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01.09.2014 | Magnetic Resonance

Aortic stiffness is associated with white matter integrity in patients with type 1 diabetes

verfasst von: Nathanja Tjeerdema, Linda D. Van Schinkel, Jos J. Westenberg, Saskia G. Van Elderen, Mark A. Van Buchem, Johannes W. Smit, Jeroen Van der Grond, Albert De Roos

Erschienen in: European Radiology | Ausgabe 9/2014

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Abstract

Objective

To assess the association between aortic pulse wave velocity (PWV) as a marker of arterial stiffness and diffusion tensor imaging of brain white matter integrity in patients with type 1 diabetes using advanced magnetic resonance imaging (MRI) technology.

Methods

Forty-one patients with type 1 diabetes (23 men, mean age 44 ± 12 years, mean diabetes duration 24 ± 13 years) were included. Aortic PWV was assessed using through-plane velocity-encoded MRI. Brain diffusion tensor imaging (DTI) measurements were performed on 3-T MRI. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated for white and grey matter integrity. Pearson correlation and multivariable linear regression analyses including cardiovascular risk factors as covariates were assessed.

Results

Multivariable linear regression analyses revealed that aortic PWV is independently associated with white matter integrity FA (β = −0.777, p = 0.008) in patients with type 1 diabetes. This effect was independent of age, gender, mean arterial pressure, body mass index, smoking, duration of diabetes and glycated haemoglobin levels. Aortic PWV was not significantly related to grey matter integrity.

Conclusions

Our data suggest that aortic stiffness is independently associated with reduced white matter integrity in patients with type 1 diabetes.

Key Points

• Aortic stiffness is associated with brain injury.

• Aortic stiffness exposes small vessels to high pressure fluctuations and flow.

• Aortic stiffness is associated with microvascular brain injury in diabetes.

• This suggests a vascular contribution to early subtle microstructural deficits.

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Titel: Aortic stiffness is associated with white matter integrity in patients with type 1 diabetes
verfasst von: Nathanja Tjeerdema
Linda D. Van Schinkel
Jos J. Westenberg
Saskia G. Van Elderen
Mark A. Van Buchem
Johannes W. Smit
Jeroen Van der Grond
Albert De Roos
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3179-9

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Aortic stiffness is associated with white matter integrity in patients with type 1 diabetes

Abstract

Objective

Methods

Results

Conclusions

Key Points

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Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

Key Points

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