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01.07.2014 | Cardiac

Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET

verfasst von: Yasuka Kikuchi, Noriko Oyama-Manabe, Masanao Naya, Osamu Manabe, Yuuki Tomiyama, Tsukasa Sasaki, Chietsugu Katoh, Kohsuke Kudo, Nagara Tamaki, Hiroki Shirato

Erschienen in: European Radiology | Ausgabe 7/2014

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Abstract

Objectives

This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against ¹⁵O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.

Methods

Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7).

Results

Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFR_CT in the CAD group (2.3 ± 0.8) was significantly lower than that in the validation group (5.2 ± 1.8) (P = 0.0011).

Conclusions

We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP.

Key Points

• MBF and CFR can be calculated using dynamic CTP with 320-row MDCT.

• MBF and CFR showed good correlation between dynamic CTP and PET.

• Lower CFR was well demonstrated in CAD patients by dynamic CTP.

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Titel: Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET
verfasst von: Yasuka Kikuchi
Noriko Oyama-Manabe
Masanao Naya
Osamu Manabe
Yuuki Tomiyama
Tsukasa Sasaki
Chietsugu Katoh
Kohsuke Kudo
Nagara Tamaki
Hiroki Shirato
Publikationsdatum: 01.07.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 7/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3164-3

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Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Neu im Fachgebiet Radiologie

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Wie toxische Männlichkeit der Gesundheit von Männern schadet

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Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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