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European Radiology

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01.04.2015 | Hepatobiliary-Pancreas

The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis

verfasst von: Chong Hyun Suh, Kyung Won Kim, Gene Young Kim, Yong Moon Shin, Pyo Nyun Kim, Seong Ho Park

Erschienen in: European Radiology | Ausgabe 4/2015

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Abstract

Objective

We aimed to systematically review the gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) findings of focal nodular hyperplasia (FNH) and its diagnostic value.

Methods

A thorough literature search was conducted in Ovid-MEDLINE and EMBASE databases to identify studies evaluating Gd-EOB-DTPA-MRI findings of FNH. To evaluate the frequency of characteristic imaging findings on Gd-EOB-DTPA-MRI, pooled proportions of high/iso signal intensity (SI) on the hepatobiliary phase (HBP), arterial enhancement, high/iso SI on the portal-venous phase (PVP) or equilibrium phase (EP), and the central scar were calculated. Meta-analysis was performed to evaluate the diagnostic accuracy of high/iso SI on HBP for distinguishing FNH from hepatocellular adenoma.

Results

A review of 96 articles identified ten eligible articles with 304 patients with FNHs for meta-analysis. Pooled proportion of the Gd-EOB-DTPA-MRI findings showed that high/iso SI on the HBP, arterial enhancement, and high/iso SI on the PVP/EP were observed in 93% (95% CI, 90–97%), 99% (95% CI, 97–100%), and 97% (95% CI, 95–99%) of FNHs, respectively, while a central scar was observed in 61% of FNHs (95% CI, 47–74%). High/iso SI on the HBP was highly accurate for distinguishing FNH from hepatocellular adenoma, with a summary sensitivity of 93.9% (95% CI, 89.1–97.1%) and a specificity of 95.3% (95% CI, 88.4–98.7%).

Conclusions

High/iso SI on the HBP of Gd-EOB-DTPA-MRI is characteristic and a prevalent finding of FNHs and can be helpful in the management of patients with FNH.

Key Points

• The vast majority (94–97 %) of FNHs show high/iso SI on HBP.

• High/iso SI on HBP was accurate for distinguishing FNH from hepatocellular adenoma.

• HBP of Gd-EOB-DTPA-MRI can reduce unnecessary biopsies for the diagnosis of FNHs.

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Titel: The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis
verfasst von: Chong Hyun Suh
Kyung Won Kim
Gene Young Kim
Yong Moon Shin
Pyo Nyun Kim
Seong Ho Park
Publikationsdatum: 01.04.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 4/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3499-9

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The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis

Abstract

Objective

Methods

Results

Conclusions

Key Points

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Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

Key Points

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