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01.10.2014 | Neuro

Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study

verfasst von: Anastasia K. Zikou, Maria Kosmidou, Loukas G. Astrakas, Loukia C. Tzarouchi, Epameinondas Tsianos, Maria I. Argyropoulou

Erschienen in: European Radiology | Ausgabe 10/2014

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Abstract

Objectives

To investigate structural brain changes in inflammatory bowel disease (IBD).

Methods

Brain magnetic resonance imaging (MRI) was performed on 18 IBD patients (aged 45.16 ± 14.71 years) and 20 aged-matched control subjects. The imaging protocol consisted of a sagittal-FLAIR, a T1-weighted high-resolution three-dimensional spoiled gradient-echo sequence, and a multisession spin-echo echo-planar diffusion-weighted sequence. Differences between patients and controls in brain volume and diffusion indices were evaluated using the voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) methods, respectively. The presence of white-matter hyperintensities (WMHIs) was evaluated on FLAIR images.

Results

VBM revealed decreased grey matter (GM) volume in patients in the fusiform and the inferior temporal gyrus bilaterally, the right precentral gyrus, the right supplementary motor area, the right middle frontal gyrus and the left superior parietal gyrus (p < 0.05). TBSS showed decreased axial diffusivity (AD) in the right corticospinal tract and the right superior longitudinal fasciculus in patients compared with controls. A larger number of WMHIs was observed in patients (p < 0.05).

Conclusions

Patients with IBD show an increase in WMHIs and GM atrophy, probably related to cerebral vasculitis and ischaemia. Decreased AD in major white matter tracts could be a secondary phenomenon, representing Wallerian degeneration.

Key Points

• There is evidence of central nervous system involvement in IBD.

• Diffusion tensor imaging detects microstructural brain abnormalities in IBD.

• Voxel based morphometry reveals brain atrophy in IBD.

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Titel: Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study
verfasst von: Anastasia K. Zikou
Maria Kosmidou
Loukas G. Astrakas
Loukia C. Tzarouchi
Epameinondas Tsianos
Maria I. Argyropoulou
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3242-6

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Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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