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01.01.2015 | Magnetic Resonance

Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning – an ultrahigh-field MR pilot study

verfasst von: Tim Sinnecker, Timm Oberwahrenbrock, Imke Metz, Hanna Zimmermann, Caspar F. Pfueller, Lutz Harms, Klemens Ruprecht, Caren Ramien, Katrin Hahn, Wolfgang Brück, Thoralf Niendorf, Friedemann Paul, Alexander U. Brandt, Jan Dörr, Jens Wuerfel

Erschienen in: European Radiology | Ausgabe 1/2015

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Abstract

Objective

To investigate posterior visual pathway damage in multiple sclerosis using ultrahigh-field magnetic resonance imaging (MRI) at 7 Tesla (7 T), and to determine its correlation with visual disability and retinal fibre layer (RNFL) damage detectable by optic coherence tomography (OCT).

Methods

We studied 7 T MRI, OCT, functional acuity contrast testing (FACT), and visually evoked potentials (VEP, n = 16) in 30 patients (including 26 relapsing-remitting MS and four clinically isolated syndrome patients) and 12 healthy controls to quantify RNFL thickness, optic radiation lesion volume, and optic radiation thickness.

Results

Optic radiation lesion volume was associated with thinning of the optic radiation (p < 0.001), delayed VEP (p = 0.031), and visual disability indicated by FACT (p = 0.020). Furthermore, we observed an inverse correlation between optic radiation lesion volume and RNFL thickness (p < 0.001), including patients without previous optic neuritis (p < 0.001).

Conclusions

Anterior visual pathway damage, but also (subclinical) optic radiation integrity loss detectable by 7 T MRI are common findings in MS that are mutually affected. Given the association between optic radiation damage, visual impairment, and increased VEP latency in this exploratory study of a limited sample size, clinicians should be aware of acute lesions within the optic radiation in patients with (bilateral) visual disturbances.

Key Points

• Focal destruction of the optic radiation is detectable by 7 T MRI.

• Focal optic radiation damage is common in MS.

• Optic radiation damage is associated with RNFL thinning, detectable by OCT.

• Optic radiation damage is associated with delayed VEP and visual dysfunction.

• RNFL thickness in non-optic neuritis eyes correlates with optic radiation demyelination.

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Titel: Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning – an ultrahigh-field MR pilot study
verfasst von: Tim Sinnecker
Timm Oberwahrenbrock
Imke Metz
Hanna Zimmermann
Caspar F. Pfueller
Lutz Harms
Klemens Ruprecht
Caren Ramien
Katrin Hahn
Wolfgang Brück
Thoralf Niendorf
Friedemann Paul
Alexander U. Brandt
Jan Dörr
Jens Wuerfel
Publikationsdatum: 01.01.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 1/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3358-8

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Springer Medizin

Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning – an ultrahigh-field MR pilot study

Abstract

Objective

Methods

Results

Conclusions

Key Points

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Abstract

Objective

Methods

Results

Conclusions

Key Points

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