Erschienen in:
01.02.2014 | Neuro
Grading of Cerebral Glioma with Multiparametric MR Imaging and 18F-FDG-PET: Concordance and Accuracy
verfasst von:
Jeong Hee Yoon, Ji-hoon Kim, Won Jun Kang, Chul-Ho Sohn, Seung Hong Choi, Tae Jin Yun, Yong Eun, Yong Sub Song, Kee-Hyun Chang
Erschienen in:
European Radiology
|
Ausgabe 2/2014
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Abstract
Objectives
To retrospectively evaluate concordance rates and predictive values in concordant cases among multiparametric MR techniques and FDG-PET to grade cerebral gliomas.
Methods
Multiparametric MR imaging and FDG-PET were performed in 60 consecutive patients with cerebral gliomas (12 low-grade and 48 high-grade gliomas). As the dichotomic variables, conventional MRI, minimum apparent diffusion coefficient in diffusion-weighted imaging, maximum relative cerebral blood volume ratio in perfusion-weighted imaging, choline/creatine ratio and (lipid and lactate)/creatine ratio in MR spectroscopy, and maximum standardised uptake value ratio in FDG-PET in low- and high-grade gliomas were compared. Their concordance rates and positive/negative predictive values (PPV/NPV) in concordant cases were obtained for the various combinations of multiparametric MR techniques and FDG-PET.
Results
There were significant differences between low- and high-grade gliomas in all techniques. Combinations of two, three, four, and five out of the five techniques showed concordance rates of 77.0 ± 4.8 %, 65.5 ± 4.0 %, 58.3 ± 2.6 % and 53.3 %, PPV in high-grade concordant cases of 97.3 ± 1.7 %, 99.1 ± 1.4 %, 100.0 ± 0 % and 100.0 % and NPV in low-grade concordant cases of 70.2 ± 7.5 %, 78.0 ± 6.0 %, 80.3 ± 3.4 % and 80.0 %, respectively.
Conclusion
Multiparametric MR techniques and FDG-PET have a concordant tendency in a two-tiered classification for the grading of cerebral glioma. If at least two examinations concordantly indicated high-grade gliomas, the PPV was about 95 %.
Key Points
• Modern imaging techniques can help predict the aggressiveness of cerebral gliomas.
• Multiparametric MRI and FDG-PET have a concordant tendency to grade cerebral gliomas.
• Their high-grade concordant cases revealed at least 95 % positive predictive values.
• Their low-grade concordant cases revealed about 70–80 % negative predictive values.