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European Radiology

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01.06.2014 | Magnetic Resonance

Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (¹H/²³Na) coil: initial experience

verfasst von: Chan Hong Moon, Alessandro Furlan, Jung-Hwan Kim, Tiejun Zhao, Ron Shapiro, Kyongtae Ty Bae

Erschienen in: European Radiology | Ausgabe 6/2014

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Abstract

Objectives

To compare sodium (²³Na) characteristics between native and transplanted kidneys using dual-tuned proton (¹H)/sodium MRI.

Methods

Six healthy volunteers and six renal transplant patients (3 normal function, 3 acute allograft rejection) were included. Proton/sodium MRI was obtained at 3 T using a dual-tuned coil. Signal to noise ratio (SNR), sodium concentration ([²³Na]) and cortico-medullary sodium gradient (CMSG) were measured. Reproducibility of [²³Na] measurement was also tested. SNR, [²³Na] and CMSG of the native and transplanted kidneys were compared.

Results

Proton and sodium images of kidneys were successfully acquired. SNR and [²³Na] measurements of the native kidneys were reproducible at two different sessions. [²³Na] and CMSG of the transplanted kidneys was significantly lower than those of the native kidneys: 153.5 ± 11.9 vs. 192.9 ± 9.6 mM (P = 0.002) and 8.9 ± 1.5 vs. 10.5 ± 0.9 mM/mm (P = 0.041), respectively. [²³Na] and CMSG of the transplanted kidneys with normal function vs. acute rejection were not statistically different.

Conclusions

Sodium quantification of kidneys was reliably performed using proton/sodium MRI. [²³Na] and CMSG of the transplanted kidneys were lower than those of the native kidneys, but without a statistically significant difference between patients with or without renal allograft rejection.

Key Points

• Dual-tuned proton/sodium RF coil enables co-registered proton and sodium MRI.

• Structural and sodium biochemical property can be acquired by dual-tuned proton/sodium MRI.

• Sodium and sodium gradient of kidneys can be measured by dual-tuned MRI.

• Sodium concentration was lower in transplanted kidneys than in native kidneys.

• Sodium gradient of transplanted kidneys was lower than for native kidneys.

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Titel: Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: initial experience
verfasst von: Chan Hong Moon
Alessandro Furlan
Jung-Hwan Kim
Tiejun Zhao
Ron Shapiro
Kyongtae Ty Bae
Publikationsdatum: 01.06.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3138-5

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Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (¹H/²³Na) coil: initial experience

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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