef Lemke A, Laun FB, Simon D, Stieltjes B, Schad LR (2010) An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen. Magn Reson Med 64:1580–1585PubMedCrossRef
44.
Zurück zum Zitat Kartalis N, Loizou L, Edsborg N, Segersvard R, Albiin N (2012) Optimising diffusion-weighted MR imaging for demonstrating pancreatic cancer: A comparison of respiratory-triggered, free-breathing and breath-hold techniques. Eur Radiol 22:2186–2192PubMedCrossRef Kartalis N, Loizou L, Edsborg N, Segersvard R, Albiin N (2012) Optimising diffusion-weighted MR imaging for demonstrating pancreatic cancer: A comparison of respiratory-triggered, free-breathing and breath-hold techniques. Eur Radiol 22:2186–2192PubMedCrossRef
45.
Zurück zum Zitat Taouli B, Sandberg A, Stemmer A et al (2009) Diffusion-weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions. J Magn Reson Imaging 30:561–568PubMedCrossRef Taouli B, Sandberg A, Stemmer A et al (2009) Diffusion-weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions. J Magn Reson Imaging 30:561–568PubMedCrossRef
46.
Zurück zum Zitat Kwee TC, Takahara T, Niwa T et al (2009) Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver. MAGMA 22:319–325PubMedCrossRef Kwee TC, Takahara T, Niwa T et al (2009) Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver. MAGMA 22:319–325PubMedCrossRef
47.
Zurück zum Zitat Nasu K, Kuroki Y, Sekiguchi R, Kazama T, Nakajima H (2006) Measurement of the apparent diffusion coefficient in the liver: Is it a reliable index for hepatic disease diagnosis? Radiat Med 24:438–444PubMedCrossRef Nasu K, Kuroki Y, Sekiguchi R, Kazama T, Nakajima H (2006) Measurement of the apparent diffusion coefficient in the liver: Is it a reliable index for hepatic disease diagnosis? Radiat Med 24:438–444PubMedCrossRef
48.
Zurück zum Zitat Mürtz P, Flacke S, Träber F, van den Brink JS, Gieseke J, Schild HH (2002) Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences. Radiology 224:258–264PubMedCrossRef Mürtz P, Flacke S, Träber F, van den Brink JS, Gieseke J, Schild HH (2002) Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences. Radiology 224:258–264PubMedCrossRef
49.
Zurück zum Zitat Hollingsworth KG, Lomas DJ (2006) Influence of perfusion on hepatic MR diffusion measurement. NMR Biomed 19:231–235PubMedCrossRef Hollingsworth KG, Lomas DJ (2006) Influence of perfusion on hepatic MR diffusion measurement. NMR Biomed 19:231–235PubMedCrossRef
50.
Zurück zum Zitat Bilgili MY (2012) Reproducibility of apparent diffusion coefficients measurements in diffusion-weighted MRI of the abdomen with different b values. Eur J Radiol 81:2066–2068PubMedCrossRef Bilgili MY (2012) Reproducibility of apparent diffusion coefficients measurements in diffusion-weighted MRI of the abdomen with different b values. Eur J Radiol 81:2066–2068PubMedCrossRef
51.
Zurück zum Zitat Rosenkrantz AB, Oei M, Babb JS, Niver BE, Taouli B (2011) Diffusion-weighted imaging of the abdomen at 3.0 Tesla: Image quality and apparent diffusion coefficient reproducibility compared with 1.5 Tesla. J Magn Reson Imaging 33:128–135PubMedCrossRef Rosenkrantz AB, Oei M, Babb JS, Niver BE, Taouli B (2011) Diffusion-weighted imaging of the abdomen at 3.0 Tesla: Image quality and apparent diffusion coefficient reproducibility compared with 1.5 Tesla. J Magn Reson Imaging 33:128–135PubMedCrossRef
52.
Zurück zum Zitat Braithwaite AC, Dale BM, Boll DT, Merkle EM (2009) Short- and midterm reproducibility of apparent diffusion coefficient measurements at 3.0-T diffusion-weighted imaging of the abdomen. Radiology 250:459–465PubMedCrossRef Braithwaite AC, Dale BM, Boll DT, Merkle EM (2009) Short- and midterm reproducibility of apparent diffusion coefficient measurements at 3.0-T diffusion-weighted imaging of the abdomen. Radiology 250:459–465PubMedCrossRef
53.
Zurück zum Zitat Kwee TC, Takahara T, Koh DM, Nievelstein RA, Luijten PR (2008) Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free-breathing diffusion-weighted MR imaging of the liver. J Magn Reson Imaging 28:1141–1148PubMedCrossRef Kwee TC, Takahara T, Koh DM, Nievelstein RA, Luijten PR (2008) Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free-breathing diffusion-weighted MR imaging of the liver. J Magn Reson Imaging 28:1141–1148PubMedCrossRef
54.
Zurück zum Zitat Kim SY, Soo LS, Bumwoo P et al (2012) Reproducibility of measurement of apparent diffusion coefficients of malignant hepatic tumors: Effect of DWI techniques and calculation methods. J Magn Reson Imaging 36:1131–1138PubMedCrossRef Kim SY, Soo LS, Bumwoo P et al (2012) Reproducibility of measurement of apparent diffusion coefficients of malignant hepatic tumors: Effect of DWI techniques and calculation methods. J Magn Reson Imaging 36:1131–1138PubMedCrossRef
55.
Zurück zum Zitat Kim SY, Lee SS, Byun JH et al (2010) Malignant hepatic tumors: short-term reproducibility of apparent diffusion coefficients with breath-hold and respiratory-triggered diffusion-weighted MR imaging. Radiology 255:815–823PubMedCrossRef Kim SY, Lee SS, Byun JH et al (2010) Malignant hepatic tumors: short-term reproducibility of apparent diffusion coefficients with breath-hold and respiratory-triggered diffusion-weighted MR imaging. Radiology 255:815–823PubMedCrossRef
Metadaten
Titel
Intravoxel incoherent motion model-based liver lesion characterisation from three b-value diffusion-weighted MRI
verfasst von
A.-H. Penner
A. M. Sprinkart
G. M. Kukuk
I. Gütgemann
J. Gieseke
H. H. Schild
W. A. Willinek
P. Mürtz
Publikationsdatum
01.10.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 10/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-013-2869-z

Weitere Artikel der Ausgabe 10/2013

European Radiology 10/2013 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.